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Dylan J Taatjes

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentChemistry & Biochemistry
ORCID ORCID Icon0000-0003-4444-5688 Additional info

    Collapse Research 
    Collapse research activities and funding
    R01CA127364     (TAATJES, DYLAN J)Sep 21, 2007 - Jul 31, 2012
    Mechanistic Studies of Mediator and the p53 Tumor Suppressor
    Role: Principal Investigator

    R03AG035228     (TAATJES, DYLAN J)Feb 1, 2010 - Jan 31, 2012
    Biochemical Analysis of a p53 Isoform that Accelerates Mammalian Aging
    Role: Principal Investigator

    R01CA170741     (SCHEPARTZ, ALANNA)Aug 1, 2012 - May 31, 2017
    Directing the Mediator Complex: Bivalent approaches to Reconstituting or Inhibiti
    Role: Co-Principal Investigator

    R21CA175849     (RANISH, JEFFREY A)Mar 8, 2013 - Feb 28, 2015
    Mapping the Dynamic Architecture of the Human Mediator Complex
    Role: Co-Principal Investigator

    R21CA205912     (OLD, WILLIAM MARLAND)Apr 1, 2016 - Mar 31, 2018
    Mediator Kinases and AML Cell Proliferation
    Role: Co-Principal Investigator

    R01GM117370     (TAATJES, DYLAN J)Jun 28, 2016 - Mar 31, 2020
    Mediator Kinases and Transcription Regulation
    Role: Principal Investigator

    S10OD021603     (TAATJES, DYLAN J)Jul 1, 2016 - Jun 30, 2017
    Microscale Thermophoresis - Monolith NT.115
    Role: Principal Investigator

    R01GM110064     (RANISH, JEFFREY A)Sep 22, 2016 - May 31, 2020
    TFIIH and Transcription Regulation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. Mol Cell Biol. 2017 Jul 01; 37(13). PMID: 28416637.
      View in: PubMed
    2. Alhadid Y, Chung S, Lerner E, Taatjes DJ, Borukhov S, Weiss S. Studying transcription initiation by RNA polymerase with diffusion-based single-molecule fluorescence. Protein Sci. 2017 Jul; 26(7):1278-1290. PMID: 28370550.
      View in: PubMed
    3. Lerner E, Chung S, Allen BL, Wang S, Lee J, Lu SW, Grimaud LW, Ingargiola A, Michalet X, Alhadid Y, Borukhov S, Strick TR, Taatjes DJ, Weiss S. Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43):E6562-E6571. PMID: 27729537.
      View in: PubMed
    4. Passmore LA, Taatjes DJ. Macromolecular Complexes in Transcription and Co-Transcriptional RNA Processing. J Mol Biol. 2016 Jun 19; 428(12):2539-41. PMID: 27155574.
      View in: PubMed
    5. Poss ZC, Ebmeier CC, Odell AT, Tangpeerachaikul A, Lee T, Pelish HE, Shair MD, Dowell RD, Old WM, Taatjes DJ. Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Rep. 2016 Apr 12; 15(2):436-50. PMID: 27050516; PMCID: PMC4833653.
    6. Rubin JD, Taatjes DJ. Molecular biology: Mediating transcription and RNA export. Nature. 2015 Oct 08; 526(7572):199-200. PMID: 26450052; PMCID: PMC4959006.
    7. Luo J, Cimermancic P, Viswanath S, Ebmeier CC, Kim B, Dehecq M, Raman V, Greenberg CH, Pellarin R, Sali A, Taatjes DJ, Hahn S, Ranish J. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Mol Cell. 2015 Sep 03; 59(5):794-806. PMID: 26340423; PMCID: PMC4560838.
    8. Fant CB, Taatjes DJ. All in the family: a portrait of a nuclear receptor co-activator complex. Mol Cell. 2015 Mar 19; 57(6):952-4. PMID: 25794613; PMCID: PMC4963822.
    9. Allen BL, Taatjes DJ. The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol. 2015 Mar; 16(3):155-66. PMID: 25693131; PMCID: PMC4963239.
    10. Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nat Struct Mol Biol. 2014 Oct; 21(10):876-83. PMID: 25173174; PMCID: PMC4189995.
    11. Sennett NC, Taatjes DJ. Mediator redefines itself. Cell Res. 2014 Jul; 24(7):775-6. PMID: 24913192; PMCID: PMC4085770.
    12. Poss ZC, Ebmeier CC, Taatjes DJ. The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48(6):575-608. PMID: 24088064; PMCID: PMC3852498.
    13. Lin SC, Taatjes DJ. ?Np53 and aging. Aging (Albany NY). 2013 Oct; 5(10):717-8. PMID: 24145197; PMCID: PMC3838772.
    14. Phillips AJ, Taatjes DJ. Small molecule probes to target the human Mediator complex. Isr J Chem. 2013 Aug; 53(8):588-595. PMID: 25705053.
      View in: PubMed
    15. Lin SC, Karoly ED, Taatjes DJ. The human ?Np53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function. Aging Cell. 2013 Oct; 12(5):863-72. PMID: 23734707; PMCID: PMC3773055.
    16. He Y, Fang J, Taatjes DJ, Nogales E. Structural visualization of key steps in human transcription initiation. Nature. 2013 Mar 28; 495(7442):481-6. PMID: 23446344; PMCID: PMC3612373.
    17. Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature. 2013 Feb 28; 494(7438):497-501. PMID: 23417068; PMCID: PMC4109059.
    18. Bancerek J, Poss ZC, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dölken L, Strobl B, Müller M, Taatjes DJ, Kovarik P. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity. 2013 Feb 21; 38(2):250-62. PMID: 23352233; PMCID: PMC3580287.
    19. Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev. 2013 Jan 15; 27(2):151-6. PMID: 23322298; PMCID: PMC3566307.
    20. Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev. 2012 Dec 15; 26(24):2690-5. PMID: 23249733; PMCID: PMC3533074.
    21. Bernecky C, Taatjes DJ. Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly. J Mol Biol. 2012 Apr 13; 417(5):387-94. PMID: 22343046; PMCID: PMC4582759.
    22. Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7. PMID: 21596049; PMCID: PMC3157753.
    23. Bernecky C, Grob P, Ebmeier CC, Nogales E, Taatjes DJ. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biol. 2011 Mar; 9(3):e1000603. PMID: 21468301; PMCID: PMC3066130.
    24. Knuesel MT, Taatjes DJ. Mediator and post-recruitment regulation of RNA polymerase II. Transcription. 2011 Jan-Feb; 2(1):28-31. PMID: 21326907; PMCID: PMC3023644.
    25. De Carlo S, Lin SC, Taatjes DJ, Hoenger A. Molecular basis of transcription initiation in Archaea. Transcription. 2010 Sep-Oct; 1(2):103-11. PMID: 21326901; PMCID: PMC3023638.
    26. Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010 Sep 23; 467(7314):430-5. PMID: 20720539; PMCID: PMC2953795.
    27. Ebmeier CC, Taatjes DJ. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11283-8. PMID: 20534441; PMCID: PMC2895140.
    28. Meyer KD, Lin SC, Bernecky C, Gao Y, Taatjes DJ. p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol. 2010 Jun; 17(6):753-60. PMID: 20453859; PMCID: PMC2932482.
    29. Taatjes DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci. 2010 Jun; 35(6):315-22. PMID: 20299225; PMCID: PMC2891401.
    30. Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol. 2010 Feb; 17(2):194-201. PMID: 20098423; PMCID: PMC2920286.
    31. Knuesel MT, Meyer KD, Bernecky C, Taatjes DJ. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev. 2009 Feb 15; 23(4):439-51. PMID: 19240132; PMCID: PMC2648653.
    32. Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol. 2009 Feb; 29(3):650-61. PMID: 19047373; PMCID: PMC2630685.
    33. Panning B, Taatjes DJ. Transcriptional regulation: it takes a village. Mol Cell. 2008 Sep 05; 31(5):622-9. PMID: 18775322; PMCID: PMC4479147.
    34. Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J. 2008 May 21; 27(10):1447-57. PMID: 18418385; PMCID: PMC2396395.
    35. Taatjes DJ, Schneider-Poetsch T, Tjian R. Distinct conformational states of nuclear receptor-bound CRSP-Med complexes. Nat Struct Mol Biol. 2004 Jul; 11(7):664-71. PMID: 15195149.
      View in: PubMed
    36. Taatjes DJ, Tjian R. Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex. Mol Cell. 2004 Jun 04; 14(5):675-83. PMID: 15175162.
      View in: PubMed
    37. Taatjes DJ, Marr MT, Tjian R. Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol. 2004 May; 5(5):403-10. PMID: 15122353.
      View in: PubMed
    38. Näär AM, Taatjes DJ, Zhai W, Nogales E, Tjian R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 2002 Jun 01; 16(11):1339-44. PMID: 12050112; PMCID: PMC186316.
    39. Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R. Structure, function, and activator-induced conformations of the CRSP coactivator. Science. 2002 Feb 08; 295(5557):1058-62. PMID: 11834832.
      View in: PubMed
    40. Dernell WS, Powers BE, Taatjes DJ, Cogan P, Gaudiano G, Koch TH. Evaluation of the epidoxorubicin--formaldehyde conjugate, epidoxoform, in a mouse mammary carcinoma model. Cancer Invest. 2002; 20(5-6):713-24. PMID: 12197227.
      View in: PubMed
    41. Taatjes DJ, Koch TH. Nuclear targeting and retention of anthracycline antitumor drugs in sensitive and resistant tumor cells. Curr Med Chem. 2001 Jan; 8(1):15-29. PMID: 11172689.
      View in: PubMed
    42. Kato S, Burke PJ, Fenick DJ, Taatjes DJ, Bierbaum VM, Koch TH. Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. Chem Res Toxicol. 2000 Jun; 13(6):509-16. PMID: 10858324.
      View in: PubMed
    43. Podell ER, Harrington DJ, Taatjes DJ, Koch TH. Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells. Acta Crystallogr D Biol Crystallogr. 1999 Sep; 55(Pt 9):1516-23. PMID: 10489446.
      View in: PubMed
    44. Taatjes DJ, Fenick DJ, Koch TH. Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines. Chem Res Toxicol. 1999 Jul; 12(7):588-96. PMID: 10409398.
      View in: PubMed
    45. Taatjes DJ, Koch TH. Growth inhibition, nuclear uptake, and retention of anthracycline-formaldehyde conjugates in prostate cancer cells relative to clinical anthracyclines. Anticancer Res. 1999 Mar-Apr; 19(2A):1201-8. PMID: 10368676.
      View in: PubMed
    46. Taatjes DJ, Fenick DJ, Gaudiano G, Koch TH. A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer. Curr Pharm Des. 1998 Jun; 4(3):203-18. PMID: 10197040.
      View in: PubMed
    47. Taatjes DJ, Fenick DJ, Koch TH. Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells. J Med Chem. 1998 Apr 09; 41(8):1306-14. PMID: 9548820.
      View in: PubMed
    48. Sritharan KC, Quinn AS, Taatjes DJ, Jena BP. Binding contribution between synaptic vesicle membrane and plasma membrane proteins in neurons: an AFM study. Cell Biol Int. 1998; 22(9-10):649-55. PMID: 10452835.
      View in: PubMed
    49. Taatjes DJ, Gaudiano G, Koch TH. Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron. Chem Res Toxicol. 1997 Sep; 10(9):953-61. PMID: 9305576.
      View in: PubMed
    50. Fenick DJ, Taatjes DJ, Koch TH. Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells. J Med Chem. 1997 Aug 01; 40(16):2452-61. PMID: 9258351.
      View in: PubMed
    51. Taatjes DJ, Gaudiano G, Resing K, Koch TH. Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem. 1997 Apr 11; 40(8):1276-86. PMID: 9111302.
      View in: PubMed
    52. Taatjes DJ, Gaudiano G, Resing K, Koch TH. Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem. 1996 Oct 11; 39(21):4135-8. PMID: 8863788.
      View in: PubMed
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