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Dylan J Taatjes

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/492-6929
ORCID ORCID Icon0000-0003-4444-5688 Additional info

    Collapse Research 
    Collapse research activities and funding
    R01CA127364     (TAATJES, DYLAN J)Sep 21, 2007 - Jul 31, 2012
    NIH/NCI
    Mechanistic Studies of Mediator and the p53 Tumor Suppressor
    Role: Principal Investigator

    R03AG035228     (TAATJES, DYLAN J)Feb 1, 2010 - Jan 31, 2012
    NIH/NIA
    Biochemical Analysis of a p53 Isoform that Accelerates Mammalian Aging
    Role: Principal Investigator

    R01CA170741     (SCHEPARTZ, ALANNA)Aug 1, 2012 - May 31, 2017
    NIH/NCI
    Directing the Mediator Complex: Bivalent approaches to Reconstituting or Inhibiti
    Role: Co-Principal Investigator

    R21CA175849     (RANISH, JEFFREY A)Mar 8, 2013 - Feb 28, 2015
    NIH/NCI
    Mapping the Dynamic Architecture of the Human Mediator Complex
    Role: Co-Principal Investigator

    R21CA205912     (TAATJES, DYLAN J)Apr 1, 2016 - Mar 31, 2018
    NIH/NCI
    Mediator Kinases and AML Cell Proliferation
    Role: Co-Principal Investigator

    R01GM117370     (TAATJES, DYLAN J)Jun 28, 2016 - Mar 31, 2020
    NIH/NIGMS
    Mediator Kinases and Transcription Regulation
    Role: Principal Investigator

    S10OD021603     (TAATJES, DYLAN J)Jul 1, 2016 - Jun 30, 2017
    NIH
    Microscale Thermophoresis - Monolith NT.115
    Role: Principal Investigator

    R01GM110064     (TAATJES, DYLAN J)Sep 22, 2016 - May 31, 2020
    NIH/NIGMS
    TFIIH and Transcription Regulation
    Role: Principal Investigator

    R03AG061466     (DOWELL-DEEN, ROBIN DEANNE)Feb 1, 2019 - Dec 31, 2020
    NIH/NIA
    How does the naturally-occurring delta-Np53 isoform influence aging?
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Guard SE, Poss ZC, Ebmeier CC, Pagratis M, Simpson H, Taatjes DJ, Old WM. The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. Sci Rep. 2019 Apr 25; 9(1):6539. PMID: 31024071.
      View in: PubMed
    2. Fant CB, Taatjes DJ. Regulatory functions of the Mediator kinases CDK8 and CDK19. Transcription. 2019 04; 10(2):76-90. PMID: 30585107.
      View in: PubMed
    3. Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Cell. 2018 Dec 13; 175(7):1842-1855.e16. PMID: 30449618.
      View in: PubMed
    4. Goodrich J, Taatjes D. Transcription regulation enters a new phase. Nature. 2018 06; 558(7709):197-198. PMID: 29895907.
      View in: PubMed
    5. Rimel JK, Taatjes DJ. The essential and multifunctional TFIIH complex. Protein Sci. 2018 06; 27(6):1018-1037. PMID: 29664212.
      View in: PubMed
    6. Taatjes DJ. The Continuing SAGA of TFIID and RNA Polymerase II Transcription. Mol Cell. 2017 Oct 05; 68(1):1-2. PMID: 28985500.
      View in: PubMed
    7. Harper TM, Taatjes DJ. The complex structure and function of Mediator. J Biol Chem. 2018 09 07; 293(36):13778-13785. PMID: 28912271.
      View in: PubMed
    8. Ebmeier CC, Erickson B, Allen BL, Allen MA, Kim H, Fong N, Jacobsen JR, Liang K, Shilatifard A, Dowell RD, Old WM, Bentley DL, Taatjes DJ. Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications. Cell Rep. 2017 08 01; 20(5):1173-1186. PMID: 28768201.
      View in: PubMed
    9. Taatjes DJ. Transcription Factor-Mediator Interfaces: Multiple and Multi-Valent. J Mol Biol. 2017 10 13; 429(20):2996-2998. PMID: 28716626.
      View in: PubMed
    10. Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. Mol Cell Biol. 2017 07 01; 37(13). PMID: 28416637.
      View in: PubMed
    11. Alhadid Y, Chung S, Lerner E, Taatjes DJ, Borukhov S, Weiss S. Studying transcription initiation by RNA polymerase with diffusion-based single-molecule fluorescence. Protein Sci. 2017 Jul; 26(7):1278-1290. PMID: 28370550.
      View in: PubMed
    12. Lerner E, Chung S, Allen BL, Wang S, Lee J, Lu SW, Grimaud LW, Ingargiola A, Michalet X, Alhadid Y, Borukhov S, Strick TR, Taatjes DJ, Weiss S. Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):E6562-E6571. PMID: 27729537.
      View in: PubMed
    13. Passmore LA, Taatjes DJ. Macromolecular Complexes in Transcription and Co-Transcriptional RNA Processing. J Mol Biol. 2016 06 19; 428(12):2539-2541. PMID: 27155574.
      View in: PubMed
    14. Poss ZC, Ebmeier CC, Odell AT, Tangpeerachaikul A, Lee T, Pelish HE, Shair MD, Dowell RD, Old WM, Taatjes DJ. Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Rep. 2016 Apr 12; 15(2):436-50. PMID: 27050516.
      View in: PubMed
    15. Rubin JD, Taatjes DJ. Molecular biology: Mediating transcription and RNA export. Nature. 2015 Oct 08; 526(7572):199-200. PMID: 26450052.
      View in: PubMed
    16. Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, Si C, Ebmeier CC, Bronson RT, Krivtsov AV, Myers AG, Kohl NE, Kung AL, Armstrong SA, Lemieux ME, Taatjes DJ, Shair MD. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 2015 Oct 08; 526(7572):273-276. PMID: 26416749.
      View in: PubMed
    17. Luo J, Cimermancic P, Viswanath S, Ebmeier CC, Kim B, Dehecq M, Raman V, Greenberg CH, Pellarin R, Sali A, Taatjes DJ, Hahn S, Ranish J. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Mol Cell. 2015 Sep 03; 59(5):794-806. PMID: 26340423.
      View in: PubMed
    18. Fant CB, Taatjes DJ. All in the family: a portrait of a nuclear receptor co-activator complex. Mol Cell. 2015 Mar 19; 57(6):952-954. PMID: 25794613.
      View in: PubMed
    19. Allen BL, Taatjes DJ. The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol. 2015 Mar; 16(3):155-66. PMID: 25693131.
      View in: PubMed
    20. Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nat Struct Mol Biol. 2014 Oct; 21(10):876-83. PMID: 25173174.
      View in: PubMed
    21. Sennett NC, Taatjes DJ. Mediator redefines itself. Cell Res. 2014 Jul; 24(7):775-6. PMID: 24913192.
      View in: PubMed
    22. Poss ZC, Ebmeier CC, Taatjes DJ. The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48(6):575-608. PMID: 24088064.
      View in: PubMed
    23. Lin SC, Taatjes DJ. ?Np53 and aging. Aging (Albany NY). 2013 Oct; 5(10):717-8. PMID: 24145197.
      View in: PubMed
    24. Phillips AJ, Taatjes DJ. Small molecule probes to target the human Mediator complex. Isr J Chem. 2013 Aug; 53(8):588-595. PMID: 25705053.
      View in: PubMed
    25. Lin SC, Karoly ED, Taatjes DJ. The human ?Np53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function. Aging Cell. 2013 Oct; 12(5):863-72. PMID: 23734707.
      View in: PubMed
    26. He Y, Fang J, Taatjes DJ, Nogales E. Structural visualization of key steps in human transcription initiation. Nature. 2013 Mar 28; 495(7442):481-6. PMID: 23446344.
      View in: PubMed
    27. Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature. 2013 Feb 28; 494(7438):497-501. PMID: 23417068.
      View in: PubMed
    28. Bancerek J, Poss ZC, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dölken L, Strobl B, Müller M, Taatjes DJ, Kovarik P. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity. 2013 Feb 21; 38(2):250-62. PMID: 23352233.
      View in: PubMed
    29. Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev. 2013 Jan 15; 27(2):151-6. PMID: 23322298.
      View in: PubMed
    30. Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev. 2012 Dec 15; 26(24):2690-5. PMID: 23249733.
      View in: PubMed
    31. Bernecky C, Taatjes DJ. Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly. J Mol Biol. 2012 Apr 13; 417(5):387-94. PMID: 22343046.
      View in: PubMed
    32. Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7. PMID: 21596049.
      View in: PubMed
    33. Bernecky C, Grob P, Ebmeier CC, Nogales E, Taatjes DJ. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biol. 2011 Mar; 9(3):e1000603. PMID: 21468301.
      View in: PubMed
    34. Knuesel MT, Taatjes DJ. Mediator and post-recruitment regulation of RNA polymerase II. Transcription. 2011 Jan-Feb; 2(1):28-31. PMID: 21326907.
      View in: PubMed
    35. De Carlo S, Lin SC, Taatjes DJ, Hoenger A. Molecular basis of transcription initiation in Archaea. Transcription. 2010 Sep-Oct; 1(2):103-11. PMID: 21326901.
      View in: PubMed
    36. Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010 Sep 23; 467(7314):430-5. PMID: 20720539.
      View in: PubMed
    37. Ebmeier CC, Taatjes DJ. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11283-8. PMID: 20534441.
      View in: PubMed
    38. Meyer KD, Lin SC, Bernecky C, Gao Y, Taatjes DJ. p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol. 2010 Jun; 17(6):753-60. PMID: 20453859.
      View in: PubMed
    39. Taatjes DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci. 2010 Jun; 35(6):315-22. PMID: 20299225.
      View in: PubMed
    40. Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol. 2010 Feb; 17(2):194-201. PMID: 20098423.
      View in: PubMed
    41. Knuesel MT, Meyer KD, Bernecky C, Taatjes DJ. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev. 2009 Feb 15; 23(4):439-51. PMID: 19240132.
      View in: PubMed
    42. Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol. 2009 Feb; 29(3):650-61. PMID: 19047373.
      View in: PubMed
    43. Panning B, Taatjes DJ. Transcriptional regulation: it takes a village. Mol Cell. 2008 Sep 05; 31(5):622-9. PMID: 18775322.
      View in: PubMed
    44. Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J. 2008 May 21; 27(10):1447-57. PMID: 18418385.
      View in: PubMed
    45. Taatjes DJ, Schneider-Poetsch T, Tjian R. Distinct conformational states of nuclear receptor-bound CRSP-Med complexes. Nat Struct Mol Biol. 2004 Jul; 11(7):664-71. PMID: 15195149.
      View in: PubMed
    46. Taatjes DJ, Tjian R. Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex. Mol Cell. 2004 Jun 04; 14(5):675-83. PMID: 15175162.
      View in: PubMed
    47. Taatjes DJ, Marr MT, Tjian R. Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol. 2004 May; 5(5):403-10. PMID: 15122353.
      View in: PubMed
    48. Näär AM, Taatjes DJ, Zhai W, Nogales E, Tjian R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 2002 Jun 01; 16(11):1339-44. PMID: 12050112.
      View in: PubMed
    49. Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R. Structure, function, and activator-induced conformations of the CRSP coactivator. Science. 2002 Feb 08; 295(5557):1058-62. PMID: 11834832.
      View in: PubMed
    50. Dernell WS, Powers BE, Taatjes DJ, Cogan P, Gaudiano G, Koch TH. Evaluation of the epidoxorubicin--formaldehyde conjugate, epidoxoform, in a mouse mammary carcinoma model. Cancer Invest. 2002; 20(5-6):713-24. PMID: 12197227.
      View in: PubMed
    51. Taatjes DJ, Koch TH. Nuclear targeting and retention of anthracycline antitumor drugs in sensitive and resistant tumor cells. Curr Med Chem. 2001 Jan; 8(1):15-29. PMID: 11172689.
      View in: PubMed
    52. Kato S, Burke PJ, Fenick DJ, Taatjes DJ, Bierbaum VM, Koch TH. Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. Chem Res Toxicol. 2000 Jun; 13(6):509-16. PMID: 10858324.
      View in: PubMed
    53. Podell ER, Harrington DJ, Taatjes DJ, Koch TH. Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells. Acta Crystallogr D Biol Crystallogr. 1999 Sep; 55(Pt 9):1516-23. PMID: 10489446.
      View in: PubMed
    54. Taatjes DJ, Fenick DJ, Koch TH. Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines. Chem Res Toxicol. 1999 Jul; 12(7):588-96. PMID: 10409398.
      View in: PubMed
    55. Taatjes DJ, Koch TH. Growth inhibition, nuclear uptake, and retention of anthracycline-formaldehyde conjugates in prostate cancer cells relative to clinical anthracyclines. Anticancer Res. 1999 Mar-Apr; 19(2A):1201-8. PMID: 10368676.
      View in: PubMed
    56. Taatjes DJ, Fenick DJ, Gaudiano G, Koch TH. A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer. Curr Pharm Des. 1998 Jun; 4(3):203-18. PMID: 10197040.
      View in: PubMed
    57. Taatjes DJ, Fenick DJ, Koch TH. Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells. J Med Chem. 1998 Apr 09; 41(8):1306-14. PMID: 9548820.
      View in: PubMed
    58. Sritharan KC, Quinn AS, Taatjes DJ, Jena BP. Binding contribution between synaptic vesicle membrane and plasma membrane proteins in neurons: an AFM study. Cell Biol Int. 1998; 22(9-10):649-55. PMID: 10452835.
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    59. Taatjes DJ, Gaudiano G, Koch TH. Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron. Chem Res Toxicol. 1997 Sep; 10(9):953-61. PMID: 9305576.
      View in: PubMed
    60. Fenick DJ, Taatjes DJ, Koch TH. Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells. J Med Chem. 1997 Aug 01; 40(16):2452-61. PMID: 9258351.
      View in: PubMed
    61. Taatjes DJ, Gaudiano G, Resing K, Koch TH. Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem. 1997 Apr 11; 40(8):1276-86. PMID: 9111302.
      View in: PubMed
    62. Taatjes DJ, Gaudiano G, Resing K, Koch TH. Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem. 1996 Oct 11; 39(21):4135-8. PMID: 8863788.
      View in: PubMed
    63. Roth J, Taatjes DJ, Lucocq JM, Weinstein J, Paulson JC. Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell. 1985 Nov; 43(1):287-95. PMID: 3000603.
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