Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

Jelena Klawitter

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Sundaram SS, Halbower AC, Klawitter J, Pan Z, Robbins K, Capocelli KE, Sokol RJ. Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2018 May 08. PMID: 29752170.
      View in: PubMed
    2. Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 Feb 01. PMID: 29389016.
      View in: PubMed
    3. Persson JN, Baird CH, Tong S, Urban TT, Klawitter J, Wischmeyer PE, Davidson JA. Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. Pediatr Res. 2018 Apr; 83(4):858-865. PMID: 29278640.
      View in: PubMed
    4. Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res. 2018 Feb; 59(2):380-390. PMID: 29229740.
      View in: PubMed
    5. Alloway RR, Vinks AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J, Klawitter J, Christians U. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS Med. 2017 Nov; 14(11):e1002428. PMID: 29135993.
      View in: PubMed
    6. Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2018 May; 103(5):888-898. PMID: 28857147.
      View in: PubMed
    7. Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct; 39(5):556-564. PMID: 28640062.
      View in: PubMed
    8. Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 Sep 05; 7(1):10540. PMID: 28874678.
      View in: PubMed
    9. Klawitter J, Hildreth KL, Christians U, Kohrt WM, Moreau KL. A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition. Physiol Rep. 2017 Sep; 5(17). PMID: 28904082.
      View in: PubMed
    10. Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 Sep; 95(9):1009-1018. PMID: 28467859.
      View in: PubMed
    11. Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017 09; 118(9):2933-2940. PMID: 28230282.
      View in: PubMed
    12. Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB. Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data. J Proteome Res. 2017 04 07; 16(4):1515-1525. PMID: 28314371.
      View in: PubMed
    13. Tavera-Mendoza LE, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, Cameron LA, Ficarro SB, Marto JA, Klawitter J, Brown M. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2186-E2194. PMID: 28242709.
      View in: PubMed
    14. Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN. Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med. 2016 12; 121:59-66. PMID: 27888993.
      View in: PubMed
    15. Sundaram SS, Halbower A, Pan Z, Robbins K, Capocelli KE, Klawitter J, Shearn CT, Sokol RJ. Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease. J Hepatol. 2016 Sep; 65(3):560-9. PMID: 27501738.
      View in: PubMed
    16. Davidson JA, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer PE, Klawitter J. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. PLoS One. 2016; 11(7):e0158981. PMID: 27384524; PMCID: PMC4934870.
    17. Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U. Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent? Clin Biochem. 2016 Sep; 49(13-14):955-61. PMID: 27288551.
      View in: PubMed
    18. Christians U, Klawitter J, Klawitter J. Biomarkers in Transplantation--Proteomics and Metabolomics. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S70-4. PMID: 26418702; PMCID: PMC4769975 [Available on 04/01/17].
    19. Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 2016; 51(6):366-73. PMID: 26950528.
      View in: PubMed
    20. Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish. J Chromatogr A. 2016 Feb 05; 1432:58-72. PMID: 26787163.
      View in: PubMed
    21. Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682; PMCID: PMC4665776.
    22. Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 04; 10(9):1534-41. PMID: 26224879; PMCID: PMC4559520.
    23. Jablonski KL, Klawitter J, Chonchol M, Bassett CJ, Racine ML, Seals DR. Effect of dietary sodium restriction on human urinary metabolomic profiles. Clin J Am Soc Nephrol. 2015 Jul 07; 10(7):1227-34. PMID: 25901092; PMCID: PMC4491302.
    24. Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15; 446:43-53. PMID: 25871999.
      View in: PubMed
    25. Quillinan N, Grewal H, Klawitter J, Herson PS. Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion(1,2,3). eNeuro. 2014 Nov-Dec; 1(1). PMID: 26464961; PMCID: PMC4596140.
    26. Klawitter J, Reed-Gitomer BY, McFann K, Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M, Christians U, Schrier RW. Endothelial dysfunction and oxidative stress in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1198-206. PMID: 25234311; PMCID: PMC4254971.
    27. Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep; 121(3):469-81. PMID: 24809976; PMCID: PMC4165799.
    28. Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boernsen KO. Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct; 406(25):6399-408. PMID: 25116600.
      View in: PubMed
    29. Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC. Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia. Am J Hematol. 2014 Sep; 89(9):896-903. PMID: 24891015; PMCID: PMC4134764.
    30. Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014; 9(1):e86202. PMID: 24497939; PMCID: PMC3907404.
    31. Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2014 Jun; 55(6):1139-49. PMID: 24343898; PMCID: PMC4031945.
    32. Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christians U, Thurman JM. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol. 2013 Nov; 24(11):1849-62. PMID: 24092930; PMCID: PMC3810078.
    33. Fernandez-Bustamante A, Klawitter J, Wilson P, Elkins ND, Agazio A, Shibata T, Uchida K, Christians U, Repine JE. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation. 2013 Oct; 36(5):1030-40. PMID: 23616184.
      View in: PubMed
    34. Klawitter J, Zafar I, Klawitter J, Pennington AT, Klepacki J, Gitomer BY, Schrier RW, Christians U, Edelstein CL. Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease. BMC Nephrol. 2013 Jul 31; 14:165. PMID: 23902712; PMCID: PMC3751441.
    35. Shimizu T, Macey TA, Quillinan N, Klawitter J, Perraud AL, Traystman RJ, Herson PS. Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1549-55. PMID: 23801245; PMCID: PMC3790922.
    36. Klepacki J, Brunner N, Schmitz V, Klawitter J, Christians U, Klawitter J. Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma. Clin Chim Acta. 2013 Jun 05; 421:91-7. PMID: 23499573; PMCID: PMC4033670.
    37. Herson PS, Bombardier CG, Parker SM, Shimizu T, Klawitter J, Klawitter J, Quillinan N, Exo JL, Goldenberg NA, Traystman RJ. Experimental pediatric arterial ischemic stroke model reveals sex-specific estrogen signaling. Stroke. 2013 Mar; 44(3):759-63. PMID: 23349190; PMCID: PMC3930081.
    38. Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis? Transpl Int. 2013 Mar; 26(3):225-41. PMID: 23350848; PMCID: PMC4006577.
    39. Niederlechner S, Klawitter J, Baird C, Kallweit AR, Christians U, Wischmeyer PE. Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. PLoS One. 2012; 7(11):e50185. PMID: 23185570; PMCID: PMC3502344.
    40. Christians U, Klepacki J, Shokati T, Klawitter J, Klawitter J. Mass Spectrometry-Based Multiplexing for the Analysis of Biomarkers in Drug Development and Clinical Diagnostics- How Much is too Much? Microchem J. 2012 Nov 01; 105:32-38. PMID: 23645936.
      View in: PubMed
    41. Bohra R, Schöning W, Klawitter J, Brunner N, Schmitz V, Shokati T, Lawrence R, Arbelaez MF, Schniedewind B, Christians U, Klawitter J. Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PLoS One. 2012; 7(10):e48063. PMID: 23118926; PMCID: PMC3485290.
    42. Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res. 2012 Nov 02; 11(11):5135-44. PMID: 23057591; PMCID: PMC3831655.
    43. Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc Res. 2013 Jan 01; 97(1):66-76. PMID: 23015639.
      View in: PubMed
    44. Tanabe K, Lanaspa MA, Kitagawa W, Rivard CJ, Miyazaki M, Klawitter J, Schreiner GF, Saleem MA, Mathieson PW, Makino H, Johnson RJ, Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse. Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1151-60. PMID: 22338086; PMCID: PMC3362173.
    45. Sirota JC, Klawitter J, Edelstein CL. Biomarkers of acute kidney injury. J Toxicol. 2011; 2011:328120. PMID: 22131986; PMCID: PMC3205656.
    46. Klepacki J, Klawitter J, Bendrick-Peart J, Schniedewind B, Heischmann S, Shokati T, Christians U, Klawitter J. A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 01; 883-884:113-9. PMID: 21839692; PMCID: PMC3232328.
    47. Christians U, Klawitter J, Hornberger A, Klawitter J. How unbiased is non-targeted metabolomics and is targeted pathway screening the solution? Curr Pharm Biotechnol. 2011 Jul; 12(7):1053-66. PMID: 21466457.
      View in: PubMed
    48. Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel HM, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom. 2011 Jul; 46(7):615-24. PMID: 21671437.
      View in: PubMed
    49. Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U. Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer. 2011 Dec 15; 129(12):2945-57. PMID: 21509784.
      View in: PubMed
    50. Klawitter J, Haschke M, Shokati T, Klawitter J, Christians U. Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared. Rapid Commun Mass Spectrom. 2011 Feb 28; 25(4):463-8. PMID: 21259353.
      View in: PubMed
    51. Christians U, Klawitter J, Klawitter J, Brunner N, Schmitz V. Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions. Expert Opin Drug Metab Toxicol. 2011 Feb; 7(2):175-200. PMID: 21241200; PMCID: PMC3079351.
    52. Klawitter J, Haschke M, Kahle C, Dingmann C, Klawitter J, Leibfritz D, Christians U. Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. Br J Clin Pharmacol. 2010 Aug; 70(2):241-51. PMID: 20653677; PMCID: PMC2911554.
    53. Klawitter J, Gottschalk S, Hainz C, Leibfritz D, Christians U, Serkova NJ. Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism. Chem Res Toxicol. 2010 Mar 15; 23(3):608-19. PMID: 20148532; PMCID: PMC2841482.
    54. Klawitter J, Shokati T, Moll V, Christians U, Klawitter J. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. Breast Cancer Res. 2010; 12(2):R16. PMID: 20205716; PMCID: PMC2879560.
    55. Christians U, Klawitter J, Clavijo CF. Bioequivalence testing of immunosuppressants: concepts and misconceptions. Kidney Int Suppl. 2010 Mar; (115):S1-7. PMID: 20150904.
      View in: PubMed
    56. Faeste CK, Jonscher KR, Sit L, Klawitter J, Løvberg KE, Moen LH. Differentiating cross-reacting allergens in the immunological analysis of celery (Apium graveolens) by mass spectrometry. J AOAC Int. 2010 Mar-Apr; 93(2):451-61. PMID: 20480890.
      View in: PubMed
    57. Klawitter J, Klawitter J, Kushner E, Jonscher K, Bendrick-Peart J, Leibfritz D, Christians U, Schmitz V. Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study. J Proteome Res. 2010 Feb 05; 9(2):865-75. PMID: 19994912; PMCID: PMC3955702.
    58. Klawitter J, Zhang YL, Klawitter J, Anderson N, Serkova NJ, Christians U. Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture. Biomed Chromatogr. 2009 Dec; 23(12):1251-8. PMID: 19517424; PMCID: PMC3044679.
    59. Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res. 2009 Sep 15; 69(18):7262-9. PMID: 19738065; PMCID: PMC2745506.
    60. Klawitter J, Kominsky DJ, Brown JL, Klawitter J, Christians U, Leibfritz D, Melo JV, Eckhardt SG, Serkova NJ. Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells. Br J Pharmacol. 2009 Sep; 158(2):588-600. PMID: 19663881; PMCID: PMC2757699.
    61. Kominsky DJ, Klawitter J, Brown JL, Boros LG, Melo JV, Eckhardt SG, Serkova NJ. Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res. 2009 May 15; 15(10):3442-50. PMID: 19401345.
      View in: PubMed
    62. Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L, Tran ZV, Leibfritz D, Christians U. Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron Exp Nephrol. 2009; 111(4):e80-91. PMID: 19293597.
      View in: PubMed
    63. Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V. Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chem Res Toxicol. 2009 Jan; 22(1):118-28. PMID: 19099400; PMCID: PMC2646011.
    64. Christians U, Schmitz V, Schöning W, Bendrick-Peart J, Klawitter J, Haschke M, Klawitter J. Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges. Ther Drug Monit. 2008 Apr; 30(2):151-8. PMID: 18367974.
      View in: PubMed
    65. Klawitter J, Schmitz V, Klawitter J, Leibfritz D, Christians U. Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS. Anal Biochem. 2007 Jun 15; 365(2):230-9. PMID: 17475198.
      View in: PubMed
    66. Haschke M, Zhang YL, Kahle C, Klawitter J, Korecka M, Shaw LM, Christians U. HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma. Clin Chem. 2007 Mar; 53(3):489-97. PMID: 17259231.
      View in: PubMed
    Klawitter's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)