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David H Wagner Jr.

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Webb Waring Center
Phone303/724-4787

    Collapse Research 
    Collapse research activities and funding
    R01DK075013     (WAGNER, DAVID H.)Aug 1, 2007 - Apr 30, 2013
    NIH/NIDDK
    CD40-Induced TCR Revision: A Mechanism for Autoimmunity
    Role: Principal Investigator

    R21AI106011     (WAGNER, DAVID H.)Aug 7, 2013 - Jul 31, 2015
    NIH/NIAID
    A unique approach to control the CD40/CD154 inflammatory axis in type 1 diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wagner DH. Overlooked Mechanisms in Type 1 Diabetes Etiology: How Unique Costimulatory Molecules Contribute to Diabetogenesis. Front Endocrinol (Lausanne). 2017; 8:208. PMID: 28878738.
      View in: PubMed
    2. Vaitaitis GM, Waid DM, Yussman MG, Wagner DH. CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes. Immunology. 2017 May 19. PMID: 28542921.
      View in: PubMed
    3. Wagner DH. Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). Clin Exp Immunol. 2016 Sep; 185(3):271-80. PMID: 27271348; PMCID: PMC4991519 [Available on 09/01/17].
    4. Vaitaitis GM, Olmstead MH, Waid DM, Carter JR, Wagner DH. A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice. Diabetologia. 2014 Nov; 57(11):2366-73. PMID: 25104468; PMCID: PMC4183717.
    5. Deng G, Carter J, Traystman RJ, Wagner DH, Herson PS. Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation. J Neuroimmunol. 2014 Sep 15; 274(1-2):132-40. PMID: 25084739; PMCID: PMC4152553.
    6. Waid DM, Schreiner T, Vaitaitis G, Carter JR, Corboy JR, Wagner DH. Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells. J Neuroimmunol. 2014 May 15; 270(1-2):75-85. PMID: 24690203; PMCID: PMC4038952.
    7. Vaitaitis GM, Wagner DH. CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression. Cell Mol Immunol. 2013 Nov; 10(6):483-9. PMID: 24037181; PMCID: PMC3818448.
    8. Vaitaitis GM, Carter JR, Waid DM, Olmstead MH, Wagner DH. An alternative role for Foxp3 as an effector T cell regulator controlled through CD40. J Immunol. 2013 Jul 15; 191(2):717-25. PMID: 23776180; PMCID: PMC3712636.
    9. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173; PMCID: PMC3641738.
    10. Wagner DH. The specific antigen approach in multiple sclerosis: can it ever be enough? Clin Immunol. 2012 Aug; 144(2):139-41. PMID: 22729132.
      View in: PubMed
    11. Vaitaitis GM, Wagner DH. Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity. PLoS One. 2012; 7(6):e38708. PMID: 22685601; PMCID: PMC3369903.
    12. Carter J, Vaitaitis GM, Waid DM, Wagner DH. CD40 engagement of CD4+ CD40+ T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance. Eur J Immunol. 2012 Feb; 42(2):424-35. PMID: 22105491.
      View in: PubMed
    13. Chow KS, Jun D, Helm KM, Wagner DH, Majka SM. Isolation & characterization of Hoechst(low) CD45(negative) mouse lung mesenchymal stem cells. J Vis Exp. 2011 Oct 26; (56):e3159. PMID: 22064472; PMCID: PMC3227187.
    14. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr; 29(4):725-35. PMID: 21312316; PMCID: PMC3322548.
    15. Vaitaitis GM, Wagner DH. CD40 glycoforms and TNF-receptors 1 and 2 in the formation of CD40 receptor(s) in autoimmunity. Mol Immunol. 2010 Aug; 47(14):2303-13. PMID: 20646763; PMCID: PMC2918662.
    16. Wagner DH. The co-evolution of our understanding of CD40 and inflammation. Diabetologia. 2009 Jun; 52(6):997-9. PMID: 19360393.
      View in: PubMed
    17. Baker RL, Wagner DH, Haskins K. CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J Autoimmun. 2008 Dec; 31(4):385-92. PMID: 18951762.
      View in: PubMed
    18. Waid DM, Vaitaitis GM, Pennock ND, Wagner DH. Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol. 2008 Aug; 84(2):431-9. PMID: 18469093; PMCID: PMC2493071.
    19. Vaitaitis GM, Wagner DH. High distribution of CD40 and TRAF2 in Th40 T cell rafts leads to preferential survival of this auto-aggressive population in autoimmunity. PLoS One. 2008 Apr 30; 3(4):e2076. PMID: 18446238; PMCID: PMC2324204.
    20. Siebert JC, Inokuma M, Waid DM, Pennock ND, Vaitaitis GM, Disis ML, Dunne JF, Wagner DH, Maecker HT. An analytical workflow for investigating cytokine profiles. Cytometry A. 2008 Apr; 73(4):289-98. PMID: 18163472.
      View in: PubMed
    21. Waid DM, Wagner RJ, Putnam A, Vaitaitis GM, Pennock ND, Calverley DC, Gottlieb P, Wagner DH. A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes. Clin Immunol. 2007 Aug; 124(2):138-48. PMID: 17560173.
      View in: PubMed
    22. Wagner DH. Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad. Clin Immunol. 2007 Apr; 123(1):1-6. PMID: 16990051.
      View in: PubMed
    23. Waid DM, Vaitaitis GM, Wagner DH. Peripheral CD4loCD40+ auto-aggressive T cell expansion during insulin-dependent diabetes mellitus. Eur J Immunol. 2004 May; 34(5):1488-97. PMID: 15114683.
      View in: PubMed
    24. Vaitaitis GM, Poulin M, Sanderson RJ, Haskins K, Wagner DH. Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. J Immunol. 2003 Apr 01; 170(7):3455-9. PMID: 12646605.
      View in: PubMed
    25. Wagner DH, Vaitaitis G, Sanderson R, Poulin M, Dobbs C, Haskins K. Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3782-7. PMID: 11891296; PMCID: PMC122601.
    26. Wagner DH, Newell E, Sanderson RJ, Freed JH, Newell MK. Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire. Int J Mol Med. 1999 Sep; 4(3):231-42. PMID: 10425271.
      View in: PubMed
    27. Huber SA, Stone JE, Wagner DH, Kupperman J, Pfeiffer L, David C, O'Brien RL, Davis GS, Newell MK. gamma delta+ T cells regulate major histocompatibility complex class II(IA and IE)-dependent susceptibility to coxsackievirus B3-induced autoimmune myocarditis. J Virol. 1999 Jul; 73(7):5630-6. PMID: 10364312; PMCID: PMC112621.
    28. Poe JC, Wagner DH, Miller RW, Stout RD, Suttles J. IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-1beta synthesis and rescue from apoptosis. J Immunol. 1997 Jul 15; 159(2):846-52. PMID: 9218603.
      View in: PubMed
    29. Wagner DH, Hagman J, Linsley PS, Hodsdon W, Freed JH, Newell MK. Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2. J Exp Med. 1996 Nov 01; 184(5):1631-8. PMID: 8920853; PMCID: PMC2192898.
    30. Wagner DH, Stout RD, Suttles J. Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur J Immunol. 1994 Dec; 24(12):3148-54. PMID: 7528671.
      View in: PubMed
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