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James D Orth

TitleAsst Professor-Research
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-5057
    Other Positions
    TitleResearch Associate
    InstitutionUniversity of Colorado Boulder
    DepartmentBiology-MCD Instruction


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Burke RT, Orth JD. Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics. J Vis Exp. 2016 May 14; (111). PMID: 27213923.
      View in: PubMed
    2. Marcus JM, Burke RT, DeSisto JA, Landesman Y, Orth JD. Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor. Sci Rep. 2015 Sep 24; 5:14391. PMID: 26399741.
      View in: PubMed
    3. Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ. In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015 Jun; 12(6):577-85. PMID: 25867850.
      View in: PubMed
    4. Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 05; 6(261):261ra152. PMID: 25378644.
      View in: PubMed
    5. Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell. 2012 Feb; 23(4):567-76. PMID: 22171325.
      View in: PubMed
    6. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 01; 71(13):4608-16. PMID: 21712408.
      View in: PubMed
    7. Tang Y, Orth JD, Xie T, Mitchison TJ. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 01; 310(1):15-24. PMID: 21782324.
      View in: PubMed
    8. Huang HC, Shi J, Orth JD, Mitchison TJ. Cell death when the SAC is out of commission. Cell Cycle. 2010 Jun 01; 9(11):2049-50. PMID: 20559025.
      View in: PubMed
    9. Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 2009 Oct 06; 16(4):347-58. PMID: 19800579.
      View in: PubMed
    10. Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009 Oct 05; 4(10):e7339. PMID: 19802393.
      View in: PubMed
    11. Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther. 2008 Nov; 7(11):3480-9. PMID: 18974392.
      View in: PubMed
    12. Shi J, Orth JD, Mitchison T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 2008 May 01; 68(9):3269-76. PMID: 18451153.
      View in: PubMed
    13. Orth JD, McNiven MA. Get off my back! Rapid receptor internalization through circular dorsal ruffles. Cancer Res. 2006 Dec 01; 66(23):11094-6. PMID: 17145849.
      View in: PubMed
    14. Orth JD, Krueger EW, Weller SG, McNiven MA. A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Res. 2006 Apr 01; 66(7):3603-10. PMID: 16585185.
      View in: PubMed
    15. Yao Q, Chen J, Cao H, Orth JD, McCaffery JM, Stan RV, McNiven MA. Caveolin-1 interacts directly with dynamin-2. J Mol Biol. 2005 Apr 29; 348(2):491-501. PMID: 15811383.
      View in: PubMed
    16. Cao H, Weller S, Orth JD, Chen J, Huang B, Chen JL, Stamnes M, McNiven MA. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol. 2005 May; 7(5):483-92. PMID: 15821732.
      View in: PubMed
    17. Buccione R, Orth JD, McNiven MA. Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat Rev Mol Cell Biol. 2004 Aug; 5(8):647-57. PMID: 15366708.
      View in: PubMed
    18. Chen XM, Huang BQ, Splinter PL, Orth JD, Billadeau DD, McNiven MA, LaRusso NF. Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum. Infect Immun. 2004 May; 72(5):3011-21. PMID: 15102814.
      View in: PubMed
    19. Cao H, Orth JD, Chen J, Weller SG, Heuser JE, McNiven MA. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol. 2003 Mar; 23(6):2162-70. PMID: 12612086.
      View in: PubMed
    20. Krueger EW, Orth JD, Cao H, McNiven MA. A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Mol Biol Cell. 2003 Mar; 14(3):1085-96. PMID: 12631725.
      View in: PubMed
    21. Orth JD, McNiven MA. Dynamin at the actin-membrane interface. Curr Opin Cell Biol. 2003 Feb; 15(1):31-9. PMID: 12517701.
      View in: PubMed
    22. Orth JD, Krueger EW, Cao H, McNiven MA. The large GTPase dynamin regulates actin comet formation and movement in living cells. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):167-72. PMID: 11782546.
      View in: PubMed
    23. Busch C, Orth J, Djouder N, Aktories K. Biological activity of a C-terminal fragment of Pasteurella multocida toxin. Infect Immun. 2001 Jun; 69(6):3628-34. PMID: 11349023.
      View in: PubMed
    24. Hart PE, Poynter GM, Whitehead CM, Orth JD, Glantz JN, Busby RC, Barrett SL, Salisbury JL. Characterization of the X-linked murine centrin Cetn2 gene. Gene. 2001 Feb 21; 264(2):205-13. PMID: 11250075.
      View in: PubMed
    25. McNiven MA, Kim L, Krueger EW, Orth JD, Cao H, Wong TW. Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. J Cell Biol. 2000 Oct 02; 151(1):187-98. PMID: 11018064.
      View in: PubMed
    26. Hart PE, Glantz JN, Orth JD, Poynter GM, Salisbury JL. Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein. Genomics. 1999 Sep 01; 60(2):111-20. PMID: 10486202.
      View in: PubMed
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