Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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James Veblen DeGregori

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3230

    Collapse Research 
    Collapse research activities and funding
    F32CA059259     (DEGREGORI, JAMES V)Aug 1, 1993
    NIH/NCI
    E2F FACTOR AND CELL CYCLE REGULATION
    Role: Principal Investigator

    R01CA077314     (DEGREGORI, JAMES V)May 1, 1998 - Feb 28, 2008
    NIH/NCI
    Regulation of the Lymphocytic cell cycle by E2F
    Role: Principal Investigator

    T32GM008730     (SCLAFANI, ROBERT A)Jul 1, 1999 - Jun 30, 2020
    NIH/NIGMS
    Predoctoral Training Program in Molecular Biology
    Role: Co-Principal Investigator

    R21DK063299     (DEGREGORI, JAMES V)Jun 4, 2003 - May 31, 2005
    NIH/NIDDK
    Noncell autonomous control of Beta islet cells
    Role: Principal Investigator

    R01CA109657     (DEGREGORI, JAMES V.)Sep 13, 2005 - Jun 30, 2011
    NIH/NCI
    Poor competition in hematopoietic stem/progenitor pools favors tumorigenesis
    Role: Principal Investigator

    R21CA137262     (DEGREGORI, JAMES V.)Mar 1, 2009 - Feb 28, 2011
    NIH/NCI
    Diet-Induced Adaptive Leukemogenesis: BCR-Abl dependent upregulation of folate re
    Role: Principal Investigator

    R01CA157850     (DEGREGORI, JAMES V.)Sep 26, 2011 - Jul 31, 2016
    NIH/NCI
    Rationally designed targeted therapeutic approaches for NSCLC
    Role: Principal Investigator

    R01CA180175     (DEGREGORI, JAMES V.)Sep 1, 2013 - Jun 30, 2018
    NIH/NCI
    Aging-associated alterations in adaptive landscapes and the evolution of leukemia
    Role: Principal Investigator

    R21CA179501     (DEGREGORI, JAMES V.)Dec 18, 2014 - Nov 30, 2016
    NIH/NCI
    Nrf2-mediated impaired hematopoietic stem cell fitness following irradiation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2017 Sep 22. PMID: 28947392.
      View in: PubMed
    2. DeGregori J. Connecting cancer to its causes requires incorporation of effects on tissue microenvironments. Cancer Res. 2017 Jul 28. PMID: 28754675.
      View in: PubMed
    3. Liggett LA, DeGregori J. Changing mutational and adaptive landscapes and the genesis of cancer. Biochim Biophys Acta. 2017 04; 1867(2):84-94. PMID: 28167050.
      View in: PubMed
    4. Zhang G, Scarborough H, Kim J, Rozhok AI, Chen YA, Zhang X, Song L, Bai Y, Fang B, Liu RZ, Koomen J, Tan AC, Degregori J, Haura EB. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Sci Signal. 2016 Oct 18; 9(450):rs12. PMID: 27811184.
      View in: PubMed
    5. Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43):E6669-E6678. PMID: 27791036.
      View in: PubMed
    6. Rozhok AI, DeGregori J. The evolution of lifespan and age-dependent cancer risk. Trends Cancer. 2016 Oct; 2(10):552-560. PMID: 28439564.
      View in: PubMed
    7. Scarborough HA, Helfrich BA, Casás-Selves M, Schuller AG, Grosskurth SE, Kim J, Tan AC, Chan DC, Zhang Z, Zaberezhnyy V, Bunn PA, DeGregori J. AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition. Clin Cancer Res. 2017 Mar 15; 23(6):1531-1541. PMID: 27663586.
      View in: PubMed
    8. Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Trisomy 21 consistently activates the interferon response. Elife. 2016 Jul 29; 5. PMID: 27472900; PMCID: PMC5012864.
    9. Fernández-Cabezudo MJ, Faour I, Jones K, Champagne DP, Jaloudi MA, Mohamed YA, Bashir G, Almarzooqi S, Albawardi A, Hashim MJ, Roberts TS, El-Salhat H, El-Taji H, Kassis A, O'Sullivan DE, Christensen BC, DeGregori J, Al-Ramadi BK, Rincon M. Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer. JCI Insight. 2016 May 19; 1(7). PMID: 27275014.
      View in: PubMed
    10. Yadav VK, DeGregori J, De S. The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection. Nucleic Acids Res. 2016 Mar 18; 44(5):2075-84. PMID: 26883632; PMCID: PMC4797307.
    11. Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):1050-5. PMID: 26755588; PMCID: PMC4743806.
    12. Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682; PMCID: PMC4665776.
    13. Fleenor CJ, Higa K, Weil MM, DeGregori J. Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies. Radiat Res. 2015 Oct; 184(4):341-51. PMID: 26414506; PMCID: PMC4617554 [Available on 10/01/16].
    14. Rozhok AI, DeGregori J. Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):8914-21. PMID: 26195756; PMCID: PMC4517250.
    15. Rozhok AI, Wahl GM, DeGregori J. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4. PMID: 26122457; PMCID: PMC4849411.
    16. Avasarala S, Van Scoyk M, Karuppusamy Rathinam MK, Zerayesus S, Zhao X, Zhang W, Pergande MR, Borgia JA, DeGregori J, Port JD, Winn RA, Bikkavilli RK. PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. J Biol Chem. 2015 May 22; 290(21):13479-89. PMID: 25847239; PMCID: PMC4505594.
    17. Fleenor CJ, Rozhok AI, Zaberezhnyy V, Mathew D, Kim J, Tan AC, Bernstein ID, DeGregori J. Contrasting roles for C/EBPa and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem Cells. 2015 Apr; 33(4):1345-58. PMID: 25546133; PMCID: PMC4376650.
    18. Henry CJ, Sedjo RL, Rozhok A, Salstrom J, Ahnen D, Levin TR, D'Agostino R, Haffner S, DeGregori J, Byers T. Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma. BMC Cancer. 2015 Mar 14; 15:123. PMID: 25884547; PMCID: PMC4359784.
    19. Alvarez-Calderon F, DeGregori J. Oncogenic drivers and mitochondrial dependency. Aging (Albany NY). 2015 Mar; 7(3):148-9. PMID: 25868642; PMCID: PMC4394725.
    20. Scarborough HA, Bunn PA, DeGregori J. Personalized one-two punches for lung cancer. Cell Res. 2015 Mar; 25(3):269-70. PMID: 25547118; PMCID: PMC4349242.
    21. Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations. Clin Cancer Res. 2015 Mar 15; 21(6):1360-72. PMID: 25547679; PMCID: PMC4359967.
    22. Rozhok AI, Salstrom JL, DeGregori J. Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes. Aging (Albany NY). 2014 Dec; 6(12):1033-48. PMID: 25564763; PMCID: PMC4298364.
    23. Aghili L, Foo J, DeGregori J, De S. Patterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patients. Cell Rep. 2014 May 22; 7(4):1310-9. PMID: 24794429; PMCID: PMC4108616.
    24. Ostrow SL, Barshir R, DeGregori J, Yeger-Lotem E, Hershberg R. Cancer evolution is associated with pervasive positive selection on globally expressed genes. PLoS Genet. 2014 Mar; 10(3):e1004239. PMID: 24603726; PMCID: PMC3945297.
    25. Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME. Inhibiting tyrosine phosphorylation of protein kinase Cd (PKCd) protects the salivary gland from radiation damage. J Biol Chem. 2014 Apr 11; 289(15):10900-8. PMID: 24569990; PMCID: PMC4036201.
    26. Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW. Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. PLoS One. 2013; 8(9):e74809. PMID: 24058630; PMCID: PMC3776760.
    27. Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, Degregori JV, Messersmith WA, Winn RA, Eckhardt SG. Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clin Cancer Res. 2013 Aug 01; 19(15):4149-62. PMID: 23757356; PMCID: PMC3905307.
    28. Alvarez-Calderon F, Gregory MA, DeGregori J. Using functional genomics to overcome therapeutic resistance in hematological malignancies. Immunol Res. 2013 Mar; 55(1-3):100-15. PMID: 22941562; PMCID: PMC3673782.
    29. Gore L, DeGregori J, Porter CC. Targeting developmental pathways in children with cancer: what price success? Lancet Oncol. 2013 Feb; 14(2):e70-8. PMID: 23369685; PMCID: PMC3673778.
    30. Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Mol Pharmacol. 2013 Apr; 83(4):882-93. PMID: 23371912; PMCID: PMC3608435.
    31. Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, Weekes C, Sclafani R, Degregori J, Eisenmesser E. Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B. Cancer Cell Int. 2012 Jul 04; 12(1):19. PMID: 22631225; PMCID: PMC3390265.
    32. DeGregori J. Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age? Oncogene. 2013 Apr 11; 32(15):1869-75. PMID: 22751134; PMCID: PMC3670419.
    33. Casás-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA, Chan DC, Tan AC, DeGregori J. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res. 2012 Aug 15; 72(16):4154-64. PMID: 22738915; PMCID: PMC3673784.
    34. Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol. 2012 Jul; 8(7):646-54. PMID: 22660439; PMCID: PMC3430605.
    35. Porter CC, Kim J, Fosmire S, Gearheart CM, van Linden A, Baturin D, Zaberezhnyy V, Patel PR, Gao D, Tan AC, DeGregori J. Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia. Leukemia. 2012 Jun; 26(6):1266-76. PMID: 22289989; PMCID: PMC3678731.
    36. Casás-Selves M, Degregori J. How cancer shapes evolution, and how evolution shapes cancer. Evolution (N Y). 2011 Dec; 4(4):624-634. PMID: 23705033.
      View in: PubMed
    37. Henry CJ, Marusyk A, DeGregori J. Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? Aging (Albany NY). 2011 Jun; 3(6):643-56. PMID: 21765201; PMCID: PMC3164372.
    38. Degregori J. A new role for E2F1 in DNA repair: all for the greater good. Cell Cycle. 2011 Jun 01; 10(11):1716. PMID: 21532333; PMCID: PMC3685610.
    39. DeGregori J. Evolved tumor suppression: why are we so good at not getting cancer? Cancer Res. 2011 Jun 01; 71(11):3739-44. PMID: 21610109; PMCID: PMC3677553.
    40. Porter CC, Baturin D, Choudhary R, DeGregori J. Relative fitness of hematopoietic progenitors influences leukemia progression. Leukemia. 2011 May; 25(5):891-5. PMID: 21331070; PMCID: PMC3670417.
    41. Schaack J, Bennett ML, Shapiro GS, DeGregori J, McManaman JL, Moorhead JW. Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors. Virology. 2011 Mar 30; 412(1):28-35. PMID: 21255815; PMCID: PMC4419336.
    42. Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, DeGregori J. Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21713-8. PMID: 21098275; PMCID: PMC3003039.
    43. Fleenor CJ, Marusyk A, DeGregori J. Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape. Cell Cycle. 2010 Aug 01; 9(15):3005-11. PMID: 20676038; PMCID: PMC3040925.
    44. Gregory MA, Phang TL, Neviani P, Alvarez-Calderon F, Eide CA, O'Hare T, Zaberezhnyy V, Williams RT, Druker BJ, Perrotti D, Degregori J. Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell. 2010 Jul 13; 18(1):74-87. PMID: 20609354; PMCID: PMC2904512.
    45. Bui MR, Hodson V, King T, Leopold D, Dai S, Fiolkoski V, Oakes S, Duke R, Apelian D, Franzusoff A, DeGregori J. Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model. Vaccine. 2010 Aug 23; 28(37):6028-35. PMID: 20619375; PMCID: PMC3066561.
    46. Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 2010 Jun; 9(3):398-409. PMID: 20331441; PMCID: PMC2894262.
    47. Marusyk A, Porter CC, Zaberezhnyy V, DeGregori J. Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol. 2010 Mar 02; 8(3):e1000324. PMID: 20208998; PMCID: PMC2830447.
    48. Alvarez DF, Helm K, Degregori J, Roederer M, Majka S. Publishing flow cytometry data. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L127-30. PMID: 19915158; PMCID: PMC2822558.
    49. Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res. 2009 Sep 15; 69(18):7262-9. PMID: 19738065; PMCID: PMC2745506.
    50. Schlegel J, Redzic JS, Porter CC, Yurchenko V, Bukrinsky M, Labeikovsky W, Armstrong GS, Zhang F, Isern NG, DeGregori J, Hodges R, Eisenmesser EZ. Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A. J Mol Biol. 2009 Aug 21; 391(3):518-35. PMID: 19500591; PMCID: PMC2940942.
    51. Porter CC, DeGregori J. Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection. Blood. 2008 Dec 01; 112(12):4466-74. PMID: 18587011; PMCID: PMC2597122.
    52. Tessem JS, Jensen JN, Pelli H, Dai XM, Zong XH, Stanley ER, Jensen J, DeGregori J. Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes. 2008 Jun; 57(6):1605-17. PMID: 18375440; PMCID: PMC2575065.
    53. Marusyk A, DeGregori J. Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta. 2008 Jan; 1785(1):1-11. PMID: 17980163; PMCID: PMC2234267.
    54. Marusyk A, DeGregori J. Replicational stress selects for p53 mutation. Cell Cycle. 2007 Sep 01; 6(17):2148-51. PMID: 17786047; PMCID: PMC2394679.
    55. Marusyk A, Wheeler LJ, Mathews CK, DeGregori J. p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol. 2007 Aug; 27(15):5336-51. PMID: 17515610; PMCID: PMC1952086.
    56. Höglinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3585-90. PMID: 17360686; PMCID: PMC1805567.
    57. Johnson DG, Degregori J. Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Curr Mol Med. 2006 Nov; 6(7):731-8. PMID: 17100599.
      View in: PubMed
    58. DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med. 2006 Nov; 6(7):739-48. PMID: 17100600.
      View in: PubMed
    59. Marusyk A, DeGregori J. Building a better model of cancer. Cell Div. 2006 Oct 18; 1:24. PMID: 17049090; PMCID: PMC1622745.
    60. Shapiro GS, Van Peursem C, Ornelles DA, Schaack J, DeGregori J. Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 protein. J Virol. 2006 Jun; 80(11):5349-60. PMID: 16699015; PMCID: PMC1472169.
    61. DeGregori J. Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis. Mol Cell Biol. 2006 Feb; 26(4):1165-9. PMID: 16449632; PMCID: PMC1367209.
    62. Bilousova G, Marusyk A, Porter CC, Cardiff RD, DeGregori J. Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol. 2005 Dec; 3(12):e401. PMID: 16277552; PMCID: PMC1283331.
    63. DeGregori J. E2F and cell survival: context really is key. Dev Cell. 2005 Oct; 9(4):442-4. PMID: 16198285.
      View in: PubMed
    64. DeRyckere D, DeGregori J. E2F1 and E2F2 are differentially required for homeostasis-driven and antigen-induced T cell proliferation in vivo. J Immunol. 2005 Jul 15; 175(2):647-55. PMID: 16002659.
      View in: PubMed
    65. Pappa A, Brown D, Koutalos Y, DeGregori J, White C, Vasiliou V. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem. 2005 Jul 29; 280(30):27998-8006. PMID: 15905174.
      View in: PubMed
    66. Miyamoto T, Kaneko T, Yamashita M, Tenda Y, Inami M, Suzuki A, Ishii S, Kimura M, Hashimoto K, Shimada H, Yahata H, Ochiai T, Saito I, DeGregori J, Nakayama T. Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. Int Immunol. 2005 Jun; 17(6):759-68. PMID: 15899924.
      View in: PubMed
    67. Tessem JS, DeGregori J. Roles for bone-marrow-derived cells in beta-cell maintenance. Trends Mol Med. 2004 Nov; 10(11):558-64. PMID: 15519282.
      View in: PubMed
    68. DeGregori J. The Rb network. J Cell Sci. 2004 Jul 15; 117(Pt 16):3411-3. PMID: 15252123.
      View in: PubMed
    69. Chau BN, Chen TT, Wan YY, DeGregori J, Wang JY. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol. 2004 May; 24(10):4438-47. PMID: 15121862; PMCID: PMC400462.
    70. Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem. 2004 Jun 25; 279(26):26983-90. PMID: 15087456.
      View in: PubMed
    71. Li FX, Zhu JW, Tessem JS, Beilke J, Varella-Garcia M, Jensen J, Hogan CJ, DeGregori J. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12935-40. PMID: 14566047; PMCID: PMC240722.
    72. DeRyckere D, Mann DL, DeGregori J. Characterization of transcriptional regulation during negative selection in vivo. J Immunol. 2003 Jul 15; 171(2):802-11. PMID: 12847248.
      View in: PubMed
    73. Marchbank A, Su LJ, Walsh P, DeGregori J, Penheiter K, Grayson TB, Dellavalle RP, Lee LA. The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation. J Dermatol Sci. 2003 Jun; 32(1):71-4. PMID: 12788532.
      View in: PubMed
    74. Li FX, Zhu JW, Hogan CJ, DeGregori J. Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol Cell Biol. 2003 May; 23(10):3607-22. PMID: 12724419; PMCID: PMC164755.
    75. Wan YY, DeGregori J. The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression. Immunity. 2003 Mar; 18(3):331-42. PMID: 12648451.
      View in: PubMed
    76. Roshon M, DeGregori JV, Ruley HE. Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene. BMC Genomics. 2003 Jan 20; 4(1):2. PMID: 12546712; PMCID: PMC149352.
    77. Bhattacharya D, Logue EC, Bakkour S, DeGregori J, Sha WC. Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8838-43. PMID: 12084928; PMCID: PMC124385.
    78. DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim Biophys Acta. 2002 Jun 21; 1602(2):131-50. PMID: 12020800.
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    79. Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES. Active RB elicits late G1/S inhibition. Exp Cell Res. 2002 Jun 10; 276(2):201-13. PMID: 12027450.
      View in: PubMed
    80. Dellavalle RP, Walsh P, Marchbank A, Grayson TE, Su LJ, Parker ER, DeGregori J, Penheiter K, Aszterbaum M, Epstein EH, Lee LA. CUSP/p63 expression in basal cell carcinoma. Exp Dermatol. 2002 Jun; 11(3):203-8. PMID: 12102658.
      View in: PubMed
    81. Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1347-52. PMID: 11805305; PMCID: PMC122193.
    82. DeRyckere D, DeGregori J. Identification and characterization of transcription factor target genes using gene-targeted mice. Methods. 2002 Jan; 26(1):57-75. PMID: 12054905.
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    83. Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol. 2001 Dec; 21(24):8547-64. PMID: 11713289; PMCID: PMC100017.
    84. Orlicky DJ, DeGregori J, Schaack J. Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells. J Lipid Res. 2001 Jun; 42(6):910-5. PMID: 11369798.
      View in: PubMed
    85. Cripe TP, Dunphy EJ, Holub AD, Saini A, Vasi NH, Mahller YY, Collins MH, Snyder JD, Krasnykh V, Curiel DT, Wickham TJ, DeGregori J, Bergelson JM, Currier MA. Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells. Cancer Res. 2001 Apr 01; 61(7):2953-60. PMID: 11306473.
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    86. Wan YY, Leon RP, Marks R, Cham CM, Schaack J, Gajewski TF, DeGregori J. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13784-9. PMID: 11095726; PMCID: PMC17653.
    87. Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ. 2000 Dec; 11(12):625-33. PMID: 11149597.
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    88. Schwertfeger KL, Hunter S, Heasley LE, Levresse V, Leon RP, DeGregori J, Anderson SM. Prolactin stimulates activation of c-jun N-terminal kinase (JNK). Mol Endocrinol. 2000 Oct; 14(10):1592-602. PMID: 11043575.
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    89. Williamson DJ, Banik-Maiti S, DeGregori J, Ruley HE. hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability. Mol Cell Biol. 2000 Jun; 20(11):4094-105. PMID: 10805751; PMCID: PMC85779.
    90. Zhu JW, DeRyckere D, Li FX, Wan YY, DeGregori J. A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection. Cell Growth Differ. 1999 Dec; 10(12):829-38. PMID: 10616908.
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    91. Leone G, DeGregori J, Jakoi L, Cook JG, Nevins JR. Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. Proc Natl Acad Sci U S A. 1999 Jun 08; 96(12):6626-31. PMID: 10359762; PMCID: PMC21965.
    92. Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability. Mol Cell. 1999 Feb; 3(2):169-79. PMID: 10078200.
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    93. Leon RP, Hedlund T, Meech SJ, Li S, Schaack J, Hunger SP, Duke RC, DeGregori J. Adenoviral-mediated gene transfer in lymphocytes. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13159-64. PMID: 9789058; PMCID: PMC23744.
    94. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 1998 Jul 15; 12(14):2120-30. PMID: 9679057; PMCID: PMC317011.
    95. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3603-8. PMID: 9520412; PMCID: PMC19882.
    96. Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 1998 Feb; 9(2):113-8. PMID: 9486847.
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    97. Nevins JR, Leone G, DeGregori J, Jakoi L. Role of the Rb/E2F pathway in cell growth control. J Cell Physiol. 1997 Nov; 173(2):233-6. PMID: 9365528.
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    98. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7245-50. PMID: 9207076; PMCID: PMC23805.
    99. Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature. 1997 May 22; 387(6631):422-6. PMID: 9163430.
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    100. Nevins JR, DeGregori J, Jakoi L, Leone G. Functional analysis of E2F transcription factor. Methods Enzymol. 1997; 283:205-19. PMID: 9251021.
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    101. Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol. 1996 Dec; 16(12):6965-76. PMID: 8943352; PMCID: PMC231700.
    102. Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol. 1996 Dec; 16(12):6977-84. PMID: 8943353; PMCID: PMC231701.
    103. Khleif SN, DeGregori J, Yee CL, Otterson GA, Kaye FJ, Nevins JR, Howley PM. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4350-4. PMID: 8633069; PMCID: PMC39540.
    104. Ohtani K, DeGregori J, Nevins JR. Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12146-50. PMID: 8618861; PMCID: PMC40313.
    105. DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 1995 Dec 01; 9(23):2873-87. PMID: 7498785.
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    106. DeGregori J, Kowalik T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol. 1995 Aug; 15(8):4215-24. PMID: 7623816; PMCID: PMC230660.
    107. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol. 1995 Apr; 69(4):2491-500. PMID: 7884898; PMCID: PMC188925.
    108. DeGregori J, Russ A, von Melchner H, Rayburn H, Priyaranjan P, Jenkins NA, Copeland NG, Ruley HE. A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 1994 Feb 01; 8(3):265-76. PMID: 8314081.
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    109. von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE. Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun; 6(6):919-27. PMID: 1317320.
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    110. Ragozzino MM, Kuo A, DeGregori J, Kohl N, Ruley HE. Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist. Environ Health Perspect. 1991 Jun; 93:97-103. PMID: 1837777; PMCID: PMC1568054.
    111. Reddy S, DeGregori JV, von Melchner H, Ruley HE. Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells. J Virol. 1991 Mar; 65(3):1507-15. PMID: 1704929; PMCID: PMC239931.
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