Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

James Veblen DeGregori

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3230

    Collapse Research 
    Collapse research activities and funding
    R01CA292432     (DEGREGORI, JAMES V)Jul 3, 2024 - Jun 30, 2029
    NIH
    IAP inhibition as a therapeutic strategy to target therapy-resistant leukemia initiating cells
    Role: Principal Investigator
    U01CA271830     (LI, SHENG)Sep 23, 2021 - Aug 31, 2026
    NIH
    The impact of reduction of cellular senescence on age-related epigenetic heterogeneity
    Role: Co-Principal Investigator
    R01HD103828     (THORBURN, ANDREW M)Sep 18, 2020 - Sep 17, 2024
    NIH
    Down Syndrome as a systemic autophagy deficiency disorder
    Role: Co-Principal Investigator
    R01AG066544     (DEGREGORI, JAMES V)Jan 1, 2020 - Nov 30, 2024
    NIH
    Aged tissue environments as drivers of oncogenic adaptation in hematopoiesis
    Role: Principal Investigator
    R01AG067584     (DEGREGORI, JAMES V)Sep 30, 2019 - May 31, 2024
    NIH
    Determining how aging-associated changes in the microenvironment contribute to leukemogenesis
    Role: Principal Investigator
    U01AG066099     (DEGREGORI, JAMES V.)Jun 1, 2019 - May 31, 2021
    NIH
    Understanding and circumventing aging-dependent changes in the bone marrow microenvironment that promote leukemogenesis
    Role: Principal Investigator
    I01BX004495     (DEGREGORI, JAMES V)Apr 1, 2019 - Mar 31, 2024
    NIH
    Dissecting the Role of Inflammation in Smoking and Aging Associated Lung Cancers
    Role: Principal Investigator
    R21CA223439     (DEGREGORI, JAMES V.)Jul 1, 2018 - Jun 30, 2020
    NIH
    Targeting MCJ/DNAJC15 and the mitochondrial electron transport chain in acute myeloid leukemia
    Role: Principal Investigator
    R21CA179501     (DEGREGORI, JAMES V.)Dec 18, 2014 - Nov 30, 2016
    NIH
    Nrf2-mediated impaired hematopoietic stem cell fitness following irradiation
    Role: Principal Investigator
    R01CA180175     (DEGREGORI, JAMES V.)Sep 1, 2013 - Jun 30, 2019
    NIH
    Aging-associated alterations in adaptive landscapes and the evolution of leukemia
    Role: Principal Investigator
    R01CA157850     (DEGREGORI, JAMES V.)Sep 26, 2011 - Jul 31, 2016
    NIH
    Rationally designed targeted therapeutic approaches for NSCLC
    Role: Principal Investigator
    R01CA150925     (DEGREGORI, JAMES V)Apr 19, 2010 - Apr 30, 2025
    NIH
    Autophagy regulation of apoptosis and necroptosis within cell populations
    Role: Principal Investigator
    R21CA137262     (DEGREGORI, JAMES V.)Mar 1, 2009 - Feb 28, 2011
    NIH
    Diet-Induced Adaptive Leukemogenesis: BCR-Abl dependent upregulation of folate re
    Role: Principal Investigator
    R01CA109657     (DEGREGORI, JAMES V.)Sep 13, 2005 - Jun 30, 2011
    NIH
    Poor competition in hematopoietic stem/progenitor pools favors tumorigenesis
    Role: Principal Investigator
    R21DK063299     (DEGREGORI, JAMES V)Jun 4, 2003 - May 31, 2005
    NIH
    Noncell autonomous control of Beta islet cells
    Role: Principal Investigator
    T32GM008730     (PREKERIS, RYTIS)Jul 1, 1999 - Jun 30, 2020
    NIH
    Predoctoral Training Program in Molecular Biology
    Role: Co-Principal Investigator
    R01CA077314     (DEGREGORI, JAMES V)May 1, 1998 - Feb 28, 2008
    NIH
    Regulation of the Lymphocytic cell cycle by E2F
    Role: Principal Investigator
    F32CA059259     (DEGREGORI, JAMES V)Aug 1, 1993
    NIH
    E2F FACTOR AND CELL CYCLE REGULATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Assante A, Lkhagvadorj K, Clambey ET, Danhorn T, Merrick DT, Keith RL, New ML, Degregori J, Miller YE, Ghosh M. Reduced Progenitor Function and Altered Immune Landscape Contribute to Field Cancerization of Lung Adenocarcinoma. Am J Respir Crit Care Med. 2023 Oct 15; 208(8):903-905. PMID: 37639330.
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    2. De Dominici M, DeGregori J. Our ancestry dictates clonal architecture and skin cancer susceptibility. Nat Genet. 2023 09; 55(9):1428-1429. PMID: 37537258.
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    3. Capp JP, Thomas F, Marusyk A, M Dujon A, Tissot S, Gatenby R, Roche B, Ujvari B, DeGregori J, Brown JS, Nedelcu AM. The paradox of cooperation among selfish cancer cells. Evol Appl. 2023 Jul; 16(7):1239-1256. PMID: 37492150.
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    4. Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, van Maldegem F, Boumelha J, Veeriah S, Rowan A, Naceur-Lombardelli C, Karasaki T, Sivakumar M, De S, Caswell DR, Nagano A, Black JRM, Mart?nez-Ruiz C, Ryu MH, Huff RD, Li S, Fav? MJ, Magness A, Su?rez-Bonnet A, Priestnall SL, L?chtenborg M, Lavelle K, Pethick J, Hardy S, McRonald FE, Lin MH, Troccoli CI, Ghosh M, Miller YE, Merrick DT, Keith RL, Al Bakir M, Bailey C, Hill MS, Saal LH, Chen Y, George AM, Abbosh C, Kanu N, Lee SH, McGranahan N, Berg CD, Sasieni P, Houlston R, Turnbull C, Lam S, Awadalla P, Gr?nroos E, Downward J, Jacks T, Carlsten C, Malanchi I, Hackshaw A, Litchfield K, DeGregori J, Jamal-Hanjani M, Swanton C. Lung adenocarcinoma promotion by air pollutants. Nature. 2023 04; 616(7955):159-167. PMID: 37020004.
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    5. Park HJ, Gregory MA, Zaberezhnyy V, Goodspeed A, Jordan CT, Kieft JS, DeGregori J. Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation. Elife. 2022 10 19; 11. PMID: 36259537.
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    6. Pietras EM, DeGregori J. Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis. Cancer Discov. 2022 10 05; 12(10):2234-2236. PMID: 36196576.
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    7. Evans EJ, DeGregori J. Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia. J Clin Invest. 2022 07 15; 132(14). PMID: 35838049.
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    8. Braithwaite D, Anton S, Mohile S, DeGregori J, Gillis N, Zhou D, Bloodworth S, Pahor M, Licht J. Cancer and aging: A call to action. Aging Cancer. 2022 Jun; 3(2):87-94. PMID: 36188489.
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    9. Somarelli JA, DeGregori J, Gerlinger M, Heng HH, Marusyk A, Welch DR, Laukien FH. Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes. Med Oncol. 2022 Jul 04; 39(9):137. PMID: 35781581.
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    10. Marongiu F, DeGregori J. The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging-related disease. Mol Oncol. 2022 09; 16(18):3238-3258. PMID: 35726685.
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    11. Florez MA, Tran BT, Wathan TK, DeGregori J, Pietras EM, King KY. Clonal hematopoiesis: Mutation-specific adaptation to environmental change. Cell Stem Cell. 2022 06 02; 29(6):882-904. PMID: 35659875.
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    12. De Dominici M, DeGregori J. Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFN? Signaling to Gain Clonal Advantage. Blood Cancer Discov. 2022 05 05; 3(3):178-180. PMID: 35394495.
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    13. Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. Resilience integrates concepts in aging research. iScience. 2022 May 20; 25(5):104199. PMID: 35494229.
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    14. Evans EJ, DeGregori J. Cells with Cancer-associated Mutations Overtake Our Tissues as We Age. Aging Cancer. 2021 Sep; 2(3):82-97. PMID: 34888527.
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    15. Chavez JS, Rabe JL, Loeffler D, Higa KC, Hernandez G, Mills TS, Ahmed N, Gessner RL, Ke Z, Idler BM, Ni?o KE, Kim H, Myers JR, Stevens BM, Davizon-Castillo P, Jordan CT, Nakajima H, Ashton J, Welner RS, Schroeder T, DeGregori J, Pietras EM. PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress. J Exp Med. 2021 06 07; 218(6). PMID: 33857288.
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    16. Higa KC, Goodspeed A, Chavez JS, De Dominici M, Danis E, Zaberezhnyy V, Rabe JL, Tenen DG, Pietras EM, DeGregori J. Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors. J Exp Med. 2021 06 07; 218(6). PMID: 33914855.
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    17. Chia SB, DeGregori J. Cancer stem cells in the gut have a bad influence on neighbouring cells. Nature. 2021 06; 594(7863):340-341. PMID: 34079113.
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    18. Liggett LA, Galbraith MD, Smith KP, Sullivan KD, Granrath RE, Enriquez-Estrada B, Kinning KT, Shaw JR, Rachubinski AL, Espinosa JM, DeGregori J. Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation. Blood Adv. 2021 04 13; 5(7):1791-1796. PMID: 33787858.
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    19. Capp JP, DeGregori J, Nedelcu AM, Dujon AM, Boutry J, Pujol P, Alix-Panabi?res C, Hamede R, Roche B, Ujvari B, Marusyk A, Gatenby R, Thomas F. Group phenotypic composition in cancer. Elife. 2021 03 30; 10. PMID: 33784238.
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    20. Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33649199.
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    21. Dujon AM, Aktipis A, Alix-Panabi?res C, Amend SR, Boddy AM, Brown JS, Capp JP, DeGregori J, Ewald P, Gatenby R, Gerlinger M, Giraudeau M, Hamede RK, Hansen E, Kareva I, Maley CC, Marusyk A, McGranahan N, Metzger MJ, Nedelcu AM, Noble R, Nunney L, Pienta KJ, Polyak K, Pujol P, Read AF, Roche B, Sebens S, Solary E, Stankov? K, Swain Ewald H, Thomas F, Ujvari B. Identifying key questions in the ecology and evolution of cancer. Evol Appl. 2021 Apr; 14(4):877-892. PMID: 33897809.
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    22. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-G?mez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ?lvarez ?MC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Ant?n Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Ara?jo WL, Araya J, Arden C, Ar?valo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaun?-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, ?valos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, B?nr?ti ?, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Baril? D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touz? N, Bellarosa C, Belleudi F, Bell? P?rez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Bur?n MI, Bustos V, B?ttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cair? M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cant? C, Cao B, Caraglia M, Caram?s B, Carchman EH, Cardenal-Mu?oz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751.
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    23. De Dominici M, DeGregori J. Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin. Cancer Discov. 2021 02; 11(2):227-229. PMID: 33531425.
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    24. Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds. Aging Cell. 2021 02; 20(2):e13309. PMID: 33480151.
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    25. Ciccarelli FD, DeGregori J. Approaching Cancer Evolution from Different Angles. iScience. 2020 Nov 20; 23(11):101661. PMID: 33134891.
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    26. DeGregori J, Pharoah P, Sasieni P, Swanton C. Cancer Screening, Surrogates of Survival, and the Soma. Cancer Cell. 2020 10 12; 38(4):433-437. PMID: 32946774.
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    27. Jones CL, Stevens BM, Pollyea DA, Culp-Hill R, Reisz JA, Nemkov T, Gehrke S, Gamboni F, Krug A, Winters A, Pei S, Gustafson A, Ye H, Inguva A, Amaya M, Minhajuddin M, Abbott D, Becker MW, DeGregori J, Smith CA, D'Alessandro A, Jordan CT. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells. Cell Stem Cell. 2020 11 05; 27(5):748-764.e4. PMID: 32822582.
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    28. Rozhok AI, Silberman RE, Higa KC, Liggett LA, Amon A, DeGregori J. A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution. Sci Rep. 2020 07 22; 10(1):12198. PMID: 32699207.
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    29. DeGregori J. The special issue on cancer and evolution: Lessons learned. Evol Appl. 2020 Aug; 13(7):1784-1790. PMID: 32821282.
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    30. DeGregori J. Aging, inflammation, and HSC. Blood. 2020 07 09; 136(2):153-154. PMID: 32645167.
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    31. Rozhok AI, DeGregori J. The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis. Evol Appl. 2020 Aug; 13(7):1569-1580. PMID: 32821273.
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    32. Laconi E, Marongiu F, DeGregori J. Cancer as a disease of old age: changing mutational and microenvironmental landscapes. Br J Cancer. 2020 03; 122(7):943-952. PMID: 32042067.
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    33. Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP. Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol. 2020 02 01; 37(2):320-326. PMID: 31642480.
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    34. DeGregori J. Of mice, genes and aging. Haematologica. 2020; 105(2):246-248. PMID: 32005650.
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    35. Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O'Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A. Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. J Natl Cancer Inst. 2019 12 01; 111(12):1245-1254. PMID: 31321426.
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    36. Liggett LA, Sharma A, De S, DeGregori J. FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue. G3 (Bethesda). 2019 09 04; 9(9):2977-2987. PMID: 31352405.
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    37. Rozhok A, DeGregori J. Somatic maintenance impacts the evolution of mutation rate. BMC Evol Biol. 2019 08 23; 19(1):172. PMID: 31443631.
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    38. Pham-Danis C, DeGregori J. Studying Cancer Evolution and Therapeutic Responses in Different Organs: The Pros and Cons of a Broad Focus. Cancer Res. 2019 Sep 15; 79(18):4582-4584. PMID: 31439547.
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    39. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. TNF-a-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood. 2019 08 29; 134(9):727-740. PMID: 31311815.
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    40. Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood. 2019 07 25; 134(4):389-394. PMID: 31101624.
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    41. Rozhok A, DeGregori J. A generalized theory of age-dependent carcinogenesis. Elife. 2019 04 29; 8. PMID: 31034356.
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    42. Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J. Targeting Glutamine Metabolism and Redox State for Leukemia Therapy. Clin Cancer Res. 2019 07 01; 25(13):4079-4090. PMID: 30940653.
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    43. Bilousova G, DeGregori J. Elimination of unfit cells in young and ageing skin. Nature. 2019 04; 568(7752):318-319. PMID: 30980033.
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    44. Higa KC, DeGregori J. Decoy fitness peaks, tumor suppression, and aging. Aging Cell. 2019 06; 18(3):e12938. PMID: 30848555.
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    45. Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D, Collins C, Paola JTD, D'Alessandro A, DeGregori J. Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC. Mol Cancer Res. 2019 06; 17(6):1351-1364. PMID: 30808730.
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    46. Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2019 Feb 11; 35(2):333-335. PMID: 30753831.
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    47. Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program. Cancer Res. 2019 02 15; 79(4):720-734. PMID: 30606720.
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    48. Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2018 11 12; 34(5):724-740.e4. PMID: 30423294.
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    49. Tippimanchai DD, Nolan K, Poczobutt J, Verzosa G, Li H, Scarborough H, Huang J, Young C, DeGregori J, Nemenoff RA, Malkoski SP. Adenoviral vectors transduce alveolar macrophages in lung cancer models. Oncoimmunology. 2018; 7(6):e1438105. PMID: 29872579.
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    50. Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC. ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer. Oncotarget. 2018 Feb 06; 9(10):8823-8835. PMID: 29507657.
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    51. Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2018 02; 58:52-58. PMID: 28947392.
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    52. Henry CJ, Nemkov T, Cas?s-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. 2017 12; 102(12):1985-1994. PMID: 28883079.
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    53. DeGregori J. Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments. Cancer Res. 2017 11 15; 77(22):6065-6068. PMID: 28754675.
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    54. Liggett LA, DeGregori J. Changing mutational and adaptive landscapes and the genesis of cancer. Biochim Biophys Acta Rev Cancer. 2017 Apr; 1867(2):84-94. PMID: 28167050.
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    77. Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME. Inhibiting tyrosine phosphorylation of protein kinase Cd (PKCd) protects the salivary gland from radiation damage. J Biol Chem. 2014 Apr 11; 289(15):10900-10908. PMID: 24569990.
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    78. Yang X, La Rosa FG, Genova EE, Huber K, Schaack J, Degregori J, Serkova NJ, Li Y, Su LJ, Kessler E, Flaig TW. Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. PLoS One. 2013; 8(9):e74809. PMID: 24058630.
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    104. Tessem JS, Jensen JN, Pelli H, Dai XM, Zong XH, Stanley ER, Jensen J, DeGregori J. Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes. 2008 Jun; 57(6):1605-17. PMID: 18375440.
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    108. H?glinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3585-90. PMID: 17360686.
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    109. Johnson DG, Degregori J. Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Curr Mol Med. 2006 Nov; 6(7):731-8. PMID: 17100599.
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    117. Pappa A, Brown D, Koutalos Y, DeGregori J, White C, Vasiliou V. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem. 2005 Jul 29; 280(30):27998-8006. PMID: 15905174.
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    118. Miyamoto T, Kaneko T, Yamashita M, Tenda Y, Inami M, Suzuki A, Ishii S, Kimura M, Hashimoto K, Shimada H, Yahata H, Ochiai T, Saito I, DeGregori J, Nakayama T. Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. Int Immunol. 2005 Jun; 17(6):759-68. PMID: 15899924.
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    119. Tessem JS, DeGregori J. Roles for bone-marrow-derived cells in beta-cell maintenance. Trends Mol Med. 2004 Nov; 10(11):558-64. PMID: 15519282.
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    122. Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem. 2004 Jun 25; 279(26):26983-90. PMID: 15087456.
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    123. Li FX, Zhu JW, Tessem JS, Beilke J, Varella-Garcia M, Jensen J, Hogan CJ, DeGregori J. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12935-40. PMID: 14566047.
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    125. Marchbank A, Su LJ, Walsh P, DeGregori J, Penheiter K, Grayson TB, Dellavalle RP, Lee LA. The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation. J Dermatol Sci. 2003 Jun; 32(1):71-4. PMID: 12788532.
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    127. Wan YY, DeGregori J. The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression. Immunity. 2003 Mar; 18(3):331-42. PMID: 12648451.
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    128. Roshon M, DeGregori JV, Ruley HE. Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene. BMC Genomics. 2003 Jan 20; 4(1):2. PMID: 12546712.
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    129. Bhattacharya D, Logue EC, Bakkour S, DeGregori J, Sha WC. Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8838-43. PMID: 12084928.
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    130. DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim Biophys Acta. 2002 Jun 21; 1602(2):131-50. PMID: 12020800.
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    131. Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES. Active RB elicits late G1/S inhibition. Exp Cell Res. 2002 Jun 10; 276(2):201-13. PMID: 12027450.
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    132. Dellavalle RP, Walsh P, Marchbank A, Grayson TE, Su LJ, Parker ER, DeGregori J, Penheiter K, Aszterbaum M, Epstein EH, Lee LA. CUSP/p63 expression in basal cell carcinoma. Exp Dermatol. 2002 Jun; 11(3):203-8. PMID: 12102658.
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    133. Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1347-52. PMID: 11805305.
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    135. Orlicky DJ, DeGregori J, Schaack J. Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells. J Lipid Res. 2001 Jun; 42(6):910-5. PMID: 11369798.
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    136. Cripe TP, Dunphy EJ, Holub AD, Saini A, Vasi NH, Mahller YY, Collins MH, Snyder JD, Krasnykh V, Curiel DT, Wickham TJ, DeGregori J, Bergelson JM, Currier MA. Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells. Cancer Res. 2001 Apr 01; 61(7):2953-60. PMID: 11306473.
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    137. Wan YY, Leon RP, Marks R, Cham CM, Schaack J, Gajewski TF, DeGregori J. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13784-9. PMID: 11095726.
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    138. Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth Differ. 2000 Dec; 11(12):625-33. PMID: 11149597.
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    139. Schwertfeger KL, Hunter S, Heasley LE, Levresse V, Leon RP, DeGregori J, Anderson SM. Prolactin stimulates activation of c-jun N-terminal kinase (JNK). Mol Endocrinol. 2000 Oct; 14(10):1592-602. PMID: 11043575.
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    140. Williamson DJ, Banik-Maiti S, DeGregori J, Ruley HE. hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability. Mol Cell Biol. 2000 Jun; 20(11):4094-105. PMID: 10805751.
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    143. Sears R, Leone G, DeGregori J, Nevins JR. Ras enhances Myc protein stability. Mol Cell. 1999 Feb; 3(2):169-79. PMID: 10078200.
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    150. Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature. 1997 May 22; 387(6631):422-6. PMID: 9163430.
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    151. Nevins JR, DeGregori J, Jakoi L, Leone G. Functional analysis of E2F transcription factor. Methods Enzymol. 1997; 283:205-19. PMID: 9251021.
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    152. Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol. 1996 Dec; 16(12):6965-76. PMID: 8943352.
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    153. Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol. 1996 Dec; 16(12):6977-84. PMID: 8943353.
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    154. Khleif SN, DeGregori J, Yee CL, Otterson GA, Kaye FJ, Nevins JR, Howley PM. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4350-4. PMID: 8633069.
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    155. Ohtani K, DeGregori J, Nevins JR. Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12146-50. PMID: 8618861.
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    156. DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 1995 Dec 01; 9(23):2873-87. PMID: 7498785.
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    157. DeGregori J, Kowalik T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol. 1995 Aug; 15(8):4215-24. PMID: 7623816.
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    158. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol. 1995 Apr; 69(4):2491-500. PMID: 7884898.
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    159. DeGregori J, Russ A, von Melchner H, Rayburn H, Priyaranjan P, Jenkins NA, Copeland NG, Ruley HE. A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 1994 Feb 01; 8(3):265-76. PMID: 8314081.
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    160. von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE. Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun; 6(6):919-27. PMID: 1317320.
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    161. Ragozzino MM, Kuo A, DeGregori J, Kohl N, Ruley HE. Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist. Environ Health Perspect. 1991 Jun; 93:97-103. PMID: 1837777.
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    162. Reddy S, DeGregori JV, von Melchner H, Ruley HE. Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells. J Virol. 1991 Mar; 65(3):1507-15. PMID: 1704929.
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