Anthony N. Gerber
Title | Affiliate - NJH |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-MED |
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Research R13HL168870 (GERBER, ANTHONY N)May 1, 2023 - Apr 30, 2024 NIH Aspen Lung Conference: Asthma: Pathogenesis, Phenotypes, Therapies and Gaps Role: Principal Investigator |
| R01HL109557 (GERBER, ANTHONY N)Apr 15, 2012 - Feb 28, 2026 NIH Mechanisms and Consequences of Gene Induction by Glucocorticoids in Airway Smooth Muscle Role: Principal Investigator |
| K08HL077159 (GERBER, ANTHONY N)Sep 29, 2005 - Jun 30, 2010 NIH Gli1 in murine lung development and differentiation Role: Principal Investigator |
Bibliographic
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Sasse SK, Dahlin A, Sanford L, Gruca MA, Gupta A, Gally F, Wu AC, Iribarren C, Dowell RD, Weiss ST, Gerber AN. Enhancer RNA transcription pinpoints functional genetic variants linked to asthma. Nat Commun. 2025 Mar 31; 16(1):2750. PMID: 40164603.
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Gerber AN. Airway Smooth Muscle Dysfunction in Asthma: Releasing the Anchor. Am J Respir Cell Mol Biol. 2025 Feb; 72(2):117-118. PMID: 39173148.
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Bridges JP, Vladar EK, Kurche JS, Krivoi A, Stancil IT, Dobrinskikh E, Hu Y, Sasse SK, Lee JS, Blumhagen RZ, Yang IV, Gerber AN, Peljto AL, Evans CM, Redente EF, Riches DW, Schwartz DA. Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium. J Clin Invest. 2025 Jan 02; 135(1). PMID: 39744946.
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Sharma S, Gerber AN, Kraft M, Wenzel SE. Asthma Pathogenesis: Phenotypes, Therapies, and Gaps: Summary of the Aspen Lung Conference 2023. Am J Respir Cell Mol Biol. 2024 Aug; 71(2):154-168. PMID: 38635858.
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Necker-Brown A, Kooi C, Thorne AJ, Bansal A, Mostafa MM, Chandramohan P, Gao A, Kalyanaraman K, Milani A, Gill S, Georgescu A, Sasse SK, Gerber AN, Leigh R, Newton R. Inducible gene expression of I?B-kinase e is dependent on nuclear factor-?B in human pulmonary epithelial cells. Biochem J. 2024 07 17; 481(14):959-980. PMID: 38941070.
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El Kharbili M, Sasse SK, Sanford L, Jacobson S, Aviszus K, Gupta A, Guo C, Majka SM, Dowell RD, Gerber AN, Bowler RP, Gally F. Noncoding SNPs decrease expression of FABP5 during COPD exacerbations. J Clin Invest. 2023 Dec 19; 134(3). PMID: 38113113.
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Liu H, Aviszus K, Zelarney P, Liao SY, Gerber AN, Make B, Wechsler ME, Marrack P, Reinhardt RL. Vaccine-elicited B- and T-cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients. ERJ Open Res. 2023 Sep; 9(5). PMID: 37583809.
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Campeau S, McNulty C, Stanley JT, Gerber AN, Sasse SK, Dowell RD. Determination of steady-state transcriptome modifications associated with repeated homotypic stress in the rat rostral posterior hypothalamic region. Front Neurosci. 2023; 17:1173699. PMID: 37360161.
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Liu H, Aviszus K, Zelarney P, Liao SY, Gerber AN, Make B, Wechsler ME, Marrack P, Reinhardt RL. Vaccine-elicited B and T cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients. medRxiv. 2023 Jan 28. PMID: 36747750.
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Borie R, Cardwell J, Konigsberg IR, Moore CM, Zhang W, Sasse SK, Gally F, Dobrinskikh E, Walts A, Powers J, Brancato J, Rojas M, Wolters PJ, Brown KK, Blackwell TS, Nakanishi T, Richards JB, Gerber AN, Fingerlin TE, Sachs N, Pulit SL, Zappala Z, Schwartz DA, Yang IV. Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 11 15; 206(10):1259-1270. PMID: 35816432.
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Bai X, Bai A, Tomasicchio M, Hagman JR, Buckle AM, Gupta A, Kadiyala V, Bevers S, Serban KA, Kim K, Feng Z, Spendier K, Hagen G, Fornis L, Griffith DE, Dzieciatkowska M, Sandhaus RA, Gerber AN, Chan ED. a1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages. J Immunol. 2022 11 01; 209(9):1746-1759. PMID: 36162872.
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Gupta A, Sasse SK, Berman R, Gruca MA, Dowell RD, Chu HW, Downey GP, Gerber AN. Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells. Physiol Genomics. 2022 10 01; 54(10):389-401. PMID: 36062885.
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Liao SY, Gerber AN, Zelarney P, Make B, Wechsler ME. SARS-CoV-2 mRNA Vaccine Antibody Response in Patients with Asthma Receiving Biologic Therapy: A Real-World Analysis. Am J Respir Crit Care Med. 2022 09 01; 206(5):644-648. PMID: 35549647.
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El Kharbili M, Aviszus K, Sasse SK, Zhao X, Serban KA, Majka SM, Gerber AN, Gally F. Macrophage programming is regulated by a cooperative interaction between fatty acid binding protein 5 and peroxisome proliferator-activated receptor ?. FASEB J. 2022 05; 36(5):e22300. PMID: 35436029.
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Bansal A, Mostafa MM, Kooi C, Sasse SK, Michi AN, Shah SV, Leigh R, Gerber AN, Newton R. Interplay between nuclear factor-?B, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells. J Biol Chem. 2022 04; 298(4):101747. PMID: 35189144.
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Liao SY, Gerber AN, Zelarney P, Make B, Wechsler ME. Impaired SARS-CoV-2 mRNA Vaccine Antibody Response in Chronic Medical Conditions: A Real-World Analysis. Chest. 2022 06; 161(6):1490-1493. PMID: 35016912.
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Gupta A, Sasse SK, Gruca MA, Sanford L, Dowell RD, Gerber AN. Deconvolution of multiplexed transcriptional responses to wood smoke particles defines rapid aryl hydrocarbon receptor signaling dynamics. J Biol Chem. 2021 10; 297(4):101147. PMID: 34520756.
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Gerber AN, Newton R, Sasse SK. Repression of transcription by the glucocorticoid receptor: A?parsimonious model for the genomics era. J Biol Chem. 2021 Jan-Jun; 296:100687. PMID: 33891947.
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Gally F, Sasse SK, Kurche JS, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion OB, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021 01 25; 6(2). PMID: 33320836.
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Mostafa MM, Bansal A, Michi AN, Sasse SK, Proud D, Gerber AN, Newton R. Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells. J Biol Chem. 2021 Jan-Jun; 296:100065. PMID: 33184061.
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Altonsy MO, Kurwa HA, Lauzon GJ, Amrein M, Gerber AN, Almishri W, Mydlarski PR. Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-?B inflammatory signaling pathway in human skin cells. Immun Inflamm Dis. 2020 03; 8(1):62-79. PMID: 31912662.
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Sasse SK, Gruca M, Allen MA, Kadiyala V, Song T, Gally F, Gupta A, Pufall MA, Dowell RD, Gerber AN. Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression. Genome Res. 2019 11; 29(11):1753-1765. PMID: 31519741.
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Sasse SK, Gerber AN. Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction? Am J Respir Cell Mol Biol. 2019 Jul; 61(1):3-4. PMID: 30576224.
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Riemondy KA, Jansing NL, Jiang P, Redente EF, Gillen AE, Fu R, Miller AJ, Spence JR, Gerber AN, Hesselberth JR, Zemans RL. Single cell RNA sequencing identifies TGF? as a key regenerative cue following LPS-induced lung injury. JCI Insight. 2019 03 26; 5. PMID: 30913038.
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Britt RD, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L71-L81. PMID: 30335498.
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Evans CM, Seibold MA, Gerber AN. SPDEFending the Lung through Mucin Expression. Am J Respir Cell Mol Biol. 2018 09; 59(3):287-288. PMID: 29723043.
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Rider CF, Altonsy MO, Mostafa MM, Shah SV, Sasse S, Manson ML, Yan D, K?rrman-M?rdh C, Miller-Larsson A, Gerber AN, Giembycz MA, Newton R. Long-Acting ?2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)-Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR. Mol Pharmacol. 2018 09; 94(3):1031-1046. PMID: 29959223.
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Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 10; 142(4):1173-1184. PMID: 29277702.
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Swaminathan S, Qirko K, Smith T, Corcoran E, Wysham NG, Bazaz G, Kappel G, Gerber AN. A machine learning approach to triaging patients with chronic obstructive pulmonary disease. PLoS One. 2017; 12(11):e0188532. PMID: 29166411.
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Sasse SK, Kadiyala V, Danhorn T, Panettieri RA, Phang TL, Gerber AN. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. Am J Respir Cell Mol Biol. 2017 08; 57(2):226-237. PMID: 28375666.
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Helling BA, Gerber AN, Kadiyala V, Sasse SK, Pedersen BS, Sparks L, Nakano Y, Okamoto T, Evans CM, Yang IV, Schwartz DA. Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 07; 57(1):91-99. PMID: 28272906.
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Katial RK, Bensch GW, Busse WW, Chipps BE, Denson JL, Gerber AN, Jacobs JS, Kraft M, Martin RJ, Nair P, Wechsler ME. Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies. J Allergy Clin Immunol Pract. 2017 Mar - Apr; 5(2S):S1-S14. PMID: 28143691.
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Altonsy MO, Mostafa MM, Gerber AN, Newton R. Long-acting ?2-agonists promote glucocorticoid-mediated repression of NF-?B by enhancing expression of the feedback regulator TNFAIP3. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 01; 312(3):L358-L370. PMID: 28039105.
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Gerber AN. Measuring safety of inhaled corticosteroids in asthma. Ann Allergy Asthma Immunol. 2016 12; 117(6):577-581. PMID: 27979012.
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Sasse SK, Altonsy MO, Kadiyala V, Cao G, Panettieri RA, Gerber AN. Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol. 2016 08 01; 311(2):L421-32. PMID: 27371733.
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Kadiyala V, Sasse SK, Altonsy MO, Berman R, Chu HW, Phang TL, Gerber AN. Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-?B Orchestrates Anti-inflammatory Effects. J Biol Chem. 2016 Jun 10; 291(24):12673-12687. PMID: 27076634.
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Kadiyala V, Sasse SK, Altonsy MO, Phang TL, Gerber AN. Cistrome Analysis of Glucocorticoid Receptor Activity in Bronchial Epithelial Cells Defines Novel Mechanisms of Steroid Efficacy. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S103. PMID: 27027943.
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Kraft M, Gerber AN, Szefler SJ, Wechsler ME. Introduction to the 58th Annual Thomas L. Petty Aspen Lung Conference: Asthma 2015: Mechanisms to Personalized Medicine. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S23-4. PMID: 27027947.
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Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6780-9. PMID: 26598680.
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Sasse SK, Zuo Z, Kadiyala V, Zhang L, Pufall MA, Jain MK, Phang TL, Stormo GD, Gerber AN. Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops. J Biol Chem. 2015 Aug 07; 290(32):19756-69. PMID: 26088140.
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Gerber AN. Glucocorticoids and the Lung. Adv Exp Med Biol. 2015; 872:279-98. PMID: 26215999.
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Sasse SK, Gerber AN. Feed-forward transcriptional programming by nuclear receptors: regulatory principles and therapeutic implications. Pharmacol Ther. 2015 Jan; 145:85-91. PMID: 25168919.
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Altonsy MO, Sasse SK, Phang TL, Gerber AN. Context-dependent cooperation between nuclear factor ?B (NF-?B) and the glucocorticoid receptor at a TNFAIP3 intronic enhancer: a mechanism to maintain negative feedback control of inflammation. J Biol Chem. 2014 Mar 21; 289(12):8231-9. PMID: 24500711.
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Gerber AN. Glucocorticoids and airway smooth muscle: some answers, more questions. Am J Respir Crit Care Med. 2013 May 15; 187(10):1040-1. PMID: 23675710.
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Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Mol Cell Biol. 2013 Jun; 33(11):2104-15. PMID: 23508109.
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Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6739-44. PMID: 22493257.
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Gerber AN. Genetics of glucocorticoids in asthma. N Engl J Med. 2011 12 22; 365(25):2435; author reply 2435-6. PMID: 22187997.
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Gerber AN, Sutherland ER. Vitamin D and asthma: another dimension. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1324-5. PMID: 22174108.
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Masuno K, Haldar SM, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA, Jain MK, Gerber AN. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):642-9. PMID: 21257922.
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Gerber AN, Masuno K, Diamond MI. Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4929-34. PMID: 19255438.
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Yun AJ, Lee PY, Gerber AN. Integrating systems biology and medical imaging: understanding disease distribution in the lung model. AJR Am J Roentgenol. 2006 Apr; 186(4):925-30. PMID: 16554557.
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Yun AJ, Bazar KA, Gerber A, Lee PY, Daniel SM. The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeutics. Med Hypotheses. 2005; 65(1):173-8. PMID: 15893136.
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Yun AJ, Bazar KA, Lee PY, Gerber A, Daniel SM. The smoking gun: many conditions associated with tobacco exposure may be attributable to paradoxical compensatory autonomic responses to nicotine. Med Hypotheses. 2005; 64(6):1073-9. PMID: 15823687.
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Year | Publications |
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2005 | 2 | 2006 | 1 | 2009 | 1 | 2011 | 3 | 2012 | 1 | 2013 | 2 | 2014 | 2 | 2015 | 3 | 2016 | 6 | 2017 | 5 | 2018 | 3 | 2019 | 3 | 2020 | 2 | 2021 | 3 | 2022 | 7 | 2023 | 4 | 2024 | 2 | 2025 | 3 |
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