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Christopher Jon Phiel

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Denver Campus
DepartmentCLAS-Biology
Phone303/556-5681
    Other Positions
    TitleAsst Professor
    InstitutionUniversity of Colorado Denver - Denver Campus
    DepartmentCLAS-Biology


    Collapse Research 
    Collapse research activities and funding
    R01AG031883     (PHIEL, CHRISTOPHER J)Aug 1, 2008 - May 31, 2014
    NIH/NIA
    Effects of Conditional GSK3 Knockout on the Pathogenesis of Alzheimers Disease
    Role: Principal Investigator

    R15GM119103     (PHIEL, CHRISTOPHER J)May 1, 2016 - Apr 30, 2019
    NIH/NIGMS
    The Regulation of mRNA Methylation by Glycogen Synthase Kinase-3
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Meredith GD, D'Ippolito A, Dudas M, Zeidner LC, Hostetter L, Faulds K, Arnold TH, Popkie AP, Doble BW, Marnellos G, Adams C, Wang Y, Phiel CJ. Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells. Mol Biol Cell. 2015 Jun 01; 26(11):2139-50. PMID: 25833708; PMCID: PMC4472022.
    2. Bhattacharjee R, Goswami S, Dudiki T, Popkie AP, Phiel CJ, Kline D, Vijayaraghavan S. Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility. Biol Reprod. 2015 Mar; 92(3):65. PMID: 25568307; PMCID: PMC4358024.
    3. Zhen CY, Duc HN, Kokotovic M, Phiel CJ, Ren X. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell. 2014 Nov 15; 25(23):3726-39. PMID: 25232004; PMCID: PMC4230780.
    4. Bartman CM, Egelston J, Kattula S, Zeidner LC, D'Ippolito A, Doble BW, Phiel CJ. Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/ß-Catenin Signaling Pathways. Front Endocrinol (Lausanne). 2014; 5:133. PMID: 25165462; PMCID: PMC4131280.
    5. Bartman CM, Egelston J, Ren X, Das R, Phiel CJ. A simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine. Exp Cell Res. 2015 Jan 01; 330(1):178-85. PMID: 25102378; PMCID: PMC4268182.
    6. Fleming JL, Phiel CJ, Toland AE. The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease. Curr Alzheimer Res. 2012 Nov; 9(9):1077-96. PMID: 21605062.
      View in: PubMed
    7. Zeidner LC, Buescher JL, Phiel CJ. A novel interaction between Glycogen Synthase Kinase-3a (GSK-3a) and the scaffold protein Receptor for Activated C-Kinase 1 (RACK1) regulates the circadian clock. Int J Biochem Mol Biol. 2011; 2(4):318-27. PMID: 22187666; PMCID: PMC3242428.
    8. He F, Popkie AP, Xiong W, Li L, Wang Y, Phiel CJ, Chen Y. Gsk3ß is required in the epithelium for palatal elevation in mice. Dev Dyn. 2010 Dec; 239(12):3235-46. PMID: 20981831; PMCID: PMC3069642.
    9. Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem. 2010 Dec 31; 285(53):41337-47. PMID: 21047779; PMCID: PMC3009859.
    10. Yang J, Phiel C. Functions of B56-containing PP2As in major developmental and cancer signaling pathways. Life Sci. 2010 Dec 18; 87(23-26):659-66. PMID: 20934435; PMCID: PMC2993835.
    11. Buescher JL, Phiel CJ. A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity. J Biol Chem. 2010 Mar 12; 285(11):7957-63. PMID: 20080974; PMCID: PMC2832946.
    12. Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, Yang J. PP2A:B56epsilon is required for eye induction and eye field separation. Dev Biol. 2007 Feb 15; 302(2):477-93. PMID: 17074314.
      View in: PubMed
    13. Checler F, Frédéric C, Alves da Costa C, Cristine Ada C, Ayral E, Erwan A, Andrau D, David A, Dumanchin C, Cécile D, Farzan M, Michael F, Hernandez JF, Jean-François H, Martinez J, Lefranc-Jullien S, Solveig LJ, Marambaud P, Philippe M, Pasini A, Andrea P, Petit A, Agnès P, Phiel C, Christopher P, Robert P, Philippe R, St George-Hyslop P, Peter SG, Wilk S, Sherwin W. JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway. Curr Alzheimer Res. 2005 Jul; 2(3):327-34. PMID: 15974898.
      View in: PubMed
    14. Petit A, Pasini A, Alves Da Costa C, Ayral E, Hernandez JF, Dumanchin-Njock C, Phiel CJ, Marambaud P, Wilk S, Farzan M, Fulcrand P, Martinez J, Andrau D, Checler F. JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. J Neurosci Res. 2003 Nov 01; 74(3):370-7. PMID: 14598313.
      View in: PubMed
    15. Gabetta V, Trzyna W, Phiel C, McHugh KM. Vesicle-associated protein-A is differentially expressed during intestinal smooth muscle cell differentiation. Dev Dyn. 2003 Sep; 228(1):11-20. PMID: 12950075.
      View in: PubMed
    16. Zhang F, Phiel CJ, Spece L, Gurvich N, Klein PS. Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J Biol Chem. 2003 Aug 29; 278(35):33067-77. PMID: 12796505.
      View in: PubMed
    17. Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. 2003 May 22; 423(6938):435-9. PMID: 12761548.
      View in: PubMed
    18. Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28; 276(39):36734-41. PMID: 11473107.
      View in: PubMed
    19. Phiel CJ, Gabbeta V, Parsons LM, Rothblat D, Harvey RP, McHugh KM. Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues. J Biol Chem. 2001 Sep 14; 276(37):34637-50. PMID: 11457859.
      View in: PubMed
    20. Phiel CJ, Klein PS. Molecular targets of lithium action. Annu Rev Pharmacol Toxicol. 2001; 41:789-813. PMID: 11264477.
      View in: PubMed
    21. Brittingham J, Phiel C, Trzyna WC, Gabbeta V, McHugh KM. Identification of distinct molecular phenotypes in cultured gastrointestinal smooth muscle cells. Gastroenterology. 1998 Sep; 115(3):605-17. PMID: 9721158.
      View in: PubMed
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