Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Jeffrey Jacot

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentCEDC-Bioengineering
    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentCEDC-Bioengineering


    Collapse Research 
    Collapse research activities and funding
    R01HL130436     (JACOT, JEFFREY G)Jan 20, 2016 - May 31, 2021
    NIH
    PRE-VASCULARIZED AND DEGRADABLE PATCHES FOR CORRECTION OF CONGENITAL HEART DEFECTS
    Role: Principal Investigator
    R13HD071726     (JACOT, JEFFREY G)Dec 6, 2011 - Nov 30, 2012
    NIH
    Tissue Engineering for Pediatric Applications
    Role: Principal Investigator
    R21HL110330     (JACOT, JEFFREY G)Jul 19, 2011 - Nov 30, 2013
    NIH
    Dependence of Cardiomyocyte Electrophysiology Development on Contractile Strain
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Garcia C, Lyons KU, Contreras JG, Liu T, Donnelly AJ, Novak AJ, Argabright A, Anderson C, Grier A, Smith S, Michlin J, Olusoji J, Mikeska RG, Zhou X, Geng H, Rahkola JT, Patel HN, Jacot JG, Müschen M, D'Alessandro A, Dick JE, Iacobucci I, Mullighan CG, Reisz JA, Phang T, Eric Kohler M, Witkowski MT. FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia. Leukemia. 2026 Aug; 40(8):1763-1777. PMID: 42380664.
      View in: PubMed
    2. Tanneberger AE, Blomberg R, Yendamuri T, Noelle H, Jacot JG, Burgess JK, Magin CM. Hydrogel-Embedded Precision-Cut Lung Slices Recapitulate Fibrotic Gene Expression and Enable Therapeutic Response Evaluation. bioRxiv. 2026 Mar 27. PMID: 41929172.
      View in: PubMed
    3. Reeser RS, VeDepo MC, Hewawasam RS, Waugh KA, Schade KA, Abdel-Hafiz M, Peña B, Mestroni L, Sbaizero O, Espinosa JM, Magin CM, Jacot JG. Aberrant tissue mechanics and mechanotransduction during heart development in down syndrome. J Biomech. 2026 Jan; 195:113103. PMID: 41468742.
      View in: PubMed
    4. Lennon ML, Frieman A, Salazar AK, Kogut I, Bilousova G, Jacot JG. Amniotic fluid collected from vaginal birth as a source of stem cells for clinical applications and disease modeling. Stem Cells Transl Med. 2025 06 25; 14(7). PMID: 40558383.
      View in: PubMed
    5. Coughlan C, Lindenberger J, Jacot JG, Johnson NR, Anton P, Bevers S, Welty R, Graner MW, Potter H. Specific Binding of Alzheimer's Aß Peptides to Extracellular Vesicles. Int J Mol Sci. 2024 Mar 26; 25(7). PMID: 38612514.
      View in: PubMed
    6. Reeser RS, Salazar AK, Prutton KM, Roede JR, VeDepo MC, Jacot JG. Trisomy 21 Alters Cell Proliferation and Migration of iPSC-Derived Cardiomyocytes on Type VI Collagen. Cell Mol Bioeng. 2024 Feb; 17(1):25-34. PMID: 38435791.
      View in: PubMed
    7. Vanderslice EJ, Golding SGH, Jacot JG. Vascularization of PEGylated fibrin hydrogels increases the proliferation of human iPSC-cardiomyocytes. J Biomed Mater Res A. 2024 04; 112(4):625-634. PMID: 38155509.
      View in: PubMed
    8. Ibarra DE, Jewett ME, Jarrell DK, Pinales A, VeDepo MC, Jacot JG. Bioreactor Design for Culturing Vascularized Engineered Tissue in Flow Conditions. Tissue Eng Part A. 2024 06; 30(11-12):304-313. PMID: 37917107.
      View in: PubMed
    9. Jarrell DK, Jacot JG. An In Vitro Characterization of a PCL-Fibrin Scaffold for Myocardial Repair. Mater Today Commun. 2023 Dec; 37. PMID: 38130877.
      View in: PubMed
    10. Tao ZW, Jarrell DK, Robinson A, Cosgriff-Hernandez EM, Jacot JG. A Prevascularized Polyurethane-Reinforced Fibrin Patch Improves Regenerative Remodeling in a Rat Right Ventricle Replacement Model. Adv Healthc Mater. 2021 12; 10(23):e2101018. PMID: 34626079.
      View in: PubMed
    11. Jarrell DK, Vanderslice EJ, Lennon ML, Lyons AC, VeDepo MC, Jacot JG. Increasing salinity of fibrinogen solvent generates stable fibrin hydrogels for cell delivery or tissue engineering. PLoS One. 2021; 16(5):e0239242. PMID: 34010323.
      View in: PubMed
    12. Beck EC, Jarrell DK, Lyons AC, Vanderslice EJ, VeDepo MC, Jacot JG. Assessment of electrospun cardiac patches made with sacrificial particles and polyurethane-polycaprolactone blends. J Biomed Mater Res A. 2021 11; 109(11):2154-2163. PMID: 33876870.
      View in: PubMed
    13. VeDepo MC, Flores K, Jacot JG. Chemokine-Induced PBMC and Subsequent MSC Migration Toward Decellularized Heart Valve Tissue. Cardiovasc Eng Technol. 2021 06; 12(3):325-338. PMID: 33565031.
      View in: PubMed
    14. Ferrari MR, Di Maria MV, Jacot JG. Review on Mechanical Support and Cell-Based Therapies for the Prevention and Recovery of the Failed Fontan-Kreutzer Circulation. Front Pediatr. 2020; 8:627660. PMID: 33575233.
      View in: PubMed
    15. Jarrell DK, Vanderslice EJ, VeDepo MC, Jacot JG. Engineering Myocardium for Heart Regeneration-Advancements, Considerations, and Future Directions. Front Cardiovasc Med. 2020; 7:586261. PMID: 33195474.
      View in: PubMed
    16. Bailey KE, Pino C, Lennon ML, Lyons A, Jacot JG, Lammers SR, Königshoff M, Magin CM. Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture. Am J Respir Cell Mol Biol. 2020 01; 62(1):14-22. PMID: 31513744.
      View in: PubMed
    17. Tao ZW, Wu S, Cosgriff-Hernandez EM, Jacot JG. Evaluation of a polyurethane-reinforced hydrogel patch in a rat right ventricle wall replacement model. Acta Biomater. 2020 01 01; 101:206-218. PMID: 31654774.
      View in: PubMed
    18. Jarrell DK, Lennon ML, Jacot JG. Epigenetics and Mechanobiology in Heart Development and Congenital Heart Disease. Diseases. 2019 Sep 01; 7(3). PMID: 31480510.
      View in: PubMed
    19. Tsao CJ, Taraballi F, Pandolfi L, Velasquez-Mao AJ, Ruano R, Tasciotti E, Jacot JG. Controlled Release of Small Molecules for Cardiac Differentiation of Pluripotent Stem Cells. Tissue Eng Part A. 2018 12; 24(23-24):1798-1807. PMID: 30129882.
      View in: PubMed
    20. Tao ZW, Mohamed M, Jacot JG, Birla RK. Bioengineering Cardiac Tissue Constructs With Adult Rat Cardiomyocytes. ASAIO J. 2018 Sep/Oct; 64(5):e105-e114. PMID: 29538014.
      View in: PubMed
    21. Velasquez-Mao AJ, Tsao CJM, Monroe MN, Legras X, Bissig-Choisat B, Bissig KD, Ruano R, Jacot JG. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS One. 2017; 12(5):e0177824. PMID: 28545044.
      View in: PubMed
    22. Pok S, Stupin IV, Tsao C, Pautler RG, Gao Y, Nieto RM, Tao ZW, Fraser CD, Annapragada AV, Jacot JG. Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model. Adv Healthc Mater. 2017 Mar; 6(5). PMID: 28081298.
      View in: PubMed
    23. Boothe SD, Myers JD, Pok S, Sun J, Xi Y, Nieto RM, Cheng J, Jacot JG. The Effect of Substrate Stiffness on Cardiomyocyte Action Potentials. Cell Biochem Biophys. 2016 Dec; 74(4):527-535. PMID: 27722948.
      View in: PubMed
    24. Del Bufalo F, Manzo T, Hoyos V, Yagyu S, Caruana I, Jacot J, Benavides O, Rosen D, Brenner MK. 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials. 2016 Apr; 84:76-85. PMID: 26826297.
      View in: PubMed
    25. Scully BB, Fan C, Grigoryan B, Jacot JG, Vick GW, Kim JJ, Fraser CD, Grande-Allen KJ, Morales DL. Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study. J Biomed Mater Res B Appl Biomater. 2016 11; 104(8):1713-1720. PMID: 26348258.
      View in: PubMed
    26. Gao Y, Jacot JG. Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects. Biomark Insights. 2015; 10(Suppl 1):139-46. PMID: 26379417.
      View in: PubMed
    27. Weia BC, Adachi I, Jacot JG. Clinical and Molecular Comparison of Pediatric and Adult Reverse Remodeling With Ventricular Assist Devices. Artif Organs. 2015 Aug; 39(8):691-700. PMID: 25865791.
      View in: PubMed
    28. Connell JP, Ruano R, Jacot JG. Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway. Biomed Mater. 2015 Mar 18; 10(3):034103. PMID: 25784677.
      View in: PubMed
    29. Benavides OM, Brooks AR, Cho SK, Petsche Connell J, Ruano R, Jacot JG. In situ vascularization of injectable fibrin/poly(ethylene glycol) hydrogels by human amniotic fluid-derived stem cells. J Biomed Mater Res A. 2015 Aug; 103(8):2645-53. PMID: 25631778.
      View in: PubMed
    30. Benavides OM, Quinn JP, Pok S, Petsche Connell J, Ruano R, Jacot JG. Capillary-like network formation by human amniotic fluid-derived stem cells within fibrin/poly(ethylene glycol) hydrogels. Tissue Eng Part A. 2015 Apr; 21(7-8):1185-94. PMID: 25517426.
      View in: PubMed
    31. Gao Y, Connell JP, Wadhwa L, Ruano R, Jacot JG. Amniotic fluid-derived stem cells demonstrated cardiogenic potential in indirect co-culture with human cardiac cells. Ann Biomed Eng. 2014 Dec; 42(12):2490-500. PMID: 25266932.
      View in: PubMed
    32. Pok S, Vitale F, Eichmann SL, Benavides OM, Pasquali M, Jacot JG. Biocompatible carbon nanotube-chitosan scaffold matching the electrical conductivity of the heart. ACS Nano. 2014 Oct 28; 8(10):9822-32. PMID: 25233037.
      View in: PubMed
    33. Pok S, Jacot JG. Work and tension: new evidence that adherent cells of the same area do the same work independent of stiffness and focal adhesions. Biophys J. 2014 Aug 19; 107(4):798-9. PMID: 25140413.
      View in: PubMed
    34. Pok S, Benavides OM, Hallal P, Jacot JG. Use of myocardial matrix in a chitosan-based full-thickness heart patch. Tissue Eng Part A. 2014 Jul; 20(13-14):1877-87. PMID: 24433519.
      View in: PubMed
    35. Mondy WL, Casteleyn C, Loo DV, Raja M, Singleton C, Jacot JG. Osmium tetroxide labeling of (poly)methyl methacrylate corrosion casts for enhancement of micro-CT microvascular imaging. Microsc Microanal. 2013 Dec; 19(6):1416-27. PMID: 24103507.
      View in: PubMed
    36. Connell JP, Augustini E, Moise KJ, Johnson A, Jacot JG. Formation of functional gap junctions in amniotic fluid-derived stem cells induced by transmembrane co-culture with neonatal rat cardiomyocytes. J Cell Mol Med. 2013 Jun; 17(6):774-81. PMID: 23634988.
      View in: PubMed
    37. Petsche Connell J, Camci-Unal G, Khademhosseini A, Jacot JG. Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications. Tissue Eng Part B Rev. 2013 Aug; 19(4):368-79. PMID: 23350771.
      View in: PubMed
    38. Pok S, Myers JD, Madihally SV, Jacot JG. A multilayered scaffold of a chitosan and gelatin hydrogel supported by a PCL core for cardiac tissue engineering. Acta Biomater. 2013 Mar; 9(3):5630-42. PMID: 23128158.
      View in: PubMed
    39. Benavides OM, Petsche JJ, Moise KJ, Johnson A, Jacot JG. Evaluation of endothelial cells differentiated from amniotic fluid-derived stem cells. Tissue Eng Part A. 2012 Jun; 18(11-12):1123-31. PMID: 22250756.
      View in: PubMed
    40. Jacot JG, Kita-Matsuo H, Wei KA, Chen HS, Omens JH, Mercola M, McCulloch AD. Cardiac myocyte force development during differentiation and maturation. Ann N Y Acad Sci. 2010 Feb; 1188:121-7. PMID: 20201894.
      View in: PubMed
    41. Jacot JG, Martin JC, Hunt DL. Mechanobiology of cardiomyocyte development. J Biomech. 2010 Jan 05; 43(1):93-8. PMID: 19819458.
      View in: PubMed
    42. Jacot JG, Dianis S, Schnall J, Wong JY. A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues. J Biomed Mater Res A. 2006 Dec 01; 79(3):485-94. PMID: 16779854.
      View in: PubMed
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