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Nicole Harlaar

TitleAsst Professor Adjoint
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Overview 
    Collapse overview
    Research methodologist with interests in maternal and child health, child welfare, health disparities, and causal inference in statistics.


    PhD, King's College London
    BSc, University of Wales, UK

    Collapse Research 
    Collapse research activities and funding
    K99AA020536     (HARLAAR, NICOLE)Sep 1, 2012 - Aug 31, 2014
    Epigenetic Profiles Associated with Alcohol Use in At-risk Samples
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chiesa AE, Kallechey L, Harlaar N, Rashaan Ford C, Garrido EF, Betts WR, Maguire S. Intimate partner violence victimization and parenting: A systematic review. Child Abuse Negl. 2018 Jun; 80:285-300. PMID: 29665506.
      View in: PubMed
    2. Tosto MG, Hayiou-Thomas ME, Harlaar N, Prom-Wormley E, Dale PS, Plomin R. The genetic architecture of oral language, reading fluency, and reading comprehension: A twin study from 7 to 16 years. Dev Psychol. 2017 06; 53(6):1115-1129. PMID: 28541066.
      View in: PubMed
    3. Ruzas CM, DeWitt PE, Bennett KS, Chapman KE, Harlaar N, Bennett TD. EEG Monitoring and Antiepileptic Drugs in Children with Severe TBI. Neurocrit Care. 2017 04; 26(2):256-266. PMID: 27873234.
      View in: PubMed
    4. Bennett KS, DeWitt PE, Harlaar N, Bennett TD. Seizures in Children With Severe Traumatic Brain Injury. Pediatr Crit Care Med. 2017 01; 18(1):54-63. PMID: 27654815.
      View in: PubMed
    5. Harlaar N, DeThorne LS, Smith JM, Betancourt MA, Petrill SA. Longitudinal Effects on Early Adolescent Language: A Twin Study. J Speech Lang Hear Res. 2016 Oct 01; 59(5):1059-1073. PMID: 27732720.
      View in: PubMed
    6. Hagerty SL, Bidwell LC, Harlaar N, Hutchison KE. An Exploratory Association Study of Alcohol Use Disorder and DNA Methylation. Alcohol Clin Exp Res. 2016 08; 40(8):1633-40. PMID: 27388583.
      View in: PubMed
    7. Lewis T, McElroy E, Harlaar N, Runyan D. Does the impact of child sexual abuse differ from maltreated but non-sexually abused children? A prospective examination of the impact of child sexual abuse on internalizing and externalizing behavior problems. Child Abuse Negl. 2016 Jan; 51:31-40. PMID: 26712421; PMCID: PMC4713277 [Available on 01/01/17].
    8. Krapohl E, Rimfeld K, Shakeshaft NG, Trzaskowski M, McMillan A, Pingault JB, Asbury K, Harlaar N, Kovas Y, Dale PS, Plomin R. The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15273-8. PMID: 25288728; PMCID: PMC4210287.
    9. Davis OS, Band G, Pirinen M, Haworth CM, Meaburn EL, Kovas Y, Harlaar N, Docherty SJ, Hanscombe KB, Trzaskowski M, Curtis CJ, Strange A, Freeman C, Bellenguez C, Su Z, Pearson R, Vukcevic D, Langford C, Deloukas P, Hunt S, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Edkins S, Bumpstead SJ, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski JA, Markus HS, Mathew CG, Palmer CN, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Barroso I, Peltonen L, Dale PS, Petrill SA, Schalkwyk LS, Craig IW, Lewis CM, Price TS, Donnelly P, Plomin R, Spencer CC. The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nat Commun. 2014 Jul 08; 5:4204. PMID: 25003214.
      View in: PubMed
    10. Harlaar N, Meaburn EL, Hayiou-Thomas ME, Davis OS, Docherty S, Hanscombe KB, Haworth CM, Price TS, Trzaskowski M, Dale PS, Plomin R. Genome-wide association study of receptive language ability of 12-year-olds. J Speech Lang Hear Res. 2014 Feb; 57(1):96-105. PMID: 24687471; PMCID: PMC3974169.
    11. Harlaar N, Trzaskowski M, Dale PS, Plomin R. Word reading fluency: role of genome-wide single-nucleotide polymorphisms in developmental stability and correlations with print exposure. Child Dev. 2014 May-Jun; 85(3):1190-1205. PMID: 24392801; PMCID: PMC4064251.
    12. Trzaskowski M, Harlaar N, Arden R, Krapohl E, Rimfeld K, McMillan A, Dale PS, Plomin R. Genetic influence on family socioeconomic status and children's intelligence. Intelligence. 2014 Jan; 42(100):83-88. PMID: 24489417.
      View in: PubMed
    13. Harlaar N, Bryan AD, Thayer RE, Karoly HC, Oien N, Hutchison KE. Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes. Alcohol Clin Exp Res. 2014 Mar; 38(3):713-21. PMID: 24236815.
      View in: PubMed
    14. Harlaar N, Hutchison KE. Alcohol and the methylome: design and analysis considerations for research using human samples. Drug Alcohol Depend. 2013 Dec 01; 133(2):305-16. PMID: 23968814.
      View in: PubMed
    15. Karoly HC, Harlaar N, Hutchison KE. Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. Ann N Y Acad Sci. 2013 Apr; 1282:71-91. PMID: 23470155.
      View in: PubMed
    16. Bryan AD, Magnan RE, Hooper AE, Harlaar N, Hutchison KE. Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation. Ann Behav Med. 2013 Feb; 45(1):89-98. PMID: 23054940.
      View in: PubMed
    17. Yeo RA, Thoma RJ, Gasparovic C, Monnig M, Harlaar N, Calhoun VD, Kalyanam R, Mayer AR, Durazzo TC, Hutchison KE. Neurometabolite concentration and clinical features of chronic alcohol use: a proton magnetic resonance spectroscopy study. Psychiatry Res. 2013 Feb 28; 211(2):141-7. PMID: 23154093; PMCID: PMC3570754.
    18. Blaine S, Claus E, Harlaar N, Hutchison K. TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. Alcohol Clin Exp Res. 2013 Jan; 37 Suppl 1:E125-30. PMID: 23078527.
      View in: PubMed
    19. Harlaar N, Kovas Y, Dale PS, Petrill SA, Plomin R. Mathematics is differentially related to reading comprehension and word decoding: Evidence from a genetically-sensitive design. J Educ Psychol. 2012 Aug; 104(3). PMID: 24319294.
      View in: PubMed
    20. Karoly HC, Stevens CJ, Magnan RE, Harlaar N, Hutchison KE, Bryan AD. Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults. J Cancer Epidemiol. 2012; 2012:540563. PMID: 22899923; PMCID: PMC3414053.
    21. DeThorne LS, Harlaar N, Petrill SA, Deater-Deckard K. Longitudinal stability in genetic effects on children's conversational language productivity. J Speech Lang Hear Res. 2012 Jun; 55(3):739-53. PMID: 22232406.
      View in: PubMed
    22. Dale, P. S., Harlaar, N., Plomin, R. Nature and nurture in school-based second language achievement. Language Learning. 2012; 62:28-48.
    23. Harlaar N, Deater-Deckard K, Thompson LA, Dethorne LS, Petrill SA. Associations between reading achievement and independent reading in early elementary school: a genetically informative cross-lagged study. Child Dev. 2011 Nov-Dec; 82(6):2123-37. PMID: 22026450; PMCID: PMC3610326.
    24. Greven CU, Harlaar N, Dale PS, Plomin R. Genetic Overlap between ADHD Symptoms and Reading is largely Driven by Inattentiveness rather than Hyperactivity-Impulsivity. J Can Acad Child Adolesc Psychiatry. 2011 Feb; 20(1):6-14. PMID: 21286364; PMCID: PMC3024726.
    25. Harlaar N, Cutting L, Deater-Deckard K, Dethorne LS, Justice LM, Schatschneider C, Thompson LA, Petrill SA. Predicting individual differences in reading comprehension: a twin study. Ann Dyslexia. 2010 Dec; 60(2):265-88. PMID: 20814768; PMCID: PMC2981603.
    26. Dale PS, Harlaar N, Hayiou-Thomas ME, Plomin R. The etiology of diverse receptive language skills at 12 years. J Speech Lang Hear Res. 2010 Aug; 53(4):982-92. PMID: 20605943; PMCID: PMC4040409.
    27. Chamorro-Premuzic T, Harlaar N, Greven CU, Plomin R. More than just IQ: A longitudinal examination of self-perceived abilities as predictors of academic performance in a large sample of UK twins. Intelligence. 2010 Jul; 38(4):385-392. PMID: 25473141.
      View in: PubMed
    28. Dale PS, Harlaar N, Haworth CM, Plomin R. Two by two: a twin study of second-language acquisition. Psychol Sci. 2010 May; 21(5):635-40. PMID: 20483839.
      View in: PubMed
    29. Hayiou-Thomas ME, Harlaar N, Dale PS, Plomin R. Preschool speech, language skills, and reading at 7, 9, and 10 years: etiology of the relationship. J Speech Lang Hear Res. 2010 Apr; 53(2):311-32. PMID: 20360459.
      View in: PubMed
    30. Petrill SA, Hart SA, Harlaar N, Logan J, Justice LM, Schatschneider C, Thompson L, Dethorne LS, Deater-Deckard K, Cutting L. Genetic and environmental influences on the growth of early reading skills. J Child Psychol Psychiatry. 2010 Jun; 51(6):660-7. PMID: 20059623; PMCID: PMC2891369.
    31. Haworth CM, Kovas Y, Harlaar N, Hayiou-Thomas ME, Petrill SA, Dale PS, Plomin R. Generalist genes and learning disabilities: a multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8000 12-year-old twins. J Child Psychol Psychiatry. 2009 Oct; 50(10):1318-25. PMID: 19573035; PMCID: PMC2749077.
    32. Greven CU, Harlaar N, Kovas Y, Chamorro-Premuzic T, Plomin R. More than just IQ: school achievement is predicted by self-perceived abilities--but for genetic rather than environmental reasons. Psychol Sci. 2009 Jun; 20(6):753-62. PMID: 19470122; PMCID: PMC4018661.
    33. Friend A, DeFries JC, Olson RK, Pennington B, Harlaar N, Byrne B, Samuelsson S, Willcutt EG, Wadsworth SJ, Corley R, Keenan JM. Heritability of high reading ability and its interaction with parental education. Behav Genet. 2009 Jul; 39(4):427-36. PMID: 19296213; PMCID: PMC3387983.
    34. Alanko K, Santtila P, Harlaar N, Witting K, Varjonen M, Jern P, Johansson A, von der Pahlen B, Sandnabba NK. Common genetic effects of gender atypical behavior in childhood and sexual orientation in adulthood: a study of Finnish twins. Arch Sex Behav. 2010 Feb; 39(1):81-92. PMID: 19172387.
      View in: PubMed
    35. Asbury K, Almeida D, Hibel J, Harlaar N, Plomin R. Clones in the classroom: a daily diary study of the nonshared environmental relationship between monozygotic twin differences in school experience and achievement. Twin Res Hum Genet. 2008 Dec; 11(6):586-95. PMID: 19016614; PMCID: PMC2981605.
    36. Harlaar N, Santtila P, Björklund J, Alanko K, Jern P, Varjonen M, von der Pahlen B, Sandnabba K. Retrospective reports of parental physical affection and parenting style: a study of Finnish twins. J Fam Psychol. 2008 Aug; 22(4):605-13. PMID: 18729674.
      View in: PubMed
    37. Harlaar N, Hayiou-Thomas ME, Dale PS, Plomin R. Why do preschool language abilities correlate with later reading? A twin study. J Speech Lang Hear Res. 2008 Jun; 51(3):688-705. PMID: 18506044.
      View in: PubMed
    38. Johansson A, Santtila P, Harlaar N, von der Pahlen B, Witting K, Algars M, Alanko K, Jern P, Varjonen M, Sandnabba NK. Genetic effects on male sexual coercion. Aggress Behav. 2008 Mar-Apr; 34(2):190-202. PMID: 17828754.
      View in: PubMed
    39. Santtila P, Wager I, Witting K, Harlaar N, Jern P, Johansson A, Varjonen M, Sandnabba NK. Discrepancies between sexual desire and sexual activity: gender differences and associations with relationship satisfaction. J Sex Marital Ther. 2008; 34(1):31-44. PMID: 18396727.
      View in: PubMed
    40. Witting K, Santtila P, Alanko K, Harlaar N, Jern P, Johansson A, Von Der Pahlen B, Varjonen M, Algars M, Sandnabba NK. Female sexual function and its associations with number of children, pregnancy, and relationship satisfaction. J Sex Marital Ther. 2008; 34(2):89-106. PMID: 18224545.
      View in: PubMed
    41. Harlaar N, Dale PS, Plomin R. Reading exposure: a (largely) environmental risk factor with environmentally-mediated effects on reading performance in the primary school years. J Child Psychol Psychiatry. 2007 Dec; 48(12):1192-9. PMID: 18093024.
      View in: PubMed
    42. Haworth CM, Meaburn EL, Harlaar N, Plomin R. Reading and Generalist Genes. Mind Brain Educ. 2007 Dec; 1(4):173-180. PMID: 20383260.
      View in: PubMed
    43. Jern P, Santtila P, Witting K, Alanko K, Harlaar N, Johansson A, von der Pahlen B, Varjonen M, Vikström N, Algars M, Sandnabba K. Premature and delayed ejaculation: genetic and environmental effects in a population-based sample of Finnish twins. J Sex Med. 2007 Nov; 4(6):1739-49. PMID: 17888070.
      View in: PubMed
    44. Santtila P, Sandnabba NK, Harlaar N, Varjonen M, Alanko K, von der Pahlen B. Potential for homosexual response is prevalent and genetic. Biol Psychol. 2008 Jan; 77(1):102-5. PMID: 17904267.
      View in: PubMed
    45. Meaburn EL, Harlaar N, Craig IW, Schalkwyk LC, Plomin R. Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Mol Psychiatry. 2008 Jul; 13(7):729-40. PMID: 17684495.
      View in: PubMed
    46. Haworth CM, Harlaar N, Kovas Y, Davis OS, Oliver BR, Hayiou-Thomas ME, Frances J, Busfield P, McMillan A, Dale PS, Plomin R. Internet cognitive testing of large samples needed in genetic research. Twin Res Hum Genet. 2007 Aug; 10(4):554-63. PMID: 17708696.
      View in: PubMed
    47. Harlaar N, Dale PS, Plomin R. From learning to read to reading to learn: substantial and stable genetic influence. Child Dev. 2007 Jan-Feb; 78(1):116-31. PMID: 17328696.
      View in: PubMed
    48. Arden, R., Harlaar, N., & Plomin, R. Sex differences in childhood associations between DNA markers and general cognitive ability. Journal of Individual Differences. 2007; 28:161-164.
    49. Hayiou-Thomas ME, Kovas Y, Harlaar N, Plomin R, Bishop DV, Dale PS. Common aetiology for diverse language skills in 4 1/2-year-old twins. J Child Lang. 2006 May; 33(2):339-68. PMID: 16826830.
      View in: PubMed
    50. Hayiou-Thomas, M. E., Harlaar, N., Dale, P., & Plomin, R. Journal of Research in Reading. Genetic and environmental mediation of the prediction from preschool language and non-verbal ability to 7-year reading. 2006; 29:50-74.
    51. Spinath, B., Spinath, F. M., Harlaar, N., & Plomin, R. Predicting school achievement from general cognitive ability, self-perceived ability and intrinsic value. Intelligence. 2006; 34:363-374.
    52. Harlaar N, Butcher LM, Meaburn E, Sham P, Craig IW, Plomin R. A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds. J Child Psychol Psychiatry. 2005 Oct; 46(10):1097-107. PMID: 16178934.
      View in: PubMed
    53. Harlaar N, Spinath FM, Dale PS, Plomin R. Genetic influences on early word recognition abilities and disabilities: a study of 7-year-old twins. J Child Psychol Psychiatry. 2005 Apr; 46(4):373-84. PMID: 15819646.
      View in: PubMed
    54. Kovas, Y., Harlaar, N., Petrill, S. A., & Plomin, R. ‘Generalist genes’ and mathematics in 7-year-old twins. Intelligence. 2005; 5:473-489.
    55. Harlaar, N., Hayiou-Thomas, M. E., & Plomin, R. Reading and general cognitive ability: A multivariate analysis of 7-year-old twins. Scientific Studies of Reading. 2005; 9.
    56. Harlaar, N., Dale, P. S., & Plomin, R. (2005). Correspondence between telephone testing and teacher assessments of reading in 7-year-olds: II. Strong genetic overlap in a sample of 2660 twin pairs. Reading & Writing: An Interdisciplinary Journal. 2005; 9:197-218.
    57. Dale, P. S., Harlaar, N., & Plomin, R. Telephone testing and teacher assessment of reading skills in 7-year-olds: I. Substantial correspondence for a sample of 5808 children and for extremes. Reading and Writing: An Interdisciplinary Journal,. 2005; 18:385-400.
    58. Spinath FM, Harlaar N, Ronald A, Plomin R. Substantial genetic influence on mild mental impairment in early childhood. Am J Ment Retard. 2004 Jan; 109(1):34-43. PMID: 14651451.
      View in: PubMed
    59. Spinath, F. M., Ronald, A., Harlaar, N., Price, T. S., & Plomin, R. Phenotypic 'g' early in life: On the etiology of general cognitive ability in a large population sample of twin children aged 2 to 4 years. Intelligence. 2003; 31:195–210.
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