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Thomas Edward Morrison

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
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    F32AR052600     (MORRISON, THOMAS E)May 15, 2005 - May 14, 2008
    Pathogenesis of alphavirus-induced arthritis in mice.
    Role: Principal Investigator

    K22AI079163     (MORRISON, THOMAS E)Apr 25, 2009 - Mar 31, 2011
    Pathogenesis of Arthritis and Myositis-Associated Alphaviruses
    Role: Principal Investigator

    R21AI096289     (MORRISON, THOMAS E)Jul 1, 2011 - Jun 30, 2013
    Persistent chikungunya virus infection and disease
    Role: Principal Investigator

    R01AI108725     (MORRISON, THOMAS E)Jul 15, 2014 - Jun 30, 2019
    Mechanisms of immune suppression during arthritogenic alphavirus infections
    Role: Principal Investigator

    R01AI123348     (DERMODY, TERENCE S)Mar 1, 2016 - Feb 28, 2021
    Chikungunya Virus Replication and Pathogenesis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. J Virol. 2018 03 15; 92(6). PMID: 29263267.
      View in: PubMed
    2. Gunn BM, Jones JE, Shabman RS, Whitmore AC, Sarkar S, Blevins LK, Morrison TE, Heise MT. Ross River virus envelope glycans contribute to disease through activation of the host complement system. Virology. 2018 02; 515:250-260. PMID: 29324290.
      View in: PubMed
    3. Haist KC, Burrack KS, Davenport BJ, Morrison TE. Inflammatory monocytes mediate control of acute alphavirus infection in mice. PLoS Pathog. 2017 Dec; 13(12):e1006748. PMID: 29244871.
      View in: PubMed
    4. Carpentier KS, Morrison TE. Innate immune control of alphavirus infection. Curr Opin Virol. 2018 Feb; 28:53-60. PMID: 29175515.
      View in: PubMed
    5. Sokoloski KJ, Nease LM, May NA, Gebhart NN, Jones CE, Morrison TE, Hardy RW. Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants. PLoS Pathog. 2017 Jun; 13(6):e1006473. PMID: 28662211.
      View in: PubMed
    6. Morrison TE, Diamond MS. Animal Models of Zika Virus Infection, Pathogenesis, and Immunity. J Virol. 2017 04 15; 91(8). PMID: 28148798.
      View in: PubMed
    7. McCarthy MK, Morrison TE. Persistent RNA virus infections: do PAMPS drive chronic disease? Curr Opin Virol. 2017 04; 23:8-15. PMID: 28214732.
      View in: PubMed
    8. Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE, Streblow DN. Animal Models of Chikungunya Virus Infection and Disease. J Infect Dis. 2016 Dec 15; 214(suppl 5):S482-S487. PMID: 27920178.
      View in: PubMed
    9. Shives KD, Massey AR, May NA, Morrison TE, Beckham JD. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016 10 18; 8(10). PMID: 27763553.
      View in: PubMed
    10. Hawman DW, Fox JM, Ashbrook AW, May NA, Schroeder KMS, Torres RM, Crowe JE, Dermody TS, Diamond MS, Morrison TE. Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence. Cell Rep. 2016 08 02; 16(5):1326-1338. PMID: 27452455; PMCID: PMC5003573.
    11. Ashbrook AW, Lentscher AJ, Zamora PF, Silva LA, May NA, Bauer JA, Morrison TE, Dermody TS. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio. 2016 05 24; 7(3). PMID: 27222471.
      View in: PubMed
    12. McCarthy MK, Morrison TE. Chronic chikungunya virus musculoskeletal disease: what are the underlying mechanisms? Future Microbiol. 2016; 11(3):331-4. PMID: 26939523; PMCID: PMC4842256 [Available on 03/04/17].
    13. Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain. J Virol. 2015 Dec 30; 90(6):2767-82. PMID: 26719256; PMCID: PMC4810656.
    14. Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA. Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. J Clin Invest. 2015 Dec; 125(12):4699-713. PMID: 26571397; PMCID: PMC4665786.
    15. Burrack KS, Tan JJ, McCarthy MK, Her Z, Berger JN, Ng LF, Morrison TE. Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005191. PMID: 26436766; PMCID: PMC4593600.
    16. McSweegan E, Weaver SC, Lecuit M, Frieman M, Morrison TE, Hrynkow S. The Global Virus Network: Challenging chikungunya. Antiviral Res. 2015 Aug; 120:147-52. PMID: 26071007; PMCID: PMC4843800.
    17. Sokoloski KJ, Haist KC, Morrison TE, Mukhopadhyay S, Hardy RW. Noncapped Alphavirus Genomic RNAs and Their Role during Infection. J Virol. 2015 Jun; 89(11):6080-92. PMID: 25833042; PMCID: PMC4442418.
    18. Halemano K, Barrett BS, Heilman KJ, Morrison TE, Santiago ML. Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response. J Virol. 2015 Apr; 89(7):4011-4. PMID: 25589647; PMCID: PMC4403405.
    19. Burrack KS, Montgomery SA, Homann D, Morrison TE. CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice. J Immunol. 2015 Jan 15; 194(2):678-89. PMID: 25488988; PMCID: PMC4282972.
    20. Burrack KS, Morrison TE. The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases. Front Immunol. 2014; 5:428. PMID: 25250029; PMCID: PMC4157561.
    21. Ashbrook AW, Burrack KS, Silva LA, Montgomery SA, Heise MT, Morrison TE, Dermody TS. Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice. J Virol. 2014 Nov; 88(21):12180-92. PMID: 25142598; PMCID: PMC4248890.
    22. Morrison TE. Reemergence of chikungunya virus. J Virol. 2014 Oct; 88(20):11644-7. PMID: 25078691; PMCID: PMC4178719.
    23. Banda NK, Mehta G, Kjaer TR, Takahashi M, Schaack J, Morrison TE, Thiel S, Arend WP, Holers VM. Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression. J Immunol. 2014 Sep 01; 193(5):2455-68. PMID: 25070856; PMCID: PMC4134985.
    24. Pal P, Fox JM, Hawman DW, Huang YJ, Messaoudi I, Kreklywich C, Denton M, Legasse AW, Smith PP, Johnson S, Axthelm MK, Vanlandingham DL, Streblow DN, Higgs S, Morrison TE, Diamond MS. Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes. J Virol. 2014 Aug; 88(15):8213-26. PMID: 24829346; PMCID: PMC4135940.
    25. Stoermer Burrack KA, Hawman DW, Jupille HJ, Oko L, Minor M, Shives KD, Gunn BM, Long KM, Morrison TE. Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection. J Virol. 2014 Apr; 88(7):3719-32. PMID: 24429363; PMCID: PMC3993543.
    26. Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS. A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization. J Virol. 2014 Mar; 88(5):2385-97. PMID: 24371059; PMCID: PMC3958064.
    27. Hawman DW, Stoermer KA, Montgomery SA, Pal P, Oko L, Diamond MS, Morrison TE. Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response. J Virol. 2013 Dec; 87(24):13878-88. PMID: 24131709; PMCID: PMC3838294.
    28. Jupille HJ, Medina-Rivera M, Hawman DW, Oko L, Morrison TE. A tyrosine-to-histidine switch at position 18 of the Ross River virus E2 glycoprotein is a determinant of virus fitness in disparate hosts. J Virol. 2013 May; 87(10):5970-84. PMID: 23514884; PMCID: PMC3648194.
    29. Stoermer KA, Burrack A, Oko L, Montgomery SA, Borst LB, Gill RG, Morrison TE. Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus. J Immunol. 2012 Oct 15; 189(8):4047-59. PMID: 22972923; PMCID: PMC3466331.
    30. Dickson AM, Anderson JR, Barnhart MD, Sokoloski KJ, Oko L, Opyrchal M, Galanis E, Wilusz CJ, Morrison TE, Wilusz J. Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasm. J Biol Chem. 2012 Oct 19; 287(43):36229-38. PMID: 22915590; PMCID: PMC3476290.
    31. Gunn BM, Morrison TE, Whitmore AC, Blevins LK, Hueston L, Fraser RJ, Herrero LJ, Ramirez R, Smith PN, Mahalingam S, Heise MT. Mannose binding lectin is required for alphavirus-induced arthritis/myositis. PLoS Pathog. 2012; 8(3):e1002586. PMID: 22457620; PMCID: PMC3310795.
    32. O'Brien KB, Morrison TE, Dundore DY, Heise MT, Schultz-Cherry S. A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS One. 2011 Mar 09; 6(3):e17377. PMID: 21408070; PMCID: PMC3052313.
    33. Stoermer KA, Morrison TE. Complement and viral pathogenesis. Virology. 2011 Mar 15; 411(2):362-73. PMID: 21292294; PMCID: PMC3073741.
    34. Morrison TE, Oko L, Montgomery SA, Whitmore AC, Lotstein AR, Gunn BM, Elmore SA, Heise MT. A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence. Am J Pathol. 2011 Jan; 178(1):32-40. PMID: 21224040; PMCID: PMC3069999.
    35. Jupille HJ, Oko L, Stoermer KA, Heise MT, Mahalingam S, Gunn BM, Morrison TE. Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model. Virology. 2011 Feb 05; 410(1):216-27. PMID: 21131014; PMCID: PMC3017666.
    36. Frieman MB, Chen J, Morrison TE, Whitmore A, Funkhouser W, Ward JM, Lamirande EW, Roberts A, Heise M, Subbarao K, Baric RS. SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism. PLoS Pathog. 2010 Apr 08; 6(4):e1000849. PMID: 20386712; PMCID: PMC2851658.
    37. Cruz CC, Suthar MS, Montgomery SA, Shabman R, Simmons J, Johnston RE, Morrison TE, Heise MT. Modulation of type I IFN induction by a virulence determinant within the alphavirus nsP1 protein. Virology. 2010 Mar 30; 399(1):1-10. PMID: 20097400; PMCID: PMC2830325.
    38. Simmons JD, White LJ, Morrison TE, Montgomery SA, Whitmore AC, Johnston RE, Heise MT. Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff. J Virol. 2009 Oct; 83(20):10571-81. PMID: 19656875; PMCID: PMC2753124.
    39. Bristol JA, Morrison TE, Kenney SC. CCAAT/enhancer binding proteins alpha and beta regulate the tumor necrosis factor receptor 1 gene promoter. Mol Immunol. 2009 Aug; 46(13):2706-13. PMID: 19523687; PMCID: PMC2724677.
    40. Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT. MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. PLoS Pathog. 2008 Dec; 4(12):e1000240. PMID: 19079579; PMCID: PMC2587915.
    41. Morrison TE, Simmons JD, Heise MT. Complement receptor 3 promotes severe ross river virus-induced disease. J Virol. 2008 Nov; 82(22):11263-72. PMID: 18787004; PMCID: PMC2573283.
    42. Morrison TE, Heise MT. The host complement system and arbovirus pathogenesis. Curr Drug Targets. 2008 Feb; 9(2):165-72. PMID: 18288968.
      View in: PubMed
    43. Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, Ting JP. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature. 2008 Jan 31; 451(7178):573-7. PMID: 18200010.
      View in: PubMed
    44. Morrison TE, Fraser RJ, Smith PN, Mahalingam S, Heise MT. Complement contributes to inflammatory tissue destruction in a mouse model of Ross River virus-induced disease. J Virol. 2007 May; 81(10):5132-43. PMID: 17314163; PMCID: PMC1900244.
    45. Shabman RS, Morrison TE, Moore C, White L, Suthar MS, Hueston L, Rulli N, Lidbury B, Ting JP, Mahalingam S, Heise MT. Differential induction of type I interferon responses in myeloid dendritic cells by mosquito and mammalian-cell-derived alphaviruses. J Virol. 2007 Jan; 81(1):237-47. PMID: 17079324; PMCID: PMC1797231.
    46. Frieman MB, Yount B, Sims AC, Deming DJ, Morrison TE, Sparks J, Denison M, Heise M, Baric RS. SARS coronavirus accessory ORFs encode luxury functions. Adv Exp Med Biol. 2006; 581:149-52. PMID: 17037522.
      View in: PubMed
    47. Morrison TE, Whitmore AC, Shabman RS, Lidbury BA, Mahalingam S, Heise MT. Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis. J Virol. 2006 Jan; 80(2):737-49. PMID: 16378976; PMCID: PMC1346871.
    48. Morrison TE, Kenney SC. BZLF1, an Epstein-Barr virus immediate-early protein, induces p65 nuclear translocation while inhibiting p65 transcriptional function. Virology. 2004 Oct 25; 328(2):219-32. PMID: 15464842.
      View in: PubMed
    49. Holland W, Morrison T, Chang Y, Wiernsperger N, Stith BJ. Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 01; 67(11):2081-91. PMID: 15135305.
      View in: PubMed
    50. Hong GK, Delecluse HJ, Gruffat H, Morrison TE, Feng WH, Sergeant A, Kenney SC. The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1. J Virol. 2004 May; 78(10):4983-92. PMID: 15113878; PMCID: PMC400377.
    51. Morrison TE, Mauser A, Klingelhutz A, Kenney SC. Epstein-Barr virus immediate-early protein BZLF1 inhibits tumor necrosis factor alpha-induced signaling and apoptosis by downregulating tumor necrosis factor receptor 1. J Virol. 2004 Jan; 78(1):544-9. PMID: 14671137; PMCID: PMC303403.
    52. Morrison TE, Mauser A, Wong A, Ting JP, Kenney SC. Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein. Immunity. 2001 Nov; 15(5):787-99. PMID: 11728340.
      View in: PubMed
    53. Castillo M, Morrison T, Shaw JA, Bouldin TW. MR imaging and histologic features of capillary telangiectasia of the basal ganglia. AJNR Am J Neuroradiol. 2001 Sep; 22(8):1553-5. PMID: 11559504.
      View in: PubMed
    54. Morrison T, Waggoner L, Whitworth-Langley L, Stith BJ. Nongenomic action of progesterone: activation of Xenopus oocyte phospholipase C through a plasma membrane-associated tyrosine kinase. Endocrinology. 2000 Jun; 141(6):2145-52. PMID: 10830302.
      View in: PubMed
    55. McGinnes L, Sergel T, Morrison T. Mutations in the transmembrane domain of the HN protein of Newcastle disease virus affect the structure and activity of the protein. Virology. 1993 Sep; 196(1):101-10. PMID: 8356787.
      View in: PubMed
    56. Morrison T, McQuain C, Sergel T, McGinnes L, Reitter J. The role of the amino terminus of F1 of the Newcastle disease virus fusion protein in cleavage and fusion. Virology. 1993 Apr; 193(2):997-1000. PMID: 8460504.
      View in: PubMed
    57. Wang C, Raghu G, Morrison T, Peeples ME. Intracellular processing of the paramyxovirus F protein: critical role of the predicted amphipathic alpha helix adjacent to the fusion domain. J Virol. 1992 Jul; 66(7):4161-9. PMID: 1602539; PMCID: PMC241219.
    58. McGinnes L, McQuain C, Morrison T. The P protein and the nonstructural 38K and 29K proteins of Newcastle disease virus are derived from the same open reading frame. Virology. 1988 May; 164(1):256-64. PMID: 3363866.
      View in: PubMed
    59. Wilde A, Morrison T. Structural and functional characterization of Newcastle disease virus polycistronic RNA species. J Virol. 1984 Jul; 51(1):71-6. PMID: 6726896; PMCID: PMC254401.
    60. Morrison T, Stampfer M, Baltimore D, Lodish HF. Translation of vesicular stomatitis messenger RNA by extracts from mammalian and plant cells. J Virol. 1974 Jan; 13(1):62-72. PMID: 4359431; PMCID: PMC355259.
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