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Cheng Jun Hu

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology

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    Hypoxia, hypoxic response, HIF1 alpha, HIF2 alpha, USF2, STAT3, HIF target genes, hypoxia inducible genes, HIF target gene specificity, RNA splicing, tumor biology, stress response, SC35, SRP20, splicing factor, transcription, tumor progression, metastasis

    Collapse Research 
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    RO1CA134687     (Cheng Jun Hu)Jul 1, 2008 - May 31, 2013
    Regulation of Transcriptional activity of hypoxia inducible factor 2
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Stenmark KR, Hu CJ, Pullamsetti SS. How Many FOXs Are There on The Road to Pulmonary Hypertension? Am J Respir Crit Care Med. 2018 Sep 15; 198(6):704-707. PMID: 29694238.
      View in: PubMed
    2. Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J Physiol. 2018 Jun 19. PMID: 29920674.
      View in: PubMed
    3. Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19; 136(25):2468-2485. PMID: 28972001.
      View in: PubMed
    4. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16; 6(1):e287. PMID: 28092369.
      View in: PubMed
    5. Cheng-Jun Hu. Editorial in Oncoscience. Hypoxia regulates RNA splicing of HIF targets. 2014; 1(8).
    6. Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1a in activation of ?-secretase and notch signaling in breast cancer. Cell Rep. 2014 Aug 21; 8(4):1077-92. PMID: 25131208; PMCID: PMC4346175.
    7. Sena JA, Wang L, Heasley LE, Hu CJ. Hypoxia regulates alternative splicing of HIF and non-HIF target genes. Mol Cancer Res. 2014 Sep; 12(9):1233-43. PMID: 24850901; PMCID: PMC4163527.
    8. Sena JA, Wang L, Pawlus MR, Hu CJ. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014 May; 12(5):728-41. PMID: 24523299; PMCID: PMC4020993.
    9. Storti F, Santambrogio S, Crowther LM, Otto T, Abreu-Rodríguez I, Kaufmann M, Hu CJ, Dame C, Fandrey J, Wenger RH, Hoogewijs D. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica. 2014 Apr; 99(4):e45-8. PMID: 24510339; PMCID: PMC3971092.
    10. Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ. STAT3 or USF2 contributes to HIF target gene specificity. PLoS One. 2013; 8(8):e72358. PMID: 23991099; PMCID: PMC3749168.
    11. Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, Liakos P. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013 Nov; 45(11):2359-68. PMID: 23958427; PMCID: PMC3855297.
    12. Sena JA, Wang L, Hu CJ. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013 Oct; 33(19):3849-63. PMID: 23897427; PMCID: PMC3811865.
    13. You Q, Holt M, Yin H, Li G, Hu CJ, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013 Sep 15; 86(6):836-43. PMID: 23876342; PMCID: PMC3863645.
    14. Pawlus MR, Hu CJ. Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal. 2013 Sep; 25(9):1895-903. PMID: 23707522; PMCID: PMC3700616.
    15. Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1a cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014 Mar 27; 33(13):1670-9. PMID: 23604114; PMCID: PMC3868635.
    16. Pawlus MR, Wang L, Ware K, Hu CJ. Upstream stimulatory factor 2 and hypoxia-inducible factor 2a (HIF2a) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012 Nov; 32(22):4595-610. PMID: 22966206; PMCID: PMC3486188.
    17. Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007 Nov; 18(11):4528-42. PMID: 17804822.
      View in: PubMed
    18. Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr; 11(4):335-47. PMID: 17418410; PMCID: PMC3145406.
    19. Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2301-6. PMID: 17284606; PMCID: PMC1892942.
    20. Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res. 2007 Jan 01; 313(1):1-9. PMID: 17045587.
      View in: PubMed
    21. Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006 May; 26(9):3514-26. PMID: 16611993; PMCID: PMC1447431.
    22. Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 01; 20(5):557-70. PMID: 16510872; PMCID: PMC1410808.
    23. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003 Dec; 23(24):9361-74. PMID: 14645546; PMCID: PMC309606.
    24. CJ Hu Y Pan MC Simon. Oxygen and angiogenesis. Genetics of angiogenesis. 2003.
    25. Simon MC, Ramirez-Bergeron D, Mack F, Hu CJ, Pan Y, Mansfield K. Hypoxia, HIFs, and cardiovascular development. Cold Spring Harb Symp Quant Biol. 2002; 67:127-32. PMID: 12858533.
      View in: PubMed
    26. Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC. PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct; 15(4):545-55. PMID: 11672537.
      View in: PubMed
    27. Hu Cj, Gupta KC. Functional significance of alternate phosphorylation in Sendai virus P protein. Virology. 2000 Mar 15; 268(2):517-32. PMID: 10704359.
      View in: PubMed
    28. Hu CJ, Kato A, Bowman MC, Kiyotani K, Yoshida T, Moyer SA, Nagai Y, Gupta KC. Role of primary constitutive phosphorylation of Sendai virus P and V proteins in viral replication and pathogenesis. Virology. 1999 Oct 10; 263(1):195-208. PMID: 10544094.
      View in: PubMed
    29. Zhang JF, Hu C, Geng Y, Selm J, Klein SB, Orazi A, Taylor MW. Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4513-8. PMID: 8633100; PMCID: PMC39570.
    30. Zhang JF, Hu C, Geng Y, Blatt LM, Taylor MW. Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression. Cancer Gene Ther. 1996 Jan-Feb; 3(1):31-8. PMID: 8785709.
      View in: PubMed
    31. Hu CJ, Ozes ON, Klein SB, Blatt LM, Taylor MW. Comparison of the in vitro host range of recombinant met-interferon-con1, interferon-alpha 2b, and interferon-beta [corrected]. J Interferon Cytokine Res. 1995 Mar; 15(3):231-4. PMID: 7584668.
      View in: PubMed
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