Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Cheng Jun Hu

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology
Address2SOD
School of Dentistry
13065 E 17th Avenue
Aurora CO 80045
Phone303/724-4576

 Overview 
 overview
Hypoxia, hypoxic response, HIF1 alpha, HIF2 alpha, USF2, STAT3, HIF target genes, hypoxia inducible genes, HIF target gene specificity, RNA splicing, tumor biology, stress response, SC35, SRP20, splicing factor, transcription, tumor progression, metastasis


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sena JA, Wang L, Pawlus MR, Hu CJ. HIFs Enhance the Transcriptional Activation and Splicing of Adrenomedullin. Mol Cancer Res. 2014 Feb 12.
    View in: PubMed
  2. Storti F, Santambrogio S, Crowther L, Otto T, Abreu-Rodríguez I, Kaufmann M, Hu CJ, Dame C, Fandrey J, Wenger RH, Hoogewijs D. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica. 2014 Feb 7.
    View in: PubMed
  3. Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ. STAT3 or USF2 contributes to HIF target gene specificity. PLoS One. 2013; 8(8):e72358.
    View in: PubMed
  4. Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, Liakos P. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013 Nov; 45(11):2359-68.
    View in: PubMed
  5. Sena JA, Wang L, Hu CJ. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013 Oct; 33(19):3849-63.
    View in: PubMed
  6. You Q, Holt M, Yin H, Li G, Hu CJ, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013 Sep 15; 86(6):836-43.
    View in: PubMed
  7. Pawlus MR, Hu CJ. Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal. 2013 Sep; 25(9):1895-903.
    View in: PubMed
  8. Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1a cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2013 Apr 22.
    View in: PubMed
  9. Pawlus MR, Wang L, Ware K, Hu CJ. Upstream stimulatory factor 2 and hypoxia-inducible factor 2a (HIF2a) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012 Nov; 32(22):4595-610.
    View in: PubMed
  10. Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007 Nov; 18(11):4528-42.
    View in: PubMed
  11. Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr; 11(4):335-47.
    View in: PubMed
  12. Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2301-6.
    View in: PubMed
  13. Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res. 2007 Jan 1; 313(1):1-9.
    View in: PubMed
  14. Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006 May; 26(9):3514-26.
    View in: PubMed
  15. Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 1; 20(5):557-70.
    View in: PubMed
  16. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003 Dec; 23(24):9361-74.
    View in: PubMed
  17. Simon MC, Ramirez-Bergeron D, Mack F, Hu CJ, Pan Y, Mansfield K. Hypoxia, HIFs, and cardiovascular development. Cold Spring Harb Symp Quant Biol. 2002; 67:127-32.
    View in: PubMed
  18. Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC. PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct; 15(4):545-55.
    View in: PubMed
  19. Hu Cj, Gupta KC. Functional significance of alternate phosphorylation in Sendai virus P protein. Virology. 2000 Mar 15; 268(2):517-32.
    View in: PubMed
  20. Hu CJ, Kato A, Bowman MC, Kiyotani K, Yoshida T, Moyer SA, Nagai Y, Gupta KC. Role of primary constitutive phosphorylation of Sendai virus P and V proteins in viral replication and pathogenesis. Virology. 1999 Oct 10; 263(1):195-208.
    View in: PubMed
  21. Zhang JF, Hu C, Geng Y, Selm J, Klein SB, Orazi A, Taylor MW. Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4513-8.
    View in: PubMed
  22. Zhang JF, Hu C, Geng Y, Blatt LM, Taylor MW. Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression. Cancer Gene Ther. 1996 Jan-Feb; 3(1):31-8.
    View in: PubMed
  23. Hu CJ, Ozes ON, Klein SB, Blatt LM, Taylor MW. Comparison of the in vitro host range of recombinant met-interferon-con1, interferon-alpha 2b, and interferon-beta [corrected]. J Interferon Cytokine Res. 1995 Mar; 15(3):231-4.
    View in: PubMed
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