Cheng Jun Hu
Title | Assoc Professor-Research |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SDM-Craniofacial Biology |
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Phone | 303/724-4576 |
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ORCID
![ORCID Icon](https://profiles.ucdenver.edu/Framework/Images/orcid_16x16(1).gif) | 0000-0003-0985-1285 ![Additional info](https://profiles.ucdenver.edu/Framework/Images/info.png) |
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Overview Hypoxia, hypoxic response, HIF1 alpha, HIF2 alpha, USF2, STAT3, HIF target genes, hypoxia inducible genes, HIF target gene specificity, RNA splicing, tumor biology, stress response, SC35, SRP20, splicing factor, transcription, tumor progression, metastasis
Research W81XWH2010249 (Kurt Stenmark)Apr 1, 2020 - Mar 30, 2023 DOD-USAMRAA Role of Mitochondrial/Metabolic Reprogramming in Controlling Aberrant Gene Expression in Pulmonary Hypertension Role: Co-Investigator |
| W81XWH1910259 (Kurt Stenmark)Jul 5, 2019 - Jul 4, 2022 DOD – USAMRAA Targeting Epigenetic Mechanisms for Novel Therapies of Chronic Lung Vascular Diseases Role: Co-investigator |
| PR140977 (Kurt Stenmark)Jul 1, 2015 - Mar 31, 2019 DOD - Congressionally Directed Medical Research Programs (CDMRP) Metabolic and Epigenetic Interactions Regulate Vascular Phenotypic Change and Maintenance in PH Role: Co-investigator |
| R01ES020868 (Jiang Binghua)Dec 15, 2013 - Aug 31, 2017 NIH/NIEHS Molecular Mechanism of Arsenic Carcinogenesis Role: Co-investigator |
| R01CA134687 (HU, CHENG-JUN)Jul 1, 2008 - May 31, 2014 NIH Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2 Role: Principal Investigator |
Bibliographic
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Zhang H, Li M, Hu CJ, Stenmark KR. Fibroblasts in Pulmonary Hypertension: Roles and Molecular Mechanisms. Cells. 2024 May 25; 13(11). PMID: 38891046.
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Kim H, Liu Y, Kim J, Kim Y, Klouda T, Fisch S, Baek SH, Liu T, Dahlberg S, Hu CJ, Tian W, Jiang X, Kosmas K, Christou HA, Korman BD, Vargas SO, Wu JC, Stenmark KR, Perez VJ, Nicolls MR, Raby BA, Yuan K. Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling. EMBO Rep. 2024 Feb; 25(2):616-645. PMID: 38243138.
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Li M, Plecit?-Hlavat? L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR. SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 11; 69(5):570-583. PMID: 37343939.
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Zhang H, Gerasimovskaya E, McCarthy MK, May NA, Prasad RR, Riddle S, McKeon BA, Kumar S, Li M, Hu CJ, Frid MG, Morrison TE, Stenmark KR. Local Complement Contributes to Pathogenic Activation of Lung Endothelial Cells in SARS-CoV-2 Infection. Am J Respir Cell Mol Biol. 2023 08; 69(2):210-219. PMID: 37071849.
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Plecit?-Hlavat? L, Br?zdov? A, Krivonoskov? M, Hu CJ, Phang T, Tauber J, Li M, Zhang H, Hoetzenecker K, Crnkovic S, Kwapiszewska G, Stenmark KR. Microenvironmental regulation of T-cells in pulmonary hypertension. Front Immunol. 2023; 14:1223122. PMID: 37497214.
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Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 07; 69(1):73-86. PMID: 36944195.
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Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H804-H820. PMID: 36961489.
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Kleczko EK, Le AT, Hinz TK, Nguyen TT, Navarro A, Hu CJ, Selman AM, Clambey ET, Merrick DT, Lu S, Weiser-Evans M, Nemenoff RA, Heasley LE. Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response. Cancer Lett. 2023 03 01; 556:216062. PMID: 36657561.
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Zhang H, Laux A, Stenmark KR, Hu CJ. Mechanisms Contributing to the Dysregulation of miRNA-124 in Pulmonary Hypertension. Int J Mol Sci. 2021 Apr 08; 22(8). PMID: 33917769.
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Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021; 12:640718. PMID: 33868271.
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Zhang H, Brown RD, Stenmark KR, Hu CJ. RNA-Binding Proteins in Pulmonary Hypertension. Int J Mol Sci. 2020 May 26; 21(11). PMID: 32466553.
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Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L773-L786. PMID: 32159369.
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Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 12; 54(6). PMID: 31515405.
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Stenmark KR, Hu CJ, Pullamsetti SS. How Many FOXs Are There on The Road to Pulmonary Hypertension? Am J Respir Crit Care Med. 2018 09 15; 198(6):704-707. PMID: 29694238.
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Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J Physiol. 2019 02; 597(4):1103-1119. PMID: 29920674.
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Zhang H, Wang D, Li M, Plecit?-Hlavat? L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Je?ek P, Morrell NW, Hu CJ, Stenmark KR. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19; 136(25):2468-2485. PMID: 28972001.
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Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16; 6(1):e287. PMID: 28092369.
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Hu CJ. Hypoxia regulates RNA splicing of HIF targets. Oncoscience. 2014; 1(8):500-1. PMID: 25594055.
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Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1a in activation of ?-secretase and notch signaling in breast cancer. Cell Rep. 2014 Aug 21; 8(4):1077-92. PMID: 25131208.
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Sena JA, Wang L, Heasley LE, Hu CJ. Hypoxia regulates alternative splicing of HIF and non-HIF target genes. Mol Cancer Res. 2014 Sep; 12(9):1233-43. PMID: 24850901.
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Sena JA, Wang L, Pawlus MR, Hu CJ. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014 May; 12(5):728-41. PMID: 24523299.
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Storti F, Santambrogio S, Crowther LM, Otto T, Abreu-Rodr?guez I, Kaufmann M, Hu CJ, Dame C, Fandrey J, Wenger RH, Hoogewijs D. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica. 2014 Apr; 99(4):e45-8. PMID: 24510339.
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Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ. STAT3 or USF2 contributes to HIF target gene specificity. PLoS One. 2013; 8(8):e72358. PMID: 23991099.
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Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, Liakos P. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013 Nov; 45(11):2359-68. PMID: 23958427.
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Sena JA, Wang L, Hu CJ. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013 Oct; 33(19):3849-63. PMID: 23897427.
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You Q, Holt M, Yin H, Li G, Hu CJ, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013 Sep 15; 86(6):836-43. PMID: 23876342.
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Pawlus MR, Hu CJ. Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal. 2013 Sep; 25(9):1895-903. PMID: 23707522.
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Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1a cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014 Mar 27; 33(13):1670-9. PMID: 23604114.
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Pawlus MR, Wang L, Ware K, Hu CJ. Upstream stimulatory factor 2 and hypoxia-inducible factor 2a (HIF2a) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012 Nov; 32(22):4595-610. PMID: 22966206.
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Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007 Nov; 18(11):4528-42. PMID: 17804822.
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Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr; 11(4):335-47. PMID: 17418410.
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Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2301-6. PMID: 17284606.
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Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res. 2007 Jan 01; 313(1):1-9. PMID: 17045587.
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Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006 May; 26(9):3514-26. PMID: 16611993.
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Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 01; 20(5):557-70. PMID: 16510872.
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Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003 Dec; 23(24):9361-74. PMID: 14645546.
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CJ Hu
Y Pan
MC Simon. Oxygen and angiogenesis. Genetics of angiogenesis. 2003.
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Simon MC, Ramirez-Bergeron D, Mack F, Hu CJ, Pan Y, Mansfield K. Hypoxia, HIFs, and cardiovascular development. Cold Spring Harb Symp Quant Biol. 2002; 67:127-32. PMID: 12858533.
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Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC. PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct; 15(4):545-55. PMID: 11672537.
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Hu Cj, Gupta KC. Functional significance of alternate phosphorylation in Sendai virus P protein. Virology. 2000 Mar 15; 268(2):517-32. PMID: 10704359.
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Hu CJ, Kato A, Bowman MC, Kiyotani K, Yoshida T, Moyer SA, Nagai Y, Gupta KC. Role of primary constitutive phosphorylation of Sendai virus P and V proteins in viral replication and pathogenesis. Virology. 1999 Oct 10; 263(1):195-208. PMID: 10544094.
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Zhang JF, Hu C, Geng Y, Selm J, Klein SB, Orazi A, Taylor MW. Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4513-8. PMID: 8633100.
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Zhang JF, Hu C, Geng Y, Blatt LM, Taylor MW. Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression. Cancer Gene Ther. 1996 Jan-Feb; 3(1):31-8. PMID: 8785709.
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Hu CJ, Ozes ON, Klein SB, Blatt LM, Taylor MW. Comparison of the in vitro host range of recombinant met-interferon-con1, interferon-alpha 2b, and interferon-beta [corrected]. J Interferon Cytokine Res. 1995 Mar; 15(3):231-4. PMID: 7584668.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1995 | 1 | 1996 | 2 | 1999 | 1 | 2000 | 1 | 2001 | 1 | 2002 | 1 | 2003 | 2 | 2006 | 3 | 2007 | 3 | 2012 | 1 | 2013 | 6 | 2014 | 5 | 2017 | 2 | 2018 | 2 | 2019 | 1 | 2020 | 2 | 2021 | 2 | 2023 | 6 | 2024 | 2 |
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