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Cheng Jun Hu

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology
Phone303/724-4576
ORCID ORCID Icon0000-0003-0985-1285 Additional info

    Collapse Overview 
    Collapse overview
    Hypoxia, hypoxic response, HIF1 alpha, HIF2 alpha, USF2, STAT3, HIF target genes, hypoxia inducible genes, HIF target gene specificity, RNA splicing, tumor biology, stress response, SC35, SRP20, splicing factor, transcription, tumor progression, metastasis

    Collapse Research 
    Collapse research activities and funding
    W81XWH2010249     (Kurt Stenmark)Apr 1, 2020 - Mar 30, 2023
    DOD-USAMRAA
    Role of Mitochondrial/Metabolic Reprogramming in Controlling Aberrant Gene Expression in Pulmonary Hypertension
    Role: Co-Investigator
    W81XWH1910259     (Kurt Stenmark)Jul 5, 2019 - Jul 4, 2022
    DOD – USAMRAA
    Targeting Epigenetic Mechanisms for Novel Therapies of Chronic Lung Vascular Diseases
    Role: Co-investigator
    PR140977     (Kurt Stenmark)Jul 1, 2015 - Mar 31, 2019
    DOD - Congressionally Directed Medical Research Programs (CDMRP)
    Metabolic and Epigenetic Interactions Regulate Vascular Phenotypic Change and Maintenance in PH
    Role: Co-investigator
    R01ES020868     (Jiang Binghua)Dec 15, 2013 - Aug 31, 2017
    NIH/NIEHS
    Molecular Mechanism of Arsenic Carcinogenesis
    Role: Co-investigator
    R01CA134687     (HU, CHENG-JUN)Jul 1, 2008 - May 31, 2014
    NIH
    Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim H, Liu Y, Kim J, Kim Y, Klouda T, Fisch S, Baek SH, Liu T, Dahlberg S, Hu CJ, Tian W, Jiang X, Kosmas K, Christou HA, Korman BD, Vargas SO, Wu JC, Stenmark KR, Perez VJ, Nicolls MR, Raby BA, Yuan K. Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling. EMBO Rep. 2024 Feb; 25(2):616-645. PMID: 38243138.
      View in: PubMed
    2. Li M, Plecit?-Hlavat? L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR. SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 11; 69(5):570-583. PMID: 37343939.
      View in: PubMed
    3. Zhang H, Gerasimovskaya E, McCarthy MK, May NA, Prasad RR, Riddle S, McKeon BA, Kumar S, Li M, Hu CJ, Frid MG, Morrison TE, Stenmark KR. Local Complement Contributes to Pathogenic Activation of Lung Endothelial Cells in SARS-CoV-2 Infection. Am J Respir Cell Mol Biol. 2023 08; 69(2):210-219. PMID: 37071849.
      View in: PubMed
    4. Plecit?-Hlavat? L, Br?zdov? A, Krivonoskov? M, Hu CJ, Phang T, Tauber J, Li M, Zhang H, Hoetzenecker K, Crnkovic S, Kwapiszewska G, Stenmark KR. Microenvironmental regulation of T-cells in pulmonary hypertension. Front Immunol. 2023; 14:1223122. PMID: 37497214.
      View in: PubMed
    5. Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 07; 69(1):73-86. PMID: 36944195.
      View in: PubMed
    6. Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H804-H820. PMID: 36961489.
      View in: PubMed
    7. Kleczko EK, Le AT, Hinz TK, Nguyen TT, Navarro A, Hu CJ, Selman AM, Clambey ET, Merrick DT, Lu S, Weiser-Evans M, Nemenoff RA, Heasley LE. Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response. Cancer Lett. 2023 03 01; 556:216062. PMID: 36657561.
      View in: PubMed
    8. Zhang H, Laux A, Stenmark KR, Hu CJ. Mechanisms Contributing to the Dysregulation of miRNA-124 in Pulmonary Hypertension. Int J Mol Sci. 2021 Apr 08; 22(8). PMID: 33917769.
      View in: PubMed
    9. Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021; 12:640718. PMID: 33868271.
      View in: PubMed
    10. Zhang H, Brown RD, Stenmark KR, Hu CJ. RNA-Binding Proteins in Pulmonary Hypertension. Int J Mol Sci. 2020 May 26; 21(11). PMID: 32466553.
      View in: PubMed
    11. Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L773-L786. PMID: 32159369.
      View in: PubMed
    12. Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 12; 54(6). PMID: 31515405.
      View in: PubMed
    13. Stenmark KR, Hu CJ, Pullamsetti SS. How Many FOXs Are There on The Road to Pulmonary Hypertension? Am J Respir Crit Care Med. 2018 09 15; 198(6):704-707. PMID: 29694238.
      View in: PubMed
    14. Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J Physiol. 2019 02; 597(4):1103-1119. PMID: 29920674.
      View in: PubMed
    15. Zhang H, Wang D, Li M, Plecit?-Hlavat? L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Je?ek P, Morrell NW, Hu CJ, Stenmark KR. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19; 136(25):2468-2485. PMID: 28972001.
      View in: PubMed
    16. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16; 6(1):e287. PMID: 28092369.
      View in: PubMed
    17. Hu CJ. Hypoxia regulates RNA splicing of HIF targets. Oncoscience. 2014; 1(8):500-1. PMID: 25594055.
      View in: PubMed
    18. Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1a in activation of ?-secretase and notch signaling in breast cancer. Cell Rep. 2014 Aug 21; 8(4):1077-92. PMID: 25131208.
      View in: PubMed
    19. Sena JA, Wang L, Heasley LE, Hu CJ. Hypoxia regulates alternative splicing of HIF and non-HIF target genes. Mol Cancer Res. 2014 Sep; 12(9):1233-43. PMID: 24850901.
      View in: PubMed
    20. Sena JA, Wang L, Pawlus MR, Hu CJ. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014 May; 12(5):728-41. PMID: 24523299.
      View in: PubMed
    21. Storti F, Santambrogio S, Crowther LM, Otto T, Abreu-Rodr?guez I, Kaufmann M, Hu CJ, Dame C, Fandrey J, Wenger RH, Hoogewijs D. A novel distal upstream hypoxia response element regulating oxygen-dependent erythropoietin gene expression. Haematologica. 2014 Apr; 99(4):e45-8. PMID: 24510339.
      View in: PubMed
    22. Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ. STAT3 or USF2 contributes to HIF target gene specificity. PLoS One. 2013; 8(8):e72358. PMID: 23991099.
      View in: PubMed
    23. Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, Liakos P. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013 Nov; 45(11):2359-68. PMID: 23958427.
      View in: PubMed
    24. Sena JA, Wang L, Hu CJ. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013 Oct; 33(19):3849-63. PMID: 23897427.
      View in: PubMed
    25. You Q, Holt M, Yin H, Li G, Hu CJ, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013 Sep 15; 86(6):836-43. PMID: 23876342.
      View in: PubMed
    26. Pawlus MR, Hu CJ. Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal. 2013 Sep; 25(9):1895-903. PMID: 23707522.
      View in: PubMed
    27. Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1a cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014 Mar 27; 33(13):1670-9. PMID: 23604114.
      View in: PubMed
    28. Pawlus MR, Wang L, Ware K, Hu CJ. Upstream stimulatory factor 2 and hypoxia-inducible factor 2a (HIF2a) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012 Nov; 32(22):4595-610. PMID: 22966206.
      View in: PubMed
    29. Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007 Nov; 18(11):4528-42. PMID: 17804822.
      View in: PubMed
    30. Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell. 2007 Apr; 11(4):335-47. PMID: 17418410.
      View in: PubMed
    31. Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2301-6. PMID: 17284606.
      View in: PubMed
    32. Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res. 2007 Jan 01; 313(1):1-9. PMID: 17045587.
      View in: PubMed
    33. Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006 May; 26(9):3514-26. PMID: 16611993.
      View in: PubMed
    34. Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 01; 20(5):557-70. PMID: 16510872.
      View in: PubMed
    35. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003 Dec; 23(24):9361-74. PMID: 14645546.
      View in: PubMed
    36. CJ Hu Y Pan MC Simon. Oxygen and angiogenesis. Genetics of angiogenesis. 2003.
    37. Simon MC, Ramirez-Bergeron D, Mack F, Hu CJ, Pan Y, Mansfield K. Hypoxia, HIFs, and cardiovascular development. Cold Spring Harb Symp Quant Biol. 2002; 67:127-32. PMID: 12858533.
      View in: PubMed
    38. Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC. PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct; 15(4):545-55. PMID: 11672537.
      View in: PubMed
    39. Hu Cj, Gupta KC. Functional significance of alternate phosphorylation in Sendai virus P protein. Virology. 2000 Mar 15; 268(2):517-32. PMID: 10704359.
      View in: PubMed
    40. Hu CJ, Kato A, Bowman MC, Kiyotani K, Yoshida T, Moyer SA, Nagai Y, Gupta KC. Role of primary constitutive phosphorylation of Sendai virus P and V proteins in viral replication and pathogenesis. Virology. 1999 Oct 10; 263(1):195-208. PMID: 10544094.
      View in: PubMed
    41. Zhang JF, Hu C, Geng Y, Selm J, Klein SB, Orazi A, Taylor MW. Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4513-8. PMID: 8633100.
      View in: PubMed
    42. Zhang JF, Hu C, Geng Y, Blatt LM, Taylor MW. Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression. Cancer Gene Ther. 1996 Jan-Feb; 3(1):31-8. PMID: 8785709.
      View in: PubMed
    43. Hu CJ, Ozes ON, Klein SB, Blatt LM, Taylor MW. Comparison of the in vitro host range of recombinant met-interferon-con1, interferon-alpha 2b, and interferon-beta [corrected]. J Interferon Cytokine Res. 1995 Mar; 15(3):231-4. PMID: 7584668.
      View in: PubMed
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