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Aaron W. Michels

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Barbara Davis Center
Phone303/724-1923

    Collapse Research 
    Collapse research activities and funding
    K08DK095995     (MICHELS, AARON W)Jul 1, 2012 - Apr 30, 2017
    NIH/NIDDK
    Small Molecules Targeting Allele Specific MHC Class II Presentation
    Role: Principal Investigator

    DP3DK110845     (MICHELS, AARON W)Aug 1, 2016 - Jul 31, 2019
    NIH/NIDDK
    Insulin Specific T and B cells in Type 1 Diabetes
    Role: Principal Investigator

    R01DK108868     (MICHELS, AARON W)Jan 11, 2017 - Dec 31, 2020
    NIH/NIDDK
    Insulin Specific T Cell Response Shaped by Diabetes Protective MHC Class II Molecules
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A. TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care. 2017 Oct 12. PMID: 29025879.
      View in: PubMed
    2. Kent SC, Mannering SI, Michels AW, Babon JAB. Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime". Curr Diab Rep. 2017 Sep 02; 17(10):95. PMID: 28864875.
      View in: PubMed
    3. Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT. Increased Effector Memory Insulin-Specific CD4+T-cells Correlate with Insulin Autoantibodies in Recent-Onset Type 1 Diabetic Patients. Diabetes. 2017 Aug 25. PMID: 28842400.
      View in: PubMed
    4. Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). PLoS One. 2017; 12(4):e0174840. PMID: 28380011.
      View in: PubMed
    5. Acevedo-Calado M, James EA, Morran MP, Pietropaolo SL, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017 Apr; 40(4):561-568. PMID: 28174261.
      View in: PubMed
    6. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes. 2017 Mar; 66(3):722-734. PMID: 27920090.
      View in: PubMed
    7. Simmons KM, Alkanani AK, McDaniel KA, Goyne C, Miao D, Zhao Z, Yu L, Michels AW. Islet Autoantibody Measurements from Dried Blood Spots on Filter Paper Strongly Correlate to Serum Levels. PLoS One. 2016; 11(11):e0166213. PMID: 27846247.
      View in: PubMed
    8. Simmons KM, Gottlieb PA, Michels AW. Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes. Curr Diab Rep. 2016 Oct; 16(10):97. PMID: 27558810.
      View in: PubMed
    9. Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA. Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. Diabetes. 2016 Dec; 65(12):3765-3775. PMID: 27669730.
      View in: PubMed
    10. Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK. Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects? Diabetes Care. 2016 Oct; 39(10):1738-44. PMID: 27456836; PMCID: PMC5033080 [Available on 10/01/17].
    11. Wasserfall C, Montgomery E, Yu L, Michels A, Gianani R, Pugliese A, Nierras C, Kaddis JS, Schatz DA, Bonifacio E, Atkinson MA. Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease. Clin Exp Immunol. 2016 Jul; 185(1):33-41. PMID: 27029857; PMCID: PMC4908288 [Available on 07/01/17].
    12. Saxon DR, McDermott MT, Michels AW. Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring. J Clin Endocrinol Metab. 2016 May; 101(5):1931-4. PMID: 26982011.
      View in: PubMed
    13. Zhao Z, Miao D, Michels A, Steck A, Dong F, Rewers M, Yu L. A multiplex assay combining insulin, GAD, IA-2 and transglutaminase autoantibodies to facilitate screening for pre-type 1 diabetes and celiac disease. J Immunol Methods. 2016 Mar; 430:28-32. PMID: 26809048.
      View in: PubMed
    14. Nakayama M, Simmons KM, Michels AW. Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes. Curr Diab Rep. 2015 Dec; 15(12):113. PMID: 26458384; PMCID: PMC4807868 [Available on 12/01/16].
    15. Simmons KM, Michels AW. Alternate Ways to Quantify Antibodies. Diabetes Technol Ther. 2015 Dec; 17(12):854-6. PMID: 26544921.
      View in: PubMed
    16. Michels AW, Ostrov DA. New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity. J Allergy Clin Immunol. 2015 Aug; 136(2):252-7. PMID: 26254052; PMCID: PMC4529959.
    17. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov; 16(7):465-84. PMID: 26202050; PMCID: PMC4592445 [Available on 11/01/16].
    18. Simmons KM, Michels AW. Type 1 diabetes: A predictable disease. World J Diabetes. 2015 Apr 15; 6(3):380-90. PMID: 25897349; PMCID: PMC4398895.
    19. Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4429-34. PMID: 25831495; PMCID: PMC4394309.
    20. Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal SM, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA. Anti-thymocyte globulin/G-CSF treatment preserves ß cell function in patients with established type 1 diabetes. J Clin Invest. 2015 Jan; 125(1):448-55. PMID: 25500887; PMCID: PMC4382237.
    21. Maturu A, Michels A, Draznin B. Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II. Endocr Pract. 2014 Dec; 20(12):e250-5. PMID: 25148815.
      View in: PubMed
    22. Simmons K, Michels AW. Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov; 40(4):797-811. PMID: 25437293; PMCID: PMC4250578.
    23. Michels A, Michels N. Addison disease: early detection and treatment principles. Am Fam Physician. 2014 Apr 01; 89(7):563-8. PMID: 24695602.
      View in: PubMed
    24. Liu E, McDaniel K, Case S, Yu L, Gerhartz B, Ostermann N, Fankhauser G, Hungerford V, Zou C, Luyten M, Seidl KJ, Michels AW. Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease. Autoimmune Dis. 2014; 2014:927190. PMID: 24724018; PMCID: PMC3958769.
    25. Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. a1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1ß responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1418-26. PMID: 24527714; PMCID: PMC4121034.
    26. Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2656-61. PMID: 24550292; PMCID: PMC3932899.
    27. Gottlieb PA, Delong T, Baker RL, Fitzgerald-Miller L, Wagner R, Cook G, Rewers MR, Michels A, Haskins K. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun. 2014 May; 50:38-41. PMID: 24239002; PMCID: PMC3995825.
    28. Garg SK, Michels AW, Shah VN. Use of non-insulin therapies for type 1 diabetes. Diabetes Technol Ther. 2013 Nov; 15(11):901-8. PMID: 24131372.
      View in: PubMed
    29. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 04; 383(9911):69-82. PMID: 23890997; PMCID: PMC4380133.
    30. Weinstock RS, Xing D, Maahs DM, Michels A, Rickels MR, Peters AL, Bergenstal RM, Harris B, Dubose SN, Miller KM, Beck RW. Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab. 2013 Aug; 98(8):3411-9. PMID: 23760624.
      View in: PubMed
    31. Michels AW. Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention. Diabetes Technol Ther. 2013 Jun; 15 Suppl 2:S2-8-S2-12. PMID: 23786298; PMCID: PMC3676662.
    32. Michels AW. Targeting the trimolecular complex. Clin Immunol. 2013 Dec; 149(3):339-44. PMID: 23537861; PMCID: PMC3700599.
    33. Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb; 56(2):391-400. PMID: 23086558; PMCID: PMC3537871.
    34. Zhang L, Stadinski BD, Michels A, Kappler JW, Eisenbarth GS. Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev. 2011 Nov; 27(8):784-9. PMID: 22069260.
      View in: PubMed
    35. Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 01; 187(11):5921-30. PMID: 22043012; PMCID: PMC3221928.
    36. Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16729-34. PMID: 21949373; PMCID: PMC3189014.
    37. Michels AW, Eisenbarth GS. Immune intervention in type 1 diabetes. Semin Immunol. 2011 Jun; 23(3):214-9. PMID: 21852151; PMCID: PMC3177994.
    38. Michels AW, von Herrath M. 2011 Update: antigen-specific therapy in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2011 Aug; 18(4):235-40. PMID: 21844706; PMCID: PMC4016762.
    39. Michels AW, Nakayama M. The anti-insulin trimolecular complex in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Aug; 17(4):329-34. PMID: 20489610; PMCID: PMC4012426.
    40. Michels A, Haugen B. Malignant struma ovarii. J Clin Endocrinol Metab. 2010 Apr; 95(4):1505. PMID: 20375218.
      View in: PubMed
    41. Michels AW, Gottlieb PA. Autoimmune polyglandular syndromes. Nat Rev Endocrinol. 2010 May; 6(5):270-7. PMID: 20309000.
      View in: PubMed
    42. Michels AW, Eisenbarth GS. Immunologic endocrine disorders. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S226-37. PMID: 20176260; PMCID: PMC2835296.
    43. Michels AW, Eisenbarth GS. Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2). J Intern Med. 2009 May; 265(5):530-40. PMID: 19382992.
      View in: PubMed
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