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Chad G. Pearson

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

    Collapse Research 
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    R01GM099820     (PEARSON, CHAD G)Sep 24, 2012 - Jul 31, 2021
    Mechanisms of basal body assembly, stability and positioning
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sankaran DG, Stemm-Wolf AJ, Pearson CG. CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells. Mol Biol Cell. 2019 Feb 27; mbcE18100674. PMID: 30811267.
      View in: PubMed
    2. Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW. Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein. J Cell Sci. 2019 Jan 22; 132(2). PMID: 30584065.
      View in: PubMed
    3. Louka P, Vasudevan KK, Guha M, Joachimiak E, Wloga D, Tomasi RF, Baroud CN, Dupuis-Williams P, Galati DF, Pearson CG, Rice LM, Moresco JJ, Yates JR, Jiang YY, Lechtreck K, Dentler W, Gaertig J. Proteins that control the geometry of microtubules at the ends of cilia. J Cell Biol. 2018 Dec 03; 217(12):4298-4313. PMID: 30217954.
      View in: PubMed
    4. Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. Trisomy 21 Represses Cilia Formation and Function. Dev Cell. 2018 09 10; 46(5):641-650.e6. PMID: 30100262.
      View in: PubMed
    5. Baschal EE, Terhune EA, Wethey CI, Baschal RM, Robinson KD, Cuevas MT, Pradhan S, Sutphin BS, Taylor MRG, Gowan K, Pearson CG, Niswander LA, Jones KL, Miller NH. Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology. G3 (Bethesda). 2018 07 31; 8(8):2663-2672. PMID: 29930198.
      View in: PubMed
    6. Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762. PMID: 28039486.
      View in: PubMed
    7. Galati DF, Mitchell BJ, Pearson CG. Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life. Dev Cell. 2016 11 21; 39(4):387-389. PMID: 27875681.
      View in: PubMed
    8. Bayless BA, Galati DF, Junker AD, Backer CB, Gaertig J, Pearson CG. Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces. J Cell Biol. 2016 Nov 21; 215(4):457-466. PMID: 27807131.
      View in: PubMed
    9. Wall KP, Pagratis M, Armstrong G, Balsbaugh JL, Verbeke E, Pearson CG, Hough LE. Molecular Determinants of Tubulin's C-Terminal Tail Conformational Ensemble. ACS Chem Biol. 2016 11 18; 11(11):2981-2990. PMID: 27541566.
      View in: PubMed
    10. Ruehle MD, Orias E, Pearson CG. Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools. Genetics. 2016 06; 203(2):649-65. PMID: 27270699; PMCID: PMC4896184 [Available on 06/01/17].
    11. Meehl JB, Bayless BA, Giddings TH, Pearson CG, Winey M. Tetrahymena Poc1 ensures proper intertriplet microtubule linkages to maintain basal body integrity. Mol Biol Cell. 2016 08 01; 27(15):2394-403. PMID: 27251062; PMCID: PMC4966981 [Available on 10/16/16].
    12. Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016 07 01; 143(13):2292-304. PMID: 27226318; PMCID: PMC4958328 [Available on 07/01/17].
    13. Garcia G, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J. Assembly, molecular organization, and membrane-binding properties of development-specific septins. J Cell Biol. 2016 Feb 29; 212(5):515-29. PMID: 26929450; PMCID: PMC4772501.
    14. Bayless BA, Galati DF, Pearson CG. Tetrahymena basal bodies. Cilia. 2015; 5:1. PMID: 26793300; PMCID: PMC4719566.
    15. Galati DF, Abuin DS, Tauber GA, Pham AT, Pearson CG. Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays. Biol Open. 2015 Dec 23; 5(1):20-31. PMID: 26700722; PMCID: PMC4728305.
    16. Dahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH, Pearson CG. A Short CEP135 Splice Isoform Controls Centriole Duplication. Curr Biol. 2015 Oct 05; 25(19):2591-6. PMID: 26412126; PMCID: PMC4596786 [Available on 10/05/16].
    17. Galati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CG. DisAp-dependent striated fiber elongation is required to organize ciliary arrays. J Cell Biol. 2014 Dec 22; 207(6):705-15. PMID: 25533842.
      View in: PubMed
    18. Pearson CG. Choosing sides--asymmetric centriole and basal body assembly. J Cell Sci. 2014 Jul 01; 127(Pt 13):2803-10. PMID: 24895399; PMCID: PMC4075354.
    19. Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ. Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-ß1 and EMMPRIN. PLoS One. 2013; 8(8):e71225. PMID: 23936495; PMCID: PMC3731303.
    20. Bayless BA, Giddings TH, Winey M, Pearson CG. Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces. Mol Biol Cell. 2012 Dec; 23(24):4820-32. PMID: 23115304; PMCID: PMC3521689.
    21. Backer CB, Gutzman JH, Pearson CG, Cheeseman IM. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. Mol Biol Cell. 2012 Jun; 23(11):2122-30. PMID: 22493317; PMCID: PMC3364176.
    22. Winey M, Stemm-Wolf AJ, Giddings TH, Pearson CG. Cytological analysis of Tetrahymena thermophila. Methods Cell Biol. 2012; 109:357-78. PMID: 22444152.
      View in: PubMed
    23. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100. PMID: 22004680; PMCID: PMC3341644.
    24. Pearson CG. A kinesin in command of primary ciliogenesis. Cell. 2011 Jun 10; 145(6):817-9. PMID: 21663786.
      View in: PubMed
    25. Pearson CG, Winey M. Plk4/SAK/ZYG-1 in the regulation of centriole duplication. F1000 Biol Rep. 2010 Aug 09; 2:58. PMID: 21173875; PMCID: PMC2990628.
    26. Gardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJ. Model Convolution: A Computational Approach to Digital Image Interpretation. Cell Mol Bioeng. 2010 Jun; 3(2):163-170. PMID: 20461132.
      View in: PubMed
    27. Giddings TH, Meehl JB, Pearson CG, Winey M. Electron tomography and immuno-labeling of Tetrahymena thermophila basal bodies. Methods Cell Biol. 2010; 96:117-41. PMID: 20869521.
      View in: PubMed
    28. Pearson CG, Osborn DP, Giddings TH, Beales PL, Winey M. Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol. 2009 Dec 14; 187(6):905-20. PMID: 20008567; PMCID: PMC2806327.
    29. Pearson CG, Winey M. Basal body assembly in ciliates: the power of numbers. Traffic. 2009 May; 10(5):461-71. PMID: 19192246; PMCID: PMC2743681.
    30. Pearson CG, Giddings TH, Winey M. Basal body components exhibit differential protein dynamics during nascent basal body assembly. Mol Biol Cell. 2009 Feb; 20(3):904-14. PMID: 19056680.
      View in: PubMed
    31. Kilburn CL, Pearson CG, Romijn EP, Meehl JB, Giddings TH, Culver BP, Yates JR, Winey M. New Tetrahymena basal body protein components identify basal body domain structure. J Cell Biol. 2007 Sep 10; 178(6):905-12. PMID: 17785518; PMCID: PMC2064616.
    32. Pearson CG, Culver BP, Winey M. Centrioles want to move out and make cilia. Dev Cell. 2007 Sep; 13(3):319-21. PMID: 17765674.
      View in: PubMed
    33. Beales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, Rix S, Pearson CG, Kai M, Hartley J, Johnson C, Irving M, Elcioglu N, Winey M, Tada M, Scambler PJ. IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet. 2007 Jun; 39(6):727-9. PMID: 17468754.
      View in: PubMed
    34. Pearson CG, Gardner MK, Paliulis LV, Salmon ED, Odde DJ, Bloom K. Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy. Mol Biol Cell. 2006 Sep; 17(9):4069-79. PMID: 16807354.
      View in: PubMed
    35. Gardner MK, Pearson CG, Sprague BL, Zarzar TR, Bloom K, Salmon ED, Odde DJ. Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast. Mol Biol Cell. 2005 Aug; 16(8):3764-75. PMID: 15930123.
      View in: PubMed
    36. De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio A. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol. 2005 Feb 08; 15(3):214-25. PMID: 15694304.
      View in: PubMed
    37. Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr Biol. 2005 Jan 26; 15(2):160-5. PMID: 15668173.
      View in: PubMed
    38. Pearson CG, Yeh E, Gardner M, Odde D, Salmon ED, Bloom K. Stable kinetochore-microtubule attachment constrains centromere positioning in metaphase. Curr Biol. 2004 Nov 09; 14(21):1962-7. PMID: 15530400.
      View in: PubMed
    39. Pearson CG, Bloom K. Dynamic microtubules lead the way for spindle positioning. Nat Rev Mol Cell Biol. 2004 Jun; 5(6):481-92. PMID: 15173827.
      View in: PubMed
    40. Pearson CG, Maddox PS, Zarzar TR, Salmon ED, Bloom K. Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Mol Biol Cell. 2003 Oct; 14(10):4181-95. PMID: 14517328.
      View in: PubMed
    41. Sprague BL, Pearson CG, Maddox PS, Bloom KS, Salmon ED, Odde DJ. Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophys J. 2003 Jun; 84(6):3529-46. PMID: 12770865; PMCID: PMC1302941.
    42. Yoder TJ, Pearson CG, Bloom K, Davis TN. The Saccharomyces cerevisiae spindle pole body is a dynamic structure. Mol Biol Cell. 2003 Aug; 14(8):3494-505. PMID: 12925780.
      View in: PubMed
    43. Gupta ML, Bode CJ, Thrower DA, Pearson CG, Suprenant KA, Bloom KS, Himes RH. beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast. Mol Biol Cell. 2002 Aug; 13(8):2919-32. PMID: 12181356.
      View in: PubMed
    44. Kosco KA, Pearson CG, Maddox PS, Wang PJ, Adams IR, Salmon ED, Bloom K, Huffaker TC. Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol Biol Cell. 2001 Sep; 12(9):2870-80. PMID: 11553724.
      View in: PubMed
    45. Hoffman DB, Pearson CG, Yen TJ, Howell BJ, Salmon ED. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell. 2001 Jul; 12(7):1995-2009. PMID: 11451998.
      View in: PubMed
    46. Pearson CG, Maddox PS, Salmon ED, Bloom K. Budding yeast chromosome structure and dynamics during mitosis. J Cell Biol. 2001 Mar 19; 152(6):1255-66. PMID: 11257125; PMCID: PMC2199205.
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