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James P. Maloney

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionPUL GENERAL OPERATIONS


    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R01HL071618     (MALONEY, JAMES P)Sep 24, 2004 - Aug 31, 2009
    NIH
    Structure and Function of TSP1 in Acute Lung Injury
    Role: Principal Investigator
    K08HL003545     (MALONEY, JAMES P)Jul 10, 1997 - Jun 30, 2002
    NIH
    VEGF--PULMONARY VASCULAR LEAK IN ACUTE LUNG INJURY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Castleman MJ, Santos AL, Lesteberg KE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection. Front Immunol. 2023; 14:1213344. PMID: 37638016.
      View in: PubMed
    2. Gao L, Rafaels N, Dudenkov TM, Damarla M, Damico R, Maloney JP, Moss M, Martin GS, Sevransky J, Shanholtz C, Herr DL, Garcia JGN, Hernandez-Beeftink T, Villar J, Flores C, Beaty TH, Brower R, Hassoun PM, Barnes KC. Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure. Respir Res. 2023 Jul 06; 24(1):177. PMID: 37415141.
      View in: PubMed
    3. Zagona-Prizio C, Pascoe MA, Corbisiero MF, Simon VC, Mann SE, Mayer KA, Maloney JP. Cadaveric emergency cricothyrotomy training for non-surgeons using a bronchoscopy-enhanced curriculum. PLoS One. 2023; 18(3):e0282403. PMID: 36952528.
      View in: PubMed
    4. Vargas Barahona L, Molina KC, Pedraza-Ar?valo LC, Sillau S, Tagawa A, Scherger S, Chastain DB, Shapiro L, Tuells J, Franco-Paredes C, Hawkins KL, Maloney JP, Thompson GR, Henao-Mart?nez AF. Previous corticosteroid exposure associates with an increased Pneumocystis jirovecii pneumonia mortality among HIV-negative patients: a global research network with a follow-up multicenter case-control study. Ther Adv Infect Dis. 2023 Jan-Dec; 10:20499361231159481. PMID: 36938147.
      View in: PubMed
    5. Arguinchona LM, Zagona-Prizio C, Joyce ME, Chan ED, Maloney JP. Microvascular significance of TGF-? axis activation in COVID-19. Front Cardiovasc Med. 2022; 9:1054690. PMID: 36684608.
      View in: PubMed
    6. Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022; 13:988125. PMID: 36131937.
      View in: PubMed
    7. Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 06 06; 219(6). PMID: 35420627.
      View in: PubMed
    8. Lee MH, Cool CD, Maloney JP. Histopathological Correlation of Acute on Chronic Eosinophilic Pneumonitis Caused by Vaporized Cannabis Oil Inhalation. Chest. 2021 03; 159(3):e137-e139. PMID: 33678280.
      View in: PubMed
    9. Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan; 146:110394. PMID: 33239231.
      View in: PubMed
    10. Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension. Cardiovasc Res. 2020 10 01; 116(12):2021-2030. PMID: 31710666.
      View in: PubMed
    11. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-? activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 05 30; 8:15494. PMID: 28555642.
      View in: PubMed
    12. Maloney JP. Putting skin in the game: dermis-derived stem cells provide insight into familial pulmonary hypertension. Stem Cell Investig. 2017; 4:35. PMID: 28607909.
      View in: PubMed
    13. Maloney JP, Branchford BR, Brodsky GL, Cosmic MS, Calabrese DW, Aquilante CL, Maloney KW, Gonzalez JR, Zhang W, Moreau KL, Wiggins KL, Smith NL, Broeckel U, Di Paola J. The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk. FASEB J. 2017 07; 31(7):2771-2784. PMID: 28302652.
      View in: PubMed
    14. Maloney JP, Narasimhan J, Biller J. Decreased TGF-?1 and VEGF Release in Cystic Fibrosis Platelets: Further Evidence for Platelet Defects in Cystic Fibrosis. Lung. 2016 10; 194(5):791-8. PMID: 27423781.
      View in: PubMed
    15. Maloney JP, Gao L. Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells. Mediators Inflamm. 2015; 2015:387842. PMID: 26424968.
      View in: PubMed
    16. Maloney JP, Ambruso DR, Voelkel NF, Silliman CC. Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury. J Pulm Respir Med. 2014; 4. PMID: 25705568.
      View in: PubMed
    17. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One. 2012; 7(1):e28268. PMID: 22295056.
      View in: PubMed
    18. Maloney JP, Stearman RS, Bull TM, Calabrese DW, Tripp-Addison ML, Wick MJ, Broeckel U, Robbins IM, Wheeler LA, Cogan JD, Loyd JE. Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L541-54. PMID: 22198906.
      View in: PubMed
    19. Han S, Martin GS, Maloney JP, Shanholtz C, Barnes KC, Murray S, Sevransky JE. Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study. Crit Care. 2011; 15(6):R262. PMID: 22044724.
      View in: PubMed
    20. Maloney JP. Genetic factors impacting therapy in acute lung injury/acute respiratory distress syndrome. J Investig Med. 2009 Dec; 57(8):865-9. PMID: 18827716.
      View in: PubMed
    21. Hodgin KE, Maloney JP. Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease. JAMA. 2009 Mar 25; 301(12):1224; author reply 1225-6. PMID: 19318647.
      View in: PubMed
    22. Wurfel MM, Gordon AC, Holden TD, Radella F, Strout J, Kajikawa O, Ruzinski JT, Rona G, Black RA, Stratton S, Jarvik GP, Hajjar AM, Nickerson DA, Rieder M, Sevransky J, Maloney JP, Moss M, Martin G, Shanholtz C, Garcia JG, Gao L, Brower R, Barnes KC, Walley KR, Russell JA, Martin TR. Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):710-20. PMID: 18635889.
      View in: PubMed
    23. Bo? DM, Schwarz MI, Groshong SD, Maloney JP. A 64-year-old woman with a history of rheumatoid arthritis and new cavitary lung lesions. Chest. 2007 Dec; 132(6):2046-52. PMID: 18079242.
      View in: PubMed
    24. Gao L, Flores C, Fan-Ma S, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JG. Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Transl Res. 2007 Jul; 150(1):18-29. PMID: 17585860.
      View in: PubMed
    25. Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Mu?oz M, Watson H, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JG, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol. 2007 May; 119(5):1111-8. PMID: 17472811.
      View in: PubMed
    26. Arcaroli J, Silva E, Maloney JP, He Q, Svetkauskaite D, Murphy JR, Abraham E. Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med. 2006 Jun 15; 173(12):1335-41. PMID: 16528020.
      View in: PubMed
    27. Gao L, Grant A, Halder I, Brower R, Sevransky J, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Shriver MD, Ingersoll R, Scott AF, Beaty TH, Moitra J, Ma SF, Ye SQ, Barnes KC, Garcia JG. Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):487-95. PMID: 16399953.
      View in: PubMed
    28. Maloney JP, Broeckel U. Epidemiology, risk factors, and genetics of high-altitude-related pulmonary disease. Clin Chest Med. 2005 Sep; 26(3):395-404, v. PMID: 16140134.
      View in: PubMed
    29. Ye SQ, Simon BA, Maloney JP, Zambelli-Weiner A, Gao L, Grant A, Easley RB, McVerry BJ, Tuder RM, Standiford T, Brower RG, Barnes KC, Garcia JG. Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med. 2005 Feb 15; 171(4):361-70. PMID: 15579727.
      View in: PubMed
    30. Rice TW, Maloney JP. Nutrition and lung disease. Nutr Clin Pract. 2004 Dec; 19(6):547-9. PMID: 16215152.
      View in: PubMed
    31. Maloney JP. Expression of thrombospondins in skeletal muscle. FASEB J. 2004 Jul; 18(10):1049. PMID: 15226264.
      View in: PubMed
    32. Maloney JP. Advances in the treatment of secondary pulmonary hypertension. Curr Opin Pulm Med. 2003 Mar; 9(2):139-43. PMID: 12574694.
      View in: PubMed
    33. Maloney JP, Ryan TA. Detection of aspiration in enterally fed patients: a requiem for bedside monitors of aspiration. JPEN J Parenter Enteral Nutr. 2002 Nov-Dec; 26(6 Suppl):S34-41; discussion S41-2. PMID: 12405621.
      View in: PubMed
    34. McClave SA, DeMeo MT, DeLegge MH, DiSario JA, Heyland DK, Maloney JP, Metheny NA, Moore FA, Scolapio JS, Spain DA, Zaloga GP. North American Summit on Aspiration in the Critically Ill Patient: consensus statement. JPEN J Parenter Enteral Nutr. 2002 Nov-Dec; 26(6 Suppl):S80-5. PMID: 12405628.
      View in: PubMed
    35. Maloney JP. Lessening the punch of heparin-induced thrombocytopenia. Chest. 2002 Jul; 122(1):5-6. PMID: 12114329.
      View in: PubMed
    36. Maloney JP, Ryan TA, Brasel KJ, Binion DG, Johnson DR, Halbower AC, Frankel EH, Nyffeler M, Moss M. Food dye use in enteral feedings: a review and a call for a moratorium. Nutr Clin Pract. 2002 Jun; 17(3):169-81. PMID: 16214982.
      View in: PubMed
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