Lorna Grindlay Moore
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-OB/GYN RS GENERAL OPS |
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Phone | 303/724-7474 |
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Biography 2010 | Fran Boas Distinguished Achievement Award, Human Biology Association | 2013 | Grover Prize, American Thoracic Society |
Overview My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.
Research R21TW010797 (JULIAN, COLLEEN GLYDE)Sep 15, 2017 - Jun 30, 2020 NIH Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in Bolivia Role: Co-Principal Investigator |
| R01HD088590 (MOORE, LORNA G.)Aug 1, 2016 - May 31, 2028 NIH Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growth Role: Principal Investigator |
| R03TW007957 (MOORE, LORNA G.)Apr 8, 2009 - Mar 31, 2012 NIH Perinatal Origins of Chronic Mountain Sickness Role: Principal Investigator |
| R01HL079647 (MOORE, LORNA G.)Feb 1, 2005 - Jan 31, 2011 NIH Genetic Regulation of Hypoxia-Induced IUGR Role: Principal Investigator |
| R13HD042450 (MOORE, LORNA G.)Jul 1, 2002 - Jun 30, 2003 NIH Human Biology Association 2002 Annual Meeting Role: Principal Investigator |
| R03TW001188 (MOORE, LORNA G.)Sep 30, 1999 - Aug 31, 2003 NIH INTRAUTERINE GROWTH RESTRICTION AT HIGH ALTITUDES Role: Principal Investigator |
| R01HL060131 (MOORE, LORNA G.)Jan 1, 1999 - Dec 31, 2004 NIH CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION &GROWTH Role: Principal Investigator |
| K04HD000681 (MOORE, LORNA G.)Aug 1, 1985 - Jul 31, 1990 NIH MATERNAL VENTILATORY ADAPTATION TO PREGNANCY Role: Principal Investigator |
Bibliographic
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O'Brien KA, Gu W, Houck JA, Holzner LMW, Yung HW, Armstrong JL, Sowton AP, Baxter R, Darwin PM, Toledo-Jaldin L, Lazo-Vega L, Moreno-Aramayo AE, Miranda-Garrido V, Shortt JA, Matarazzo CJ, Yasini H, Burton GJ, Moore LG, Simonson TS, Murray AJ, Julian CG. Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia. Hypertension. 2024 Feb; 81(2):319-329. PMID: 38018457.
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Toledo-Jaldin L, Lazo-Vega L, Grau L, Lawrence I, Larrea-Alvarado A, Mizutani R, Rocabado S, Vasan V, Sammel M, Julian CG, Moore LG. Increased adherence to ACOG diagnostic guidelines for HDP following a workshop in Bolivia, a LMIC. Pregnancy Hypertens. 2023 Dec; 34:19-26. PMID: 37778281.
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Julian CG, Houck JA, Fallahi S, Lazo-Vega L, Matarazzo CJ, Diamond B, Miranda-Garrido V, Krause BJ, Moore LG, Shortt JA, Toledo-Jaldin L, Lorca RA. Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies. Physiol Genomics. 2023 09 01; 55(9):357-367. PMID: 37458464.
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Kyllo HM, Wang D, Lorca RA, Julian CG, Moore LG, Wilkening RB, Rozance PJ, Brown LD, Wesolowski SR. Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. Am J Physiol Endocrinol Metab. 2023 06 01; 324(6):E556-E568. PMID: 37126847.
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Mundo W, Toledo-Jaldin L, Heath-Freudenthal A, Huayacho J, Lazo-Vega L, Larrea-Alvarado A, Miranda-Garrido V, Mizutani R, Moore LG, Moreno-Aramayo A, Gomez R, Gutierrez P, Julian CG. Is Maternal Cardiovascular Performance Impaired in Altitude-Associated Fetal Growth Restriction? High Alt Med Biol. 2022 12; 23(4):352-360. PMID: 36472463.
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Fallahi S, Houck JA, Euser AG, Julian CG, Moore LG, Lorca RA. High altitude differentially modulates potassium channel-evoked vasodilatation in pregnant human myometrial arteries. J Physiol. 2022 12; 600(24):5353-5364. PMID: 36286320.
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Moore LG, Wesolowski SR, Lorca RA, Murray AJ, Julian CG. Why is human uterine artery blood flow during pregnancy so high? Am J Physiol Regul Integr Comp Physiol. 2022 11 01; 323(5):R694-R699. PMID: 36094446.
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Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O'Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, V?zquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS. Time Domains of Hypoxia Responses and -Omics Insights. Front Physiol. 2022; 13:885295. PMID: 36035495.
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Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG. Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations. Hypertension. 2022 06; 79(6):1286-1296. PMID: 35437031.
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Lazo-Vega L, Toledo-Jaldin L, Badner A, Barriga-Vera JL, Castro-Monrroy M, Euser AG, Larrea-Alvarado A, Lawrence I, M?rida C, Mizutani R, P?rez Y, Rocabado S, Vargas M, Vasan V, Julian CG, Moore LG. ACOG and local diagnostic criteria for hypertensive disorders of pregnancy (HDP) in La Paz-El Alto, Bolivia: A retrospective case-control study. Lancet Reg Health Am. 2022 May; 9. PMID: 35719175.
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Moore LG. How hypoxia slows fetal growth: insights from high altitude. Pediatr Res. 2022 01; 91(1):17-18. PMID: 34650197.
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Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 09; 9(18):e15033. PMID: 34558219.
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Lorca RA, Houck JA, Laurent LC, Matarazzo CJ, Baker K, Horii M, Nelson KK, Bales ES, Euser AG, Parast MM, Moore LG, Julian CG. High altitude regulates the expression of AMPK pathways in human placenta. Placenta. 2021 01 15; 104:267-276. PMID: 33472134.
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Mundo W, Wolfson G, Moore LG, Houck JA, Park D, Julian CG. Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2021 03 01; 320(3):H980-H990. PMID: 33416457.
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Moore LG. HYPOXIA AND REPRODUCTIVE HEALTH: Reproductive challenges at high altitude: fertility, pregnancy and neonatal well-being. Reproduction. 2021 Jan; 161(1):F81-F90. PMID: 33112770.
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Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow. J Physiol. 2020 09; 598(18):4093-4105. PMID: 32592403.
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Lorca RA, Matarazzo CJ, Bales ES, Houck JA, Orlicky DJ, Euser AG, Julian CG, Moore LG. AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies. Am J Physiol Heart Circ Physiol. 2020 07 01; 319(1):H203-H212. PMID: 32502374.
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Bailey B, Euser AG, Bol KA, Julian CG, Moore LG. High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy. J Matern Fetal Neonatal Med. 2022 Apr; 35(7):1264-1271. PMID: 32228111.
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Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction?. Biol Reprod. 2020 03 13; 102(3):660-670. PMID: 31711123.
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M??tt? J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P. Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2020 Mar 03; 10(1):4260. PMID: 32123262.
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Lamale-Smith LM, Gumina DL, Kramer AW, Browne VA, Toledo-Jaldin L, Julian CG, Winn VD, Moore LG. Uteroplacental Ischemia Is Associated with Increased PAPP-A2. Reprod Sci. 2020 02; 27(2):529-536. PMID: 31994005.
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Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 03; 34(3):4283-4292. PMID: 31970838.
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Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 01 01; 128(1):127-133. PMID: 31804891.
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Bailey BA, Donnelly M, Bol K, Moore LG, Julian CG. High Altitude Continues to Reduce Birth Weights in Colorado. Matern Child Health J. 2019 Nov; 23(11):1573-1580. PMID: 31243627.
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Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 06; 73(6):1319-1326. PMID: 31006328.
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Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 08; 33(8):8999-9007. PMID: 31039323.
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Toledo-Jaldin L, Bull S, Contag S, Escudero C, Gutierrez P, Heath A, Roberts JM, Scandlyn J, Julian CG, Moore LG. Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia. Pregnancy Hypertens. 2019 Apr; 16:139-144. PMID: 31056149.
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Julian CG, Moore LG. Human Genetic Adaptation to High Altitude: Evidence from the Andes. Genes (Basel). 2019 02 15; 10(2). PMID: 30781443.
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Euser AG, Hammes A, Ahrendsen JT, Neshek B, Weitzenkamp DA, Gutierrez J, Koivunen P, Julian CG, Moore LG. Gestational Diabetes Prevalence at Moderate and High Altitude. High Alt Med Biol. 2018 Dec; 19(4):367-372. PMID: 30281336.
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M??tt? J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P. Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2018 09 11; 8(1):13583. PMID: 30206264.
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Moore LG. Queen of the mountain: successful pregnancy while exercising up to 5,300 m. J Appl Physiol (1985). 2018 08 01; 125(2):577-579. PMID: 30001156.
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Crawford JE, Amaru R, Song J, Julian CG, Racimo F, Cheng JY, Guo X, Yao J, Ambale-Venkatesh B, Lima JA, Rotter JI, Stehlik J, Moore LG, Prchal JT, Nielsen R. Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans. Am J Hum Genet. 2017 Nov 02; 101(5):752-767. PMID: 29100088.
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Moore LG. Measuring high-altitude adaptation. J Appl Physiol (1985). 2017 Nov 01; 123(5):1371-1385. PMID: 28860167.
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Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R. Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2a) polymorphism lowers hemoglobin concentration in Tibetan highlanders. J Mol Med (Berl). 2017 06; 95(6):665-670. PMID: 28233034.
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Wolfson GH, Vargas E, Browne VA, Moore LG, Julian CG. Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy. J Clin Endocrinol Metab. 2017 01 01; 102(1):242-250. PMID: 27809650.
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Moore LG. Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects. Quat Int. 2017 Dec 15; 461:4-13. PMID: 29375239.
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Julian CG, Pedersen BS, Salmon CS, Yang IV, Gonzales M, Vargas E, Moore LG, Schwartz DA. Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy. Clin Transl Sci. 2015 Dec; 8(6):740-5. PMID: 26546417.
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Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG. Hypoxia, AMPK activation and uterine artery vasoreactivity. J Physiol. 2016 Mar 01; 594(5):1357-69. PMID: 26110512.
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Julian CG, Gonzales M, Rodriguez A, Bellido D, Salmon CS, Ladenburger A, Reardon L, Vargas E, Moore LG. Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ Physiol. 2015 Aug 15; 309(4):H565-73. PMID: 26092986.
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Pomeroy E, Wells JC, Stanojevic S, Miranda JJ, Moore LG, Cole TJ, Stock JT. Surname-inferred Andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level. Am J Hum Biol. 2015 Nov-Dec; 27(6):798-806. PMID: 25960137.
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Browne VA, Julian CG, Toledo-Jaldin L, Cioffi-Ragan D, Vargas E, Moore LG. Uterine artery blood flow, fetal hypoxia and fetal growth. Philos Trans R Soc Lond B Biol Sci. 2015 Mar 05; 370(1663):20140068. PMID: 25602072.
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Niermeyer S, Andrade-M MP, Vargas E, Moore LG. Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitude (2013 Grover Conference series). Pulm Circ. 2015 Mar; 5(1):48-62. PMID: 25992270.
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Bigham AW, Julian CG, Wilson MJ, Vargas E, Browne VA, Shriver MD, Moore LG. Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude. Physiol Genomics. 2014 Sep 15; 46(18):687-97. PMID: 25225183.
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Hale A, Lee C, Annis S, Min PK, Pande R, Creager MA, Julian CG, Moore LG, Mitsialis SA, Hwang SJ, Kourembanas S, Chan SY. An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells. Biochim Biophys Acta. 2014 Nov; 1843(11):2528-42. PMID: 24983771.
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Charles SM, Julian CG, Vargas E, Moore LG. Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity. J Clin Endocrinol Metab. 2014 Aug; 99(8):2908-16. PMID: 24684460.
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Osol G, Moore LG. Maternal uterine vascular remodeling during pregnancy. Microcirculation. 2014 Jan; 21(1):38-47. PMID: 23941526.
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Julian CG, Yang IV, Browne VA, Vargas E, Rodriguez C, Pedersen BS, Moore LG, Schwartz DA. Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J. 2014 Mar; 28(3):1268-79. PMID: 24307415.
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Soria R, Julian CG, Vargas E, Moore LG, Giussani DA. Graduated effects of high-altitude hypoxia and highland ancestry on birth size. Pediatr Res. 2013 Dec; 74(6):633-8. PMID: 23999073.
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Schwartz J, Cioffi-Ragan D, Wilson MJ, Julian CG, Beatty B, Moore LG, Galan HL. Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation. Am J Hum Biol. 2013 Jul-Aug; 25(4):544-9. PMID: 23754523.
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Gabory A, Roseboom TJ, Moore T, Moore LG, Junien C. Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. Biol Sex Differ. 2013 Mar 21; 4(1):5. PMID: 23514128.
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Julian CG, Vargas E, Gonzales M, D?vila RD, Ladenburger A, Reardon L, Schoo C, Powers RW, Lee-Chiong T, Moore LG. Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis). Respir Physiol Neurobiol. 2013 Apr 01; 186(2):188-96. PMID: 23380170.
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Bigham AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD. Andean and Tibetan patterns of adaptation to high altitude. Am J Hum Biol. 2013 Mar-Apr; 25(2):190-7. PMID: 23348729.
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Eckman DM, Gupta R, Rosenfeld CR, Morgan TM, Charles SM, Mertz H, Moore LG. Pregnancy increases myometrial artery myogenic tone via NOS- or COX-independent mechanisms. Am J Physiol Regul Integr Comp Physiol. 2012 Aug 15; 303(4):R368-75. PMID: 22739352.
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Jean D, Moore LG. Travel to high altitude during pregnancy: frequently asked questions and recommendations for clinicians. High Alt Med Biol. 2012 Jun; 13(2):73-81. PMID: 22724609.
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Ji F, Sharpley MS, Derbeneva O, Alves LS, Qian P, Wang Y, Chalkia D, Lvova M, Xu J, Yao W, Simon M, Platt J, Xu S, Angelin A, Davila A, Huang T, Wang PH, Chuang LM, Moore LG, Qian G, Wallace DC. Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7391-6. PMID: 22517755.
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Galanter JM, Fernandez-Lopez JC, Gignoux CR, Barnholtz-Sloan J, Fernandez-Rozadilla C, Via M, Hidalgo-Miranda A, Contreras AV, Figueroa LU, Raska P, Jimenez-Sanchez G, Zolezzi IS, Torres M, Ponte CR, Ruiz Y, Salas A, Nguyen E, Eng C, Borjas L, Zabala W, Barreto G, Gonz?lez FR, Ibarra A, Taboada P, Porras L, Moreno F, Bigham A, Gutierrez G, Brutsaert T, Le?n-Velarde F, Moore LG, Vargas E, Cruz M, Escobedo J, Rodriguez-Santana J, Rodriguez-Cintr?n W, Chapela R, Ford JG, Bustamante C, Seminara D, Shriver M, Ziv E, Burchard EG, Haile R, Parra E, Carracedo A. Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas. PLoS Genet. 2012; 8(3):e1002554. PMID: 22412386.
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D?vila RD, Julian CG, Browne VA, Toledo-Jaldin L, Wilson MJ, Rodriguez A, Vargas E, Moore LG. Role of cytokines in altitude-associated preeclampsia. Pregnancy Hypertens. 2012 Jan; 2(1):65-70. PMID: 22247821.
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Julian CG, Vargas E, Browne VA, Wilson MJ, Bigham AW, Rodriguez C, McCord JM, Moore LG. Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA. J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1233-40. PMID: 22082238.
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Julian CG, Hageman JL, Wilson MJ, Vargas E, Moore LG. Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight. Am J Hum Biol. 2011 Jul-Aug; 23(4):509-16. PMID: 21538651.
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Moore LG, Charles SM, Julian CG. Humans at high altitude: hypoxia and fetal growth. Respir Physiol Neurobiol. 2011 Aug 31; 178(1):181-90. PMID: 21536153.
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Pulgar VM, Yamashiro H, Rose JC, Moore LG. Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. J Renin Angiotensin Aldosterone Syst. 2011 Sep; 12(3):176-83. PMID: 21421654.
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Browne VA, Toledo-Jaldin L, Davila RD, Lopez LP, Yamashiro H, Cioffi-Ragan D, Julian CG, Wilson MJ, Bigham AW, Shriver MD, Honigman B, Vargas E, Roach R, Moore LG. High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude. Am J Physiol Regul Integr Comp Physiol. 2011 May; 300(5):R1221-9. PMID: 21325643.
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D?vila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG. Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude? Reprod Sci. 2011 Jan; 18(1):79-87. PMID: 20841404.
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Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, L?pez Herr?ez D, Brutsaert T, Parra EJ, Moore LG, Shriver MD. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 2010 Sep 09; 6(9):e1001116. PMID: 20838600.
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D?vila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG. Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry? Reprod Sci. 2010 Sep; 17(9):861-70. PMID: 20601535.
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Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG, Shriver MD. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics. 2009 Dec; 4(2):79-90. PMID: 20038496.
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Julian CG, Wilson MJ, Moore LG. Evolutionary adaptation to high altitude: a view from in utero. Am J Hum Biol. 2009 Sep-Oct; 21(5):614-22. PMID: 19367578.
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Julian CG, Wilson MJ, Lopez M, Yamashiro H, Tellez W, Rodriguez A, Bigham AW, Shriver MD, Rodriguez C, Vargas E, Moore LG. Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1564-75. PMID: 19244584.
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Bennett A, Sain SR, Vargas E, Moore LG. Evidence that parent-of-origin affects birth-weight reductions at high altitude. Am J Hum Biol. 2008 Sep-Oct; 20(5):592-7. PMID: 18449923.
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Julian CG, Galan HL, Wilson MJ, Desilva W, Cioffi-Ragan D, Schwartz J, Moore LG. Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. Am J Physiol Regul Integr Comp Physiol. 2008 Sep; 295(3):R906-15. PMID: 18579652.
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Moore LG, Niermeyer S, Vargas E. Does chronic mountain sickness (CMS) have perinatal origins? Respir Physiol Neurobiol. 2007 Sep 30; 158(2-3):180-9. PMID: 17706469.
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Vargas M, Vargas E, Julian CG, Armaza JF, Rodriguez A, Tellez W, Niermeyer S, Wilson M, Parra E, Shriver M, Moore LG. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1303-12. PMID: 17609312.
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Wilson MJ, Lopez M, Vargas M, Julian C, Tellez W, Rodriguez A, Bigham A, Armaza JF, Niermeyer S, Shriver M, Vargas E, Moore LG. Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1313-24. PMID: 17581833.
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Mao X, Bigham AW, Mei R, Gutierrez G, Weiss KM, Brutsaert TD, Leon-Velarde F, Moore LG, Vargas E, McKeigue PM, Shriver MD, Parra EJ. A genomewide admixture mapping panel for Hispanic/Latino populations. Am J Hum Genet. 2007 Jun; 80(6):1171-8. PMID: 17503334.
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Julian CG, Vargas E, Armaza JF, Wilson MJ, Niermeyer S, Moore LG. High-altitude ancestry protects against hypoxia-associated reductions in fetal growth. Arch Dis Child Fetal Neonatal Ed. 2007 Sep; 92(5):F372-7. PMID: 17329275.
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Mateev SN, Mouser R, Young DA, Mecham RP, Moore LG. Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy. J Appl Physiol (1985). 2006 Jun; 100(6):1842-50. PMID: 16714414.
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Shriver MD, Mei R, Bigham A, Mao X, Brutsaert TD, Parra EJ, Moore LG. Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Adv Exp Med Biol. 2006; 588:89-100. PMID: 17089882.
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Moore LG, Shriver M, Bemis L, Vargas E. An evolutionary model for identifying genetic adaptation to high altitude. Adv Exp Med Biol. 2006; 588:101-18. PMID: 17089883.
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Rockwell LC, Dempsey EC, Moore LG. Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro. High Alt Med Biol. 2006; 7(3):237-44. PMID: 16978136.
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Moore LG, Grover RF. Jack Reeves and his science. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):96-108. PMID: 16386471.
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Le?n-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, Bernardi L, Ge RL, Hackett P, Kobayashi T, Moore LG, Penaloza D, Richalet JP, Roach R, Wu T, Vargas E, Zubieta-Castillo G, Zubieta-Calleja G. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol. 2005; 6(2):147-57. PMID: 16060849.
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Jean D, Leal C, Kriemler S, Meijer H, Moore LG. Medical recommendations for women going to altitude. High Alt Med Biol. 2005; 6(1):22-31. PMID: 15772497.
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Moore LG, Shriver M, Bemis L, Hickler B, Wilson M, Brutsaert T, Parra E, Vargas E. Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review. Placenta. 2004 Apr; 25 Suppl A:S60-71. PMID: 15033310.
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Mazzeo RS, Dubay A, Kirsch J, Braun B, Butterfield GE, Rock PB, Wolfel EE, Zamudio S, Moore LG. Influence of alpha-adrenergic blockade on the catecholamine response to exercise at 4,300 meters. Metabolism. 2003 Nov; 52(11):1471-7. PMID: 14624409.
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Rockwell LC, Vargas E, Moore LG. Human physiological adaptation to pregnancy: inter- and intraspecific perspectives. Am J Hum Biol. 2003 May-Jun; 15(3):330-41. PMID: 12704709.
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Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young DA, Moore LG. Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia. Pediatr Res. 2003 Jul; 54(1):20-5. PMID: 12700368.
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Moore LG. Fetal growth restriction and maternal oxygen transport during high altitude pregnancy. High Alt Med Biol. 2003; 4(2):141-56. PMID: 12855048.
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Moore LG. The quest for riches, or how mining silver in Bolivia has enriched our knowledge of the mechanisms underlying reproductive success. High Alt Med Biol. 2003; 4(2):105-9. PMID: 12877152.
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Coussons-Read ME, Mazzeo RS, Whitford MH, Schmitt M, Moore LG, Zamudio S. High altitude residence during pregnancy alters cytokine and catecholamine levels. Am J Reprod Immunol. 2002 Nov; 48(5):344-54. PMID: 12516658.
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Cymerman A, Lieberman P, Hochstadt J, Rock PB, Butterfield GE, Moore LG. Speech motor control and acute mountain sickness. Aviat Space Environ Med. 2002 Aug; 73(8):766-72. PMID: 12182216.
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Moore LG, Zamudio S, Zhuang J, Droma T, Shohet RV. Analysis of the myoglobin gene in Tibetans living at high altitude. High Alt Med Biol. 2002; 3(1):39-47. PMID: 12006163.
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Zamudio S, Douglas M, Mazzeo RS, Wolfel EE, Young DA, Rock PB, Braun B, Muza SR, Butterfield GE, Moore LG. Women at altitude: forearm hemodynamics during acclimatization to 4,300 m with alpha(1)-adrenergic blockade. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2636-44. PMID: 11709433.
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Fulco CS, Rock PB, Muza SR, Wolfel EE, Moore LG, Cymerman A. Circulatory responses to orthostasis during alpha1-adrenergic receptor blockade at high altitude. Aviat Space Environ Med. 2001 Dec; 72(12):1075-80. PMID: 11763107.
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Reeves JT, Zamudio S, Dahms TE, Asmus I, Braun B, Butterfield GE, McCullough RG, Muza SR, Rock PB, Moore LG. Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. J Appl Physiol (1985). 2001 Dec; 91(6):2579-86. PMID: 11717222.
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Mazzeo RS, Donovan D, Fleshner M, Butterfield GE, Zamudio S, Wolfel EE, Moore LG. Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade. J Appl Physiol (1985). 2001 Nov; 91(5):2143-9. PMID: 11641355.
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Muza SR, Rock PB, Fulco CS, Zamudio S, Braun B, Cymerman A, Butterfield GE, Moore LG. Women at altitude: ventilatory acclimatization at 4,300 m. J Appl Physiol (1985). 2001 Oct; 91(4):1791-9. PMID: 11568164.
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Moore LG, Young D, McCullough RE, Droma T, Zamudio S. Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude. Am J Hum Biol. 2001 Sep-Oct; 13(5):635-44. PMID: 11505472.
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Braun B, Rock PB, Zamudio S, Wolfel GE, Mazzeo RS, Muza SR, Fulco CS, Moore LG, Butterfield GE. Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity. J Appl Physiol (1985). 2001 Aug; 91(2):623-31. PMID: 11457773.
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Fulco CS, Rock PB, Muza SR, Lammi E, Braun B, Cymerman A, Moore LG, Lewis SF. Gender alters impact of hypobaric hypoxia on adductor pollicis muscle performance. J Appl Physiol (1985). 2001 Jul; 91(1):100-8. PMID: 11408419.
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Mazzeo RS, Carroll JD, Butterfield GE, Braun B, Rock PB, Wolfel EE, Zamudio S, Moore LG. Catecholamine responses to alpha-adrenergic blockade during exercise in women acutely exposed to altitude. J Appl Physiol (1985). 2001 Jan; 90(1):121-6. PMID: 11133901.
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Moore LG. Human genetic adaptation to high altitude. High Alt Med Biol. 2001; 2(2):257-79. PMID: 11443005.
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Moore LG, Zamudio S, Zhuang J, Sun S, Droma T. Oxygen transport in tibetan women during pregnancy at 3,658 m. Am J Phys Anthropol. 2001 Jan; 114(1):42-53. PMID: 11150051.
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Cymerman A, Rock PB, Muza SR, Lyons TP, Fulco CS, Mazzeo RS, Butterfield G, Moore LG. Intraocular pressure and acclimatization to 4300 M altitude. Aviat Space Environ Med. 2000 Oct; 71(10):1045-50. PMID: 11051312.
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Moore LG. Comparative human ventilatory adaptation to high altitude. Respir Physiol. 2000 Jul; 121(2-3):257-76. PMID: 10963780.
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Zamudio S, Moore LG. Altitude and fetal growth: current knowledge and future directions. Ultrasound Obstet Gynecol. 2000 Jul; 16(1):6-8. PMID: 11084958.
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White MM, McCullough RE, Dyckes R, Robertson AD, Moore LG. Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2069-75. PMID: 10843906.
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Rockwell LC, Keyes LE, Moore LG. Chronic hypoxia diminishes pregnancy-associated DNA synthesis in guinea pig uteroplacental arteries. Placenta. 2000 May; 21(4):313-9. PMID: 10833365.
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Mawson JT, Braun B, Rock PB, Moore LG, Mazzeo R, Butterfield GE. Women at altitude: energy requirement at 4,300 m. J Appl Physiol (1985). 2000 Jan; 88(1):272-81. PMID: 10642390.
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Braun B, Mawson JT, Muza SR, Dominick SB, Brooks GA, Horning MA, Rock PB, Moore LG, Mazzeo RS, Ezeji-Okoye SC, Butterfield GE. Women at altitude: carbohydrate utilization during exercise at 4,300 m. J Appl Physiol (1985). 2000 Jan; 88(1):246-56. PMID: 10642387.
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Moore LG, Armaza F, Villena M, Vargas E. Comparative aspects of high-altitude adaptation in human populations. Adv Exp Med Biol. 2000; 475:45-62. PMID: 10849648.
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Fulco CS, Rock PB, Muza SR, Lammi E, Cymerman A, Butterfield G, Moore LG, Braun B, Lewis SF. Slower fatigue and faster recovery of the adductor pollicis muscle in women matched for strength with men. Acta Physiol Scand. 1999 Nov; 167(3):233-9. PMID: 10606825.
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Palmer SK, Moore LG, Young D, Cregger B, Berman JC, Zamudio S. Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado. Am J Obstet Gynecol. 1999 May; 180(5):1161-8. PMID: 10329872.
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White MM, McCullough RE, Dyckes R, Robertson AD, Moore LG. Effects of pregnancy and chronic hypoxia on contractile responsiveness to alpha1-adrenergic stimulation. J Appl Physiol (1985). 1998 Dec; 85(6):2322-9. PMID: 9843559.
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Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D, Johnson A, Osorio F, Goldberg C, Moore LG, Dahms T, Schrier RW. Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int. 1998 Dec; 54(6):2056-63. PMID: 9853271.
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Braun B, Butterfield GE, Dominick SB, Zamudio S, McCullough RG, Rock PB, Moore LG. Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle. J Appl Physiol (1985). 1998 Nov; 85(5):1966-73. PMID: 9804605.
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Niermeyer S, Moore LG. Hypoxic responses in infants. No known mechanism links hypoxia and sudden infant death syndrome. BMJ. 1998 Sep 05; 317(7159):675-6; author reply 677-8. PMID: 9758493.
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Keyes L, Rodman DM, Curran-Everett D, Morris K, Moore LG. Effect of K+ATP channel inhibition on total and regional vascular resistance in guinea pig pregnancy. Am J Physiol. 1998 08; 275(2):H680-8. PMID: 9683458.
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Halperin BD, Sun S, Zhuang J, Droma T, Moore LG. ECG observations in Tibetan and Han residents of Lhasa. J Electrocardiol. 1998 Jul; 31(3):237-43. PMID: 9682900.
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Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamudio S, Moore LG. Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women. J Appl Physiol (1985). 1998 Apr; 84(4):1151-7. PMID: 9516178.
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Curran LS, Zhuang J, Droma T, Moore LG. Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m. Am J Phys Anthropol. 1998 Jan; 105(1):21-31. PMID: 9537925.
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Moore LG, Niermeyer S, Zamudio S. Human adaptation to high altitude: regional and life-cycle perspectives. Am J Phys Anthropol. 1998; Suppl 27:25-64. PMID: 9881522.
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Curran LS, Zhuang J, Sun SF, Moore LG. Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m. J Appl Physiol (1985). 1997 Dec; 83(6):2098-104. PMID: 9390987.
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Tatsumi K, Pickett CK, Jacoby CR, Weil JV, Moore LG. Role of endogenous female hormones in hypoxic chemosensitivity. J Appl Physiol (1985). 1997 Nov; 83(5):1706-10. PMID: 9375342.
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Chapman AB, Zamudio S, Woodmansee W, Merouani A, Osorio F, Johnson A, Moore LG, Dahms T, Coffin C, Abraham WT, Schrier RW. Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol. 1997 11; 273(5):F777-82. PMID: 9374841.
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Zamudio S, Plamer SK, Regensteiner JG, Moore LG. High altitude and hypertension during pregnancy. Am J Hum Biol. 1995; 7(2):183-193. PMID: 28557208.
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Moore LG. Maternal O2 transport and fetal growth in Colorado, Peru, and Tibet high-altitude residents. Am J Hum Biol. 1990; 2(6):627-637. PMID: 28520138.
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Year | Publications |
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1995 | 1 | 1997 | 3 | 1998 | 9 | 1999 | 2 | 2000 | 8 | 2001 | 11 | 2002 | 3 | 2003 | 5 | 2004 | 1 | 2005 | 3 | 2006 | 4 | 2007 | 5 | 2008 | 2 | 2009 | 3 | 2010 | 3 | 2011 | 5 | 2012 | 5 | 2013 | 6 | 2014 | 4 | 2015 | 6 | 2016 | 1 | 2017 | 4 | 2018 | 3 | 2019 | 6 | 2020 | 7 | 2021 | 5 | 2022 | 6 | 2023 | 4 |
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