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Melissa J Mahoney

TitleSenior Instructor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin

    Collapse Research 
    Collapse research activities and funding
    U01DK089561     (KELLER, GORDON)Sep 15, 2010 - Jun 30, 2015
    Generation of functional beta cells from stem and progenitor cells
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Grace PM, Loram LC, Christianson JP, Strand KA, Flyer-Adams JG, Penzkover KR, Forsayeth JR, van Dam AM, Mahoney MJ, Maier SF, Chavez RA, Watkins LR. Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy. Brain Behav Immun. 2017 Jan; 59:49-54. PMID: 27189037.
      View in: PubMed
    2. Amer LD, Holtzinger A, Keller G, Mahoney MJ, Bryant SJ. Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates. Acta Biomater. 2015 Aug; 22:103-10. PMID: 25913222; PMCID: PMC4503244.
    3. Amer LD, Mahoney MJ, Bryant SJ. Tissue engineering approaches to cell-based type 1 diabetes therapy. Tissue Eng Part B Rev. 2014 Oct; 20(5):455-67. PMID: 24417705; PMCID: PMC4185974.
    4. Milligan ED, Penzkover KR, Soderquist RG, Mahoney MJ. Spinal interleukin-10 therapy to treat peripheral neuropathic pain. Neuromodulation. 2012 Nov-Dec; 15(6):520-6; discussion 526. PMID: 22672183; PMCID: PMC3443506.
    5. Mooney R, Haeger S, Lawal R, Mason M, Shrestha N, Laperle A, Bjugstad K, Mahoney M. Control of neural cell composition in poly(ethylene glycol) hydrogel culture with soluble factors. Tissue Eng Part A. 2011 Nov; 17(21-22):2805-15. PMID: 21823990; PMCID: PMC3204204.
    6. Lampe KJ, Kern DS, Mahoney MJ, Bjugstad KB. The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: Protein distribution and the glial response. J Biomed Mater Res A. 2011 Mar 01; 96(3):595-607. PMID: 21254391.
      View in: PubMed
    7. Mason MN, Mahoney MJ. A novel composite construct increases the vascularization potential of PEG hydrogels through the incorporation of large fibrin ribbons. J Biomed Mater Res A. 2010 Oct; 95(1):283-93. PMID: 20607870; PMCID: PMC2928881.
    8. Bjugstad KB, Lampe K, Kern DS, Mahoney M. Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: an analysis of the glial response across space and time. J Biomed Mater Res A. 2010 Oct; 95(1):79-91. PMID: 20740603.
      View in: PubMed
    9. Lampe KJ, Mooney RG, Bjugstad KB, Mahoney MJ. Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture. J Biomed Mater Res A. 2010 Sep 15; 94(4):1162-71. PMID: 20694983.
      View in: PubMed
    10. Yang PB, Seiler MJ, Aramant RB, Yan F, Mahoney MJ, Kitzes LM, Keirstead HS. Trophic factors GDNF and BDNF improve function of retinal sheet transplants. Exp Eye Res. 2010 Nov; 91(5):727-38. PMID: 20804751; PMCID: PMC4564299.
    11. Mason MN, Mahoney MJ. Inhibition of gamma-secretase activity promotes differentiation of embryonic pancreatic precursor cells into functional islet-like clusters in poly(ethylene glycol) hydrogel culture. Tissue Eng Part A. 2010 Aug; 16(8):2593-603. PMID: 20236034; PMCID: PMC2947432.
    12. Lampe KJ, Bjugstad KB, Mahoney MJ. Impact of degradable macromer content in a poly(ethylene glycol) hydrogel on neural cell metabolic activity, redox state, proliferation, and differentiation. Tissue Eng Part A. 2010 Jun; 16(6):1857-66. PMID: 20067398; PMCID: PMC2949233.
    13. Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ. PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A. 2010 Jun 01; 93(3):1169-79. PMID: 19768789; PMCID: PMC3604983.
    14. Mooney R, Tawil B, Mahoney M. Specific fibrinogen and thrombin concentrations promote neuronal rather than glial growth when primary neural cells are seeded within plasma-derived fibrin gels. Tissue Eng Part A. 2010 May; 16(5):1607-19. PMID: 20028220.
      View in: PubMed
    15. Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. Pharm Res. 2010 May; 27(5):841-54. PMID: 20224990; PMCID: PMC3583569.
    16. Soderquist RG, Mahoney MJ. Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics. Expert Opin Drug Deliv. 2010 Mar; 7(3):285-93. PMID: 20201735; PMCID: PMC4068128.
    17. Soderquist RG, Milligan ED, Sloane EM, Harrison JA, Douvas KK, Potter JM, Hughes TS, Chavez RA, Johnson K, Watkins LR, Mahoney MJ. PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution. J Biomed Mater Res A. 2009 Dec; 91(3):719-29. PMID: 19048635; PMCID: PMC3990442.
    18. Mason MN, Arnold CA, Mahoney MJ. Entrapped collagen type 1 promotes differentiation of embryonic pancreatic precursor cells into glucose-responsive beta-cells when cultured in three-dimensional PEG hydrogels. Tissue Eng Part A. 2009 Dec; 15(12):3799-808. PMID: 19537960; PMCID: PMC2792077.
    19. Lampe KJ, Namba RM, Silverman TR, Bjugstad KB, Mahoney MJ. Impact of lactic acid on cell proliferation and free radical-induced cell death in monolayer cultures of neural precursor cells. Biotechnol Bioeng. 2009 Aug 15; 103(6):1214-23. PMID: 19408314; PMCID: PMC2748734.
    20. Mason MN, Mahoney MJ. Selective beta-cell differentiation of dissociated embryonic pancreatic precursor cells cultured in synthetic polyethylene glycol hydrogels. Tissue Eng Part A. 2009 Jun; 15(6):1343-52. PMID: 19072086.
      View in: PubMed
    21. Seiler MJ, Aramant RB, Seeliger MW, Bragadottir R, Mahoney M, Narfstrom K. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration. Vet Ophthalmol. 2009 May-Jun; 12(3):158-69. PMID: 19392875.
      View in: PubMed
    22. Sloane EM, Soderquist RG, Maier SF, Mahoney MJ, Watkins LR, Milligan ED. Long-term control of neuropathic pain in a non-viral gene therapy paradigm. Gene Ther. 2009 Apr; 16(4):470-5. PMID: 19262611; PMCID: PMC2756299.
    23. Namba RM, Cole AA, Bjugstad KB, Mahoney MJ. Development of porous PEG hydrogels that enable efficient, uniform cell-seeding and permit early neural process extension. Acta Biomater. 2009 Jul; 5(6):1884-97. PMID: 19250891.
      View in: PubMed
    24. Bjugstad KB, Redmond DE, Lampe KJ, Kern DS, Sladek JR, Mahoney MJ. Biocompatibility of PEG-based hydrogels in primate brain. Cell Transplant. 2008; 17(4):409-15. PMID: 18522243.
      View in: PubMed
    25. Seiler MJ, Thomas BB, Chen Z, Arai S, Chadalavada S, Mahoney MJ, Sadda SR, Aramant RB. BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function. Exp Eye Res. 2008 Jan; 86(1):92-104. PMID: 17983616; PMCID: PMC3074939.
    26. Mahoney MJ, Anseth KS. Contrasting effects of collagen and bFGF-2 on neural cell function in degradable synthetic PEG hydrogels. J Biomed Mater Res A. 2007 May; 81(2):269-78. PMID: 17120204.
      View in: PubMed
    27. Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol. 2006 Nov; 2(4):293-308. PMID: 18079973; PMCID: PMC2133369.
    28. Alsberg E, von Recum HA, Mahoney MJ. Environmental cues to guide stem cell fate decision for tissue engineering applications. Expert Opin Biol Ther. 2006 Sep; 6(9):847-66. PMID: 16918253.
      View in: PubMed
    29. Mahoney MJ, Krewson C, Miller J, Saltzman WM. Impact of cell type and density on nerve growth factor distribution and bioactivity in 3-dimensional collagen gel cultures. Tissue Eng. 2006 Jul; 12(7):1915-27. PMID: 16889521.
      View in: PubMed
    30. Mahoney MJ, Anseth KS. Three-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogels. Biomaterials. 2006 Apr; 27(10):2265-74. PMID: 16318872.
      View in: PubMed
    31. Mahoney MJ, Chen RR, Tan J, Saltzman WM. The influence of microchannels on neurite growth and architecture. Biomaterials. 2005 Mar; 26(7):771-8. PMID: 15350782.
      View in: PubMed
    32. Mahoney MJ, Saltzman WM. Transplantation of brain cells assembled around a programmable synthetic microenvironment. Nat Biotechnol. 2001 Oct; 19(10):934-9. PMID: 11581658.
      View in: PubMed
    33. Belcheva N, Woodrow-Mumford K, Mahoney MJ, Saltzman WM. Synthesis and biological activity of polyethylene glycol-mouse nerve growth factor conjugate. Bioconjug Chem. 1999 Nov-Dec; 10(6):932-7. PMID: 10563761.
      View in: PubMed
    34. Mahoney MJ, Saltzman WM. Millimeter-scale positioning of a nerve-growth-factor source and biological activity in the brain. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4536-9. PMID: 10200297; PMCID: PMC16367.
    35. Mahoney MJ, Saltzman WM. Cultures of cells from fetal rat brain: methods to control composition, morphology, and biochemical activity. Biotechnol Bioeng. 1999 Feb 20; 62(4):461-7. PMID: 9921155.
      View in: PubMed
    36. Saltzman WM, Mak MW, Mahoney MJ, Duenas ET, Cleland JL. Intracranial delivery of recombinant nerve growth factor: release kinetics and protein distribution for three delivery systems. Pharm Res. 1999 Feb; 16(2):232-40. PMID: 10100308.
      View in: PubMed
    37. Mahoney MJ, Saltzman WM. Controlled release of proteins to tissue transplants for the treatment of neurodegenerative disorders. J Pharm Sci. 1996 Dec; 85(12):1276-81. PMID: 8961138.
      View in: PubMed
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