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Laura Maren Saba

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    R24AA013162     (TABAKOFF, BORIS)Aug 1, 2001 - Jul 31, 2022
    The Heritable Transcriptome and Alcoholism
    Role: Co-Principal Investigator

    P30DA044223     (WILLIAMS, ROBERT W.)Aug 1, 2017 - May 31, 2022
    Overall NIDA Core Center of Excellence in Transcriptomics, Systems Genetics and the Addictome
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lyu Y, Xue L, Zhang F, Koch H, Saba L, Kechris K, Li Q. Condition-adaptive fused graphical lasso (CFGL): An adaptive procedure for inferring condition-specific gene co-expression network. PLoS Comput Biol. 2018 Sep; 14(9):e1006436. PMID: 30240439.
      View in: PubMed
    2. Rudra P, Shi WJ, Russell P, Vestal B, Tabakoff B, Hoffman P, Kechris K, Saba L. Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse. BMC Genomics. 2018 Aug 29; 19(1):639. PMID: 30157779.
      View in: PubMed
    3. Lusk R, Saba LM, Vanderlinden LA, Zidek V, Silhavy J, Pravenec M, Hoffman PL, Tabakoff B. Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. Alcohol Clin Exp Res. 2018 Jul; 42(7):1177-1191. PMID: 29689131.
      View in: PubMed
    4. Shearn CT, Pulliam CF, Pedersen K, Meredith K, Mercer KE, Saba LM, Orlicky DJ, Ronis MJ, Petersen DR. Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet. Alcohol Clin Exp Res. 2018 Jul; 42(7):1192-1205. PMID: 29708596.
      View in: PubMed
    5. Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT. Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice. PLoS One. 2018; 13(5):e0198139. PMID: 29799837.
      View in: PubMed
    6. Russell PH, Vestal B, Shi W, Rudra PD, Dowell R, Radcliffe R, Saba L, Kechris K. miR-MaGiC improves quantification accuracy for small RNA-seq. BMC Res Notes. 2018 May 15; 11(1):296. PMID: 29764489.
      View in: PubMed
    7. Vestal B, Russell P, Radcliffe RA, Bemis L, Saba LM, Kechris K. miRNA-regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol. Brain Behav. 2018 Jun; 8(6):e00989. PMID: 30106247.
      View in: PubMed
    8. Johnson M, Alsaleh N, Mendoza RP, Persaud I, Bauer AK, Saba L, Brown JM. Genomic and transcriptomic comparison of allergen and silver nanoparticle-induced mast cell degranulation reveals novel non-immunoglobulin E mediated mechanisms. PLoS One. 2018; 13(3):e0193499. PMID: 29566008.
      View in: PubMed
    9. Bircsak KM, Moscovitz JE, Wen X, Archer F, Yuen PYS, Mohammed M, Memon N, Weinberger BI, Saba LM, Vetrano AM, Aleksunes LM. Interindividual Regulation of the Breast Cancer Resistance Protein/ABCG2 Transporter in Term Human Placentas. Drug Metab Dispos. 2018 05; 46(5):619-627. PMID: 29386232.
      View in: PubMed
    10. Hoffman PL, Saba LM, Vanderlinden LA, Tabakoff B. Voluntary exposure to a toxin: the genetic influence on ethanol consumption. Mamm Genome. 2018 02; 29(1-2):128-140. PMID: 29196862.
      View in: PubMed
    11. Pravenec M, Saba LM, Zídek V, Landa V, Mlejnek P, Šilhavý J, Šimáková M, Strnad H, Trnovská J, Škop V, Hüttl M, Marková I, Oliyarnyk O, Malínská H, Kazdová L, Smith H, Tabakoff B. Systems genetic analysis of brown adipose tissue function. Physiol Genomics. 2018 01 01; 50(1):52-66. PMID: 29127223.
      View in: PubMed
    12. Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR. Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. Free Radic Biol Med. 2017 12; 113:280-290. PMID: 28988798.
      View in: PubMed
    13. Reimondo G, Puglisi S, Zaggia B, Basile V, Saba L, Perotti P, De Francia S, Volante M, Zatelli MC, Cannavò S, Terzolo M. Effects of mitotane on the hypothalamic-pituitary-adrenal axis in patients with adrenocortical carcinoma. Eur J Endocrinol. 2017 Oct; 177(4):361-367. PMID: 28780517.
      View in: PubMed
    14. Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M. Rat Genome and Model Resources. ILAR J. 2017 07 01; 58(1):42-58. PMID: 28838068.
      View in: PubMed
    15. Norman JL, Fixen DR, Saseen JJ, Saba LM, Linnebur SA. Zolpidem prescribing practices before and after Food and Drug Administration required product labeling changes. SAGE Open Med. 2017; 5:2050312117707687. PMID: 28515934.
      View in: PubMed
    16. Rudra P, Shi WJ, Vestal B, Russell PH, Odell A, Dowell RD, Radcliffe RA, Saba LM, Kechris K. Model based heritability scores for high-throughput sequencing data. BMC Bioinformatics. 2017 Mar 02; 18(1):143. PMID: 28253840.
      View in: PubMed
    17. Saba L, Hoffman P, Tabakoff B. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits. Methods Mol Biol. 2017; 1488:299-317. PMID: 27933531.
      View in: PubMed
    18. Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84. PMID: 27401171; PMCID: PMC5002042.
    19. Abdelmagid N, Bereczky-Veress B, Atanur S, Musilová A, Zídek V, Saba L, Warnecke A, Khademi M, Studahl M, Aurelius E, Hjalmarsson A, Garcia-Diaz A, Denis CV, Bergström T, Sköldenberg B, Kockum I, Aitman T, Hübner N, Olsson T, Pravenec M, Diez M. Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis. PLoS One. 2016; 11(5):e0155832. PMID: 27224245.
      View in: PubMed
    20. Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152. PMID: 27124661; PMCID: PMC4849752.
    21. Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr; 7:68-77. PMID: 26654979; PMCID: PMC4683459.
    22. Shearn CT, Orlicky DJ, Saba LM, Shearn AH, Petersen DR. Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis. Free Radic Biol Med. 2015 Dec; 89:1144-53. PMID: 26518673.
      View in: PubMed
    23. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149; PMCID: PMC4546751.
    24. Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. PMID: 26183165.
      View in: PubMed
    25. Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians. Am J Med Genet B Neuropsychiatr Genet. 2015 Oct; 168(7):544-56. PMID: 26079129; PMCID: PMC4851708.
    26. Bennett B, Larson C, Richmond PA, Odell AT, Saba LM, Tabakoff B, Dowell R, Radcliffe RA. Quantitative trait locus mapping of acute functional tolerance in the LXS recombinant inbred strains. Alcohol Clin Exp Res. 2015 Apr; 39(4):611-20. PMID: 25833023; PMCID: PMC4384187.
    27. Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff B. Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption. Mamm Genome. 2015 Feb; 26(1-2):43-56. PMID: 25559016; PMCID: PMC4306387.
    28. Hoffman PL, Saba LM, Flink S, Grahame NJ, Kechris K, Tabakoff B. Genetics of gene expression characterizes response to selective breeding for alcohol preference. Genes Brain Behav. 2014 Nov; 13(8):743-57. PMID: 25160899; PMCID: PMC4241152.
    29. Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 2014 Jul; 38(7):2148-57. PMID: 24961585; PMCID: PMC4142977.
    30. Vanderlinden LA, Saba LM, Kechris K, Miles MF, Hoffman PL, Tabakoff B. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS One. 2013; 8(7):e68878. PMID: 23894363; PMCID: PMC3720886.
    31. Zuo L, Saba L, Wang K, Zhang X, Krystal JH, Tabakoff B, Luo X. Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. J Stud Alcohol Drugs. 2013 Jul; 74(4):622-5. PMID: 23739027; PMCID: PMC3711352.
    32. Procopio DO, Saba LM, Walter H, Lesch O, Skala K, Schlaff G, Vanderlinden L, Clapp P, Hoffman PL, Tabakoff B. Genetic markers of comorbid depression and alcoholism in women. Alcohol Clin Exp Res. 2013 Jun; 37(6):896-904. PMID: 23278386; PMCID: PMC3620932.
    33. Snell LD, Ramchandani VA, Saba L, Herion D, Heilig M, George DT, Pridzun L, Helander A, Schwandt ML, Phillips MJ, Hoffman PL, Tabakoff B. The biometric measurement of alcohol consumption. Alcohol Clin Exp Res. 2012 Feb; 36(2):332-41. PMID: 21895709.
      View in: PubMed
    34. Bennett B, Saba LM, Hornbaker CK, Kechris KJ, Hoffman P, Tabakoff B. Genetical genomic analysis of complex phenotypes using the PhenoGen website. Behav Genet. 2011 Jul; 41(4):625-8. PMID: 21184165; PMCID: PMC3121939.
    35. Saba LM, Bennett B, Hoffman PL, Barcomb K, Ishii T, Kechris K, Tabakoff B. A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. Neuropharmacology. 2011 Jun; 60(7-8):1269-80. PMID: 21185315; PMCID: PMC3079014.
    36. Hoffman PL, Bennett B, Saba LM, Bhave SV, Carosone-Link PJ, Hornbaker CK, Kechris KJ, Williams RW, Tabakoff B. Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes. Addict Biol. 2011 Jul; 16(3):393-404. PMID: 21054686; PMCID: PMC3115429.
    37. Pronko SP, Saba LM, Hoffman PL, Tabakoff B. Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex. J Pharmacol Exp Ther. 2010 Jul; 334(1):44-52. PMID: 20363852; PMCID: PMC2912051.
    38. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009 Oct 27; 7:70. PMID: 19874574; PMCID: PMC2777866.
    39. Tabakoff B, Saba L, Kechris K, Hu W, Bhave SV, Finn DA, Grahame NJ, Hoffman PL. The genomic determinants of alcohol preference in mice. Mamm Genome. 2008 May; 19(5):352-65. PMID: 18563486; PMCID: PMC2583933.
    40. Hu W, Saba L, Kechris K, Bhave SV, Hoffman PL, Tabakoff B. Genomic insights into acute alcohol tolerance. J Pharmacol Exp Ther. 2008 Sep; 326(3):792-800. PMID: 18550690; PMCID: PMC2574863.
    41. Buller DB, Woodall WG, Zimmerman DE, Slater MD, Heimendinger J, Waters E, Hines JM, Starling R, Hau B, Burris-Woodall P, Davis GS, Saba L, Cutter GR. Randomized trial on the 5 a day, the Rio Grande Way Website, a web-based program to improve fruit and vegetable consumption in rural communities. J Health Commun. 2008 Apr-May; 13(3):230-49. PMID: 18569356; PMCID: PMC4376106.
    42. Saba L, Hoffman PL, Hornbaker C, Bhave SV, Tabakoff B. Expression quantitative trait loci and the PhenoGen database. Alcohol Res Health. 2008; 31(3):272-4. PMID: 23584876; PMCID: PMC3860474.
    43. Buller MK, Kane IL, Martin RC, Giese AJ, Cutter GR, Saba LM, Buller DB. Randomized trial evaluating computer-based sun safety education for children in elementary school. J Cancer Educ. 2008; 23(2):74-9. PMID: 18569241.
      View in: PubMed
    44. Woodall WG, Buller DB, Saba L, Zimmerman D, Waters E, Hines JM, Cutter GR, Starling R. Effect of emailed messages on return use of a nutrition education website and subsequent changes in dietary behavior. J Med Internet Res. 2007 Sep 30; 9(3):e27. PMID: 17942389; PMCID: PMC2047284.
    45. Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B. The PhenoGen informatics website: tools for analyses of complex traits. BMC Genet. 2007 Aug 30; 8:59. PMID: 17760997; PMCID: PMC2034588.
    46. Swartz MD, Thomas DC, Daw EW, Albers K, Charlesworth JC, Dyer TC, Fridley BL, Govil M, Kraft P, Kwon S, Logue MW, Oh C, Pique-Regi R, Saba L, Schumacher FR, Uh HW. Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15. Genet Epidemiol. 2007; 31 Suppl 1:S96-102. PMID: 18046760.
      View in: PubMed
    47. Hines LM, Hoffman PL, Bhave S, Saba L, Kaiser A, Snell L, Goncharov I, LeGault L, Dongier M, Grant B, Pronko S, Martinez L, Yoshimura M, Tabakoff B. A sex-specific role of type VII adenylyl cyclase in depression. J Neurosci. 2006 Nov 29; 26(48):12609-19. PMID: 17135423.
      View in: PubMed
    48. Buller DB, Borland R, Woodall WG, Hall JR, Hines JM, Burris-Woodall P, Cutter GR, Miller C, Balmford J, Starling R, Ax B, Saba L. Randomized trials on consider this, a tailored, internet-delivered smoking prevention program for adolescents. Health Educ Behav. 2008 Apr; 35(2):260-81. PMID: 17114331; PMCID: PMC4380290.
    49. Bhave SV, Hoffman PL, Lassen N, Vasiliou V, Saba L, Deitrich RA, Tabakoff B. Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice. Alcohol Clin Exp Res. 2006 Oct; 30(10):1659-69. PMID: 17010133.
      View in: PubMed
    50. Saba L, Bhave SV, Grahame N, Bice P, Lapadat R, Belknap J, Hoffman PL, Tabakoff B. Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm Genome. 2006 Jun; 17(6):669-88. PMID: 16783646.
      View in: PubMed
    51. Wampler NS, Saba L, Rahman SM, Dignan M, Voeks JH, Strzelczyk J. Factors associated with adherence to recommendations for screening mammography among American Indian women in Colorado. Ethn Dis. 2006; 16(4):808-14. PMID: 17061731.
      View in: PubMed
    52. Saba L, Porcella A, Congeddu E, Colombo G, Peis M, Pistis M, Gessa GL, Pani L. The R100Q mutation of the GABA(A) alpha(6) receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line. Brain Res Mol Brain Res. 2001 Mar 05; 87(2):263-70. PMID: 11245930.
      View in: PubMed
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