Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Edwin F deZoeten

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-5440

    Collapse Biography 
    Collapse education and training
    University of Wisconsin, Madison, WIB.S.5/1992Bacteriology
    University of Illinois, Chicago, ILM.D., Ph.D.05/2001Medicine
    University of Illinois, Chicago, ILPh.D.05/2001Immunology
    University of Colorado-SOM, DenverResident06/2004Pediatrics
    Children's Hospital Of Philadelphia, Philadelphia, PAFellow06/2007Pediatric GI, Hepatology and Nutrition

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R01DK111856     (DE ZOETEN, EDWIN FULCO)Jan 13, 2018 - Dec 31, 2022
    NIH
    microRNA-dependent regulation of intestinal T-cells²
    Role: Co-Principal Investigator
    K08DK080189     (DE ZOETEN, EDWIN FULCO)Jul 1, 2008 - Jun 30, 2013
    NIH
    Histone Deacetylase Inhibitors and Inflammatory Bowel Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. McLaughlin L, DeZoeten E, Verneris MR. Can allogeneic haematopoietic cell transplantation be curative in classical Crohn's disease? Br J Haematol. 2023 03; 200(5):541-542. PMID: 36352551.
      View in: PubMed
    2. deZoeten EF, Battista KD, Colson SB, Lovell MA, Kessler BE, Isfort RW, Fennimore BP, Onyiah JC, Kao DJ, Yeckes A, Keely S, Murray M, Hoffenberg EJ, Colgan SP, Gerich ME. Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease. Hypoxia (Auckl). 2020; 8:1-12. PMID: 32104717.
      View in: PubMed
    3. Olbrich CL, Simerly L, de Zoeten EF, Furuta GT, Spencer LA. Climbing New Mountains: How Antibodies Blocking a4?7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract. Dig Dis Sci. 2019 08; 64(8):2068-2071. PMID: 31273593.
      View in: PubMed
    4. Denson LA, Curran M, McGovern DPB, Koltun WA, Duerr RH, Kim SC, Sartor RB, Sylvester FA, Abraham C, de Zoeten EF, Siegel CA, Burns RM, Dobes AM, Shtraizent N, Honig G, Heller CA, Hurtado-Lorenzo A, Cho JH. Challenges in IBD Research: Precision Medicine. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S31-S39. PMID: 31095701.
      View in: PubMed
    5. Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Correction: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 03; 216(6):1465. PMID: 31088899.
      View in: PubMed
    6. Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 06 03; 216(6):1255-1267. PMID: 31040184.
      View in: PubMed
    7. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. Corrigendum: C/EBP? Deletion Promotes Expansion of Functionally Poor Intestinal Regulatory T Cells. J Crohns Colitis. 2019 04 26; 13(5):672. PMID: 30624617.
      View in: PubMed
    8. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. C/EBP? Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells. J Crohns Colitis. 2018 Nov 28; 12(12):1475-1485. PMID: 30085016.
      View in: PubMed
    9. Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019 01; 12(1):200-211. PMID: 30327532.
      View in: PubMed
    10. Brumbaugh D, de Zoeten E, Dominguez S. Reply. J Pediatr. 2018 May 18. PMID: 29784510.
      View in: PubMed
    11. Mark J, Fernando SD, Masterson JC, Pan Z, Capocelli KE, Furuta GT, de Zoeten EF. Clinical Implications of Pediatric Colonic Eosinophilia. J Pediatr Gastroenterol Nutr. 2018 05; 66(5):760-766. PMID: 29095349.
      View in: PubMed
    12. Hoffenberg EJ, McWilliams SK, Mikulich-Gilbertson SK, Murphy BV, Lagueux M, Robbins K, Hoffenberg AS, de Zoeten E, Hopfer CJ. Marijuana Use by Adolescents and Young Adults with Inflammatory Bowel Disease. J Pediatr. 2018 08; 199:99-105. PMID: 29673723.
      View in: PubMed
    13. Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2018 03; 194:123-127.e1. PMID: 29198534.
      View in: PubMed
    14. Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB. Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease. J Crohns Colitis. 2017 Oct 27; 11(11):1369-1380. PMID: 28981653.
      View in: PubMed
    15. MacManus CF, Collins CB, Nguyen TT, Alfano RW, Jedlicka P, de Zoeten EF. VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1101-1112. PMID: 28472424.
      View in: PubMed
    16. Noel G, Diamond B, Auerbach S, de Zoeten E, Hoffenberg E. Colonic Crohn Disease After Cardiac Transplantation: Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):e45-e46. PMID: 26655937.
      View in: PubMed
    17. Masterson JC, Capocelli KE, Hosford L, Biette K, McNamee EN, de Zoeten EF, Harris R, Fernando SD, Jedlicka P, Protheroe C, Lee JJ, Furuta GT. Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis. Inflamm Bowel Dis. 2015 Oct; 21(10):2429-40. PMID: 26218140.
      View in: PubMed
    18. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May; 8(3):699. PMID: 25943416.
      View in: PubMed
    19. Nagy-Szakal D, Mir SA, Harris RA, Dowd SE, Yamada T, Lacorazza HD, Tatevian N, Smith CW, de Zoeten EF, Klein J, Kellermayer R. Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. FASEB J. 2015 Aug; 29(8):3151-9. PMID: 25903104.
      View in: PubMed
    20. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38. PMID: 25850656.
      View in: PubMed
    21. Shin DS, Jordan A, Basu S, Thomas RM, Bandyopadhyay S, de Zoeten EF, Wells AD, Macian F. Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms. EMBO Rep. 2014 Sep; 15(9):991-9. PMID: 25074018.
      View in: PubMed
    22. Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr; 20(4):685-94. PMID: 24552830.
      View in: PubMed
    23. Furuta GT, Atkins D, Capocelli KE, de Zoeten EF, Fleischer D, Menard-Katcher C. Antitumor necrosis factor, infliximab, and adalimumab: use with caution in eosinophilic bowel disease. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):e25. PMID: 23820407.
      View in: PubMed
    24. Gustafson CE, Higbee D, Yeckes AR, Wilson CC, De Zoeten EF, Jedlicka P, Janoff EN. Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy. Mucosal Immunol. 2014 May; 7(3):467-77. PMID: 24045575.
      View in: PubMed
    25. de Zoeten EF, Pasternak BA, Mattei P, Kramer RE, Kader HA. Diagnosis and treatment of perianal Crohn disease: NASPGHAN clinical report and consensus statement. J Pediatr Gastroenterol Nutr. 2013 Sep; 57(3):401-12. PMID: 23974063.
      View in: PubMed
    26. Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73. PMID: 23835442.
      View in: PubMed
    27. Denson LA, Long MD, McGovern DP, Kugathasan S, Wu GD, Young VB, Pizarro TT, de Zoeten EF, Stappenbeck TS, Plevy SE, Abraham C, Nusrat A, Jobin C, McCole DF, Siegel CA, Higgins PD, Herfarth HH, Hyams J, Sandborn WJ, Loftus EV, Kappelman MD, Lewis JD, Parkos CA, Sartor RB. Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):677-82. PMID: 23448796.
      View in: PubMed
    28. Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P, de Zoeten EF. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013 Sep; 6(5):960-71. PMID: 23321985.
      View in: PubMed
    29. Puthoor PR, de Zoeten EF. Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. Biol Ther. 2013; 3:1-14. PMID: 24392300.
      View in: PubMed
    30. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108.
      View in: PubMed
    31. Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE. IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. J Immunol. 2012 Aug 15; 189(4):1792-9. PMID: 22786766.
      View in: PubMed
    32. Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, Dezoeten E, Dunaief JL. DNA methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2089-105. PMID: 22410570.
      View in: PubMed
    33. de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May; 31(10):2066-78. PMID: 21444725.
      View in: PubMed
    34. Friedlander JA, Loeben GS, Finnegan PK, Puma AE, Zhang X, de Zoeten EF, Piccoli DA, Mamula P. A novel method to enhance informed consent: a prospective and randomised trial of form-based versus electronic assisted informed consent in paediatric endoscopy. J Med Ethics. 2011 Apr; 37(4):194-200. PMID: 21245476.
      View in: PubMed
    35. de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW. Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology. 2010 Feb; 138(2):583-94. PMID: 19879272.
      View in: PubMed
    36. Wang L, de Zoeten EF, Greene MI, Hancock WW. Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov. 2009 Dec; 8(12):969-81. PMID: 19855427.
      View in: PubMed
    37. de Zoeten EF, Lee I, Wang L, Chen C, Ge G, Wells AD, Hancock WW, Ozkaynak E. Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem. 2009 Feb 27; 284(9):5709-16. PMID: 19117830.
      View in: PubMed
    38. de Zoeten E, Mamula P. What are the guidelines for using biologics in pediatric patients? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S259-61. PMID: 18816770.
      View in: PubMed
    39. de Zoeten EF, Markowitz J, Loomes KM, Mamula P, Piccoli DA. A 9-month-old girl with chronic diarrhea. Medscape J Med. 2008; 10(8):195. PMID: 18924647.
      View in: PubMed
    40. de Zoeten EF, Hancock WW. Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells. Gastroenterology. 2008 Jun; 134(7):2171-4. PMID: 18482583.
      View in: PubMed
    41. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. 2007 Nov; 13(11):1299-307. PMID: 17922010.
      View in: PubMed
    42. Tao R, de Zoeten EF, Ozkaynak E, Wang L, Li B, Greene MI, Wells AD, Hancock WW. Histone deacetylase inhibitors and transplantation. Curr Opin Immunol. 2007 Oct; 19(5):589-95. PMID: 17719760.
      View in: PubMed
    43. de Zoeten EF, Markovic D, Cohen EP. An optimum anti-melanoma response in mice immunized with fibroblasts transfected with DNA from mouse melanoma cells requires the expression of both syngeneic and allogeneic MHC-determinants. Gene Ther. 2002 Sep; 9(17):1163-72. PMID: 12170380.
      View in: PubMed
    44. de Zoeten EF, Li D, Cohen EP. Tumor immunity in mice immunized with fibroblasts transfected with tumor DNA. Adv Exp Med Biol. 2001; 495:393-401. PMID: 11774600.
      View in: PubMed
    45. Glick RP, Lichtor T, de Zoeten E, Deshmukh P, Cohen EP. Prolongation of survival of mice with glioma treated with semiallogeneic fibroblasts secreting interleukin-2. Neurosurgery. 1999 Oct; 45(4):867-74. PMID: 10515482.
      View in: PubMed
    46. de Zoeten E, Carr-Brendel V, Markovic D, Taylor-Papadimitriou J, Cohen EP. Treatment of breast cancer with fibroblasts transfected with DNA from breast cancer cells. J Immunol. 1999 Jun 01; 162(11):6934-41. PMID: 10352316.
      View in: PubMed
    47. de Zoeten EF, Carr-Brendel V, Cohen EP. Resistance to melanoma in mice immunized with semiallogeneic fibroblasts transfected with DNA from mouse melanoma cells. J Immunol. 1998 Mar 15; 160(6):2915-22. PMID: 9510195.
      View in: PubMed
    48. Sun T, Carr-Brendel V, De Zoeten EF, Cohen EP. Immunization with interleukin-2-secreting allogeneic cells transfected with DNA from mouse melanoma cells induces immune responses that prolong the lives of mice with melanoma. Cancer Gene Ther. 1998 Mar-Apr; 5(2):110-8. PMID: 9570302.
      View in: PubMed
    49. Xu W, de Zoeten E, Carr-Brendel V, Cohen EP. Co-expression of immunogenic determinants by the same cellular immunogen is required for the optimum immunotherapeutic benefit in mice with melanoma. Cancer Immunol Immunother. 1998 Jan; 45(5):217-24. PMID: 9439644.
      View in: PubMed
    deZoeten's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (308) concept(s)
    _
    Co-Authors Expand Description
    See all (29) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2023 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)