Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Paul Scown MacLean

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01CA258766     (MACLEAN, PAUL S.)Jan 1, 2022 - Dec 31, 2026
    NIH
    Novel dietary interventions for reducing obesity-associated breast cancer
    Role: Principal Investigator
    R01HD075285     (MCMANAMAN, JAMES LEWIS)Aug 1, 2013 - Nov 30, 2018
    NIH
    Postnatal Actions of Maternal Obesity on Neonatal Metabolic Health
    Role: Co-Principal Investigator
    R01CA164166     (MACLEAN, PAUL S.)Feb 1, 2013 - Jan 31, 2019
    NIH
    A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
    Role: Principal Investigator
    R13DK084625     (MACLEAN, PAUL S.)Aug 1, 2009 - Jul 31, 2010
    NIH
    The Physiological Basis for Obesity Therapeutics
    Role: Principal Investigator
    K01DK067403     (MACLEAN, PAUL S)Feb 1, 2005 - Nov 30, 2007
    NIH
    Functional aspects of SREBP1c in intact skeletal muscle
    Role: Principal Investigator
    P30DK048520     (MACLEAN, PAUL S.)Mar 15, 1995 - Jul 31, 2025
    NIH
    Colorado Nutrition Obesity Research Center
    Role: Principal Investigator
    R01DK038088     (MACLEAN, PAUL S)Mar 1, 1986 - Mar 31, 2013
    NIH
    Utilization of Ingested Engery During Underfeeding
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gilley SP, Zarate MA, Zheng L, Jambal P, Yazza DN, Chintapalli SV, MacLean PS, Wright CJ, Rozance PJ, Shankar K. Metabolic and fecal microbial changes in adult fetal growth restricted mice. Pediatr Res. 2024 Feb; 95(3):647-659. PMID: 37935884.
      View in: PubMed
    2. Hill EB, Konigsberg IR, Ir D, Frank DN, Jambal P, Litkowski EM, Lange EM, Lange LA, Ostendorf DM, Scorsone JJ, Wayland L, Bing K, MacLean PS, Melanson EL, Bessesen DH, Catenacci VA, Stanislawski MA, Borengasser SJ. The Microbiome, Epigenome, and Diet in Adults with Obesity during Behavioral Weight Loss. Nutrients. 2023 Aug 16; 15(16). PMID: 37630778.
      View in: PubMed
    3. Castillo-Mancilla JR, Erlandson KM, Hecker ER, Komaie G, Shomaker LB, Cicutto L, Mankin G, Maclean P. Outcomes of a Career Development Award (Pre-K) Mock Review Program for Postdoctoral Fellows and Early-Career Faculty. Acad Med. 2023 11 01; 98(11):1313-1318. PMID: 37289813.
      View in: PubMed
    4. McCoard S, Haack N, Heiser A, Maclean P. Effect of birth rank, and placentome subtype on expression of genes involved in placental nutrient transport in sheep. Theriogenology. 2023 Jun; 203:109-117. PMID: 37023492.
      View in: PubMed
    5. Roberson PA, Kincheloe GN, Welles JE, Xu D, Sam-Clarke M, MacLean PS, Lang CH, Jefferson LS, Kimball SR. Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells. J Nutr. 2023 04; 153(4):988-998. PMID: 37061344.
      View in: PubMed
    6. Varshney R, Das S, Trahan GD, Farriester JW, Mullen GP, Kyere-Davies G, Presby DM, Houck JA, Webb PG, Dzieciatkowska M, Jones KL, Rodeheffer MS, Friedman JE, MacLean PS, Rudolph MC. Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors. iScience. 2023 Jan 20; 26(1):105750. PMID: 36590177.
      View in: PubMed
    7. Hill EB, Siebert JC, Yazza DN, Ostendorf DM, Bing K, Wayland L, Scorsone JJ, Bessesen DH, MacLean PS, Melanson EL, Catenacci VA, Borengasser SJ. Proteomics, dietary intake, and changes in cardiometabolic health within a behavioral weight-loss intervention: A pilot study. Obesity (Silver Spring). 2022 Nov; 30(11):2134-2145. PMID: 36321274.
      View in: PubMed
    8. Young W, Maclean P, Dunstan K, Ryan L, Peters J, Armstrong K, Anderson R, Dewhurst H, van Gendt M, Dilger RN, Dekker J, Haggarty N, Roy N. Lacticaseibacillus rhamnosus HN001 alters the microbiota composition in the cecum but not the feces in a piglet model. Front Nutr. 2022; 9:1002369. PMID: 36386940.
      View in: PubMed
    9. Young BE, Kyere-Davies G, Farriester JW, Varshney R, MacLean PS, Krebs NF, Rudolph MC. Infant Red Blood Cell Arachidonic to Docosahexaenoic Acid Ratio Inversely Associates with Fat-Free Mass Independent of Breastfeeding Exclusivity. Nutrients. 2022 Oct 11; 14(20). PMID: 36296922.
      View in: PubMed
    10. Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, MacLean P, Gerszten RE, Libby A, Solt C, Schoen J, Bergman BC. Exploring Visceral and Subcutaneous Adipose Tissue Secretomes in Human Obesity: Implications for Metabolic Disease. Endocrinology. 2022 10 11; 163(11). PMID: 36036084.
      View in: PubMed
    11. Ostendorf DM, Caldwell AE, Zaman A, Pan Z, Bing K, Wayland LT, Creasy SA, Bessesen DH, MacLean P, Melanson EL, Catenacci VA. Comparison of weight loss induced by daily caloric restriction versus intermittent fasting (DRIFT) in individuals with obesity: study protocol for a 52-week randomized clinical trial. Trials. 2022 Aug 29; 23(1):718. PMID: 36038881.
      View in: PubMed
    12. Wellberg EA, Corleto KA, Checkley LA, Jindal S, Johnson G, Higgins JA, Obeid S, Anderson SM, Thor AD, Schedin PJ, MacLean PS, Giles ED. Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. Breast Cancer Res. 2022 06 20; 24(1):42. PMID: 35725493.
      View in: PubMed
    13. Gavin KM, Sullivan TM, Maltzahn JK, Jackman MR, Libby AE, MacLean PS, Kohrt WM, Majka SM, Klemm DJ. Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice. Front Endocrinol (Lausanne). 2022; 13:844877. PMID: 35721743.
      View in: PubMed
    14. Ward AV, Matthews SB, Fettig LM, Riley D, Finlay-Schultz J, Paul KV, Jackman M, Kabos P, MacLean PS, Sartorius CA. Estrogens and Progestins Cooperatively Shift Breast Cancer Cell Metabolism. Cancers (Basel). 2022 Mar 31; 14(7). PMID: 35406548.
      View in: PubMed
    15. De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A. Short-Term Adaptations in Skeletal Muscle Mitochondrial Oxidative Capacity and Metabolic Pathways to Breaking up Sedentary Behaviors in Overweight or Obese Adults. Nutrients. 2022 Jan 20; 14(3). PMID: 35276813.
      View in: PubMed
    16. Hopp K, Catenacci VA, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson GC, Jackman MR, Miller M, Steele CN, Serkova NJ, MacLean PS, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease. iScience. 2022 Jan 21; 25(1):103697. PMID: 35059607.
      View in: PubMed
    17. Scalzo RL, Foright RM, Hull SE, Knaub LA, Johnson-Murguia S, Kinanee F, Kaplan J, Houck JA, Johnson G, Sharp RR, Gillen AE, Jones KL, Zhang AMY, Johnson JD, MacLean PS, Reusch JEB, Wright-Hobart S, Wellberg EA. Breast Cancer Endocrine Therapy Promotes Weight Gain With Distinct Adipose Tissue Effects in Lean and Obese Female Mice. Endocrinology. 2021 11 01; 162(11). PMID: 34410380.
      View in: PubMed
    18. Stanislawski MA, Frank DN, Borengasser SJ, Ostendorf DM, Ir D, Jambal P, Bing K, Wayland L, Siebert JC, Bessesen DH, MacLean PS, Melanson EL, Catenacci VA. The Gut Microbiota during a Behavioral Weight Loss Intervention. Nutrients. 2021 Sep 18; 13(9). PMID: 34579125.
      View in: PubMed
    19. Dahle JH, Ostendorf DM, Pan Z, MacLean PS, Bessesen DH, Heymsfield SB, Melanson EL, Catenacci VA. Weight and body composition changes affect resting energy expenditure predictive equations during a 12-month weight-loss intervention. Obesity (Silver Spring). 2021 10; 29(10):1596-1605. PMID: 34431624.
      View in: PubMed
    20. Siebert JC, Stanislawski MA, Zaman A, Ostendorf DM, Konigsberg IR, Jambal P, Ir D, Bing K, Wayland L, Scorsone JJ, Lozupone CA, G?rg C, Frank DN, Bessesen D, MacLean PS, Melanson EL, Catenacci VA, Borengasser SJ. Multiomic Predictors of Short-Term Weight Loss and Clinical Outcomes During a Behavioral-Based Weight Loss Intervention. Obesity (Silver Spring). 2021 05; 29(5):859-869. PMID: 33811477.
      View in: PubMed
    21. Barnett MPG, Young W, Armstrong K, Brewster D, Cooney JM, Ellett S, Espley RV, Laing W, Maclean P, McGhie T, Pringle G, Roy NC, Ferguson LR. A Polyphenol Enriched Variety of Apple Alters Circulating Immune Cell Gene Expression and Faecal Microbiota Composition in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2021 Mar 27; 13(4). PMID: 33801641.
      View in: PubMed
    22. Presby DM, Rudolph MC, Sherk VD, Jackman MR, Foright RM, Jones KL, Houck JA, Johnson GC, Higgins JA, Neufer PD, Eckel RH, MacLean PS. Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure. Diabetes. 2021 04; 70(4):867-877. PMID: 33536195.
      View in: PubMed
    23. Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 01 11; 6(1). PMID: 33320834.
      View in: PubMed
    24. Sherk VD, Heveran CM, Foright RM, Johnson GC, Presby DM, Ferguson VL, MacLean PS. Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness. Bone. 2021 04; 145:115840. PMID: 33418101.
      View in: PubMed
    25. Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 12; 25(4):367-387. PMID: 33216249.
      View in: PubMed
    26. Foright RM, Johnson GC, Kahn D, Charleston CA, Presby DM, Bouchet CA, Wellberg EA, Sherk VD, Jackman MR, Greenwood BN, MacLean PS. Compensatory eating behaviors in male and female rats in response to exercise training. Am J Physiol Regul Integr Comp Physiol. 2020 08 01; 319(2):R171-R183. PMID: 32551825.
      View in: PubMed
    27. Nahomi RB, Nam MH, Rankenberg J, Rakete S, Houck JA, Johnson GC, Stankowska DL, Pantcheva MB, MacLean PS, Nagaraj RH. Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice. Int J Mol Sci. 2020 Mar 05; 21(5). PMID: 32151061.
      View in: PubMed
    28. Sherk VD, Jackman MR, Higgins JA, Giles ED, Foright RM, Presby DM, Carpenter RD, Johnson GC, Oljira R, Houck JA, Maclean PS. Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health Post-Ovariectomy. Med Sci Sports Exerc. 2019 12; 51(12):2465-2473. PMID: 31274683.
      View in: PubMed
    29. Giles ED, Brown IL, MacLean PS, Pan Z, Melanson EL, Heard KJ, Cornier MA, Marden T, Higgins JA. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019 Oct 16; 11(10). PMID: 31623184.
      View in: PubMed
    30. Presby DM, Checkley LA, Jackman MR, Higgins JA, Jones KL, Giles ED, Houck JA, Webb PG, Steig AJ, Johnson GC, Rudolph MC, MacLean PS. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019 11 01; 317(5):R684-R695. PMID: 31553623.
      View in: PubMed
    31. McCoard S, Heiser A, Lowe K, Molenaar A, MacLean P, Johnstone P, Leath S, Hoskin SO, Khan MA. Effect of weaning age on growth, mammary gland development, and immune function in Holstein Friesian calves fed conserved alfalfa (FiberStart). J Dairy Sci. 2019 Jul; 102(7):6076-6087. PMID: 31079903.
      View in: PubMed
    32. Grinman DY, Careaga VP, Wellberg EA, Dansey MV, Kordon EC, Anderson SM, Maier MS, Burton G, MacLean PS, Rudolph MC, Pecci A. Liver X receptor-a activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1136-E1145. PMID: 30964702.
      View in: PubMed
    33. Presby DM, Jackman MR, Rudolph MC, Sherk VD, Foright RM, Houck JA, Johnson GC, Orlicky DJ, Melanson EL, Higgins JA, MacLean PS. Compensation for cold-induced thermogenesis during weight loss maintenance and regain. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E977-E986. PMID: 30912962.
      View in: PubMed
    34. Ostendorf DM, Caldwell AE, Creasy SA, Pan Z, Lyden K, Bergouignan A, MacLean PS, Wyatt HR, Hill JO, Melanson EL, Catenacci VA. Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers. Obesity (Silver Spring). 2019 03; 27(3):496-504. PMID: 30801984.
      View in: PubMed
    35. Ostendorf DM, Melanson EL, Caldwell AE, Creasy SA, Pan Z, MacLean PS, Wyatt HR, Hill JO, Catenacci VA. No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainers. Am J Clin Nutr. 2018 10 01; 108(4):658-666. PMID: 30321282.
      View in: PubMed
    36. Young BE, Levek C, Reynolds RM, Rudolph MC, MacLean P, Hernandez TL, Friedman JE, Krebs NF. Bioactive components in human milk are differentially associated with rates of lean and fat mass deposition in infants of mothers with normal vs. elevated BMI. Pediatr Obes. 2018 10; 13(10):598-606. PMID: 30092608.
      View in: PubMed
    37. Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018 Aug 03; 10(8). PMID: 30081468.
      View in: PubMed
    38. Wellberg EA, Kabos P, Gillen AE, Jacobsen BM, Brechbuhl HM, Johnson SJ, Rudolph MC, Edgerton SM, Thor AD, Anderson SM, Elias A, Zhou XK, Iyengar NM, Morrow M, Falcone DJ, El-Hely O, Dannenberg AJ, Sartorius CA, MacLean PS. FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. JCI Insight. 2018 07 26; 3(14). PMID: 30046001.
      View in: PubMed
    39. Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018 06 14; 20(1):50. PMID: 29898754.
      View in: PubMed
    40. Monks J, Orlicky DJ, Stefanski AL, Libby AE, Bales ES, Rudolph MC, Johnson GC, Sherk VD, Jackman MR, Williamson K, Carlson NE, MacLean PS, McManaman JL. Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction. Nutr Diabetes. 2018 04 25; 8(1):18. PMID: 29695710.
      View in: PubMed
    41. MacLean PS, Rothman AJ, Nicastro HL, Czajkowski SM, Agurs-Collins T, Rice EL, Courcoulas AP, Ryan DH, Bessesen DH, Loria CM. The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach. Obesity (Silver Spring). 2018 04; 26 Suppl 2:S6-S15. PMID: 29575780.
      View in: PubMed
    42. Rosenbaum M, Agurs-Collins T, Bray MS, Hall KD, Hopkins M, Laughlin M, MacLean PS, Maruvada P, Savage CR, Small DM, Stoeckel L. Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain. Obesity (Silver Spring). 2018 04; 26 Suppl 2:S25-S34. PMID: 29575784.
      View in: PubMed
    43. Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):3138-3143. PMID: 29507217.
      View in: PubMed
    44. Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 02 08; 3(3). PMID: 29415895.
      View in: PubMed
    45. Foright RM, Presby DM, Sherk VD, Kahn D, Checkley LA, Giles ED, Bergouignan A, Higgins JA, Jackman MR, Hill JO, MacLean PS. Is regular exercise an effective strategy for weight loss maintenance? Physiol Behav. 2018 05 01; 188:86-93. PMID: 29382563.
      View in: PubMed
    46. Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS. Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes. 2018 04; 67(4):651-661. PMID: 29138256.
      View in: PubMed
    47. Wei J, Antony J, Meng F, MacLean P, Rhind R, Laible G, Oback B. KDM4B-mediated reduction of H3K9me3 and H3K36me3 levels improves somatic cell reprogramming into pluripotency. Sci Rep. 2017 08 08; 7(1):7514. PMID: 28790329.
      View in: PubMed
    48. Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Horm Cancer. 2017 12; 8(5-6):269-285. PMID: 28741260.
      View in: PubMed
    49. Pfeffer PL, Smith CS, Maclean P, Berg DK. Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation. Zygote. 2017 Jun; 25(3):265-278. PMID: 28534463.
      View in: PubMed
    50. Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, Maclean PS. Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training. Med Sci Sports Exerc. 2017 05; 49(5):888-895. PMID: 28079706.
      View in: PubMed
    51. Sherk VD, Jackman MR, Giles ED, Higgins JA, Foright RM, Presby DM, Johnson GC, Houck JA, Houser JL, Oljira R, MacLean PS. Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function. Physiol Rep. 2017 May; 5(10):e13272. PMID: 28533263.
      View in: PubMed
    52. MacLean PS, Blundell JE, Mennella JA, Batterham RL. Biological control of appetite: A daunting complexity. Obesity (Silver Spring). 2017 03; 25 Suppl 1:S8-S16. PMID: 28229538.
      View in: PubMed
    53. Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS. Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo. Cancer Prev Res (Phila). 2017 Mar; 10(3):198-207. PMID: 28154203.
      View in: PubMed
    54. Giles ED, Jackman MR, MacLean PS. Modeling Diet-Induced Obesity with Obesity-Prone Rats: Implications for Studies in Females. Front Nutr. 2016; 3:50. PMID: 27933296.
      View in: PubMed
    55. Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2017 04; 41(4):510-517. PMID: 27876761.
      View in: PubMed
    56. Song ??? Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol. 2017 02 01; 117(2):646-654. PMID: 27852737.
      View in: PubMed
    57. Rudolph MC, Young BE, Jackson KH, Krebs NF, Harris WS, MacLean PS. Human Milk Fatty Acid Composition: Comparison of Novel Dried Milk Spot Versus Standard Liquid Extraction Methods. J Mammary Gland Biol Neoplasia. 2016 12; 21(3-4):131-138. PMID: 27796616.
      View in: PubMed
    58. Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL, Troy Donahoo W. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring). 2016 09; 24(9):1874-83. PMID: 27569118.
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    59. Matthew Morris E, Meers GM, Koch LG, Britton SL, MacLean PS, Thyfault JP. Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain. Obesity (Silver Spring). 2016 09; 24(9):1929-37. PMID: 27465260.
      View in: PubMed
    60. Giles ED, Hagman J, Pan Z, MacLean PS, Higgins JA. Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats. Nutr Metab (Lond). 2016; 13:18. PMID: 26937246.
      View in: PubMed
    61. Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Lindstrom RC, MacLean PS. Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol. 2016; 7:32. PMID: 26903882.
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    62. Sladek CD, Stevens W, Song Z, Johnson GC, MacLean PS. The "metabolic sensor" function of rat supraoptic oxytocin and vasopressin neurons is attenuated during lactation but not in diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 15; 310(4):R337-45. PMID: 26661099.
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    63. Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL. Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine. PLoS One. 2015; 10(7):e0131944. PMID: 26147095.
      View in: PubMed
    64. MacLean PS, Higgins JA, Giles ED, Sherk VD, Jackman MR. The role for adipose tissue in weight regain after weight loss. Obes Rev. 2015 Feb; 16 Suppl 1:45-54. PMID: 25614203.
      View in: PubMed
    65. MacLean PS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, Perri MG, Rolls BJ, Rosenbaum M, Rothman AJ, Ryan D. NIH working group report: Innovative research to improve maintenance of weight loss. Obesity (Silver Spring). 2015 Jan; 23(1):7-15. PMID: 25469998.
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    66. Irwin DC, Garat CV, Crossno JT, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulm Circ. 2014 Dec; 4(4):638-53. PMID: 25610600.
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    67. Morris EM, Jackman MR, Johnson GC, Liu TW, Lopez JL, Kearney ML, Fletcher JA, Meers GM, Koch LG, Britton SL, Rector RS, Ibdah JA, MacLean PS, Thyfault JP. Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab. 2014 Aug 15; 307(4):E355-64. PMID: 24961240.
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    68. Saben JL, Bales ES, Jackman MR, Orlicky D, MacLean PS, McManaman JL. Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis. PLoS One. 2014; 9(5):e98066. PMID: 24849657.
      View in: PubMed
    69. Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, S?nchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov; 58(5):1632-43. PMID: 23813872.
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    70. Morris EM, Jackman MR, Meers GM, Johnson GC, Lopez JL, MacLean PS, Thyfault JP. Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1a overexpression. Am J Physiol Gastrointest Liver Physiol. 2013 Dec; 305(11):G868-80. PMID: 24091599.
      View in: PubMed
    71. Neville MC, Webb P, Ramanathan P, Mannino MP, Pecorini C, Monks J, Anderson SM, MacLean P. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab. 2013 Nov 01; 305(9):E1103-14. PMID: 23982156.
      View in: PubMed
    72. Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL. Dynamic regulation of hepatic lipid droplet properties by diet. PLoS One. 2013; 8(7):e67631. PMID: 23874434.
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    73. Strohacker K, McCaffery JM, MacLean PS, Wing RR. Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature. Int J Obes (Lond). 2014 Mar; 38(3):388-96. PMID: 23801147.
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    74. Russ AE, Peters JS, McNabb WC, Barnett MP, Anderson RC, Park Z, Zhu S, Maclean P, Young W, Reynolds GW, Roy NC. Gene expression changes in the colon epithelium are similar to those of intact colon during late inflammation in interleukin-10 gene deficient mice. PLoS One. 2013; 8(5):e63251. PMID: 23700416.
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    75. Higgins J, Hagman J, Pan Z, MacLean P. Increased physical activity not decreased energy intake is associated with inpatient medical treatment for anorexia nervosa in adolescent females. PLoS One. 2013; 8(4):e61559. PMID: 23637854.
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    76. McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May; 54(5):1346-59. PMID: 23402988.
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    77. Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Res. 2012 Dec 15; 72(24):6490-501. PMID: 23222299.
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    78. Jankowski CM, Gozansky WS, MacLean PS, Shulman B, Wolfe P, Schwartz RS, Kohrt WM. N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training. Eur J Appl Physiol. 2013 May; 113(5):1127-36. PMID: 23108581.
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    79. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723.
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    80. McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012 Oct; 61(10):2495-505. PMID: 22698915.
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    81. Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, S?nchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4320-5. PMID: 22371574.
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    82. Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS One. 2012; 7(1):e30164. PMID: 22253914.
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    83. Higgins JA, Jackman MR, Brown IL, Johnson GC, Steig A, Wyatt HR, Hill JO, Maclean PS. Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity. Nutr Metab (Lond). 2011 Jul 07; 8:49. PMID: 21736742.
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    84. Wahlig JL, Bales ES, Jackman MR, Johnson GC, McManaman JL, Maclean PS. Impact of high-fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation. Obesity (Silver Spring). 2012 Jan; 20(1):65-75. PMID: 21720435.
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    85. Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, MacLean PS. Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R656-67. PMID: 21715696.
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    86. Maclean PS, Bergouignan A, Cornier MA, Jackman MR. Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R581-600. PMID: 21677272.
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    87. MacLean PS. Comment on: Kaiyala et al. (2010) Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes;59:1657-1666. Diabetes. 2011 Jan; 60(1):e3; author reply e4. PMID: 21193727.
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    88. Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS. Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. Am J Physiol Regul Integr Comp Physiol. 2010 Dec; 299(6):R1634-42. PMID: 20926768.
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    89. Jackman MR, MacLean PS, Bessesen DH. Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet. Am J Physiol Regul Integr Comp Physiol. 2010 Oct; 299(4):R1097-105. PMID: 20686168.
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    90. Civitarese AE, MacLean PS, Carling S, Kerr-Bayles L, McMillan RP, Pierce A, Becker TC, Moro C, Finlayson J, Lefort N, Newgard CB, Mandarino L, Cefalu W, Walder K, Collier GR, Hulver MW, Smith SR, Ravussin E. Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Cell Metab. 2010 May 05; 11(5):412-26. PMID: 20444421.
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    91. Melanson EL, Gozansky WS, Barry DW, Maclean PS, Grunwald GK, Hill JO. When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals. J Appl Physiol (1985). 2009 Dec; 107(6):1847-56. PMID: 19833807.
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    92. MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman MR, Shroyer KR, Schedin PJ. A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. Obesity (Silver Spring). 2010 Apr; 18(4):696-703. PMID: 19798068.
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    93. MacLean PS, Higgins JA, Wyatt HR, Melanson EL, Johnson GC, Jackman MR, Giles ED, Brown IE, Hill JO. Regular exercise attenuates the metabolic drive to regain weight after long-term weight loss. Am J Physiol Regul Integr Comp Physiol. 2009 Sep; 297(3):R793-802. PMID: 19587114.
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    94. Melanson EL, MacLean PS, Hill JO. Exercise improves fat metabolism in muscle but does not increase 24-h fat oxidation. Exerc Sport Sci Rev. 2009 Apr; 37(2):93-101. PMID: 19305201.
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    95. Jackman MR, Steig A, Higgins JA, Johnson GC, Fleming-Elder BK, Bessesen DH, MacLean PS. Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia. Am J Physiol Regul Integr Comp Physiol. 2008 Apr; 294(4):R1117-29. PMID: 18287221.
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    96. Jensen DR, Knaub LA, Konhilas JP, Leinwand LA, MacLean PS, Eckel RH. Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype? J Lipid Res. 2008 Apr; 49(4):870-9. PMID: 18175800.
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    97. Maclean PS, Parker AN, McQuaker IG, Clark AD, Farrell E, Douglas KW. Ideal body weight correlates better with engraftment after PBSC autograft than actual body weight, but is under-estimated in myeloma patients possibly due to disease-related height loss. Bone Marrow Transplant. 2007 Oct; 40(7):665-9. PMID: 17646841.
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    98. Jackman MR, Kramer RE, MacLean PS, Bessesen DH. Trafficking of dietary fat in obesity-prone and obesity-resistant rats. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E1083-91. PMID: 16803858.
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    99. Qiao L, MacLean PS, You H, Schaack J, Shao J. knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology. 2006 Jun; 147(6):3060-9. PMID: 16543372.
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    100. MacLean PS, Higgins JA, Jackman MR, Johnson GC, Fleming-Elder BK, Wyatt HR, Melanson EL, Hill JO. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol. 2006 Jun; 290(6):R1577-88. PMID: 16455763.
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    101. MacLean PS. A peripheral perspective of weight regain. Am J Physiol Regul Integr Comp Physiol. 2005 Jun; 288(6):R1447-9. PMID: 15886355.
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    102. Qiao L, Maclean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti M, Friedman JE, Shao J. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes. 2005 Jun; 54(6):1744-54. PMID: 15919796.
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    103. MacLean PS, Vadlamudi S, MacDonald KG, Pories WJ, Barakat HA. Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005 Apr; 90(4):2250-8. PMID: 15644403.
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    104. MacLean PS, Higgins JA, Johnson GC, Fleming-Elder BK, Donahoo WT, Melanson EL, Hill JO. Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol. 2004 Dec; 287(6):R1306-15. PMID: 15331386.
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    105. MacLean PS, Higgins JA, Johnson GC, Fleming-Elder BK, Peters JC, Hill JO. Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol. 2004 Aug; 287(2):R288-97. PMID: 15044180.
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    106. MacLean PS, Bower JF, Vadlamudi S, Osborne JN, Bradfield JF, Burden HW, Bensch WH, Kauffman RF, Barakat HA. Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice. Arterioscler Thromb Vasc Biol. 2003 Aug 01; 23(8):1412-5. PMID: 12791674.
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    107. Bizeau ME, MacLean PS, Johnson GC, Wei Y. Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats. J Nutr. 2003 Jun; 133(6):1787-92. PMID: 12771318.
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    108. Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, Kraus WE. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. J Biol Chem. 2002 Jul 19; 277(29):26089-97. PMID: 12118038.
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    109. MacLean PS, Zheng D, Jones JP, Olson AL, Dohm GL. Exercise-induced transcription of the muscle glucose transporter (GLUT 4) gene. Biochem Biophys Res Commun. 2002 Mar 29; 292(2):409-14. PMID: 11906177.
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    110. Maclean PS, Tanner CJ, Houmard JA, Barakat HA. Plasma cholesteryl ester transfer protein activity is not linked to insulin sensitivity. Metabolism. 2001 Jul; 50(7):783-8. PMID: 11436182.
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    111. MacLean PS, Zheng D, Dohm GL. Muscle glucose transporter (GLUT 4) gene expression during exercise. Exerc Sport Sci Rev. 2000 Oct; 28(4):148-52. PMID: 11064847.
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    112. MacLean PS, Barakat HA. Insulin does not regulate the promoter of cholesteryl ester transfer protein (CETP) in HIRc/pCETP-CAT cells. Mol Cell Biochem. 2000 Aug; 211(1-2):1-7. PMID: 11055541.
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    113. Houmard JA, Cox JH, MacLean PS, Barakat HA. Effect of short-term exercise training on leptin and insulin action. Metabolism. 2000 Jul; 49(7):858-61. PMID: 10909995.
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    114. MacLean PS, Vadlamudi S, Hao E, Barakat HA. Differential expression of cholesteryl ester transfer protein in the liver and plasma of fasted and fed transgenic mice. J Nutr Biochem. 2000 Jun; 11(6):318-25. PMID: 11002127.
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    115. MacLean PS, Vadlamudi S, MacDonald KG, Pories WJ, Houmard JA, Barakat HA. Impact of insulin resistance on lipoprotein subpopulation distribution in lean and morbidly obese nondiabetic women. Metabolism. 2000 Mar; 49(3):285-92. PMID: 10726902.
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    116. MacLean PS, Bower JF, Vadlamudi S, Green T, Barakat HA. Lipoprotein subpopulation distributions in lean, obese, and type 2 diabetic women: a comparison of African and white Americans. Obes Res. 2000 Jan; 8(1):62-70. PMID: 10678260.
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    117. Vadlamudi S, MacLean P, Israel RG, Marks RH, Hickey M, Otvos J, Barakat H. Effects of oral combined hormone replacement therapy on plasma lipids and lipoproteins. Metabolism. 1998 Oct; 47(10):1222-6. PMID: 9781625.
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    118. Vadlamudi S, MacLean P, Green T, Shukla N, Bradfield J, Vore S, Barakat H. Role of female sex steroids in regulating cholesteryl ester transfer protein in transgenic mice. Metabolism. 1998 Sep; 47(9):1048-51. PMID: 9751231.
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    119. Maclean PS, Winder WW. Caffeine decreases malonyl-CoA in isolated perfused skeletal muscle of rats. J Appl Physiol (1985). 1995 Apr; 78(4):1496-501. PMID: 7615461.
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    120. Winder WW, MacLean PS, Lucas JC, Fernley JE, Trumble GE. Effect of fasting and refeeding on acetyl-CoA carboxylase in rat hindlimb muscle. J Appl Physiol (1985). 1995 Feb; 78(2):578-82. PMID: 7759427.
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    121. Winder WW, MacLean PS, Chandler SL, Huang W, Mills RH. Role of epinephrine during insulin-induced hypoglycemia in fasted rats. J Appl Physiol (1985). 1994 Jul; 77(1):270-6. PMID: 7961244.
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    122. Jones JP, MacLean PS, Winder WW. Correlation between fructose 2,6-bisphosphate and lactate production in skeletal muscle. J Appl Physiol (1985). 1994 May; 76(5):2169-76. PMID: 8063683.
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