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James R Lambert

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology
Phone303/724-3472

    Collapse Research 
    Collapse research activities and funding
    F32DK009554     (LAMBERT, JAMES R)Aug 5, 1997
    NIH/NIDDK
    MEDIATORS OF STEROID RECEPTOR COUPLING TO CELL SIGNALING
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gari HH, DeGala GD, Ray R, Lucia MS, Lambert JR. PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion. Cancer Lett. 2016 Oct 01; 380(2):505-12. PMID: 27452906.
      View in: PubMed
    2. Gari HH, Gearheart CM, Fosmire S, DeGala GD, Fan Z, Torkko KC, Edgerton SM, Lucia MS, Ray R, Thor AD, Porter CC, Lambert JR. Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers. Oncotarget. 2016 Mar 29; 7(13):15757-71. PMID: 26909599; PMCID: PMC4941275.
    3. De Angelis RW, Maluf NK, Yang Q, Lambert JR, Bain DL. Glucocorticoid Receptor-DNA Dissociation Kinetics Measured in Vitro Reveal Exchange on the Second Time Scale. Biochemistry. 2015 Sep 01; 54(34):5306-14. PMID: 26267475.
      View in: PubMed
    4. Bain DL, De Angelis RW, Connaghan KD, Yang Q, Degala GD, Lambert JR. Dissecting Steroid Receptor Function by Analytical Ultracentrifugation. Methods Enzymol. 2015; 562:363-89. PMID: 26412661.
      View in: PubMed
    5. Lambert JR, Whitson RJ, Iczkowski KA, La Rosa FG, Smith ML, Wilson RS, Smith EE, Torkko KC, Gari HH, Lucia MS. Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate. Prostate. 2015 Feb 15; 75(3):255-65. PMID: 25327758.
      View in: PubMed
    6. Bain DL, Connaghan KD, Maluf NK, Yang Q, Miura MT, De Angelis RW, Degala GD, Lambert JR. Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation. Nucleic Acids Res. 2014 Jan; 42(2):691-700. PMID: 24064251; PMCID: PMC3902896.
    7. Nordeen SK, Bona BJ, Jones DN, Lambert JR, Jackson TA. Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm Cancer. 2013 Oct; 4(5):293-300. PMID: 23836117; PMCID: PMC3851288.
    8. Whitson RJ, Lucia MS, Lambert JR. Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2). J Cell Biochem. 2013 Jun; 114(6):1424-33. PMID: 23280549.
      View in: PubMed
    9. Connaghan KD, Miura MT, Maluf NK, Lambert JR, Bain DL. Analysis of a glucocorticoid-estrogen receptor chimera reveals that dimerization energetics are under ionic control. Biophys Chem. 2013 Feb; 172:8-17. PMID: 23333595; PMCID: PMC3947562.
    10. Bain DL, Yang Q, Connaghan KD, Robblee JP, Miura MT, Degala GD, Lambert JR, Maluf NK. Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activity. J Mol Biol. 2012 Sep 07; 422(1):18-32. PMID: 22698871.
      View in: PubMed
    11. Ray R, Banks M, Abuzahra H, Eddy VJ, Persons KS, Lucia MS, Lambert JR, Holick MF. Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model. Anticancer Res. 2012 Mar; 32(3):727-31. PMID: 22399584.
      View in: PubMed
    12. Connaghan KD, Moody AD, Robblee JP, Lambert JR, Bain DL. From steroid receptors to cytokines: the thermodynamics of self-associating systems. Biophys Chem. 2011 Nov; 159(1):24-32. PMID: 21696881; PMCID: PMC3535432.
    13. Ray R, Lambert JR. 1a,25-Dihydroxyvitamin D3-3ß-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2537-40. PMID: 21392983; PMCID: PMC3073821.
    14. Lambert JR, Eddy VJ, Young CD, Persons KS, Sarkar S, Kelly JA, Genova E, Lucia MS, Faller DV, Ray R. A vitamin D receptor-alkylating derivative of 1a,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth. Cancer Prev Res (Phila). 2010 Dec; 3(12):1596-607. PMID: 21149334; PMCID: PMC3059596.
    15. Axlund SD, Lambert JR, Nordeen SK. HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes. Mol Cancer Res. 2010 Dec; 8(12):1643-55. PMID: 21047772.
      View in: PubMed
    16. Kelly JA, Lucia MS, Lambert JR. p53 controls prostate-derived factor/macrophage inhibitory cytokine/NSAID-activated gene expression in response to cell density, DNA damage and hypoxia through diverse mechanisms. Cancer Lett. 2009 May 08; 277(1):38-47. PMID: 19100681.
      View in: PubMed
    17. Lucia MS, Lambert JR. Growth factors in benign prostatic hyperplasia: basic science implications. Curr Urol Rep. 2008 Jul; 9(4):272-8. PMID: 18765125.
      View in: PubMed
    18. Desplats PA, Lambert JR, Thomas EA. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiol Dis. 2008 Sep; 31(3):298-308. PMID: 18595722; PMCID: PMC2569875.
    19. Soto-Cerrato V, Viñals F, Lambert JR, Pérez-Tomás R. The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway. Biochem Pharmacol. 2007 Nov 01; 74(9):1340-9. PMID: 17765876.
      View in: PubMed
    20. Lambert JR, Young CD, Persons KS, Ray R. Mechanistic and pharmacodynamic studies of a 25-hydroxyvitamin D3 derivative in prostate cancer cells. Biochem Biophys Res Commun. 2007 Sep 14; 361(1):189-95. PMID: 17658477.
      View in: PubMed
    21. Soto-Cerrato V, Viñals F, Lambert JR, Kelly JA, Pérez-Tomás R. Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells. Mol Cancer Ther. 2007 Jan; 6(1):362-9. PMID: 17237295.
      View in: PubMed
    22. Lambert JR, Kelly JA, Shim M, Huffer WE, Nordeen SK, Baek SJ, Eling TE, Lucia MS. Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J Cell Physiol. 2006 Sep; 208(3):566-74. PMID: 16741990.
      View in: PubMed
    23. Miller GJ, Miller HL, van Bokhoven A, Lambert JR, Werahera PN, Schirripa O, Lucia MS, Nordeen SK. Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Cancer Res. 2003 Sep 15; 63(18):5879-88. PMID: 14522913.
      View in: PubMed
    24. Lambert JR, Nordeen SK. CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. Mol Endocrinol. 2003 Jun; 17(6):1085-94. PMID: 12637584.
      View in: PubMed
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