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Metabolic Detoxication, Phase I

"Metabolic Detoxication, Phase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.


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This graph shows the total number of publications written about "Metabolic Detoxication, Phase I" by people in this website by year, and whether "Metabolic Detoxication, Phase I" was a major or minor topic of these publications.
Bar chart showing 4 publications over 3 distinct years, with a maximum of 2 publications in 2010
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