 Polypharmacy
"Polypharmacy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)
| Descriptor ID |
D019338
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| MeSH Number(s) |
E02.319.698
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polypharmacy".
Below are MeSH descriptors whose meaning is more specific than "Polypharmacy".
This graph shows the total number of publications written about "Polypharmacy" by people in this website by year, and whether "Polypharmacy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2006 | 1 | 0 | 1 | | 2007 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 5 | 4 | 9 | | 2016 | 3 | 3 | 6 | | 2017 | 1 | 1 | 2 | | 2018 | 2 | 1 | 3 | | 2019 | 4 | 3 | 7 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 2 | 4 | | 2022 | 2 | 6 | 8 | | 2023 | 2 | 4 | 6 | | 2024 | 5 | 1 | 6 |
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Below are the most recent publications written about "Polypharmacy" by people in Profiles.
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Dublin S, Albertson-Junkans L, Pham Nguyen TP, Pavon JM, Hastings SN, Maciejewski ML, Willis A, Zepel L, Hennessy S, Albers KB, Mowery D, Clark AG, Thomas S, Steinman MA, Boyd CM, Bayliss EA. Defining key deprescribing measures from electronic health data: A multisite data harmonization project. J Am Geriatr Soc. 2025 Feb; 73(2):399-410.
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Borgelt LM, Bliss K, Matson J, Cajuste B, Kuang X, Toohey M, Pace W, Shemesh E, Lo S, Olczyk A, Gleason K, Pincus H, Kleinman LC. Prevalence of contraindicated combinations amid behavioral and mental health medications filled in a pediatric population. BMC Prim Care. 2024 Jul 30; 25(1):276.
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Kosana P, Wu K, Tassiopoulos K, Letendre S, Ma Q, Paul R, Ellis R, Erlandson KM, Farhadian SF. Polypharmacy Is Associated With Slow Gait Speed and Recurrent Falls in Older People With HIV. Clin Infect Dis. 2024 06 14; 78(6):1608-1616.
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Jian Q, Chihuri S, Andrews HF, Betz ME, DiGuiseppi C, Eby DW, Hill LL, Jones V, Mielenz TJ, Molnar LJ, Strogatz D, Lang BH, Li G. Association between polypharmacy and hard braking events in older adult drivers. Accid Anal Prev. 2024 Sep; 204:107661.
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Thompson W, Lundby C, Bleik A, Waring H, Hong JA, Xi C, Hughes C, Salzwedel DM, McDonald EG, Pruskowski J, Scott S, Spinewine A, Kutner JS, Graab?k T, Elmi S, Moriarty F. Measuring Quality of Life in Deprescribing Trials: A Scoping Review. Drugs Aging. 2024 May; 41(5):379-397.
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Green AR, Quiles R, Daddato AE, Merrey J, Weffald L, Gleason K, Xue QL, Swarthout M, Feeser S, Boyd CM, Wolff JL, Blinka MD, Libby AM, Boxer RS. Pharmacist-led telehealth deprescribing for people living with dementia and polypharmacy in primary care: A pilot study. J Am Geriatr Soc. 2024 Jul; 72(7):1973-1984.
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Page RL, Chow SL. Polypharmacy and the Clinical Inertia?Conundrum for GDMT. JACC Heart Fail. 2023 11; 11(11):1518-1520.
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Green AR, Weffald LA, Powers JD, Drace ML, Norton JD, Boyd CM, Bayliss EA. Assessing medication appropriateness as a deprescribing outcome. J Am Geriatr Soc. 2023 12; 71(12):3918-3920.
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Dangerfield HJ, Scott JM, Zohn JH, Segal DL, Benton MJ. Relationship between anxiety and quality of life among older adults with self-reported polypharmacy in long-term care: A cross-sectional study. J Adv Nurs. 2023 Sep; 79(9):3559-3568.
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Orth LE, Feudtner C, Kempe A, Morris MA, Colborn KL, Gritz RM, Linnebur SA, Begum A, Feinstein JA. A coordinated approach for managing polypharmacy among children with medical complexity: rationale and design of the Pediatric Medication Therapy Management (pMTM) randomized controlled trial. BMC Health Serv Res. 2023 Apr 29; 23(1):414.
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