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Christian Mosimann

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Biography 
    Collapse education and training
    University of Zürich, Zürich, SwitzerlandPh.D. (Dr. sc. nat.)03/2008Molecular Biology, Developmental Biology, Genetics
    Harvard Medical School, Boston Children's Hospital, Boston, MA02/2013Cardiovasular and Hematopoietic Development, Cell Fate Determination

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kocere A, Chiavacci E, Soneson C, Wells HH, M?ndez-Acevedo KM, MacGowan JS, Jacobson ST, Hiltabidle MS, Raghunath A, Shavit JA, Pan?kov? D, Williams MLK, Robinson MD, Mosimann C, Burger A. Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling. bioRxiv. 2024 Feb 01. PMID: 37090609.
      View in: PubMed
    2. Lalonde RL, Wells HH, Kemmler CL, Nieuwenhuize S, Lerma R, Burger A, Mosimann C. pIGLET: Safe harbor landing sites for reproducible and efficient transgenesis in zebrafish. bioRxiv. 2023 Dec 12. PMID: 38106217.
      View in: PubMed
    3. Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, B?tschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A. Conserved enhancers control notochord expression of vertebrate Brachyury. Nat Commun. 2023 10 18; 14(1):6594. PMID: 37852970.
      View in: PubMed
    4. Moran HR, Mosimann C. Rosettes guide the way for mesodermal MET. Dev Cell. 2023 06 05; 58(11):917-918. PMID: 37279697.
      View in: PubMed
    5. Tzung KW, Lalonde RL, Prummel KD, Mahabaleshwar H, Moran HR, Stundl J, Cass AN, Le Y, Lea R, Dorey K, Tomecka MJ, Zhang C, Brombacher EC, White WT, Roehl HH, Tulenko FJ, Winkler C, Currie PD, Amaya E, Davis MC, Bronner ME, Mosimann C, Carney TJ. A median fin derived from the lateral plate mesoderm and the origin of paired fins. Nature. 2023 Jun; 618(7965):543-549. PMID: 37225983.
      View in: PubMed
    6. Kocere A, Lalonde RL, Mosimann C, Burger A. Lateral thinking in syndromic congenital cardiovascular disease. Dis Model Mech. 2023 05 01; 16(5). PMID: 37125615.
      View in: PubMed
    7. Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, B?tschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A. Conserved enhancer logic controls the notochord expression of vertebrate Brachyury. bioRxiv. 2023 Apr 20. PMID: 37131681.
      View in: PubMed
    8. Kemmler CL, Moran HR, Murray BF, Scoresby A, Klem JR, Eckert RL, Lepovsky E, Bertho S, Nieuwenhuize S, Burger S, D'Agati G, Betz C, Puller AC, Felker A, Ditrychova K, B?tschi S, Affolter M, Rohner N, Lovely CB, Kwan KM, Burger A, Mosimann C. Next-generation plasmids for transgenesis in zebrafish and beyond. Development. 2023 04 15; 150(8). PMID: 36975217.
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    9. Karolak JA, Welch CL, Mosimann C, Bzdega K, West JD, Montani D, Eyries M, Mullen MP, Abman SH, Prapa M, Gr?f S, Morrell NW, Hemnes AR, Perros F, Hamid R, Logan MPO, Whitsett J, Galambos C, Stankiewicz P, Chung WK, Austin ED. Molecular Function and Contribution of TBX4 in Development and Disease. Am J Respir Crit Care Med. 2023 04 01; 207(7):855-864. PMID: 36367783.
      View in: PubMed
    10. Gaillard AL, Mohamad T, Quan FB, de Cian A, Mosimann C, Tostivint H, P?zeron G. Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Dev Biol. 2023 04; 496:36-51. PMID: 36736605.
      View in: PubMed
    11. Mansour F, Hinze C, Telugu NS, Kresoja J, Shaheed IB, Mosimann C, Diecke S, Schmidt-Ott KM. The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation toward the kidney lineage. Elife. 2022 10 12; 11. PMID: 36222666.
      View in: PubMed
    12. Mattonet K, Riemslagh FW, Guenther S, Prummel KD, Kesavan G, Hans S, Ebersberger I, Brand M, Burger A, Reischauer S, Mosimann C, Stainier DYR. Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2. Sci Adv. 2022 Sep 02; 8(35):eabn2082. PMID: 36044573.
      View in: PubMed
    13. Lalonde RL, Kemmler CL, Riemslagh FW, Aman AJ, Kresoja-Rakic J, Moran HR, Nieuwenhuize S, Parichy DM, Burger A, Mosimann C. Heterogeneity and genomic loci of ubiquitous transgenic Cre reporter lines in zebrafish. Dev Dyn. 2022 10; 251(10):1754-1773. PMID: 35582941.
      View in: PubMed
    14. Prummel KD, Crowell HL, Nieuwenhuize S, Brombacher EC, Daetwyler S, Soneson C, Kresoja-Rakic J, Kocere A, Ronner M, Ernst A, Labbaf Z, Clouthier DE, Firulli AB, S?nchez-Iranzo H, Naganathan SR, O'Rourke R, Raz E, Mercader N, Burger A, Felley-Bosco E, Huisken J, Robinson MD, Mosimann C. Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nat Commun. 2022 03 30; 13(1):1677. PMID: 35354817.
      View in: PubMed
    15. Ulloa BA, Habbsa SS, Potts KS, Lewis A, McKinstry M, Payne SG, Flores JC, Nizhnik A, Feliz Norberto M, Mosimann C, Bowman TV. Definitive hematopoietic stem cells minimally contribute to embryonic hematopoiesis. Cell Rep. 2021 09 14; 36(11):109703. PMID: 34525360.
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    16. Pfefferli C, Moran HR, Felker A, Mosimann C, Jazwinska A. Persistent Ventricle Partitioning in the Adult Zebrafish Heart. J Cardiovasc Dev Dis. 2021 Apr 09; 8(4). PMID: 33918756.
      View in: PubMed
    17. Kemmler CL, Riemslagh FW, Moran HR, Mosimann C. From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish. J Cardiovasc Dev Dis. 2021 Feb 10; 8(2). PMID: 33578943.
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    18. Prummel KD, Nieuwenhuize S, Mosimann C. The lateral plate mesoderm. Development. 2020 06 19; 147(12). PMID: 32561665.
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    19. Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Czarkwiani A, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, M?ller P, Bronner M, Krumlauf R, Mosimann C. A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nat Commun. 2019 08 26; 10(1):3857. PMID: 31451684.
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    20. Sagarin KA, Redgrave AC, Mosimann C, Burke AC, Devoto SH. Anterior trunk muscle shows mix of axial and appendicular developmental patterns. Dev Dyn. 2019 10; 248(10):961-968. PMID: 31386244.
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    21. D'Agati G, Cabello EM, Frontzek K, Rushing EJ, Klemm R, Robinson MD, White RM, Mosimann C, Burger A. Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Dis Model Mech. 2019 07 16; 12(7). PMID: 31221659.
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    22. Brunner E, Yagi R, Debrunner M, Beck-Schneider D, Burger A, Escher E, Mosimann C, Hausmann G, Basler K. CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. Life Sci Alliance. 2019 Jun; 2(3). PMID: 31196871.
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    23. Parker HJ, De Kumar B, Green SA, Prummel KD, Hess C, Kaufman CK, Mosimann C, Wiedemann LM, Bronner ME, Krumlauf R. A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nat Commun. 2019 03 13; 10(1):1189. PMID: 30867425.
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    24. Cant? C, Felker A, Zimmerli D, Prummel KD, Cabello EM, Chiavacci E, M?ndez-Acevedo KM, Kirchgeorg L, Burger S, Ripoll J, Valenta T, Hausmann G, Vilain N, Aguet M, Burger A, Pan?kov? D, Basler K, Mosimann C. Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/?-catenin signaling. Genes Dev. 2018 11 01; 32(21-22):1443-1458. PMID: 30366904.
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    25. Kirchgeorg L, Felker A, van Oostrom M, Chiavacci E, Mosimann C. Cre/lox-controlled spatiotemporal perturbation of FGF signaling in zebrafish. Dev Dyn. 2018 10; 247(10):1146-1159. PMID: 30194800.
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    26. Callahan SJ, Tepan S, Zhang YM, Lindsay H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM. Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Dis Model Mech. 2018 09 27; 11(9). PMID: 30061297.
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    27. Merks AM, Swinarski M, Meyer AM, M?ller NV, ?zcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S, Pan?kov? D. Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nat Commun. 2018 06 04; 9(1):2161. PMID: 29867082.
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    28. Felker A, Prummel KD, Merks AM, Mickoleit M, Brombacher EC, Huisken J, Pan?kov? D, Mosimann C. Continuous addition of progenitors forms the cardiac ventricle in zebrafish. Nat Commun. 2018 05 21; 9(1):2001. PMID: 29784942.
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    29. Carney TJ, Mosimann C. Switch and Trace: Recombinase Genetics in Zebrafish. Trends Genet. 2018 05; 34(5):362-378. PMID: 29429760.
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    30. S?nchez-Iranzo H, Galardi-Castilla M, Minguill?n C, Sanz-Morej?n A, Gonz?lez-Rosa JM, Felker A, Ernst A, Guzm?n-Mart?nez G, Mosimann C, Mercader N. Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nat Commun. 2018 01 30; 9(1):428. PMID: 29382818.
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    31. Norris ML, Pauli A, Gagnon JA, Lord ND, Rogers KW, Mosimann C, Zon LI, Schier AF. Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. Elife. 2017 11 09; 6. PMID: 29117894.
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    32. Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G. Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes. Sci Rep. 2017 Aug 30; 7(1):10061. PMID: 28855635.
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    33. D'Agati G, Beltre R, Sessa A, Burger A, Zhou Y, Mosimann C, White RM. A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish. Dev Biol. 2017 10 01; 430(1):11-17. PMID: 28760346.
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    34. Heinze SD, Kohlbrenner T, Ippolito D, Meccariello A, Burger A, Mosimann C, Saccone G, Bopp D. CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus. Sci Rep. 2017 07 04; 7(1):4582. PMID: 28676649.
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    35. Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CV. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife. 2017 04 07; 6. PMID: 28387645.
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    36. Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L. Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 01 31; 19(2):142. PMID: 28139650.
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    37. Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, Santoro MM. An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development. 2017 02 01; 144(3):464-478. PMID: 28049660.
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    38. Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L. Clonal fate mapping quantifies the number of?haematopoietic stem cells that arise during?development. Nat Cell Biol. 2017 Jan; 19(1):17-27. PMID: 27870830.
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    39. Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C, Robinson MD. CrispRVariants charts the mutation spectrum of genome engineering experiments. Nat Biotechnol. 2016 07 12; 34(7):701-2. PMID: 27404876.
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    40. Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C. Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development. 2016 Jun 01; 143(11):2025-37. PMID: 27130213.
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    41. Felker A, Nieuwenhuize S, Dolbois A, Blazkova K, Hess C, Low LW, Burger S, Samson N, Carney TJ, Bartunek P, Nevado C, Mosimann C. In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control. PLoS One. 2016; 11(4):e0152989. PMID: 27077909.
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    42. Felker A, Mosimann C. Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments. Methods Cell Biol. 2016; 135:219-44. PMID: 27443928.
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    43. Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. PMID: 26823433.
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    44. Musso G, Mosimann C, Pan?kov? D, Burger A, Zhou Y, Zon LI, MacRae CA. Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. PMID: 26697374.
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    45. Mosimann C, Pan?kov? D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. PMID: 26306682.
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    46. Briona LK, Poulain FE, Mosimann C, Dorsky RI. Wnt/?-catenin signaling is required for radial glial neurogenesis following spinal cord injury. Dev Biol. 2015 Jul 01; 403(1):15-21. PMID: 25888075.
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    47. Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Esp?n-Palaz?n R, Lawson ND, Dorsky R, Clements WK, Traver D. Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development. 2015 Mar 15; 142(6):1050-61. PMID: 25758220.
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    48. Musso G, Tasan M, Mosimann C, Beaver JE, Plovie E, Carr LA, Chua HN, Dunham J, Zuberi K, Rodriguez H, Morris Q, Zon L, Roth FP, MacRae CA. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. PMID: 24346703.
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    49. Paik EJ, Mahony S, White RM, Price EN, Dibiase A, Dorjsuren B, Mosimann C, Davidson AJ, Gifford D, Zon LI. A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013; 1(5):425-36. PMID: 24286030.
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    50. Mosimann C, Puller AC, Lawson KL, Tschopp P, Amsterdam A, Zon LI. Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Dev Dyn. 2013 Aug; 242(8):949-963. PMID: 23723152.
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    51. Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell. 2011 Oct 28; 147(3):577-89. PMID: 22036566.
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    52. Zhou Y, Cashman TJ, Nevis KR, Obregon P, Carney SA, Liu Y, Gu A, Mosimann C, Sondalle S, Peterson RE, Heideman W, Burns CE, Burns CG. Latent TGF-? binding protein 3 identifies a second heart field in zebrafish. Nature. 2011 May 29; 474(7353):645-8. PMID: 21623370.
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    53. Mosimann C, Zon LI. Advanced zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments. Methods Cell Biol. 2011; 104:173-94. PMID: 21924163.
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    54. Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI. Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development. 2011 Jan; 138(1):169-77. PMID: 21138979.
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    55. Goetze S, Qeli E, Mosimann C, Staes A, Gerrits B, Roschitzki B, Mohanty S, Niederer EM, Laczko E, Timmerman E, Lange V, Hafen E, Aebersold R, Vandekerckhove J, Basler K, Ahrens CH, Gevaert K, Brunner E. Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol. 2009 Nov; 7(11):e1000236. PMID: 19885390.
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    56. Mosimann C, Hausmann G, Basler K. Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol. 2009 Apr; 10(4):276-86. PMID: 19305417.
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    57. Mosimann C, Hausmann G, Basler K. The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. Mech Dev. 2009 May-Jun; 126(5-6):394-405. PMID: 19368795.
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    58. Mosimann C, Hausmann G, Basler K. Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell. 2006 Apr 21; 125(2):327-41. PMID: 16630820.
      View in: PubMed
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