 Leukotriene B4
"Leukotriene B4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
| Descriptor ID |
D007975
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| MeSH Number(s) |
D10.251.355.255.100.450.411 D10.251.355.310.166.887.411 D23.469.050.175.450.415
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| Concept/Terms |
Leukotriene B4- Leukotriene B4
- Leukotriene B-4
- B-4, Leukotriene
- Leukotriene B 4
- LTB4
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Below are MeSH descriptors whose meaning is more general than "Leukotriene B4".
Below are MeSH descriptors whose meaning is more specific than "Leukotriene B4".
This graph shows the total number of publications written about "Leukotriene B4" by people in this website by year, and whether "Leukotriene B4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 2 | 1 | 3 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 1 | 2 | 3 | | 2003 | 2 | 0 | 2 | | 2004 | 1 | 3 | 4 | | 2006 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leukotriene B4" by people in Profiles.
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Salina ACG, Brandt SL, Klopfenstein N, Blackman A, Bazzano JMR, S?-Nunes A, Byers-Glosson N, Brodskyn C, Tavares NM, Da Silva IBS, Medeiros AI, Serezani CH. Leukotriene B4 licenses inflammasome activation to enhance skin host defense. Proc Natl Acad Sci U S A. 2020 12 01; 117(48):30619-30627.
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Brandt SL, Wang S, Dejani NN, Klopfenstein N, Winfree S, Filgueiras L, McCarthy BP, Territo PR, Serezani CH. Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice. JCI Insight. 2018 09 06; 3(17).
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Brandt SL, Klopfenstein N, Wang S, Winfree S, McCarthy BP, Territo PR, Miller L, Serezani CH. Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice. PLoS Pathog. 2018 08; 14(8):e1007244.
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Gelfand EW. Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma. Semin Immunol. 2017 10; 33:44-51.
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Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 2016; 51(6):366-73.
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Qian J, Tian W, Jiang X, Tamosiuniene R, Sung YK, Shuffle EM, Tu AB, Valenzuela A, Jiang S, Zamanian RT, Fiorentino DF, Voelkel NF, Peters-Golden M, Stenmark KR, Chung L, Rabinovitch M, Nicolls MR. Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension. Hypertension. 2015 Dec; 66(6):1227-1239.
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Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH. Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. J Biol Chem. 2014 Aug 08; 289(32):22482-9.
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Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, Gera L, Farkas L, Rabinovitch M, Zamanian RT, Inayathullah M, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med. 2013 Aug 28; 5(200):200ra117.
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Eun JC, Moore EE, Mauchley DC, Johnson CA, Meng X, Banerjee A, Wohlauer MV, Zarini S, Gij?n MA, Murphy RC. The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. Shock. 2012 Jun; 37(6):599-604.
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Wang JX, Bair AM, King SL, Shnayder R, Huang YF, Shieh CC, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a ?2-integrin-dependent mechanism. Blood. 2012 Aug 16; 120(7):1489-98.
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