 5'-Nucleotidase
"5'-Nucleotidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.
| Descriptor ID |
D015720
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| MeSH Number(s) |
D08.811.277.352.650.600.600
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| Concept/Terms |
5'-Nucleotidase- 5'-Nucleotidase
- 5' Nucleotidase
- 5'-Nucleotidase Phosphoribolase
- 5' Nucleotidase Phosphoribolase
- Adenylate Phosphatase
- AMP Phosphatase
- Cytidylate Phosphatase
- Ecto-5'-Nucleotidase
- Ecto 5' Nucleotidase
- IMP Nucleotidase
- CD73 Antigens
- IMPase
- Inosinate Phosphatase
- Pyrimidine 5'-Nucleotidase
- Pyrimidine 5' Nucleotidase
- Thymidine Phosphatase
- Uridylate 5'-Nucleotidase
- Uridylate 5' Nucleotidase
- Antigen, CD73
- CD73 Antigen
- Antigens, CD73
- 5'-AMP Nucleotidase
- 5' AMP Nucleotidase
- IMP Phosphatase
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Below are MeSH descriptors whose meaning is more general than "5'-Nucleotidase".
Below are MeSH descriptors whose meaning is more specific than "5'-Nucleotidase".
This graph shows the total number of publications written about "5'-Nucleotidase" by people in this website by year, and whether "5'-Nucleotidase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 2 | 0 | 2 | | 2009 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2013 | 2 | 0 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 2 | 2 | 4 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "5'-Nucleotidase" by people in Profiles.
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Kim DW, Kim SW, Camidge DR, Shu CA, Marrone KA, Le X, Blakely CM, Park K, Chang GC, Patel SP, Kar G, Cooper ZA, Samadani R, Pluta M, Kumar R, Ramalingam S. CD73 Inhibitor Oleclumab Plus Osimertinib in Previously Treated Patients With Advanced T790M-Negative EGFR-Mutated NSCLC: A Brief Report. J Thorac Oncol. 2023 05; 18(5):650-656.
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Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508.
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Sutton NR, Bou?s D, Mann KM, Rashid IM, McCubbrey AL, Hyman MC, Goldstein DR, Mei A, Pinsky DJ. CD73 Promotes Age-Dependent Accretion of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):61-71.
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Losenkova K, Zuccarini M, Helenius M, Jacquemet G, Gerasimovskaya E, Tallgren C, Jalkanen S, Yegutkin GG. Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks. Biochim Biophys Acta Mol Basis Dis. 2018 May; 1864(5 Pt A):1804-1815.
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Persson JN, Baird CH, Tong S, Urban TT, Klawitter J, Wischmeyer PE, Davidson JA. Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. Pediatr Res. 2018 04; 83(4):858-865.
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Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, V?zquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 10; 85(10).
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Tsai AK, Khan AY, Worgo CE, Wang LL, Liang Y, Davila E. A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies. Cancer Immunol Res. 2017 09; 5(9):790-803.
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Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017 02 07; 8:14108.
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Murphy PS, Wang J, Bhagwat SP, Munger JC, Janssen WJ, Wright TW, Elliott MR. CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages. Cell Death Differ. 2017 03; 24(3):559-570.
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Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia. Circulation. 2016 Aug 02; 134(5):405-21.
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