Cell Cycle Checkpoints
"Cell Cycle Checkpoints" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Descriptor ID |
D059447
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MeSH Number(s) |
G04.144.109
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Concept/Terms |
Cell Cycle Checkpoints- Cell Cycle Checkpoints
- Cell Cycle Checkpoint
- Checkpoint, Cell Cycle
- Checkpoints, Cell Cycle
Cell Cycle Transition Points- Cell Cycle Transition Points
- Cell Cycle-Transition Points
- Cell Cycle-Transition Point
- Cycle-Transition Point, Cell
- Point, Cell Cycle-Transition
Cell Cycle Arrest- Cell Cycle Arrest
- Arrest, Cell Cycle
- Arrests, Cell Cycle
- Cell Cycle Arrests
Cell Cycle Control- Cell Cycle Control
- Cell Cycle Controls
- Control, Cell Cycle
- Controls, Cell Cycle
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Below are MeSH descriptors whose meaning is more general than "Cell Cycle Checkpoints".
Below are MeSH descriptors whose meaning is more specific than "Cell Cycle Checkpoints".
This graph shows the total number of publications written about "Cell Cycle Checkpoints" by people in this website by year, and whether "Cell Cycle Checkpoints" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2011 | 1 | 1 | 2 | 2012 | 0 | 5 | 5 | 2013 | 1 | 6 | 7 | 2014 | 0 | 6 | 6 | 2015 | 1 | 3 | 4 | 2016 | 1 | 8 | 9 | 2017 | 2 | 3 | 5 | 2018 | 0 | 3 | 3 | 2019 | 2 | 5 | 7 | 2020 | 0 | 4 | 4 | 2022 | 0 | 3 | 3 | 2023 | 0 | 1 | 1 | 2024 | 0 | 1 | 1 | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cell Cycle Checkpoints" by people in Profiles.
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Esquer H, Zhou Q, LaBarbera DV. Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer. Cells. 2025 02 20; 14(5).
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Dreyer J, Ricci G, van den Berg J, Bhardwaj V, Funk J, Armstrong C, van Batenburg V, Sine C, VanInsberghe MA, Tjeerdsma RB, Marsman R, Mandemaker IK, di Sanzo S, Costantini J, Manzo SG, Biran A, Burny C, van Vugt MATM, V?lker-Albert M, Groth A, Spencer SL, van Oudenaarden A, Mattiroli F. Acute multi-level response to defective de novo chromatin assembly in S-phase. Mol Cell. 2024 Dec 19; 84(24):4711-4728.e10.
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Rong Y, Darnell AM, Sapp KM, Vander Heiden MG, Spencer SL. Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids. Cell Rep. 2023 12 26; 42(12):113539.
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Gutierrez WR, Scherer A, Rytlewski JD, Laverty EA, Sheehan AP, McGivney GR, Brockman QR, Knepper-Adrian V, Roughton GA, Quelle DE, Gordon DJ, Monga V, Dodd RD. Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism. JCI Insight. 2022 11 22; 7(22).
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Singh V, Rana NK, Kashif M, Manna PP, Basu Baul TS, Koch B. Aqua-(2-formylbenzoato)triphenyltin(IV) induces cell cycle arrest and apoptosis in hypoxic triple negative breast cancer cells. Toxicol In Vitro. 2023 Feb; 86:105484.
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McClure AW, Canal B, Diffley JFX. A DNA replication fork-centric view of the budding yeast DNA damage response. DNA Repair (Amst). 2022 11; 119:103393.
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Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021 Oct 29; 374(6567):eabb3420.
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Chui H, Caldwell J, Yordanova M, Cockovski V, Fredric D, Harel-Sterling M, Haasz M, Al-Ismaili Z, Pizzi M, Ma Q, Devarajan P, Goldstein SL, Zappitelli M. Tubular injury and cell-cycle arrest biomarkers?to predict acute kidney injury in noncritically ill children receiving aminoglycosides. Biomark Med. 2020 Jul; 14(10):879-894.
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Akturk HK, Michels AW. Adverse events associated with immune checkpoint inhibitors: a new era in autoimmune diabetes. Curr Opin Endocrinol Diabetes Obes. 2020 08; 27(4):187-193.
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Chen Y, Li X, Mamouni K, Yang Y, Danaher A, White J, Liu H, Kucuk O, Gera L, Wu D. Novel small-molecule LG1836 inhibits the in vivo growth of castration-resistant prostate cancer. Prostate. 2020 09; 80(12):993-1005.
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