 Antithrombins
"Antithrombins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
| Descriptor ID |
D000991
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| MeSH Number(s) |
D27.505.519.389.745.800.449 D27.505.954.502.119.500
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| Concept/Terms |
Antithrombins- Antithrombins
- Direct Thrombin Inhibitors
- Thrombin Inhibitors, Direct
- Direct Antithrombins
- Antithrombins, Direct
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Below are MeSH descriptors whose meaning is more general than "Antithrombins".
Below are MeSH descriptors whose meaning is more specific than "Antithrombins".
This graph shows the total number of publications written about "Antithrombins" by people in this website by year, and whether "Antithrombins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 2 | 3 | | 2014 | 2 | 0 | 2 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2020 | 2 | 1 | 3 |
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Below are the most recent publications written about "Antithrombins" by people in Profiles.
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Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan; 146:110394.
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Gluckman TJ, Wang L, Spinelli KJ, Petersen JL, Huang P, Amin A, Messenger JC, Rao SV. Differential Use and Impact of Bleeding Avoidance Strategies on Percutaneous Coronary Intervention-Related Bleeding Stratified by Predicted Risk. Circ Cardiovasc Interv. 2020 06; 13(6):e008702.
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Beyer JT, Lind SE, Fisher S, Trujillo TC, Wempe MF, Kiser TH. Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients. J Thromb Thrombolysis. 2020 Feb; 49(2):259-267.
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Hess CN, Hiatt WR. Antithrombotic Therapy for Peripheral Artery Disease in 2018. JAMA. 2018 Jun 12; 319(22):2329-2330.
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Kumar P, Gordon LA, Brooks KM, George JM, Kellogg A, McManus M, Alfaro RM, Nghiem K, Lozier J, Hadigan C, Penzak SR. Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran. Antimicrob Agents Chemother. 2017 11; 61(11).
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Borne RT, O'Donnell C, Turakhia MP, Varosy PD, Jackevicius CA, Marzec LN, Masoudi FA, Hess PL, Maddox TM, Ho PM. Adherence and outcomes to direct oral anticoagulants among patients with atrial fibrillation: findings from the veterans health administration. BMC Cardiovasc Disord. 2017 09 02; 17(1):236.
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Gordon LA, Kumar P, Brooks KM, Kellogg A, McManus M, Alfaro RM, Nghiem K, George JM, Lozier J, Penzak SR, Hadigan C. Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers. Circulation. 2016 12 06; 134(23):1909-1911.
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Vora AN, Peterson ED, McCoy LA, Garratt KN, Kutcher MA, Marso SP, Roe MT, Messenger JC, Rao SV. The Impact of Bleeding Avoidance Strategies on Hospital-Level Variation in Bleeding Rates Following Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry CathPCI Registry. JACC Cardiovasc Interv. 2016 Apr 25; 9(8):771-779.
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Shore S, Ho PM, Lambert-Kerzner A, Glorioso TJ, Carey EP, Cunningham F, Longo L, Jackevicius C, Rose A, Turakhia MP. Site-level variation in and practices associated with dabigatran adherence. JAMA. 2015 Apr 14; 313(14):1443-50.
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Abtahian F, Waldo S, Jang IK. Comparison of heparin and bivalirudin in patients undergoing percutaneous coronary intervention without use of glycoprotein IIb/IIIa inhibitors. Catheter Cardiovasc Interv. 2015 Sep; 86(3):390-6.
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