 Replication Origin
"Replication Origin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A unique DNA sequence of a replicon at which DNA REPLICATION is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D018741
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| MeSH Number(s) |
G05.360.340.024.220.760 G05.360.340.024.745.725
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| Concept/Terms |
Replication Origin- Replication Origin
- Origin, Replication
- Origins, Replication
- ori Region
- Region, ori
- Regions, ori
- ori Regions
- Origin of Replication
- Replication Origins
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Below are MeSH descriptors whose meaning is more general than "Replication Origin".
Below are MeSH descriptors whose meaning is more specific than "Replication Origin".
This graph shows the total number of publications written about "Replication Origin" by people in this website by year, and whether "Replication Origin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2002 | 1 | 2 | 3 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2017 | 1 | 2 | 3 |
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Below are the most recent publications written about "Replication Origin" by people in Profiles.
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Sclafani RA, Hesselberth JR. O Cdc7 kinase where art thou? Curr Genet. 2018 Jun; 64(3):677-680.
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Rossbach D, Bryan DS, Hesselberth JR, Sclafani R. Localization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae. G3 (Bethesda). 2017 11 06; 7(11):3757-3774.
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Guan L, He P, Yang F, Zhang Y, Hu Y, Ding J, Hua Y, Zhang Y, Ye Q, Hu J, Wang T, Jin C, Kong D. Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe. J Biol Chem. 2017 04 14; 292(15):6056-6075.
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Chen X, Liu G, Leffak M. Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Res. 2013 Jul; 41(13):6460-74.
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Ye J, Su LH, Chen CL, Hu S, Wang J, Yu J, Chiu CH. Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67. Plasmid. 2011 Mar; 65(2):132-40.
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Liu G, Chen X, Bissler JJ, Sinden RR, Leffak M. Replication-dependent instability at (CTG) x (CAG) repeat hairpins in human cells. Nat Chem Biol. 2010 Sep; 6(9):652-9.
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Chowdhury A, Liu G, Kemp M, Chen X, Katrangi N, Myers S, Ghosh M, Yao J, Gao Y, Bubulya P, Leffak M. The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol. 2010 Mar; 30(6):1495-507.
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Courbet S, Gay S, Arnoult N, Wronka G, Anglana M, Brison O, Debatisse M. Replication fork movement sets chromatin loop size and origin choice in mammalian cells. Nature. 2008 Sep 25; 455(7212):557-60.
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Liu G, Bissler JJ, Sinden RR, Leffak M. Unstable spinocerebellar ataxia type 10 (ATTCT*(AGAAT) repeats are associated with aberrant replication at the ATX10 locus and replication origin-dependent expansion at an ectopic site in human cells. Mol Cell Biol. 2007 Nov; 27(22):7828-38.
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Gray SJ, Liu G, Altman AL, Small LE, Fanning E. Discrete functional elements required for initiation activity of the Chinese hamster dihydrofolate reductase origin beta at ectopic chromosomal sites. Exp Cell Res. 2007 Jan 01; 313(1):109-20.
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