 Immunoglobulin A, Secretory
"Immunoglobulin A, Secretory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).
| Descriptor ID |
D007071
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| MeSH Number(s) |
D12.776.124.486.485.114.619.026.030 D12.776.124.790.651.114.619.026.030 D12.776.377.715.548.114.619.026.030
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| Concept/Terms |
Immunoglobulin A, Secretory- Immunoglobulin A, Secretory
- Secretory IgA
- IgA, Exocrine
- Exocrine IgA
- SIgA
- IgA, Secretory
- Secretory Immunoglobulin A
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin A, Secretory".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin A, Secretory".
This graph shows the total number of publications written about "Immunoglobulin A, Secretory" by people in this website by year, and whether "Immunoglobulin A, Secretory" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin A, Secretory" by people in Profiles.
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Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Ara?nga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Fought AJ, Anderson MR, Thomas Y, Schneider JR, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure. PLoS Pathog. 2021 06; 17(6):e1009632.
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Catanzaro JR, Strauss JD, Bielecka A, Porto AF, Lobo FM, Urban A, Schofield WB, Palm NW. IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Sci Rep. 2019 09 19; 9(1):13574.
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Xu F, Newby JM, Schiller JL, Schroeder HA, Wessler T, Chen A, Forest MG, Lai SK. Modeling Barrier Properties of Intestinal Mucus Reinforced with IgG and Secretory IgA against Motile Bacteria. ACS Infect Dis. 2019 09 13; 5(9):1570-1580.
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Medrano G, Cailleux F, Guan P, Kuruvilla K, Barlow-Anacker AJ, Gosain A. B-lymphocyte-intrinsic and -extrinsic defects in secretory immunoglobulin A production in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated enterocolitis. FASEB J. 2019 06; 33(6):7615-7624.
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Polosukhin VV, Cates JM, Lawson WE, Zaynagetdinov R, Milstone AP, Massion PP, Ocak S, Ware LB, Lee JW, Bowler RP, Kononov AV, Randell SH, Blackwell TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Aug 01; 184(3):317-27.
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Wahl SM, Redford M, Christensen S, Mack W, Cohn J, Janoff EN, Mestecky J, Jenson HB, Navazesh M, Cohen M, Reichelderfer P, Kovacs A. Systemic and mucosal differences in HIV burden, immune, and therapeutic responses. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):401-11.
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Watamura SE, Coe CL, Laudenslager ML, Robertson SS. Child care setting affects salivary cortisol and antibody secretion in young children. Psychoneuroendocrinology. 2010 Sep; 35(8):1156-66.
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Mantis NJ, Palaia J, Hessell AJ, Mehta S, Zhu Z, Corth?sy B, Neutra MR, Burton DR, Janoff EN. Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region. J Immunol. 2007 Sep 01; 179(5):3144-52.
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Fasching CE, Grossman T, Corth?sy B, Plaut AG, Weiser JN, Janoff EN. Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae. Infect Immun. 2007 Apr; 75(4):1801-10.
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Johnson DC, McFarland EJ, Muresan P, Fenton T, McNamara J, Read JS, Hawkins E, Bouquin PL, Estep SG, Tomaras GD, Vincent CA, Rathore M, Melvin AJ, Gurunathan S, Lambert J. Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women. J Infect Dis. 2005 Dec 15; 192(12):2129-33.
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