Relaxin
"Relaxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A water-soluble polypeptide (molecular weight approximately 8,000) extractable from the corpus luteum of pregnancy. It produces relaxation of the pubic symphysis and dilation of the uterine cervix in certain animal species. Its role in the human pregnant female is uncertain. (Dorland, 28th ed)
Descriptor ID |
D012065
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MeSH Number(s) |
D06.472.334.734.769 D06.472.699.715 D12.644.548.762
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Relaxin".
Below are MeSH descriptors whose meaning is more specific than "Relaxin".
This graph shows the total number of publications written about "Relaxin" by people in this website by year, and whether "Relaxin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 0 | 1 | 1998 | 2 | 0 | 2 | 2000 | 1 | 0 | 1 | 2005 | 1 | 0 | 1 | 2006 | 1 | 0 | 1 | 2009 | 1 | 0 | 1 | 2015 | 1 | 0 | 1 | 2017 | 2 | 0 | 2 | 2018 | 1 | 0 | 1 | 2019 | 1 | 0 | 1 | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Relaxin" by people in Profiles.
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Loungani RS, Teerlink JR, Metra M, Allen LA, Butler J, Carson PE, Chen CW, Cotter G, Davison BA, Eapen ZJ, Filippatos GS, Gimpelewicz C, Greenberg B, Holbro T, Januzzi JL, Lanfear DE, Pang PS, Pi?a IL, Ponikowski P, Miller AB, Voors AA, Felker GM. Cause of Death in Patients With Acute?Heart?Failure: Insights From RELAX-AHF-2. JACC Heart Fail. 2020 12; 8(12):999-1008.
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Conrad KP, Phillips EG, Jiron J, Bailes J, Dhar B, Diao Y, Aguirre JI, Yarrow JF. Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice. Physiol Rep. 2019 06; 7(11):e14106.
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Lawther AJ, Flavell A, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. Involvement of Serotonergic and Relaxin-3 Neuropeptide Systems in the Expression of Anxiety-like Behavior. Neuroscience. 2018 10 15; 390:88-103.
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Wang D, Luo Y, Myakala K, Orlicky DJ, Dobrinskikh E, Wang X, Levi M. Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats. Sci Rep. 2017 08 29; 7(1):9793.
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Valle Raleigh J, Mauro AG, Devarakonda T, Marchetti C, He J, Kim E, Filippone S, Das A, Toldo S, Abbate A, Salloum FN. Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism. Cardiovasc Res. 2017 May 01; 113(6):609-619.
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Lawther AJ, Clissold ML, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus. Neuroscience. 2015 Sep 10; 303:270-84.
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Khanna D, Clements PJ, Furst DE, Korn JH, Ellman M, Rothfield N, Wigley FM, Moreland LW, Silver R, Kim YH, Steen VD, Firestein GS, Kavanaugh AF, Weisman M, Mayes MD, Collier D, Csuka ME, Simms R, Merkel PA, Medsger TA, Sanders ME, Maranian P, Seibold JR. Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2009 Apr; 60(4):1102-11.
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Novak J, Parry LJ, Matthews JE, Kerchner LJ, Indovina K, Hanley-Yanez K, Doty KD, Debrah DO, Shroff SG, Conrad KP. Evidence for local relaxin ligand-receptor expression and function in arteries. FASEB J. 2006 Nov; 20(13):2352-62.
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Khanna D, Furst DE, Clements PJ, Park GS, Hays RD, Yoon J, Korn JH, Merkel PA, Rothfield N, Wigley FM, Moreland LW, Silver R, Steen VD, Weisman M, Mayes MD, Collier DH, Medsger TA, Seibold JR. Responsiveness of the SF-36 and the Health Assessment Questionnaire Disability Index in a systemic sclerosis clinical trial. J Rheumatol. 2005 May; 32(5):832-40.
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Seibold JR, Korn JH, Simms R, Clements PJ, Moreland LW, Mayes MD, Furst DE, Rothfield N, Steen V, Weisman M, Collier D, Wigley FM, Merkel PA, Csuka ME, Hsu V, Rocco S, Erikson M, Hannigan J, Harkonen WS, Sanders ME. Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000 Jun 06; 132(11):871-9.
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