 RNA Polymerase II
"RNA Polymerase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
| Descriptor ID |
D012319
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| MeSH Number(s) |
D08.811.913.696.445.735.270.762
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| Concept/Terms |
RNA Polymerase II- RNA Polymerase II
- RNA Polymerase B
- RNA Pol II
- DNA-Dependent RNA Polymerase II
- DNA Dependent RNA Polymerase II
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Below are MeSH descriptors whose meaning is more general than "RNA Polymerase II".
Below are MeSH descriptors whose meaning is more specific than "RNA Polymerase II".
This graph shows the total number of publications written about "RNA Polymerase II" by people in this website by year, and whether "RNA Polymerase II" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 1 | 4 | | 1997 | 3 | 0 | 3 | | 1998 | 6 | 0 | 6 | | 1999 | 2 | 0 | 2 | | 2000 | 2 | 0 | 2 | | 2001 | 2 | 1 | 3 | | 2002 | 5 | 2 | 7 | | 2003 | 6 | 0 | 6 | | 2004 | 7 | 2 | 9 | | 2005 | 2 | 4 | 6 | | 2006 | 5 | 3 | 8 | | 2007 | 3 | 1 | 4 | | 2008 | 0 | 4 | 4 | | 2009 | 6 | 4 | 10 | | 2010 | 3 | 7 | 10 | | 2011 | 4 | 4 | 8 | | 2012 | 5 | 3 | 8 | | 2013 | 7 | 5 | 12 | | 2014 | 3 | 5 | 8 | | 2015 | 6 | 1 | 7 | | 2016 | 5 | 7 | 12 | | 2017 | 5 | 8 | 13 | | 2018 | 4 | 3 | 7 | | 2019 | 5 | 3 | 8 | | 2020 | 5 | 1 | 6 | | 2021 | 4 | 3 | 7 | | 2022 | 4 | 5 | 9 | | 2023 | 1 | 1 | 2 | | 2024 | 7 | 3 | 10 | | 2025 | 6 | 2 | 8 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA Polymerase II" by people in Profiles.
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Walsh KE, Goodrich JA, Kugel JF. CPSF73 activation and 3' RNA polymerase II pausing are lost during readthrough transcription after heat shock. Cell Rep. 2026 Mar 24; 45(3):117039.
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Wang D, Ritz C, Luo Y, Suresh A, Pierce A, Veo B, Brunt B, Dahl N, Serkova N, Venkataraman S, Danis E, Kus K, Mazan M, Rzymski T, Vibhakar R. Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma. Nat Commun. 2025 Dec 16; 16(1):11152.
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Archuleta SR, Miller RC, Mirita JA, Goodrich JA, Kugel JF. Single-molecule Microscopy Reveals That TFIIE Subunits Dynamically Interact With Preinitiation Complexes in a Manner Impacted by TFIIH. J Mol Biol. 2025 Dec 15; 437(24):169528.
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Shenasa H, Fong N, Erickson B, Iosub IA, Ule J, Bentley DL. CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing. Proc Natl Acad Sci U S A. 2025 Oct 07; 122(40):e2504034122.
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Palacio M, Taatjes DJ. Real-time visualization of reconstituted transcription reveals RNAPII activation mechanisms at single promoters. Cell Rep. 2025 Sep 23; 44(9):116251.
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Luyties O, Sanford L, Rodino J, Nagel M, Jones T, Rimel JK, Ebmeier CC, Palacio M, Shelby GS, Cozzolino K, Brennan F, Hartzog A, Saucedo MB, Watts LP, Spencer S, Kugel JF, Dowell RD, Taatjes DJ. Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5'- and 3' ends. Cell Rep. 2025 Jul 22; 44(7):115904.
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Nagel M, Taatjes DJ. Regulation of RNA polymerase II transcription through re-initiation and bursting. Mol Cell. 2025 May 15; 85(10):1907-1919.
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Erickson B, Fedoryshchak R, Fong N, Sheridan R, Larson KY, Saviola AJ, Mouilleron S, Hansen KC, Treisman R, Bentley DL. PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination. Cell Rep. 2025 May 27; 44(5):115564.
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Stanley JT, Barone GEF, Townsend HA, Sigauke RF, Allen MA, Dowell RD. LIET model: capturing the kinetics of RNA polymerase from loading to termination. Nucleic Acids Res. 2025 Apr 10; 53(7).
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Blears D, Lou J, Fong N, Mitter R, Sheridan RM, He D, Dirac-Svejstrup AB, Bentley D, Svejstrup JQ. Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint. Mol Cell. 2024 Dec 19; 84(24):4790-4807.e11.
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