Large Neutral Amino Acid-Transporter 1
"Large Neutral Amino Acid-Transporter 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CD98 antigen light chain that when heterodimerized with CD98 antigen heavy chain (FUSION REGULATORY PROTEIN-1 HEAVY CHAIN) forms a protein that mediates sodium-independent L-type amino acid transport.
Descriptor ID |
D027283
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MeSH Number(s) |
D12.776.157.530.200.500.500.500.300.500 D12.776.157.530.937.313.500.625.500 D12.776.543.585.200.500.500.500.500.500 D12.776.543.585.937.313.500.625.500
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Concept/Terms |
Large Neutral Amino Acid-Transporter 1- Large Neutral Amino Acid-Transporter 1
- Large Neutral Amino Acid Transporter 1
- SLC7A5
- E16 Membrane Protein
- Membrane Protein, E16
- Solute Carrier Family-7 (Cationic Amino Acid Transporter, y+ System), Member 5
- SLC7A5 Protein
- LAT1 Protein
- Membrane Protein E16
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Below are MeSH descriptors whose meaning is more general than "Large Neutral Amino Acid-Transporter 1".
Below are MeSH descriptors whose meaning is more specific than "Large Neutral Amino Acid-Transporter 1".
This graph shows the total number of publications written about "Large Neutral Amino Acid-Transporter 1" by people in this website by year, and whether "Large Neutral Amino Acid-Transporter 1" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2007 | 0 | 1 | 1 | 2010 | 1 | 0 | 1 | 2011 | 1 | 0 | 1 | 2020 | 2 | 0 | 2 | 2021 | 0 | 1 | 1 | 2023 | 0 | 1 | 1 | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Large Neutral Amino Acid-Transporter 1" by people in Profiles.
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Nemkov T, Stephenson D, Erickson C, Dzieciatkowska M, Key A, Moore A, Earley EJ, Page GP, Lacroix IS, Stone M, Deng X, Raife T, Kleinman S, Zimring JC, Roubinian N, Hansen KC, Busch MP, Norris PJ, D'Alessandro A. Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in?vitro and in?vivo. Blood. 2024 02 01; 143(5):456-472.
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Rosario FJ, Urschitz J, Powell TL, Brown TL, Jansson T. Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling. Clin Sci (Lond). 2023 11 15; 137(21):1651-1664.
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Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Valine tRNA levels and availability regulate complex I assembly in leukaemia. Nature. 2022 01; 601(7893):428-433.
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Zaugg J, Huang X, Ziegler F, Rubin M, Graff J, M?ller J, Moser-H?ssig R, Powell T, Gertsch J, Altmann KH, Albrecht C. Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno-foetal amino acid transport. J Cell Mol Med. 2020 11; 24(21):12681-12693.
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Cao D, Mikosz AM, Ringsby AJ, Anderson KC, Beatman EL, Koike K, Petrache I. MicroRNA-126-3p Inhibits Angiogenic Function of Human Lung Microvascular Endothelial Cells via LAT1 (L-Type Amino Acid Transporter 1)-Mediated mTOR (Mammalian Target of Rapamycin) Signaling. Arterioscler Thromb Vasc Biol. 2020 05; 40(5):1195-1206.
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Cormerais Y, Pagnuzzi-Boncompagni M, Schr?tter S, Giuliano S, Tambutt? E, Endou H, Wempe MF, Pag?s G, Pouyss?gur J, Picco V. Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. J Cell Mol Med. 2019 04; 23(4):2711-2718.
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Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutt? E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018 02 23; 293(8):2877-2887.
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Kume E, Mutou T, Kansaku N, Takahashi H, Wempe MF, Ikegami M, Kanai Y, Endou H, Wakui S. Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma. Microscopy (Oxf). 2017 Jun 01; 66(3):198-203.
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Bao EL, Chystsiakova A, Brahmajothi MV, Sunday ME, Pavlisko EN, Wempe MF, Auten RL. Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung. Pediatr Pulmonol. 2016 10; 51(10):1048-1056.
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Brahmajothi MV, Tinch BT, Wempe MF, Endou H, Auten RL. Hyperoxia inhibits nitric oxide treatment effects in alveolar epithelial cells via effects on L-type amino acid transporter-1. Antioxid Redox Signal. 2014 Nov 01; 21(13):1823-36.
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