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Zachary Stephen Clayton

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R00HL159241     (CLAYTON, ZACHARY S.)Jun 10, 2024 - May 31, 2027
    NIH
    Translational studies of cellular senescence as a regulator of doxorubicin-mediated arterial dysfunction
    Role: Principal Investigator
    K99HL159241     (CLAYTON, ZACHARY S.)May 1, 2022 - Apr 30, 2024
    NIH
    Translational studies of cellular senescence as a regulator of doxorubicin-mediated arterial dysfunction
    Role: Principal Investigator
    F32HL151022     (CLAYTON, ZACHARY S.)Mar 9, 2020 - Jul 8, 2021
    NIH
    Mitochondrial oxidative stress: a target for treatment of doxorubicin-associated vascular endothelial dysfunction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 06; 46(3):3311-3324. PMID: 38265578.
      View in: PubMed
    2. Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 03; 23(3):e14060. PMID: 38062873.
      View in: PubMed
    3. Ely BR, Clayton ZS, Minson CT. The effect of hot water immersion on glucose tolerance: Differences between acute and chronic exposure. Temperature (Austin). 2023; 10(4):402-403. PMID: 38130662.
      View in: PubMed
    4. Cavalier AN, Clayton ZS, Wahl D, Hutton DA, McEntee CM, Seals DR, LaRocca TJ. Protective effects of apigenin on the brain transcriptome with aging. Mech Ageing Dev. 2024 Feb; 217:111889. PMID: 38007051.
      View in: PubMed
    5. Moreau KL, Clayton ZS, DuBose LE, Rosenberry R, Seals DR. Effects of regular exercise on vascular function with aging: Does sex matter? Am J Physiol Heart Circ Physiol. 2024 01 01; 326(1):H123-H137. PMID: 37921669.
      View in: PubMed
    6. Putera HD, Doewes RI, Shalaby MN, Ram?rez-Coronel AA, Clayton ZS, Abdelbasset WK, Murtazaev SS, Jalil AT, Rahimi P, Nattagh-Eshtivani E, Malekahmadi M, Pahlavani N. The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms. Nutr Metab (Lond). 2023 Aug 29; 20(1):35. PMID: 37644566.
      View in: PubMed
    7. Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment. Hypertension. 2023 10; 80(10):2072-2087. PMID: 37593877.
      View in: PubMed
    8. Ashoori M, Soltani S, Kolahdouz-Mohammadi R, Moghtaderi F, Clayton Z, Abdollahi S. The effect of whole grape products on blood pressure and vascular function: A systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2023 10; 33(10):1836-1848. PMID: 37482483.
      View in: PubMed
    9. Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Female C57BL/6N mice are a viable model of aortic aging in women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H893-H904. PMID: 37115626.
      View in: PubMed
    10. Soltani S, Ashoori M, Dehghani F, Meshkini F, Clayton ZS, Abdollahi S. Effects of probiotic/synbiotic supplementation on body weight in patients with diabetes: a systematic review and meta-analyses of randomized-controlled trials. BMC Endocr Disord. 2023 Apr 21; 23(1):86. PMID: 37085813.
      View in: PubMed
    11. Wahl D, Clayton ZS. Editorial: Nutrition and metabolic aging. Front Nutr. 2023; 10:1191958. PMID: 37090768.
      View in: PubMed
    12. Murray KO, Mahoney SA, Venkatasubramanian R, Seals DR, Clayton ZS. Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions. Exp Gerontol. 2023 03; 173:112105. PMID: 36731386.
      View in: PubMed
    13. Wickman BE, Clayton ZS, Rochester E, Kern M, Hong MY, Liu C, Hooshmand S. Dietary intake of pistachios or mixed nuts results in higher systemic antioxidant capacity with minimal effects on bone in adolescent male rats. J Nutr Sci. 2023; 12:e11. PMID: 36721721.
      View in: PubMed
    14. Soltani S, Sharifi-Zahabi E, Sangsefidi ZS, Ahmadi Vasmehjani A, Meshkini F, Clayton ZS, Abdollahi S. The effect of resveratrol supplementation on biomarkers of liver health: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2023 Mar; 37(3):1153-1166. PMID: 36642444.
      View in: PubMed
    15. Maurer GS, Clayton ZS. Anthracycline chemotherapy, vascular dysfunction?and cognitive impairment: burgeoning topics and future directions. Future Cardiol. 2023 09; 19(11):547-566. PMID: 36354315.
      View in: PubMed
    16. Clayton ZS, Ade CJ, Dieli-Conwright CM, Mathelier HM. A bench to bedside perspective on anthracycline chemotherapy-mediated cardiovascular dysfunction: challenges and opportunities. A symposium review. J Appl Physiol (1985). 2022 12 01; 133(6):1415-1429. PMID: 36302155.
      View in: PubMed
    17. Casso AG, VanDongen NS, Gioscia-Ryan RA, Clayton ZS, Greenberg NT, Ziemba BP, Hutton DA, Neilson AP, Davy KP, Seals DR, Brunt VE. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol. 2022 11; 600(21):4633-4651. PMID: 36111692.
      View in: PubMed
    18. Clayton ZS, Craighead DH, Darvish S, Coppock M, Ludwig KR, Brunt VE, Seals DR, Rossman MJ. Promoting healthy cardiovascular aging: emerging topics. J Cardiovasc Aging. 2022; 2. PMID: 36337728.
      View in: PubMed
    19. Maurer GS, Clayton ZS. Favourable alterations in adipose remodelling induced by exercise training without weight loss: exploring the role of microvascular endothelial function. J Physiol. 2022 08; 600(16):3647-3650. PMID: 35833700.
      View in: PubMed
    20. Firouzi S, Pahlavani N, Navashenaq JG, Clayton ZS, Beigmohammadi MT, Malekahmadi M. The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients. Clin Nutr Open Sci. 2022 Aug; 44:144-154. PMID: 35783349.
      View in: PubMed
    21. Venkatasubramanian R, Mahoney SA, Clayton ZS. Could angiotensin-II induced T-cell senescence exacerbate age-related vascular dysfunction? J Physiol. 2022 04; 600(8):1821-1823. PMID: 35238408.
      View in: PubMed
    22. Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022 Feb 18; 25(2):103848. PMID: 35198901.
      View in: PubMed
    23. Burnsed-Torres ML, Wichmann TK, Clayton ZS, Hahn ME. Comparison of the Gauntlet Test With Standard Laboratory Measures of Aerobic Fitness. J Strength Cond Res. 2022 Feb 01; 36(2):386-391. PMID: 31868814.
      View in: PubMed
    24. Clayton ZS, Gioscia-Ryan RA, Justice JN, Lubieniecki KL, Hutton DA, Rossman MJ, Zigler MC, Seals DR. Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation. Exp Gerontol. 2022 01; 157:111632. PMID: 34822971.
      View in: PubMed
    25. Malekahmadi M, Pahlavani N, Firouzi S, Clayton ZS, Islam SMS, Rezaei Zonooz S, Moradi Moghaddam O, Soltani S. Effect of enteral immunomodulatory nutrition formula on mortality and critical care parameters in critically ill patients: A systematic review with meta-analysis. Nurs Crit Care. 2022 11; 27(6):838-848. PMID: 34323346.
      View in: PubMed
    26. Clayton ZS, Hutton DA, Mahoney SA, Seals DR. Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging. Aging Cancer. 2021 Jun; 2(1-2):45-69. PMID: 34212156.
      View in: PubMed
    27. Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451. PMID: 34147619.
      View in: PubMed
    28. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196. PMID: 34114892.
      View in: PubMed
    29. Kolahdouz-Mohammadi R, Soltani S, Clayton ZS, Salehi-Abargouei A. Sodium status is associated with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies. Eur J Nutr. 2021 Oct; 60(7):3543-3565. PMID: 34052916.
      View in: PubMed
    30. Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension. 2021 08; 78(2):499-511. PMID: 33966451.
      View in: PubMed
    31. Meshkini F, Soltani S, Clayton ZS, Abdollahi S. The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2021 06; 75(6):988-989. PMID: 33772215.
      View in: PubMed
    32. Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590. PMID: 33719511.
      View in: PubMed
    33. Stone M, Clayton ZS, Buono MJ, Kern M. Exercise intensity influences plasma and sweat amino acid concentrations: a crossover trial. J Sports Med Phys Fitness. 2022 Apr; 62(4):525-530. PMID: 33687176.
      View in: PubMed
    34. Clayton ZS, Hauffe L, Liu C, Kern M, Hong MY, Brasser SM, Hooshmand S. Chronic ethanol consumption does not reduce true bone density in male Wistar rats. Alcohol. 2021 06; 93:17-23. PMID: 33662519.
      View in: PubMed
    35. Mahoney SA, Ikoba AP, Rossman MJ, Clayton ZS. WAT do you NO? Addressing obesity-related cardiometabolic dysfunction. J Physiol. 2021 04; 599(8):2137-2139. PMID: 33590885.
      View in: PubMed
    36. Khalighi Sikaroudi M, Saraf-Bank S, Clayton ZS, Soltani S. A positive effect of egg consumption on macular pigment and healthy vision: a systematic review and meta-analysis of clinical trials. J Sci Food Agric. 2021 Aug 15; 101(10):4003-4009. PMID: 33491232.
      View in: PubMed
    37. Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, Battson ML, Ziemba BP, Hutton DA, VanDongen NS, Seals DR. Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice. J Physiol. 2021 02; 599(3):911-925. PMID: 33103241.
      View in: PubMed
    38. Clayton ZS, Brunt VE, Hutton DA, VanDongen NS, D'Alessandro A, Reisz JA, Ziemba BP, Seals DR. Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. JACC CardioOncol. 2020 Sep; 2(3):475-488. PMID: 33073250.
      View in: PubMed
    39. Rossman MJ, Gioscia-Ryan RA, Clayton ZS, Murphy MP, Seals DR. Targeting mitochondrial fitness as a strategy for healthy vascular aging. Clin Sci (Lond). 2020 06 26; 134(12):1491-1519. PMID: 32584404.
      View in: PubMed
    40. Hutton DA, Cavalier AN, Clayton ZS. Cerebrovascular reactivity: a new frontier for measuring cognitive health in models of accelerated ageing? J Physiol. 2020 08; 598(16):3323-3325. PMID: 32468584.
      View in: PubMed
    41. Khalighi Sikaroudi M, Soltani S, Kolahdouz-Mohammadi R, Clayton ZS, Fernandez ML, Varse F, Shidfar F. The responses of different dosages of egg consumption on blood lipid profile: An updated systematic review and meta-analysis of randomized clinical trials. J Food Biochem. 2020 08; 44(8):e13263. PMID: 32524644.
      View in: PubMed
    42. Gioscia-Ryan RA, Clayton ZS, Fleenor BS, Eng JS, Johnson LC, Rossman MJ, Zigler MC, Evans TD, Seals DR. Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening. Geroscience. 2021 02; 43(1):423-432. PMID: 32529594.
      View in: PubMed
    43. Petrisko M, Kloss R, Bradley P, Birrenkott E, Spindler A, Clayton ZS, Kern M. Biochemical, Anthropometric, and Physiological Responses to Carbohydrate-Restricted Diets Versus a Low-Fat Diet in Obese Adults: A Randomized Crossover Trial. J Med Food. 2020 Mar; 23(3):206-214. PMID: 32119803.
      View in: PubMed
    44. Kolahdouz-Mohammadi R, Malekahmadi M, Clayton ZS, Sadat SZ, Pahlavani N, Sikaroudi MK, Soltani S. Effect of Egg Consumption on Blood Pressure: a Systematic Review and Meta-analysis of Randomized Clinical Trials. Curr Hypertens Rep. 2020 02 29; 22(3):24. PMID: 32114646.
      View in: PubMed
    45. Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 12 11; 10(12):8309. PMID: 31691687.
      View in: PubMed
    46. Al-Tamimi AM, Petrisko M, Hong MY, Rezende L, Clayton ZS, Kern M. Honey does not adversely impact blood lipids of adult men and women: a randomized cross-over trial. Nutr Res. 2020 02; 74:87-95. PMID: 31958656.
      View in: PubMed
    47. Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 Oct 16; 10(10):6851-6857. PMID: 31580380.
      View in: PubMed
    48. Sajadi Hezaveh Z, Sikaroudi MK, Vafa M, Clayton ZS, Soltani S. Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials. J Sci Food Agric. 2019 Dec; 99(15):6663-6670. PMID: 31259415.
      View in: PubMed
    49. Hutton DA, Clayton ZS. Physical activity-related suppression of cancer growth: is a transient increase in cytokine production required for tumour angiogenesis? J Physiol. 2019 08; 597(16):4137-4138. PMID: 31298739.
      View in: PubMed
    50. Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Needham KW, Comrada LN, Minson CT. Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E172-E182. PMID: 31136202.
      View in: PubMed
    51. Clayton ZS, Fusco E, Schreiber L, Carpenter JN, Hooshmand S, Hong MY, Kern M. Snack selection influences glucose metabolism, antioxidant capacity and cholesterol in healthy overweight adults: A randomized parallel arm trial. Nutr Res. 2019 05; 65:89-98. PMID: 30952505.
      View in: PubMed
    52. Frye J, Clayton ZS. Physical inactivity-induced insulin resistance: could alterations to the vasculature be to blame? J Physiol. 2019 01; 597(2):375-376. PMID: 30414182.
      View in: PubMed
    53. Clayton ZS, McCurdy CE. Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high-fat diet in lean mice. Am J Physiol Regul Integr Comp Physiol. 2018 10 01; 315(4):R627-R637. PMID: 29791203.
      View in: PubMed
    54. Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Minson CT. Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help? Temperature (Austin). 2018; 5(1):9-21. PMID: 29687041.
      View in: PubMed
    55. Clayton ZS, Fusco E, Kern M. Egg consumption and heart health: A review. Nutrition. 2017 May; 37:79-85. PMID: 28359368.
      View in: PubMed
    56. Clayton ZS, Wilds GP, Mangum JE, Hocker AD, Dawson SM. Do targeted written comments and the rubric method of delivery affect performance on future human physiology laboratory reports? Adv Physiol Educ. 2016 Sep; 40(3):359-64. PMID: 27445286.
      View in: PubMed
    57. Clayton ZS, Scholar KR, Shelechi M, Hernandez LM, Barber AM, Petrisko YJ, Hooshmand S, Kern M. Influence of resistance training combined with daily consumption of an egg-based or bagel-based breakfast on risk factors for chronic diseases in healthy untrained individuals. J Am Coll Nutr. 2015; 34(2):113-9. PMID: 25785868.
      View in: PubMed
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