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Zachary Stephen Clayton

TitleAsst Professor-Research
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology

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    F32HL151022     (CLAYTON, ZACHARY S.)Mar 9, 2020 - Jul 8, 2021
    NIH
    Mitochondrial oxidative stress: a target for treatment of doxorubicin-associated vascular endothelial dysfunction
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Maurer GS, Clayton ZS. Favourable alterations in adipose remodelling induced by exercise training without weight loss: exploring the role of microvascular endothelial function. J Physiol. 2022 Aug; 600(16):3647-3650. PMID: 35833700.
      View in: PubMed
    2. Firouzi S, Pahlavani N, Navashenaq JG, Clayton ZS, Beigmohammadi MT, Malekahmadi M. The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients. Clin Nutr Open Sci. 2022 Aug; 44:144-154. PMID: 35783349.
      View in: PubMed
    3. Venkatasubramanian R, Mahoney SA, Clayton ZS. Could angiotensin-II induced T-cell senescence exacerbate age-related vascular dysfunction? J Physiol. 2022 04; 600(8):1821-1823. PMID: 35238408.
      View in: PubMed
    4. Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022 Feb 18; 25(2):103848. PMID: 35198901.
      View in: PubMed
    5. Burnsed-Torres ML, Wichmann TK, Clayton ZS, Hahn ME. Comparison of the Gauntlet Test With Standard Laboratory Measures of Aerobic Fitness. J Strength Cond Res. 2022 Feb 01; 36(2):386-391. PMID: 31868814.
      View in: PubMed
    6. Clayton ZS, Gioscia-Ryan RA, Justice JN, Lubieniecki KL, Hutton DA, Rossman MJ, Zigler MC, Seals DR. Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation. Exp Gerontol. 2022 01; 157:111632. PMID: 34822971.
      View in: PubMed
    7. Malekahmadi M, Pahlavani N, Firouzi S, Clayton ZS, Islam SMS, Rezaei Zonooz S, Moradi Moghaddam O, Soltani S. Effect of enteral immunomodulatory nutrition formula on mortality and critical care parameters in critically ill patients: A systematic review with meta-analysis. Nurs Crit Care. 2021 Jul 29. PMID: 34323346.
      View in: PubMed
    8. Clayton ZS, Hutton DA, Mahoney SA, Seals DR. Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging. Aging Cancer. 2021 Jun; 2(1-2):45-69. PMID: 34212156.
      View in: PubMed
    9. Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451. PMID: 34147619.
      View in: PubMed
    10. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196. PMID: 34114892.
      View in: PubMed
    11. Kolahdouz-Mohammadi R, Soltani S, Clayton ZS, Salehi-Abargouei A. Sodium status is associated with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies. Eur J Nutr. 2021 Oct; 60(7):3543-3565. PMID: 34052916.
      View in: PubMed
    12. Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension. 2021 08; 78(2):499-511. PMID: 33966451.
      View in: PubMed
    13. Meshkini F, Soltani S, Clayton ZS, Abdollahi S. The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2021 06; 75(6):988-989. PMID: 33772215.
      View in: PubMed
    14. Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590. PMID: 33719511.
      View in: PubMed
    15. Stone M, Clayton ZS, Buono MJ, Kern M. Exercise intensity influences plasma and sweat amino acid concentrations: a crossover trial. J Sports Med Phys Fitness. 2022 Apr; 62(4):525-530. PMID: 33687176.
      View in: PubMed
    16. Clayton ZS, Hauffe L, Liu C, Kern M, Hong MY, Brasser SM, Hooshmand S. Chronic ethanol consumption does not reduce true bone density in male Wistar rats. Alcohol. 2021 06; 93:17-23. PMID: 33662519.
      View in: PubMed
    17. Mahoney SA, Ikoba AP, Rossman MJ, Clayton ZS. WAT do you NO? Addressing obesity-related cardiometabolic dysfunction. J Physiol. 2021 04; 599(8):2137-2139. PMID: 33590885.
      View in: PubMed
    18. Khalighi Sikaroudi M, Saraf-Bank S, Clayton ZS, Soltani S. A positive effect of egg consumption on macular pigment and healthy vision: a systematic review and meta-analysis of clinical trials. J Sci Food Agric. 2021 Aug 15; 101(10):4003-4009. PMID: 33491232.
      View in: PubMed
    19. Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, Battson ML, Ziemba BP, Hutton DA, VanDongen NS, Seals DR. Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice. J Physiol. 2021 02; 599(3):911-925. PMID: 33103241.
      View in: PubMed
    20. Clayton ZS, Brunt VE, Hutton DA, VanDongen NS, D'Alessandro A, Reisz JA, Ziemba BP, Seals DR. Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. JACC CardioOncol. 2020 Sep; 2(3):475-488. PMID: 33073250.
      View in: PubMed
    21. Rossman MJ, Gioscia-Ryan RA, Clayton ZS, Murphy MP, Seals DR. Targeting mitochondrial fitness as a strategy for healthy vascular aging. Clin Sci (Lond). 2020 06 26; 134(12):1491-1519. PMID: 32584404.
      View in: PubMed
    22. Hutton DA, Cavalier AN, Clayton ZS. Cerebrovascular reactivity: a new frontier for measuring cognitive health in models of accelerated ageing? J Physiol. 2020 08; 598(16):3323-3325. PMID: 32468584.
      View in: PubMed
    23. Gioscia-Ryan RA, Clayton ZS, Fleenor BS, Eng JS, Johnson LC, Rossman MJ, Zigler MC, Evans TD, Seals DR. Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening. Geroscience. 2021 02; 43(1):423-432. PMID: 32529594.
      View in: PubMed
    24. Khalighi Sikaroudi M, Soltani S, Kolahdouz-Mohammadi R, Clayton ZS, Fernandez ML, Varse F, Shidfar F. The responses of different dosages of egg consumption on blood lipid profile: An updated systematic review and meta-analysis of randomized clinical trials. J Food Biochem. 2020 08; 44(8):e13263. PMID: 32524644.
      View in: PubMed
    25. Petrisko M, Kloss R, Bradley P, Birrenkott E, Spindler A, Clayton ZS, Kern M. Biochemical, Anthropometric, and Physiological Responses to Carbohydrate-Restricted Diets Versus a Low-Fat Diet in Obese Adults: A Randomized Crossover Trial. J Med Food. 2020 Mar; 23(3):206-214. PMID: 32119803.
      View in: PubMed
    26. Kolahdouz-Mohammadi R, Malekahmadi M, Clayton ZS, Sadat SZ, Pahlavani N, Sikaroudi MK, Soltani S. Effect of Egg Consumption on Blood Pressure: a Systematic Review and Meta-analysis of Randomized Clinical Trials. Curr Hypertens Rep. 2020 02 29; 22(3):24. PMID: 32114646.
      View in: PubMed
    27. Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 12 11; 10(12):8309. PMID: 31691687.
      View in: PubMed
    28. Al-Tamimi AM, Petrisko M, Hong MY, Rezende L, Clayton ZS, Kern M. Honey does not adversely impact blood lipids of adult men and women: a randomized cross-over trial. Nutr Res. 2020 02; 74:87-95. PMID: 31958656.
      View in: PubMed
    29. Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 Oct 16; 10(10):6851-6857. PMID: 31580380.
      View in: PubMed
    30. Sajadi Hezaveh Z, Sikaroudi MK, Vafa M, Clayton ZS, Soltani S. Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials. J Sci Food Agric. 2019 Dec; 99(15):6663-6670. PMID: 31259415.
      View in: PubMed
    31. Hutton DA, Clayton ZS. Physical activity-related suppression of cancer growth: is a transient increase in cytokine production required for tumour angiogenesis? J Physiol. 2019 08; 597(16):4137-4138. PMID: 31298739.
      View in: PubMed
    32. Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Needham KW, Comrada LN, Minson CT. Heat therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E172-E182. PMID: 31136202.
      View in: PubMed
    33. Clayton ZS, Fusco E, Schreiber L, Carpenter JN, Hooshmand S, Hong MY, Kern M. Snack selection influences glucose metabolism, antioxidant capacity and cholesterol in healthy overweight adults: A randomized parallel arm trial. Nutr Res. 2019 05; 65:89-98. PMID: 30952505.
      View in: PubMed
    34. Frye J, Clayton ZS. Physical inactivity-induced insulin resistance: could alterations to the vasculature be to blame? J Physiol. 2019 01; 597(2):375-376. PMID: 30414182.
      View in: PubMed
    35. Clayton ZS, McCurdy CE. Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high-fat diet in lean mice. Am J Physiol Regul Integr Comp Physiol. 2018 10 01; 315(4):R627-R637. PMID: 29791203.
      View in: PubMed
    36. Ely BR, Clayton ZS, McCurdy CE, Pfeiffer J, Minson CT. Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help? Temperature (Austin). 2018; 5(1):9-21. PMID: 29687041.
      View in: PubMed
    37. Clayton ZS, Fusco E, Kern M. Egg consumption and heart health: A review. Nutrition. 2017 May; 37:79-85. PMID: 28359368.
      View in: PubMed
    38. Clayton ZS, Wilds GP, Mangum JE, Hocker AD, Dawson SM. Do targeted written comments and the rubric method of delivery affect performance on future human physiology laboratory reports? Adv Physiol Educ. 2016 Sep; 40(3):359-64. PMID: 27445286.
      View in: PubMed
    39. Clayton ZS, Scholar KR, Shelechi M, Hernandez LM, Barber AM, Petrisko YJ, Hooshmand S, Kern M. Influence of resistance training combined with daily consumption of an egg-based or bagel-based breakfast on risk factors for chronic diseases in healthy untrained individuals. J Am Coll Nutr. 2015; 34(2):113-9. PMID: 25785868.
      View in: PubMed
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