Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Jonathan S. Kurche

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
ORCID ORCID Icon0000-0002-4244-1870 Additional info

    Collapse Research 
    Collapse research activities and funding
    AWD-191474     (KURCHE, JONATHAN SCOTT)Jul 1, 2019 - Jun 30, 2022
    Parker B. Francis Family Foundation
    Epithelial biology of the gain-of-function MUC5B promoter variant for IPF.
    Role Description: Determine whether the MUC5B promoter variant is sufficient to promote cellular senescence of primary air-liquid interface cultures.
    Role: Prinicpal Investigator
    F32HL134243     (KURCHE, JONATHAN SCOTT)Jul 1, 2017 - Jun 30, 2018
    NIH
    Role of Muc5b in Honeycomb Cyst Formation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bridges JP, Vladar EK, Kurche JS, Krivoi A, Stancil IT, Dobrinskikh E, Hu Y, Sasse SK, Lee JS, Blumhagen RZ, Yang IV, Gerber AN, Peljto AL, Evans CM, Redente EF, Riches DW, Schwartz DA. Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium. J Clin Invest. 2025 Jan 02; 135(1). PMID: 39744946.
      View in: PubMed
    2. Kurche JS, Cool CD, Blumhagen RZ, Dobrinskikh E, Heinz D, Herrera JA, Yang IV, Schwartz DA. MUC5B Idiopathic Pulmonary Fibrosis Risk Variant Promotes a Mucosecretory Phenotype and Loss of Small Airway Secretory Cells. Am J Respir Crit Care Med. 2024 Aug 15; 210(4):517-521. PMID: 38924494.
      View in: PubMed
    3. Blumhagen RZ, Kurche JS, Cool CD, Walts AD, Heinz D, Fingerlin TE, Yang IV, Schwartz DA. Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis. Respir Res. 2023 Nov 17; 24(1):287. PMID: 37978501.
      View in: PubMed
    4. Dobrinskikh E, Hennessy CE, Kurche JS, Kim E, Estrella AM, Cardwell J, Yang IV, Schwartz DA. Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis. Am J Respir Cell Mol Biol. 2023 01; 68(1):62-74. PMID: 36108173.
      View in: PubMed
    5. Kurche JS, Stancil IT, Michalski JE, Yang IV, Schwartz DA. Dysregulated Cell-Cell Communication Characterizes Pulmonary Fibrosis. Cells. 2022 10 21; 11(20). PMID: 36291184.
      View in: PubMed
    6. Stancil IT, Michalski JE, Hennessy CE, Hatakka KL, Yang IV, Kurche JS, Rincon M, Schwartz DA. Interleukin-6-dependent epithelial fluidization initiates fibrotic lung remodeling. Sci Transl Med. 2022 07 20; 14(654):eabo5254. PMID: 35857823.
      View in: PubMed
    7. Ma X, Zhu L, Kurche JS, Xiao H, Dai H, Wang C. Global and regional burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2019: results from the Global Burden of Disease study 2019. Thorax. 2022 06; 77(6):596-605. PMID: 34556551.
      View in: PubMed
    8. Michalski JE, Kurche JS, Schwartz DA. From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic? Transl Res. 2022 03; 241:13-24. PMID: 34547499.
      View in: PubMed
    9. Dobrinskikh E, Estrella AM, Hennessy CE, Hara N, Schwarz MI, Kurche JS, Yang IV, Schwartz DA. Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2021 08 01; 321(2):L440-L450. PMID: 34160296.
      View in: PubMed
    10. Gally F, Sasse SK, Kurche JS, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion OB, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021 01 25; 6(2). PMID: 33320836.
      View in: PubMed
    11. Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA. Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures. Am J Respir Crit Care Med. 2020 11 15; 202(10):1430-1444. PMID: 32602730.
      View in: PubMed
    12. Kurche JS, Dobrinskikh E, Hennessy CE, Huber J, Estrella A, Hancock LA, Schwarz MI, Okamoto T, Cool CD, Yang IV, Evans CM, Schwartz DA. Muc5b Enhances Murine Honeycomb-like Cyst Formation. Am J Respir Cell Mol Biol. 2019 10; 61(4):544-546. PMID: 31573335.
      View in: PubMed
    13. Kurche JS, Schwartz DA. Deciphering the Genetics of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 01 01; 199(1):4-5. PMID: 30130126.
      View in: PubMed
    14. Evans CM, Fingerlin TE, Schwarz MI, Lynch D, Kurche J, Warg L, Yang IV, Schwartz DA. Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways. Physiol Rev. 2016 10; 96(4):1567-91. PMID: 27630174.
      View in: PubMed
    15. Laub M, Fraser R, Kurche J, Lara A, Kiser TH, Reynolds PM. Use of a Cholestyramine Washout in a Patient With Septic Shock on Leflunomide Therapy: A Case Report and Review of the Literature. J Intensive Care Med. 2016 Jul; 31(6):412-4. PMID: 26446104.
      View in: PubMed
    16. Kelmenson DA, Kurche JS, Geraci M. Spontaneous hemothorax resulting from tissue plasminogen activator in a patient with ischemic stroke and unrecognized recent myocardial infarction. Ann Am Thorac Soc. 2015 Jul; 12(7):1105-6. PMID: 26203614.
      View in: PubMed
    17. Burchill MA, Tamburini BA, Pennock ND, White JT, Kurche JS, Kedl RM. T cell vaccinology: exploring the known unknowns. Vaccine. 2013 Jan 02; 31(2):297-305. PMID: 23137843.
      View in: PubMed
    18. Kurche JS, Haluszczak C, McWilliams JA, Sanchez PJ, Kedl RM. Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression. J Immunol. 2012 Jan 15; 188(2):585-93. PMID: 22156349.
      View in: PubMed
    19. Oh JZ, Kurche JS, Burchill MA, Kedl RM. TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway. Blood. 2011 Sep 15; 118(11):3028-38. PMID: 21813451.
      View in: PubMed
    20. Kurche JS, Burchill MA, Sanchez PJ, Haluszczak C, Kedl RM. Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses. J Immunol. 2010 Aug 15; 185(4):2106-15. PMID: 20639485.
      View in: PubMed
    21. Grazia TJ, Plenter RJ, Doan AN, Kelly BP, Weber SM, Kurche JS, Cushing SO, Gill RG, Pietra BA. Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cells. Transplantation. 2007 Jun 15; 83(11):1449-58. PMID: 17565318.
      View in: PubMed
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