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Mamuka Kvaratskhelia

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing. J Biol Chem. 2017 Sep 28. PMID: 28972144.
      View in: PubMed
    2. Madison MK, Lawson DQ, Elliott J, Ozantürk AN, Koneru PC, Townsend D, Errando M, Kvaratskhelia M, Kutluay SB. Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells. J Virol. 2017 Sep 01; 91(17). PMID: 28615207.
      View in: PubMed
    3. Winans S, Larue RC, Abraham CM, Shkriabai N, Skopp A, Winkler D, Kvaratskhelia M, Beemon KL. The FACT Complex Promotes Avian Leukosis Virus DNA Integration. J Virol. 2017 Apr 01; 91(7). PMID: 28122976.
      View in: PubMed
    4. Passos DO, Li M, Yang R, Rebensburg SV, Ghirlando R, Jeon Y, Shkriabai N, Kvaratskhelia M, Craigie R, Lyumkis D. Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. Science. 2017 01 06; 355(6320):89-92. PMID: 28059769.
      View in: PubMed
    5. Ablenas CJ, Liu HW, Shkriabai N, Kvaratskhelia M, Cosa G, Götte M. Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate. ACS Infect Dis. 2017 Jan 13; 3(1):99-109. PMID: 28081608.
      View in: PubMed
    6. Ngure M, Issur M, Shkriabai N, Liu HW, Cosa G, Kvaratskhelia M, Götte M. Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap. ACS Infect Dis. 2016 Nov 11; 2(11):839-851. PMID: 27676132.
      View in: PubMed
    7. Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J Biol Chem. 2016 Nov 04; 291(45):23569-23577. PMID: 27645997.
      View in: PubMed
    8. Kudryashova E, Koneru PC, Kvaratskhelia M, Strömstedt AA, Lu W, Kudryashov DS. Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins. Sci Rep. 2016 Sep 01; 6:32499. PMID: 27581352; PMCID: PMC5007486.
    9. Pi F, Zhao Z, Chelikani V, Yoder K, Kvaratskhelia M, Guo P. Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism. J Virol. 2016 Sep 15; 90(18):8036-46. PMID: 27356896; PMCID: PMC5008075 [Available on 02/26/17].
    10. Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M. HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. Cell. 2016 Aug 25; 166(5):1257-1268.e12. PMID: 27565348; PMCID: PMC5003418 [Available on 08/25/17].
    11. Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Sci. 2016 Nov; 25(11):1911-1917. PMID: 27503276.
      View in: PubMed
    12. Agharbaoui FE, Hoyte AC, Ferro S, Gitto R, Buemi MR, Fuchs JR, Kvaratskhelia M, De Luca L. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10; 123:673-683. PMID: 27517812.
      View in: PubMed
    13. Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. ACS Chem Biol. 2016 05 20; 11(5):1313-21. PMID: 26910179; PMCID: PMC4874862.
    14. Crowe BL, Larue RC, Yuan C, Hess S, Kvaratskhelia M, Foster MP. Structure of the Brd4 ET domain bound to a C-terminal motif from ?-retroviral integrases reveals a conserved mechanism of interaction. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2086-91. PMID: 26858406; PMCID: PMC4776507.
    15. Kessl JJ, Sharma A, Kvaratskhelia M. Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase. Methods Mol Biol. 2016; 1354:149-64. PMID: 26714710; PMCID: PMC4793731.
    16. Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 01; 29(21):2287-97. PMID: 26545813; PMCID: PMC4647561.
    17. Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L. Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein. J Biol Chem. 2015 Oct 23; 290(43):26270-81. PMID: 26324707; PMCID: PMC4646275 [Available on 10/23/16].
    18. Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M. HIV-1 integrase multimerization as a therapeutic target. Curr Top Microbiol Immunol. 2015; 389:93-119. PMID: 25778682; PMCID: PMC4791179.
    19. Hilton B, Shkriabai N, Musich PR, Kvaratskhelia M, Shell S, Zou Y. A new structural insight into XPA-DNA interactions. Biosci Rep. 2014 Dec 12; 34(6):e00162. PMID: 25385088; PMCID: PMC4266923.
    20. Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25; 11:100. PMID: 25421939; PMCID: PMC4251946.
    21. Dissinger N, Shkriabai N, Hess S, Al-Saleem J, Kvaratskhelia M, Green PL. Identification and characterization of HTLV-1 HBZ post-translational modifications. PLoS One. 2014; 9(11):e112762. PMID: 25389759; PMCID: PMC4229220.
    22. Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res. 2014; 42(16):10209-25. PMID: 25147212; PMCID: PMC4176367.
    23. Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. J Biol Chem. 2014 Sep 19; 289(38):26430-40. PMID: 25118283; PMCID: PMC4176244.
    24. Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 01; 88(17):9704-17. PMID: 24942577; PMCID: PMC4136317.
    25. Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May; 10(5):e1004171. PMID: 24874515; PMCID: PMC4038613.
    26. Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ. Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction. Nucleic Acids Res. 2014 May; 42(9):5917-28. PMID: 24623816; PMCID: PMC4027182.
    27. Larue RC, Plumb MR, Crowe BL, Shkriabai N, Sharma A, DiFiore J, Malani N, Aiyer SS, Roth MJ, Bushman FD, Foster MP, Kvaratskhelia M. Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes. Nucleic Acids Res. 2014 Apr; 42(8):4868-81. PMID: 24520112; PMCID: PMC4005663.
    28. Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. BET proteins promote efficient murine leukemia virus integration at transcription start sites. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12036-41. PMID: 23818621; PMCID: PMC3718171.
    29. Engelman A, Kessl JJ, Kvaratskhelia M. Allosteric inhibition of HIV-1 integrase activity. Curr Opin Chem Biol. 2013 Jun; 17(3):339-45. PMID: 23647983; PMCID: PMC3679204.
    30. Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2013 May 31; 288(22):15813-20. PMID: 23615903; PMCID: PMC3668738.
    31. Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8690-5. PMID: 23610442; PMCID: PMC3666754.
    32. Eidahl JO, Crowe BL, North JA, McKee CJ, Shkriabai N, Feng L, Plumb M, Graham RL, Gorelick RJ, Hess S, Poirier MG, Foster MP, Kvaratskhelia M. Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes. Nucleic Acids Res. 2013 Apr 01; 41(6):3924-36. PMID: 23396443; PMCID: PMC3616739.
    33. Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec; 40(22):11518-30. PMID: 23042676; PMCID: PMC3526291.
    34. Doueiri R, Anupam R, Kvaratskhelia M, Green KB, Lairmore MD, Green PL. Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses. Retrovirology. 2012 Aug 09; 9:64. PMID: 22876852; PMCID: PMC3464894.
    35. Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). J Biol Chem. 2012 Oct 05; 287(41):34044-58. PMID: 22872640; PMCID: PMC3464514.
    36. Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2012 May 11; 287(20):16801-11. PMID: 22437836; PMCID: PMC3351293.
    37. Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M. FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. Nucleic Acids Res. 2011 Nov 01; 39(20):9009-22. PMID: 21771857; PMCID: PMC3203615.
    38. Ditzler MA, Bose D, Shkriabai N, Marchand B, Sarafianos SG, Kvaratskhelia M, Burke DH. Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. Nucleic Acids Res. 2011 Oct; 39(18):8237-47. PMID: 21727088; PMCID: PMC3185408.
    39. Anupam R, Datta A, Kesic M, Green-Church K, Shkriabai N, Kvaratskhelia M, Lairmore MD. Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival. J Biol Chem. 2011 Mar 04; 286(9):7661-8. PMID: 21216954; PMCID: PMC3045020.
    40. Ranji A, Shkriabai N, Kvaratskhelia M, Musier-Forsyth K, Boris-Lawrie K. Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs. J Biol Chem. 2011 Feb 18; 286(7):5328-37. PMID: 21123178; PMCID: PMC3037645.
    41. Raghavendra NK, Shkriabai N, Graham RLj, Hess S, Kvaratskhelia M, Wu L. Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells. Retrovirology. 2010 Aug 11; 7:66. PMID: 20698996; PMCID: PMC2924840.
    42. Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses. 2009 12; 1(3):713-36. PMID: 21994566; PMCID: PMC3185514.
    43. Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR, Kvaratskhelia M. An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule. Mol Pharmacol. 2009 Oct; 76(4):824-32. PMID: 19638533; PMCID: PMC2769043.
    44. Shell SM, Li Z, Shkriabai N, Kvaratskhelia M, Brosey C, Serrano MA, Chazin WJ, Musich PR, Zou Y. Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem. 2009 Sep 04; 284(36):24213-22. PMID: 19586908; PMCID: PMC2782015.
    45. Fowler JD, Brown JA, Kvaratskhelia M, Suo Z. Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting. J Mol Biol. 2009 Jul 17; 390(3):368-79. PMID: 19467241; PMCID: PMC2724185.
    46. Motari E, Zheng X, Su X, Liu Y, Kvaratskhelia M, Freitas M, Wang PG. Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen. Am J Biomed Sci. 2009 Jan 01; 1(1):1-11. PMID: 20407596.
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    47. McKee CJ, Kessl JJ, Norris JO, Shkriabai N, Kvaratskhelia M. Mass spectrometry-based footprinting of protein-protein interactions. Methods. 2009 Apr; 47(4):304-7. PMID: 19015031; PMCID: PMC2673337.
    48. Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. ACS Chem Biol. 2008 Oct 17; 3(10):635-44. PMID: 18831589; PMCID: PMC2941776.
    49. McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M. Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. J Biol Chem. 2008 Nov 14; 283(46):31802-12. PMID: 18801737; PMCID: PMC2581560.
    50. Kvaratskhelia M, Grice SF. Structural analysis of protein-RNA interactions with mass spectrometry. Methods Mol Biol. 2008; 488:213-9. PMID: 18982294; PMCID: PMC2586912.
    51. Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M. Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. J Biol Chem. 2008 Feb 29; 283(9):5632-41. PMID: 18093980; PMCID: PMC2806305.
    52. Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman AB, Craigie R, Dyda F. Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina. Structure. 2007 Jun; 15(6):643-53. PMID: 17562312.
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    53. Deval J, D'Abramo CM, Zhao Z, McCormick S, Coutsinos D, Hess S, Kvaratskhelia M, Götte M. High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA. J Biol Chem. 2007 Jun 08; 282(23):16907-16. PMID: 17449464.
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    54. Datta SA, Zhao Z, Clark PK, Tarasov S, Alexandratos JN, Campbell SJ, Kvaratskhelia M, Lebowitz J, Rein A. Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch. J Mol Biol. 2007 Jan 19; 365(3):799-811. PMID: 17098251; PMCID: PMC1829305.
    55. Marchand C, Krajewski K, Lee HF, Antony S, Johnson AA, Amin R, Roller P, Kvaratskhelia M, Pommier Y. Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites. Nucleic Acids Res. 2006; 34(18):5157-65. PMID: 16998183; PMCID: PMC1636436.
    56. Shkriabai N, Datta SA, Zhao Z, Hess S, Rein A, Kvaratskhelia M. Interactions of HIV-1 Gag with assembly cofactors. Biochemistry. 2006 Apr 04; 45(13):4077-83. PMID: 16566581.
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    57. Liu Y, Kvaratskhelia M, Hess S, Qu Y, Zou Y. Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem. 2005 Sep 23; 280(38):32775-83. PMID: 16006651; PMCID: PMC1450107.
    58. Shell SM, Hess S, Kvaratskhelia M, Zou Y. Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA. Biochemistry. 2005 Jan 25; 44(3):971-8. PMID: 15654753; PMCID: PMC1450108.
    59. Williams KL, Zhang Y, Shkriabai N, Karki RG, Nicklaus MC, Kotrikadze N, Hess S, Le Grice SF, Craigie R, Pathak VK, Kvaratskhelia M. Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor. J Biol Chem. 2005 Mar 04; 280(9):7949-55. PMID: 15615720.
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    60. Kvaratskhelia M, Clark PK, Hess S, Melder DC, Federspiel MJ, Hughes SH. Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry. Virology. 2004 Aug 15; 326(1):171-81. PMID: 15262505.
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    61. Shkriabai N, Patil SS, Hess S, Budihas SR, Craigie R, Burke TR, Le Grice SF, Kvaratskhelia M. Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):6894-9. PMID: 15118107; PMCID: PMC406438.
    62. Lener D, Kvaratskhelia M, Le Grice SF. Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase. J Biol Chem. 2003 Jul 18; 278(29):26526-32. PMID: 12730227.
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    63. Kvaratskhelia M, Miller JT, Budihas SR, Pannell LK, Le Grice SF. Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):15988-93. PMID: 12461175; PMCID: PMC138552.
    64. Kvaratskhelia M, Budihas SR, Le Grice SF. Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase. J Biol Chem. 2002 May 10; 277(19):16689-96. PMID: 11875059.
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    65. Kvaratskhelia M, Wardleworth BN, Bond CS, Fogg JM, Lilley DM, White MF. Holliday junction resolution is modulated by archaeal chromatin components in vitro. J Biol Chem. 2002 Jan 25; 277(4):2992-6. PMID: 11709558.
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    66. Fogg JM, Kvaratskhelia M, White MF, Lilley DM. Distortion of DNA junctions imposed by the binding of resolving enzymes: a fluorescence study. J Mol Biol. 2001 Nov 02; 313(4):751-64. PMID: 11697901.
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    67. Bond CS, Kvaratskhelia M, Richard D, White MF, Hunter WN. Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5509-14. PMID: 11331763; PMCID: PMC33243.
    68. Kvaratskhelia M, Wardleworth BN, White MF. Multiple Holliday junction resolving enzyme activities in the Crenarchaeota and Euryarchaeota. FEBS Lett. 2001 Mar 02; 491(3):243-6. PMID: 11240135.
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    69. Kvaratskhelia M, Wardleworth BN, Norman DG, White MF. A conserved nuclease domain in the archaeal Holliday junction resolving enzyme Hjc. J Biol Chem. 2000 Aug 18; 275(33):25540-6. PMID: 10940317.
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    70. Wardleworth BN, Kvaratskhelia M, White MF. Site-directed mutagenesis of the yeast resolving enzyme Cce1 reveals catalytic residues and relationship with the intron-splicing factor Mrs1. J Biol Chem. 2000 Aug 04; 275(31):23725-8. PMID: 10825168.
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    71. Kvaratskhelia M, White MF. Two Holliday junction resolving enzymes in Sulfolobus solfataricus. J Mol Biol. 2000 Apr 07; 297(4):923-32. PMID: 10736227.
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    72. Kvaratskhelia M, White MF. An archaeal Holliday junction resolving enzyme from Sulfolobus solfataricus exhibits unique properties. J Mol Biol. 2000 Jan 14; 295(2):193-202. PMID: 10623519.
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    73. Kvaratskhelia M, George SJ, Cooper A, White MF. Quantitation of metal ion and DNA junction binding to the Holliday junction endonuclease Cce1. Biochemistry. 1999 Dec 14; 38(50):16613-9. PMID: 10600123.
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    74. George SJ, Kvaratskhelia M, Dilworth MJ, Thorneley RN. Reversible alkaline inactivation of lignin peroxidase involves the release of both the distal and proximal site calcium ions and bishistidine co-ordination of the haem. Biochem J. 1999 Nov 15; 344 Pt 1:237-44. PMID: 10548556; PMCID: PMC1220636.
    75. Fraser HI, Kvaratskhelia M, White MF. The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett. 1999 Jul 23; 455(3):344-8. PMID: 10437801.
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    76. Kvaratskhelia M, George SJ, Thorneley RN. Salicylic acid is a reducing substrate and not an effective inhibitor of ascorbate peroxidase. J Biol Chem. 1997 Aug 22; 272(34):20998-1001. PMID: 9261100.
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    77. Kvaratskhelia M, Winkel C, Thorneley RN. Purification and characterization of a novel class III peroxidase isoenzyme from tea leaves. Plant Physiol. 1997 Aug; 114(4):1237-45. PMID: 9276947; PMCID: PMC158416.
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