 Xiaoqiao Xie
| Title | Associate Research Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-SRG |
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| Email |  |
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 Biography | University of North Carolina at Chapel Hill, Chapel Hill, NC | Post-doctoral | 08/2016 | Pharmacology and Glia Biology | | University of California, Riverside, Riverside, CA | Ph. D. | 08/2011 | Neuroscience and astrocyte physiology | | University of Science and Technology of China, Hefei, Anhui, China | M. S. | 07/2005 | Biophysics and Neuroscience | | University of Science and Technology of China, Hefei, Anhui, China | B. S. | 07/2002 | Biophysics |
| 2011 | University Teaching Certificate, University of California, Riverside | | 2014 | Excellence in Mentoring Undergraduates, University of North Carolina at Chapel Hill | | 2016 | Training award, Federation of American Societies for Experimental Biology/Maximizing Access to Research Careers | | 2023 | Young Investigator Award, The Society for Basic Urologic Research (SBUR) | | 2023 | Early-career Faculty Research Development Award, Ludeman Center for Women's Health Research | | 2024 | Faculty Professionalism Award, Department of surgery, School of Medicine, CU-AMC |
Overview As a neuroscientist and physiologist, I am interested in the role of peripheral glia in regulating organ functions, including heart and urinary bladder. I am also interested in the roles of peripheral glia in chronic diseases such as neurogenic hypertension, neurogenic bladder, and chronic pelvic pain. The current research focus include: 1. The analgesic role of sensory satellite glial cells in pelvic pain. Patients with pelvic pain also lower urinary tract symptoms. Nociceptive sensitization contributes to underlies visceral allodynia and hyperalgesia. Our work focuses on targeting satellite glial cells, a specialized peripheral glia in the sensory ganglia to reduce pain following injury and peripheral inflammation. 2. The neuroactive role of autonomic satellite glial cells in regulating hollow organ contractility, such as heart and urinary bladder. This part of lab research focus on the neuromodulatory role of satellite glial cells in autonomic ganglia, and how their chronic reactivity may contribute to cardiovascular diseases and neurogenic bladder.
Research Translational Method Award (XIE, XIAOQIAO)Aug 1, 2024 - Jul 30, 2025 Colorado Clinical and Translational Sciences Institute
Development of a murine pelvic ganglia-bladder preparation for the study of glial control of micturition
Role: Principal Investigator |
| Early-career Faculty Research Development Award (XIE, XIAOQIAO)Sep 1, 2023 - Aug 31, 2024 Ludeman Center for Women's Health Research
Sex differences in sympathetic glial regulation of blood pressure
Role: PI |
| R01DK129260 (XIE, XIAOQIAO)Jul 19, 2021 - May 31, 2026 NIH
Activating Peripheral Glia to Relieve Visceral Pain in Animal Models of Urological Chronic Pelvic Pain Syndrome (UCPPS)
Role: Principal Investigator |
| Surgery-AEF-Xie (Xie, XIAOQIAO)Sep 1, 2020 - Aug 31, 2021 Department of Surgery, Academic Enrichment Funds
The role of mechanosensitive TREK-1 channels in detrusor overactivity and voiding dysfunction in patients with overactive bladder (OAB)
Role: PI |
| CO-Pilot Grant (XIE, XIAOQIAO)Mar 1, 2019 - Feb 29, 2020 Colorado Clinical and Translational Sciences Institute
Beyond the neurons: the role of peripheral glia in neurogenic bladder dysfunction
Role: PI |
Bibliographic
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Yesupatham SK, Malykhina AP, Xie AX. Transcriptome profiling suggests molecular sexual dimorphism in lumbosacral dorsal root ganglia and sex-specific mechanisms underlying visceral pain. Physiol Genomics. 2026 Jan 01; 58(1):12-31. PMID: 41223072.
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Xie AX, Iguchi N, Malykhina AP. Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age. Am J Physiol Renal Physiol. 2024 Jun 01; 326(6):F957-F970. PMID: 38601986.
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Clarkson TC, Iguchi N, Xie AX, Malykhina AP. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus. PLoS One. 2022; 17(12):e0278918. PMID: 36490282.
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Xie AX, Iguchi N, Clarkson TC, Malykhina AP. Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain. PLoS One. 2022; 17(1):e0262769. PMID: 35077502.
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Xie AX*, Taves S, McCarthy KD. *Corresponding author. Nuclear factor Kappa B-COX2 pathway activation in non-myelinating Schwann cells is necessary for the maintenance of neuropathic pain in mice. Front Cell Neurosci. 2022; (15):782275.
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Iguchi N, Carrasco A, Xie AX, Pineda RH, Malykhina AP, Wilcox DT. Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways. Sci Rep. 2021 01 13; 11(1):1149. PMID: 33441874.
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Xie AX*,
Madayag A,
Minton SK,
McCarthy KD,
Malykhina AP.
*Corresponding author. Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation. Sci Rep. 2020; 1(10):14181.
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Xie AX, Pan XQ, Meacham RB, Malykhina AP. The Expression of Transcription Factors Mecp2 and CREB Is Modulated in Inflammatory Pelvic Pain. Front Syst Neurosci. 2018; 12:69. PMID: 30687029.
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Xie AX*, Chaia AI, McCarthy KD. * Corresponding author. Receptors & Clinical Investigation. Targeting sympathetic glia for treating cardiovascular diseases. 2017; (4):e1572.
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Xie AX, Lee JJ, McCarthy KD. Ganglionic GFAP + glial Gq-GPCR signaling enhances heart functions in vivo. JCI Insight. 2017 01 26; 2(2):e90565. PMID: 28138563.
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Annis RP, Swahari V, Nakamura A, Xie AX, Hammond SM, Deshmukh M. Mature neurons dynamically restrict apoptosis via redundant premitochondrial brakes. FEBS J. 2016 12; 283(24):4569-4582. PMID: 27797453.
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Xie AX, Petravicz J, McCarthy KD. Molecular approaches for manipulating astrocytic signaling in vivo. Front Cell Neurosci. 2015; 9:144. PMID: 25941472.
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Xie AX, Lauderdale K, Murphy T, Myers TL, Fiacco TA. Inducing plasticity of astrocytic receptors by manipulation of neuronal firing rates. J Vis Exp. 2014 Mar 20; (85). PMID: 24686723.
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Sun MY, Devaraju P, Xie AX, Holman I, Samones E, Murphy TR, Fiacco TA. Astrocyte calcium microdomains are inhibited by bafilomycin A1 and cannot be replicated by low-level Schaffer collateral stimulation in situ. Cell Calcium. 2014 Jan; 55(1):1-16. PMID: 24262208.
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Agulhon C, Boyt KM, Xie AX, Friocourt F, Roth BL, McCarthy KD. Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo. J Physiol. 2013 Nov 15; 591(22):5599-609. PMID: 24042499.
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Xie AX, Sun MY, Murphy T, Lauderdale K, Tiglao E, Fiacco TA. Bidirectional scaling of astrocytic metabotropic glutamate receptor signaling following long-term changes in neuronal firing rates. PLoS One. 2012; 7(11):e49637. PMID: 23166735.
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Carson MJ, Crane J, Xie AX. Modeling CNS microglia: the quest to identify predictive models. Drug Discov Today Dis Models. 2008; 5(1):19-25. PMID: 19444332.
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Wang H, Xie X, Li X, Chen B, Zhou Y. Functional degradation of visual cortical cells in aged rats. Brain Res. 2006 Nov 29; 1122(1):93-8. PMID: 17010946.
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Jia F, Wei H, Li X, Xie X, Zhou Y. Short-term synaptic plasticity in the rat geniculo-cortical pathway during development in vivo. Neurosci Lett. 2006 May 01; 398(1-2):73-7. PMID: 16406670.
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Xie X,
Wang H,
Chen B,
Zhou Y,. Neural Response Characteristic of Neuron to Flashing Stimulus in Visual Cortex of Young Rats. Progress in Biochemistry and Biophysics. 2005; 11(32):1088-1092.
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Jia F, Xie X, Zhou Y. Short-term depression of synaptic transmission from rat lateral geniculate nucleus to primary visual cortex in vivo. Brain Res. 2004 Mar 26; 1002(1-2):158-61. PMID: 14988046.
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| Year | Publications |
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| 2004 | 1 | | 2005 | 1 | | 2006 | 2 | | 2008 | 1 | | 2012 | 1 | | 2013 | 2 | | 2014 | 1 | | 2015 | 1 | | 2016 | 1 | | 2017 | 2 | | 2019 | 1 | | 2020 | 1 | | 2021 | 1 | | 2022 | 3 | | 2024 | 1 | | 2025 | 1 |
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