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Jeffrey Kavanaugh

TitleResearch Associate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hook JS, Patel PA, O'Malley A, Xie L, Kavanaugh JS, Horswill AR, Moreland JG. Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner. J Immunol. 2021 08 01; 207(3):966-973. PMID: 34290104.
      View in: PubMed
    2. Kavanaugh JS, Leidal KG, Nauseef WM, Horswill AR. Cathepsin G Degrades Staphylococcus aureus Biofilms. J Infect Dis. 2021 Jun 04; 223(11):1865-1869. PMID: 32995850.
      View in: PubMed
    3. Cau L, Williams MR, Butcher AM, Nakatsuji T, Kavanaugh JS, Cheng JY, Shafiq F, Higbee K, Hata TR, Horswill AR, Gallo RL. Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis. J Allergy Clin Immunol. 2021 03; 147(3):955-966.e16. PMID: 32634452.
      View in: PubMed
    4. Grundstad ML, Parlet CP, Kwiecinski JM, Kavanaugh JS, Crosby HA, Cho YS, Heilmann K, Diekema DJ, Horswill AR. Quorum Sensing, Virulence, and Antibiotic Resistance of USA100 Methicillin-Resistant Staphylococcus aureus Isolates. mSphere. 2019 08 14; 4(4). PMID: 31413175.
      View in: PubMed
    5. Kavanaugh JS, Flack CE, Lister J, Ricker EB, Ibberson CB, Jenul C, Moormeier DE, Delmain EA, Bayles KW, Horswill AR. Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix. mBio. 2019 06 25; 10(3). PMID: 31239382.
      View in: PubMed
    6. Parlet CP, Kavanaugh JS, Crosby HA, Raja HA, El-Elimat T, Todd DA, Pearce CJ, Cech NB, Oberlies NH, Horswill AR. Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense. Cell Rep. 2019 04 02; 27(1):187-198.e6. PMID: 30943400.
      View in: PubMed
    7. Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL. Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models. Sci Rep. 2017 02 10; 7:42275. PMID: 28186134.
      View in: PubMed
    8. Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR. Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing. J Med Chem. 2016 10 13; 59(19):8879-8888. PMID: 27585401.
      View in: PubMed
    9. Todd DA, Zich DB, Ettefagh KA, Kavanaugh JS, Horswill AR, Cech NB. Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition. J Microbiol Methods. 2016 08; 127:89-94. PMID: 27237773.
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    10. Kavanaugh JS, Horswill AR. Impact of Environmental Cues on Staphylococcal Quorum Sensing and Biofilm Development. J Biol Chem. 2016 Jun 10; 291(24):12556-12564. PMID: 27129223.
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    11. Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR. Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance. PLoS One. 2015; 10(8):e0136486. PMID: 26295163.
      View in: PubMed
    12. Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR. Rot is a key regulator of Staphylococcus aureus biofilm formation. Mol Microbiol. 2015 Apr; 96(2):388-404. PMID: 25612137.
      View in: PubMed
    13. Daly SM, Elmore BO, Kavanaugh JS, Triplett KD, Figueroa M, Raja HA, El-Elimat T, Crosby HA, Femling JK, Cech NB, Horswill AR, Oberlies NH, Hall PR. ?-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation. Antimicrob Agents Chemother. 2015 Apr; 59(4):2223-35. PMID: 25645827.
      View in: PubMed
    14. Parlet CP, Kavanaugh JS, Horswill AR, Schlueter AJ. Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses. J Leukoc Biol. 2015 Apr; 97(4):769-78. PMID: 25605871.
      View in: PubMed
    15. Figueroa M, Jarmusch AK, Raja HA, El-Elimat T, Kavanaugh JS, Horswill AR, Cooks RG, Cech NB, Oberlies NH. Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod. 2014 Jun 27; 77(6):1351-8. PMID: 24911880.
      View in: PubMed
    16. Yu J, Madsen ML, Carruthers MD, Phillips GJ, Kavanaugh JS, Boyd JM, Horswill AR, Minion FC. Analysis of autoinducer-2 quorum sensing in Yersinia pestis. Infect Immun. 2013 Nov; 81(11):4053-62. PMID: 23959719.
      View in: PubMed
    17. Junio HA, Todd DA, Ettefagh KA, Ehrmann BM, Kavanaugh JS, Horswill AR, Cech NB. Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 01; 930:7-12. PMID: 23703543.
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    18. Olson ME, Nygaard TK, Ackermann L, Watkins RL, Zurek OW, Pallister KB, Griffith S, Kiedrowski MR, Flack CE, Kavanaugh JS, Kreiswirth BN, Horswill AR, Voyich JM. Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun. 2013 Apr; 81(4):1316-24. PMID: 23381999.
      View in: PubMed
    19. Cech NB, Junio HA, Ackermann LW, Kavanaugh JS, Horswill AR. Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA). Planta Med. 2012 Sep; 78(14):1556-61. PMID: 22814821.
      View in: PubMed
    20. Kavanaugh JS, Gakhar L, Horswill AR. The structure of LsrB from Yersinia pestis complexed with autoinducer-2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 01; 67(Pt 12):1501-5. PMID: 22139152.
      View in: PubMed
    21. Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One. 2011; 6(11):e26714. PMID: 22096493.
      View in: PubMed
    22. Thoendel M, Kavanaugh JS, Flack CE, Horswill AR. Peptide signaling in the staphylococci. Chem Rev. 2011 Jan 12; 111(1):117-51. PMID: 21174435.
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    23. Malone CL, Boles BR, Lauderdale KJ, Thoendel M, Kavanaugh JS, Horswill AR. Fluorescent reporters for Staphylococcus aureus. J Microbiol Methods. 2009 Jun; 77(3):251-60. PMID: 19264102.
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    24. Kavanaugh JS, Thoendel M, Horswill AR. A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Mol Microbiol. 2007 Aug; 65(3):780-98. PMID: 17608791.
      View in: PubMed
    25. Kavanaugh JS, Rogers PH, Arnone A. Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions. Biochemistry. 2005 Apr 26; 44(16):6101-21. PMID: 15835899.
      View in: PubMed
    26. Kavanaugh JS, Rogers PH, Arnone A, Hui HL, Wierzba A, DeYoung A, Kwiatkowski LD, Noble RW, Juszczak LJ, Peterson ES, Friedman JM. Intersubunit interactions associated with Tyr42 alpha stabilize the quaternary-T tetramer but are not major quaternary constraints in deoxyhemoglobin. Biochemistry. 2005 Mar 15; 44(10):3806-20. PMID: 15751957.
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    27. Chan NL, Kavanaugh JS, Rogers PH, Arnone A. Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin. Biochemistry. 2004 Jan 13; 43(1):118-32. PMID: 14705937.
      View in: PubMed
    28. Kavanaugh JS, Weydert JA, Rogers PH, Arnone A, Hui HL, Wierzba AM, Kwiatkowski LD, Paily P, Noble RW, Bruno S, Mozzarelli A. Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces. Protein Sci. 2001 Sep; 10(9):1847-55. PMID: 11514675.
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    29. Hui HL, Kavanaugh JS, Doyle ML, Wierzba A, Rogers PH, Arnone A, Holt JM, Ackers GK, Noble RW. Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli. Biochemistry. 1999 Jan 19; 38(3):1040-9. PMID: 9894000.
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    30. Kavanaugh JS, Weydert JA, Rogers PH, Arnone A. High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,. Biochemistry. 1998 Mar 31; 37(13):4358-73. PMID: 9521756.
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    31. Bettati S, Kwiatkowski LD, Kavanaugh JS, Mozzarelli A, Arnone A, Rossi GL, Noble RW. Structure and oxygen affinity of crystalline des-his-146beta human hemoglobin in the T state. J Biol Chem. 1997 Dec 26; 272(52):33077-84. PMID: 9407091.
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    32. Kavanaugh JS, Chafin DR, Arnone A, Mozzarelli A, Rivetti C, Rossi GL, Kwiatkowski LD, Noble RW. Structure and oxygen affinity of crystalline desArg141 alpha human hemoglobin A in the T state. J Mol Biol. 1995 Apr 21; 248(1):136-50. PMID: 7731039.
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    33. Kavanaugh JS, Moo-Penn WF, Arnone A. Accommodation of insertions in helices: the mutation in hemoglobin Catonsville (Pro 37 alpha-Glu-Thr 38 alpha) generates a 3(10)-->alpha bulge. Biochemistry. 1993 Mar 16; 32(10):2509-13. PMID: 8448109.
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    34. Kavanaugh JS, Rogers PH, Arnone A. High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini. Biochemistry. 1992 Sep 15; 31(36):8640-7. PMID: 1390648.
      View in: PubMed
    35. Vasseur C, Blouquit Y, Kister J, Promé D, Kavanaugh JS, Rogers PH, Guillemin C, Arnone A, Galacteros F, Poyart C, et al. Hemoglobin Thionville. An alpha-chain variant with a substitution of a glutamate for valine at NA-1 and having an acetylated methionine NH2 terminus. J Biol Chem. 1992 Jun 25; 267(18):12682-91. PMID: 1618774.
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    36. Kavanaugh JS, Rogers PH, Case DA, Arnone A. High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site. Biochemistry. 1992 Apr 28; 31(16):4111-21. PMID: 1567857.
      View in: PubMed
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