Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Jose Henrique Ledo

TitleAssistant Professor
InstitutionUniversity of Colorado Boulder
DepartmentInstitute for Behav Genetics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. McDougle M, Glass V, Suganya S, Smith W, Frost P, DePasquale B, Ha L, Koehler A, Thomas K, Capurso J, Ledo JH, Berto S, Azevedo EP. A Neurotensin Brake on Exploratory Drive under Persistent Threat. bioRxiv. 2026 Jul 30. PMID: 42620056.
      View in: PubMed
    2. Adler D, Pinheiro-Rosa N, Millet A, Gajic ZZ, Cheng E, Gamallo-Lana B, Morizawa Y, Klann E, Gan WB, Mar AC, Ledo JH, Silva HM, Lafaille JJ. Functional border-associated macrophages limit Alzheimer's Disease progression. bioRxiv. 2026 Feb 03. PMID: 41676677.
      View in: PubMed
    3. Berdasco C, Cho WH, Lee J, Annu A, Ledo JH, Jeong YY, Kim YS, An SS, Tanaka Y, Ahn JH, Kim Y. Wasf1 deletion attenuates tau hyperphosphorylation, microglial state transition, and cognitive deficits in P301S tau mice. bioRxiv. 2026 Jan 15. PMID: 41648133.
      View in: PubMed
    4. Millet A, Ledo JH, Tavazoie SF. An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains. Immunity. 2024 01 09; 57(1):153-170.e6. PMID: 38159571.
      View in: PubMed
    5. Bhatti DL, Medrihan L, Chen MX, Jin J, McCabe KA, Wang W, Azevedo EP, Ledo JH, Kim Y. Molecular and Cellular Adaptations in Hippocampal Parvalbumin Neurons Mediate Behavioral Responses to Chronic Social Stress. Front Mol Neurosci. 2022; 15:898851. PMID: 35813065.
      View in: PubMed
    6. Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, De Felice FG, Ferreira ST. Correction: Amyloid-ß oligomers link depressive-like behavior and cognitive deficits in mice. Mol Psychiatry. 2021 Oct; 26(10):6100-6101. PMID: 32879389.
      View in: PubMed
    7. Ledo JH, Zhang R, Mesin L, Mourão-Sá D, Azevedo EP, Silva HM, Troyanskaya OG, Bustos V, Greengard P. Correction: Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development. PLoS One. 2021; 16(2):e0247680. PMID: 33606833.
      View in: PubMed
    8. Bustos V, Pulina MV, Ledo J. Amyloidogenic and anti-amyloidogenic properties of presenilin 1. Adv Pharmacol. 2021; 90:239-251. PMID: 33706935.
      View in: PubMed
    9. Ledo JH, Zhang R, Mesin L, Mourão-Sá D, Azevedo EP, Troyanskaya OG, Bustos V, Greengard P. Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development. PLoS One. 2020; 15(8):e0237773. PMID: 32822378.
      View in: PubMed
    10. Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P. Presenilin 1 phosphorylation regulates amyloid-ß degradation by microglia. Mol Psychiatry. 2021 10; 26(10):5620-5635. PMID: 32792660.
      View in: PubMed
    11. Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST. Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-ß Oligomers in Mice. J Neurosci. 2016 11 30; 36(48):12106-12116. PMID: 27903721.
      View in: PubMed
    12. Beckman D, Santos LE, Americo TA, Ledo JH, de Mello FG, Linden R. Reply to Altered Monoaminergic Systems and Depressive-like Behavior in Congenic Prion Protein Knock-out Mice. J Biol Chem. 2015 Oct 23; 290(43):26351. PMID: 26500296.
      View in: PubMed
    13. Beckman D, Santos LE, Americo TA, Ledo JH, de Mello FG, Linden R. Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice. J Biol Chem. 2015 Aug 14; 290(33):20488-98. PMID: 26152722.
      View in: PubMed
    14. Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Alzheimer-associated Aß oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015 Feb; 7(2):190-210. PMID: 25617315.
      View in: PubMed
    15. Azevedo EP, Ledo JH, Barbosa G, Sobrinho M, Diniz L, Fonseca AC, Gomes F, Romão L, Lima FR, Palhano FL, Ferreira ST, Foguel D. Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis. Cell Death Dis. 2013 Sep 05; 4:e789. PMID: 24008733.
      View in: PubMed
    16. Lourenco MV, Ledo JH. Targeting Alzheimer's pathology through PPAR? signaling: modulation of microglial function. J Neurosci. 2013 Mar 20; 33(12):5083-4. PMID: 23516274.
      View in: PubMed
    17. Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, De Felice FG, Ferreira ST. Amyloid-ß oligomers link depressive-like behavior and cognitive deficits in mice. Mol Psychiatry. 2013 Oct; 18(10):1053-4. PMID: 23183490.
      View in: PubMed
    Ledo's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (80) concept(s)
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2026 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)