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Ian M Cartwright

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4857
    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionGastroenterology


    Collapse Biography 
    Collapse education and training
    Colorado State University, Fort Collins, COPhD12/2014Toxicology
    Colorado State University, Fort Collins, COMS06/2011Environmental Health
    Colorado State University, Fort Collins, COBS12/2009Environmental and Radiological Health Sciences

    Collapse Research 
    Collapse research activities and funding
    1IK2BX005710-01     (Ian Cartwright)Oct 1, 2021 - Sep 30, 2026
    VA
    Control of Inflammatory Acidity in Mucosal Inflammation
    Role Description: The goal of this study is to elucidate the signaling axis elicited by mucosal acidosis as a window to understanding mucosal inflammation and to provide the basis for the development of new treatments for veterans suffering with mucosal diseases such as IBD.
    Role: PI
    IK2BX005710     (CARTWRIGHT, IAN MICHAEL)Oct 1, 2021 - Sep 30, 2026
    NIH
    Control of Inflammatory Acidity in Mucosal Inflammation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Dowdell AS, Roer R, Bhagavatula G, Cartwright IM, Cohen RH, Countess JA, Koch SD, Lee JS, Steiner CA, Thompson NT, Villamaria ZF, Welch NM, Worledge CS, Zhou L, Colgan SP. Regulation of Epithelial HIF by Probiotic Escherichia coli. bioRxiv. 2025 May 15. PMID: 40463037.
      View in: PubMed
    2. Bhagavatula G, Cartwright IM. Hope for the gut: new evidence suggests Western diet damage can be undone. Am J Physiol Gastrointest Liver Physiol. 2025 May 01; 328(5):G479-G481. PMID: 40139253.
      View in: PubMed
    3. Cartwright IM, Zhou L, Koch SD, Welch N, Zakharov D, Callahan R, Steiner CA, Gerich ME, Onyiah JC, Colgan SP. Chlorination of epithelial tight junction proteins by neutrophil myeloperoxidase promotes barrier dysfunction and mucosal inflammation. JCI Insight. 2024 Jun 11; 9(14). PMID: 39133648.
      View in: PubMed
    4. Callahan RC, Bhagavatula G, Curry J, Staley AW, Schaefer REM, Minhajuddin F, Zhou L, Neuhart R, Atif SM, Orlicky DJ, Cartwright IM, Gerich M, Theiss AL, Hall CHT, Colgan SP, Onyiah JC. Epithelial heme oxygenase-1 enhances colonic tumorigenesis by inhibiting ferroptosis. bioRxiv. 2024 Mar 08. PMID: 38496569.
      View in: PubMed
    5. Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Nguyen TT, Hall CHT, Lu S, de Zoeten EF, Weiser-Evans MCM, Cartwright IM, Colgan SP. The TNF?ARE Mouse as a Model of Intestinal Fibrosis. Am J Pathol. 2023 08; 193(8):1013-1028. PMID: 37169343.
      View in: PubMed
    6. Cartwright IM, Colgan SP. The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution. Front Immunol. 2023; 14:1124774. PMID: 36742292.
      View in: PubMed
    7. Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Hall CHT, Lu S, Weiser-Evans MC, Cartwright IM, Colgan SP. The TNF ?ARE mouse as a model of intestinal fibrosis. bioRxiv. 2023 Jan 14. PMID: 36712048.
      View in: PubMed
    8. Littlefield KM, Schneider JM, Neff CP, Soesanto V, Siebert JC, Nusbacher NM, Moreno-Huizar N, Cartwright IM, Armstrong AJS, Colgen SP, Lozupone CA, Palmer BE. Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function. Front Immunol. 2022; 13:1072720. PMID: 36605218.
      View in: PubMed
    9. Dowdell AS, Cartwright IM, Kitzenberg DA, Kostelecky RE, Mahjoob O, Saeedi BJ, Welch N, Glover LE, Colgan SP. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022 09 27; 40(13):111409. PMID: 36170839.
      View in: PubMed
    10. Steiner CA, Cartwright IM, Taylor CT, Colgan SP. Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis. Am J Physiol Cell Physiol. 2022 09 01; 323(3):C866-C878. PMID: 35912990.
      View in: PubMed
    11. Cartwright IM, Dowdell AS, Hanson C, Kostelecky RE, Welch N, Steiner CA, Colgan SP. Contact-dependent, polarized acidification response during neutrophil-epithelial interactions. J Leukoc Biol. 2022 12; 112(6):1543-1553. PMID: 35674095.
      View in: PubMed
    12. Larsen LD, Dockstader K, Olbrich CL, Cartwright IM, Spencer LA. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils. J Leukoc Biol. 2022 05; 111(5):943-952. PMID: 35141942.
      View in: PubMed
    13. Schaefer REM, Callahan RC, Atif SM, Orlicky DJ, Cartwright IM, Fontenot AP, Colgan SP, Onyiah JC. Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation. Mucosal Immunol. 2022 02; 15(2):244-256. PMID: 34916594.
      View in: PubMed
    14. Cartwright IM, Colgan SP. In vitro Monitoring of Extracellular pH in Real-Time. J Vis Exp. 2021 06 03; (172). PMID: 34152309.
      View in: PubMed
    15. Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). PMID: 33972436.
      View in: PubMed
    16. Cartwright IM, Colgan SP. Lung neutrophils on a paleo diet: lean, mean inflammatory machines. J Clin Invest. 2021 05 17; 131(10). PMID: 33998602.
      View in: PubMed
    17. Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, V?geli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 05; 35(5):e21552. PMID: 33826788.
      View in: PubMed
    18. Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2021 03; 14(2):479-490. PMID: 33004979.
      View in: PubMed
    19. Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell. 2020 09 15; 31(20):2249-2258. PMID: 32726170.
      View in: PubMed
    20. Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2020 03; 13(2):230-244. PMID: 31792360.
      View in: PubMed
    21. Cartwright IM, Haskins JS, Kato TA. PNA Telomere and Centromere FISH Staining for Accurate Analysis of Radiation-Induced Chromosomal Aberrations. Methods Mol Biol. 2019; 1984:95-100. PMID: 31267424.
      View in: PubMed
    22. Cartwright IM. Modified PNA Telomere and Centromere FISH Protocols. Methods Mol Biol. 2019; 1984:101-105. PMID: 31267425.
      View in: PubMed
    23. Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP. Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling. Mol Biol Cell. 2018 11 01; 29(22):2687-2699. PMID: 30188771.
      View in: PubMed
    24. Cartwright IM, Su C, Haskins JS, Salinas VA, Sunada S, Yu H, Uesaka M, Hirakawa H, Chen DJ, Fujimori A, Kato TA. DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions. Int J Mol Sci. 2018 Jul 30; 19(8). PMID: 30061540.
      View in: PubMed
    25. Cartwright IM, Liu X, Zhou M, Li F, Li CY. Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis. Elife. 2017 07 10; 6. PMID: 28691902.
      View in: PubMed
    26. Sunada S, Cartwright IM, Hirakawa H, Fujimori A, Uesaka M, Kato TA. Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells. Oncol Lett. 2017 Jun; 13(6):4911-4916. PMID: 28599495.
      View in: PubMed
    27. Maeda J, Cartwright IM, Haskins JS, Fujii Y, Fujisawa H, Hirakawa H, Uesaka M, Kitamura H, Fujimori A, Thamm DH, Kato TA. Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles. Oncol Lett. 2016 Aug; 12(2):1597-1601. PMID: 27446477.
      View in: PubMed
    28. Cartwright IM, Kato TA. Role of various DNA repair pathways in chromosomal inversion formation in CHO mutants. Int J Radiat Biol. 2015; 91(12):925-33. PMID: 26513271.
      View in: PubMed
    29. Maeda J, Fujii Y, Fujisawa H, Hirakawa H, Cartwright IM, Uesaka M, Kitamura H, Fujimori A, Kato TA. Hyperthermia-induced radiosensitization in CHO wild-type, NHEJ repair mutant and HR repair mutant following proton and carbon-ion exposure. Oncol Lett. 2015 Nov; 10(5):2828-2834. PMID: 26722249.
      View in: PubMed
    30. Cartwright IM, Bell JJ, Maeda J, Genet MD, Romero A, Fujii Y, Fujimori A, Kitamuta H, Kamada T, Chen DJ, Kato TA. Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity. Oncol Lett. 2015 Apr; 9(4):1621-1627. PMID: 25789011.
      View in: PubMed
    31. Sunada S, Fujisawa H, Cartwright IM, Maeda J, Brents CA, Mizuno K, Aizawa Y, Kato TA, Uesaka M. Monoglucosyl-rutin as a potential radioprotector in mammalian cells. Mol Med Rep. 2014 Jul; 10(1):10-4. PMID: 24788331.
      View in: PubMed
    32. Cartwright IM, Genet MD, Fujimori A, Kato TA. Role of LET and chromatin structure on chromosomal inversion in CHO10B2 cells. Genome Integr. 2014 Jan 28; 5(1):1. PMID: 24467838.
      View in: PubMed
    33. Genet MD, Cartwright IM, Kato TA. Direct DNA and PNA probe binding to telomeric regions without classical in situ hybridization. Mol Cytogenet. 2013 Oct 08; 6(1):42. PMID: 24103162.
      View in: PubMed
    34. Cartwright IM, Genet MD, Kato TA. A simple and rapid fluorescence in situ hybridization microwave protocol for reliable dicentric chromosome analysis. J Radiat Res. 2013 Mar 01; 54(2):344-8. PMID: 23161278.
      View in: PubMed
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