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David W h Riches

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology

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    R01CA050107     (RICHES, DAVID W)Apr 1, 1989 - Mar 31, 1993
    NIH/NCI
    REGULATION OF THE TUMORICIDAL MACROPHAGE PHENOTYPE
    Role: Principal Investigator

    R01HL055549     (RICHES, DAVID W)May 1, 1996 - Apr 30, 2010
    NIH/NHLBI
    Regulation of TNF receptor signaling and functions
    Role: Principal Investigator

    R01HL065326     (RICHES, DAVID W)Sep 15, 2000 - Jul 31, 2005
    NIH/NHLBI
    OSMOTIC REGULATION OF MACROPHAGES IN CYSTIC FIBROSIS
    Role: Principal Investigator

    R01HL068628     (RICHES, DAVID W.)Dec 12, 2001 - Apr 30, 2013
    NIH/NHLBI
    Mechanisms of myofibroblast death in pulmonary fibrosis
    Role: Principal Investigator

    R21AI070941     (RICHES, DAVID W)Sep 15, 2007 - Aug 31, 2010
    NIH/NIAID
    Lung specific TNF-R1 signaling in TRUSS null mice
    Role: Principal Investigator

    R21AI103727     (RICHES, DAVID W.)Apr 15, 2013 - Mar 31, 2015
    NIH/NIAID
    Initial functional characterization of TRUSS-deficient mice
    Role: Principal Investigator

    R01HL114754     (RICHES, DAVID W.)Jun 1, 2013 - May 31, 2017
    NIH/NHLBI
    DUSP1 as a therapeutic target in fibroproliferative acute lung injury
    Role: Principal Investigator

    R13HL123072     (RICHES, DAVID W.)Apr 1, 2014 - Mar 31, 2015
    NIH/NHLBI
    Aspen Lung Conference: Rebuilding the Injured Lung
    Role: Principal Investigator

    R01HL126732     (DE LANGHE, STIJN PIET JOHAN)Apr 1, 2015 - Apr 30, 2019
    NIH/NHLBI
    HL-Role of c-Myc in myofibroblast differentiation in pulmonary fibrosis
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015 Oct 07; 6:8472. PMID: 26442449.
      View in: PubMed
    2. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827.
      View in: PubMed
    3. Riches DW, Backos DS, Redente EF. ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis. Am J Pathol. 2015 Apr; 185(4):909-12. PMID: 25687558.
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    4. Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37. PMID: 24325577.
      View in: PubMed
    5. Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May; 184(5):1489-502. PMID: 24650563.
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    6. Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A. Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nat Cell Biol. 2014 Jan; 16(1):47-54. PMID: 24316673.
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    7. Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, Johnson TE, Ivanov S, Duan Q, Bala S, Condon T, van Rooijen N, Grainger JR, Belkaid Y, Ma'ayan A, Riches DW, Yokoyama WM, Ginhoux F, Henson PM, Randolph GJ. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19; 39(3):599-610. PMID: 24012416.
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    8. Keith RC, Sokolove J, Edelman BL, Lahey L, Redente EF, Holers VM, Sakaguchi S, Robinson WH, Riches DW. Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice. Arthritis Rheum. 2013 Jun; 65(6):1487-93. PMID: 23529475.
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    9. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan; 43(1):276-85. PMID: 23520315.
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    10. Trivedi R, Redente EF, Thakur A, Riches DW, Kompella UB. Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice. Nanotechnology. 2012 Dec 21; 23(50):505101. PMID: 23186914.
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    11. Fernandez-Boyanapalli R, Goleva E, Kolakowski C, Min E, Day B, Leung DY, Riches DW, Bratton DL, Sutherland ER. Obesity impairs apoptotic cell clearance in asthma. J Allergy Clin Immunol. 2013 Apr; 131(4):1041-7, 1047.e1-3. PMID: 23154082.
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    12. Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 01; 186(1):72-81. PMID: 22582160.
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    13. Rayamajhi M, Delgado C, Condon TV, Riches DW, Lenz LL. Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax. Mucosal Immunol. 2012 Jul; 5(4):444-54. PMID: 22472773.
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    14. De Arras L, Yang IV, Lackford B, Riches DW, Prekeris R, Freedman JH, Schwartz DA, Alper S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J Immunol. 2012 Mar 15; 188(6):2905-13. PMID: 22312129.
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    15. Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, Goleva E. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012 Mar 01; 188(5):2127-35. PMID: 22301548.
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    16. Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, Holers VM, Sakaguchi S, Riches DW. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice. Exp Lung Res. 2012 Mar; 38(2):55-66. PMID: 22185348.
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    17. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011 Oct; 179(4):1733-45. PMID: 21871427.
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    18. Condon TV, Sawyer RT, Fenton MJ, Riches DW. Lung dendritic cells at the innate-adaptive immune interface. J Leukoc Biol. 2011 Nov; 90(5):883-95. PMID: 21807741.
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    19. Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V. Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-ß release in lung epithelial cells. Am J Respir Cell Mol Biol. 2012 May; 46(5):573-81. PMID: 21799120.
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    20. Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L510-8. PMID: 21743030.
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    21. Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, Reisdorph N, Keith RC, Frankel SK, Riches DW. Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol. 2011 Jul 01; 187(1):527-37. PMID: 21632719.
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    22. Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL. Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp. 2011 May 02; (51). PMID: 21587154.
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    23. Mace KE, Lussier MP, Boulay G, Terry-Powers JL, Parfrey H, Perraud AL, Riches DW. TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling. J Cell Physiol. 2010 Nov; 225(2):444-53. PMID: 20458742.
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    24. Tollefson AK, Oberley-Deegan RE, Butterfield KT, Nicks ME, Weaver MR, Remigio LK, Decsesznak J, Chu HW, Bratton DL, Riches DW, Bowler RP. Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress. Free Radic Biol Med. 2010 Dec 15; 49(12):1937-46. PMID: 20887783.
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    25. Terry Powers JL, Mace KE, Parfrey H, Lee SJ, Zhang G, Riches DW. TNF receptor-1 (TNF-R1) ubiquitous scaffolding and signaling protein interacts with TNF-R1 and TRAF2 via an N-terminal docking interface. Biochemistry. 2010 Sep 14; 49(36):7821-9. PMID: 20704259.
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    26. Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010 Oct 01; 185(7):4030-41. PMID: 20805415.
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    27. Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL. PPAR? activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood. 2010 Nov 25; 116(22):4512-22. PMID: 20693431.
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    28. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol. 2010 Sep; 177(3):1549-61. PMID: 20671265.
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    29. Redente EF, Dwyer-Nield LD, Barrett BS, Riches DW, Malkinson AM. Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice. Anticancer Res. 2009 Dec; 29(12):5095-101. PMID: 20044622.
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    30. Honsho S, Nishikawa S, Amano K, Zen K, Adachi Y, Kishita E, Matsui A, Katsume A, Yamaguchi S, Nishikawa K, Isoda K, Riches DW, Matoba S, Okigaki M, Matsubara H. Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways. Circ Res. 2009 Nov 20; 105(11):1149-58. PMID: 19834007.
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    31. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86. PMID: 19633071.
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    32. Cha SI, Groshong SD, Frankel SK, Edelman BL, Cosgrove GP, Terry-Powers JL, Remigio LK, Curran-Everett D, Brown KK, Cool CD, Riches DW. Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):140-8. PMID: 19372246.
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    33. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009 Apr 17; 324(5925):387-9. PMID: 19264985.
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    34. Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009 Feb 26; 113(9):2047-55. PMID: 18952895.
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    35. Goleva E, Hauk PJ, Hall CF, Liu AH, Riches DW, Martin RJ, Leung DY. Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol. 2008 Sep; 122(3):550-9.e3. PMID: 18774390.
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    36. Riches DW, Cosgrove GP, Frankel SK. Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Introduction and perspective. Proc Am Thorac Soc. 2008 Apr 15; 5(3):287-9. PMID: 18403319.
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    37. Saavedra MT, Patterson AD, West J, Randell SH, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):679-88. PMID: 18218994.
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    38. Soond SM, Terry JL, Riches DW. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. FEBS Lett. 2006 Aug 21; 580(19):4591-6. PMID: 16876162.
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    39. Kostyk AG, Dahl KM, Wynes MW, Whittaker LA, Weiss DJ, Loi R, Riches DW. Regulation of chemokine expression by NaCl occurs independently of cystic fibrosis transmembrane conductance regulator in macrophages. Am J Pathol. 2006 Jul; 169(1):12-20. PMID: 16816357.
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    40. Frankel SK, Cosgrove GP, Cha SI, Cool CD, Wynes MW, Edelman BL, Brown KK, Riches DW. TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):293-304. PMID: 16272460.
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    41. Soond SM, Everson B, Riches DW, Murphy G. ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J Cell Sci. 2005 Jun 01; 118(Pt 11):2371-80. PMID: 15923650.
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    42. Van Linden AA, Cottin V, Frankel SK, Riches DW. Hierarchical phosphorylation of the TNF-alpha receptor, TNF-R1, by p42Mapk/Erk at basic Pro-directed kinase sites. Biochemistry. 2005 May 10; 44(18):6980-9. PMID: 15865443.
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    43. Wynes MW, Riches DW. Transcription of macrophage IGF-I exon 1 is positively regulated by the 5'-untranslated region and negatively regulated by the 5'-flanking region. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1089-98. PMID: 15681396.
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    44. Frankel SK, Moats-Staats BM, Cool CD, Wynes MW, Stiles AD, Riches DW. Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L805-12. PMID: 15618451.
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    45. Wynes MW, Frankel SK, Riches DW. IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal. J Leukoc Biol. 2004 Nov; 76(5):1019-27. PMID: 15316031.
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    46. Doan JE, Windmiller DA, Riches DW. Differential regulation of TNF-R1 signaling: lipid raft dependency of p42mapk/erk2 activation, but not NF-kappaB activation. J Immunol. 2004 Jun 15; 172(12):7654-60. PMID: 15187147.
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    47. Riches DW. Peroxisome proliferator-active receptor gamma: a legitimate target to control pulmonary inflammation? Am J Respir Crit Care Med. 2004 Jan 15; 169(2):145-6. PMID: 14718232.
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    48. Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, Johnson GL. Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. J Cell Sci. 2004 Jan 15; 117(Pt 2):243-55. PMID: 14676277.
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    49. Soond SM, Terry JL, Colbert JD, Riches DW. TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB. Mol Cell Biol. 2003 Nov; 23(22):8334-44. PMID: 14585990.
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    50. Gambelli F, Di P, Niu X, Friedman M, Hammond T, Riches DW, Ortiz LA. Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis. J Biol Chem. 2004 Jan 16; 279(3):2020-9. PMID: 14570868.
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    51. Wynes MW, Riches DW. Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J Immunol. 2003 Oct 01; 171(7):3550-9. PMID: 14500651.
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    52. Kerby GS, Cottin V, Accurso FJ, Hoffmann F, Chan ED, Fadok VA, Riches DW. Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L188-97. PMID: 12060576.
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    53. Cottin V, Doan JE, Riches DW. Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domain. J Immunol. 2002 Apr 15; 168(8):4095-102. PMID: 11937569.
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    54. Frankel SK, Van Linden AA, Riches DW. Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2). Biochem Biophys Res Commun. 2001 Oct 26; 288(2):313-20. PMID: 11606045.
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    55. Wojtczak HA, Kerby GS, Wagener JS, Copenhaver SC, Gotlin RW, Riches DW, Accurso FJ. Beclomethasone diproprionate reduced airway inflammation without adrenal suppression in young children with cystic fibrosis: a pilot study. Pediatr Pulmonol. 2001 Oct; 32(4):293-302. PMID: 11568990.
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    56. Chan ED, Riches DW, White CW. Redox paradox: effect of N-acetylcysteine and serum on oxidation reduction-sensitive mitogen-activated protein kinase signaling pathways. Am J Respir Cell Mol Biol. 2001 May; 24(5):627-32. PMID: 11350834.
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    57. Chan ED, Morris KR, Belisle JT, Hill P, Remigio LK, Brennan PJ, Riches DW. Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways. Infect Immun. 2001 Apr; 69(4):2001-10. PMID: 11254551.
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    58. Chan ED, Riches DW. IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am J Physiol Cell Physiol. 2001 Mar; 280(3):C441-50. PMID: 11171562.
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    59. Cottin V, Van Linden AA, Riches DW. Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis. J Biol Chem. 2001 May 18; 276(20):17252-60. PMID: 11278725.
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    60. Van Linden AA, Cottin V, Leu C, Riches DW. Phosphorylation of the membrane proximal region of tumor necrosis factor receptor CD120a (p55) at ERK consensus sites. J Biol Chem. 2000 Mar 10; 275(10):6996-7003. PMID: 10702263.
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    61. Uh S, Van Linden A, Riches DW. Phosphorylation of 130- and 95-kDa substrates associated with tumor necrosis factor-alpha receptor CD120a (p55). J Biol Chem. 2000 Jan 14; 275(2):793-800. PMID: 10625609.
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    62. Cottin V, Van Linden A, Riches DW. Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42(mapk/erk2) induces changes in its subcellular localization. J Biol Chem. 1999 Nov 12; 274(46):32975-87. PMID: 10551865.
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    63. Chan ED, Winston BW, Uh ST, Remigio LK, Riches DW. Systematic evaluation of the mitogen-activated protein kinases in the induction of iNOS by tumor necrosis factor-alpha and interferon-gamma. Chest. 1999 Jul; 116(1 Suppl):91S-92S. PMID: 10424611.
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    64. Sable CL, Riches DW. Cloning and functional activity of a novel truncated form of annexin IV in mouse macrophages. Biochem Biophys Res Commun. 1999 Apr 29; 258(1):162-7. PMID: 10222253.
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    65. Chan ED, Winston BW, Uh ST, Wynes MW, Rose DM, Riches DW. Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages. J Immunol. 1999 Jan 01; 162(1):415-22. PMID: 9886415.
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    66. Chan ED, Riches DW. Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNF-alpha. Biochem Biophys Res Commun. 1998 Dec 30; 253(3):790-6. PMID: 9918806.
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    67. Uh ST, Inoue Y, King TE, Chan ED, Newman LS, Riches DW. Morphometric analysis of insulin-like growth factor-I localization in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1998 Nov; 158(5 Pt 1):1626-35. PMID: 9817718.
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    68. Riches DW, Chan ED, Zahradka EA, Winston BW, Remigio LK, Lake FR. Cooperative signaling by tumor necrosis factor receptors CD120a (p55) and CD120b (p75) in the expression of nitric oxide and inducible nitric oxide synthase by mouse macrophages. J Biol Chem. 1998 Aug 28; 273(35):22800-6. PMID: 9712914.
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    69. Crippen TL, Riches DW, Hyde DM. Differential regulation of the expression of cytokine-induced neutrophil chemoattractant by mouse macrophages. Pathobiology. 1998; 66(1):24-32. PMID: 9577963.
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    70. Chan ED, Winston BW, Jarpe MB, Wynes MW, Riches DW. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF alpha. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13169-74. PMID: 9371818.
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    71. Winston BW, Chan ED, Johnson GL, Riches DW. Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages. J Immunol. 1997 Nov 01; 159(9):4491-7. PMID: 9379049.
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    72. Rose DM, Winston BW, Chan ED, Riches DW, Henson PM. Interferon-gamma and transforming growth factor-beta modulate the activation of mitogen-activated protein kinases and tumor necrosis factor-alpha production induced by Fc gamma-receptor stimulation in murine macrophages. Biochem Biophys Res Commun. 1997 Sep 08; 238(1):256-60. PMID: 9299489.
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    73. Martinez JA, King TE, Brown K, Jennings CA, Borish L, Mortenson RL, Khan TZ, Bost TW, Riches DW. Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung disease. Am J Physiol. 1997 Sep; 273(3 Pt 1):L676-83. PMID: 9316504.
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    74. Rose DM, Winston BW, Chan ED, Riches DW, Gerwins P, Johnson GL, Henson PM. Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis. J Immunol. 1997 Apr 01; 158(7):3433-8. PMID: 9120304.
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    75. Riches DW, Chan ED, Winston BW. TNF-alpha-induced regulation and signalling in macrophages. Immunobiology. 1996 Oct; 195(4-5):477-90. PMID: 8933152.
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    76. Rose DM, Fadok VA, Riches DW, Clay KL, Henson PM. Autocrine/paracrine involvement of platelet-activating factor and transforming growth factor-beta in the induction of phosphatidylserine recognition by murine macrophages. J Immunol. 1995 Dec 15; 155(12):5819-25. PMID: 7499871.
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    77. Riches DW. Signalling heterogeneity as a contributing factor in macrophage functional diversity. Semin Cell Biol. 1995 Dec; 6(6):377-84. PMID: 8748145.
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    78. Winston BW, Remigio LK, Riches DW. Preferential involvement of MEK1 in the tumor necrosis factor-alpha-induced activation of p42mapk/erk2 in mouse macrophages. J Biol Chem. 1995 Nov 17; 270(46):27391-4. PMID: 7499190.
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    79. Fournier T, Riches DW, Winston BW, Rose DM, Young SK, Noble PW, Lake FR, Henson PM. Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-alpha and prostaglandin E2. J Immunol. 1995 Aug 15; 155(4):2123-33. PMID: 7636260.
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    80. Winston BW, Riches DW. Activation of p42mapk/erk2 following engagement of tumor necrosis factor receptor CD120a (p55) in mouse macrophages. J Immunol. 1995 Aug 01; 155(3):1525-33. PMID: 7636214.
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    81. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med. 1995 Apr; 151(4):1075-82. PMID: 7697234.
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    82. Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, Riches DW. Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1614-8. PMID: 7878028.
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    83. Henson PM, Riches DW. Modulation of macrophage maturation by cytokines and lipid mediators: a potential role in resolution of pulmonary inflammation. Ann N Y Acad Sci. 1994 May 28; 725:298-308. PMID: 8031002.
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    84. Bost TW, Riches DW, Schumacher B, Carré PC, Khan TZ, Martinez JA, Newman LS. Alveolar macrophages from patients with beryllium disease and sarcoidosis express increased levels of mRNA for tumor necrosis factor-alpha and interleukin-6 but not interleukin-1 beta. Am J Respir Cell Mol Biol. 1994 May; 10(5):506-13. PMID: 8179912.
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    85. Lake FR, Noble PW, Henson PM, Riches DW. Functional switching of macrophage responses to tumor necrosis factor-alpha (TNF alpha) by interferons. Implications for the pleiotropic activities of TNF alpha. J Clin Invest. 1994 Apr; 93(4):1661-9. PMID: 7512988.
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    86. Lake FR, Dempsey EC, Spahn JD, Riches DW. Involvement of protein kinase C in macrophage activation by poly(I.C). Am J Physiol. 1994 Jan; 266(1 Pt 1):C134-42. PMID: 8304411.
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    87. Carré PC, King TE, Mortensen R, Riches DW. Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages. Am J Respir Cell Mol Biol. 1994 Jan; 10(1):100-5. PMID: 8292374.
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    88. Wenzel SE, Trudeau JB, Riches DW, Westcott JY, Henson PM. Peritoneal lavage fluid alters patterns of eicosanoid production in murine bone marrow-derived and peritoneal macrophages: dependency on inflammatory state of the peritoneum. Inflammation. 1993 Dec; 17(6):743-56. PMID: 8112832.
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    89. Fadok VA, Laszlo DJ, Noble PW, Weinstein L, Riches DW, Henson PM. Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells. J Immunol. 1993 Oct 15; 151(8):4274-85. PMID: 8409401.
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    90. Laszlo DJ, Henson PM, Remigio LK, Weinstein L, Sable C, Noble PW, Riches DW. Development of functional diversity in mouse macrophages. Mutual exclusion of two phenotypic states. Am J Pathol. 1993 Aug; 143(2):587-97. PMID: 8342604.
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    91. Noble PW, Henson PM, Lucas C, Mora-Worms M, Carré PC, Riches DW. Transforming growth factor-beta primes macrophages to express inflammatory gene products in response to particulate stimuli by an autocrine/paracrine mechanism. J Immunol. 1993 Jul 15; 151(2):979-89. PMID: 8335923.
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    92. Noble PW, Lake FR, Henson PM, Riches DW. Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. J Clin Invest. 1993 Jun; 91(6):2368-77. PMID: 8514850.
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    93. Fadok VA, Voelker DR, Campbell PA, Bratton DL, Cohen JJ, Noble PW, Riches DW, Henson PM. The ability to recognize phosphatidylserine on apoptotic cells is an inducible function in murine bone marrow-derived macrophages. Chest. 1993 Feb; 103(2 Suppl):102S. PMID: 8381344.
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    94. Underwood GA, Riches DW. Transmembrane-mediated changes in [Ca2+] are involved in the signaling pathway leading to macrophage cytocidal differentiation: implications of localized changes in intracellular [Ca2+] and of interferon priming on Ca2+ utilization. Mol Biol Cell. 1992 Mar; 3(3):335-47. PMID: 1627833.
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    95. Riches DW, Underwood GA. Expression of interferon-beta during the triggering phase of macrophage cytocidal activation. Evidence for an autocrine/paracrine role in the regulation of this state. J Biol Chem. 1991 Dec 25; 266(36):24785-92. PMID: 1761573.
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    96. Carré PC, Mortenson RL, King TE, Noble PW, Sable CL, Riches DW. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest. 1991 Dec; 88(6):1802-10. PMID: 1752942.
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    97. Lew DB, Leslie CC, Henson PM, Riches DW. Role of endogenously derived leukotrienes in the regulation of lysosomal enzyme expression in macrophages exposed to beta 1,3-glucan. J Leukoc Biol. 1991 Mar; 49(3):266-76. PMID: 1825502.
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    98. Noble PW, Henson PM, Riches DW. Insulin-like growth factor-1 (IGF-1) mRNA expression in bone marrow derived macrophages is stimulated by chrysotile asbestos and bleomycin. A potential marker for a reparative macrophage phenotype. Chest. 1991 Mar; 99(3 Suppl):79S-80S. PMID: 1705203.
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    99. De Whalley CV, Riches DW. Influence of the cytocidal macrophage phenotype on the degradation of acetylated low density lipoproteins: dual regulation of scavenger receptor activity and of intracellular degradation of endocytosed ligand. Exp Cell Res. 1991 Feb; 192(2):460-8. PMID: 1899073.
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    100. Riches DW, Young SK, Seccombe JF, Henson JE, Clay KL, Henson PM. The subcellular distribution of platelet-activating factor in stimulated human neutrophils. J Immunol. 1990 Nov 01; 145(9):3062-70. PMID: 2212673.
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    101. Riches DW, Henson PM, Remigio LK, Catterall JF, Strunk RC. Differential regulation of gene expression during macrophage activation with a polyribonucleotide. The role of endogenously derived IFN. J Immunol. 1988 Jul 01; 141(1):180-8. PMID: 3379303.
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    102. Riches DW, Channon JY, Leslie CC, Henson PM. Receptor-mediated signal transduction in mononuclear phagocytes. Prog Allergy. 1988; 42:65-122. PMID: 2845429.
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    103. Lew DB, Leslie CC, Riches DW, Henson PM. Induction of macrophage lysosomal hydrolase synthesis and secretion by beta-1,3-glucan. Cell Immunol. 1986 Jul; 100(2):340-50. PMID: 2944604.
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    104. Riches DW, Henson PM. Bacterial lipopolysaccharide suppresses the production of catalytically active lysosomal acid hydrolases in human macrophages. J Cell Biol. 1986 May; 102(5):1606-14. PMID: 3700468.
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    105. Riches DW, Henson PM. Functional aspects of mononuclear phagocyte involvement in lung inflammation. Ann N Y Acad Sci. 1986; 465:6-14. PMID: 3524364.
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    106. Riches DW, Watkins JL, Henson PM, Stanworth DR. Regulation of macrophage lysosomal secretion by adenosine, adenosine phosphate esters, and related structural analogues of adenosine. J Leukoc Biol. 1985 May; 37(5):545-57. PMID: 2984303.
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