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David W h Riches

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
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    R01CA050107     (RICHES, DAVID W)Apr 1, 1989 - Mar 31, 1993
    Role: Principal Investigator

    R01HL055549     (RICHES, DAVID W)May 1, 1996 - Apr 30, 2010
    Regulation of TNF receptor signaling and functions
    Role: Principal Investigator

    R01HL065326     (RICHES, DAVID W)Sep 15, 2000 - Jul 31, 2005
    Role: Principal Investigator

    R01HL068628     (RICHES, DAVID W.)Dec 12, 2001 - Apr 30, 2013
    Mechanisms of myofibroblast death in pulmonary fibrosis
    Role: Principal Investigator

    R21AI070941     (RICHES, DAVID W)Sep 15, 2007 - Aug 31, 2010
    Lung specific TNF-R1 signaling in TRUSS null mice
    Role: Principal Investigator

    R21AI103727     (RICHES, DAVID W.)Apr 15, 2013 - Mar 31, 2015
    Initial functional characterization of TRUSS-deficient mice
    Role: Principal Investigator

    R01HL114754     (RICHES, DAVID W.)Jun 1, 2013 - May 31, 2017
    DUSP1 as a therapeutic target in fibroproliferative acute lung injury
    Role: Principal Investigator

    R13HL123072     (RICHES, DAVID W.)Apr 1, 2014 - Mar 31, 2015
    Aspen Lung Conference: Rebuilding the Injured Lung
    Role: Principal Investigator

    R01HL126732     (DE LANGHE, STIJN PIET JOHAN)Apr 1, 2015 - Apr 30, 2019
    HL-Role of c-Myc in myofibroblast differentiation in pulmonary fibrosis
    Role: Co-Principal Investigator

    I01BX003471     (RICHES, DAVID W.)Jan 1, 2017 - Dec 31, 2020
    Therapeutic Targeting of PTPN13 in Idiopathic Pulmonary Fibrosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug; 187(8):1772-1786. PMID: 28618253.
      View in: PubMed
    2. Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015 Oct 07; 6:8472. PMID: 26442449; PMCID: PMC4598952.
    3. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827; PMCID: PMC4430970.
    4. Riches DW, Backos DS, Redente EF. ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis. Am J Pathol. 2015 Apr; 185(4):909-12. PMID: 25687558; PMCID: PMC4380839.
    5. Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37. PMID: 24325577; PMCID: PMC4068926.
    6. Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May; 184(5):1489-502. PMID: 24650563; PMCID: PMC4005983.
    7. Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A. Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nat Cell Biol. 2014 Jan; 16(1):47-54. PMID: 24316673; PMCID: PMC3876036.
    8. Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, Johnson TE, Ivanov S, Duan Q, Bala S, Condon T, van Rooijen N, Grainger JR, Belkaid Y, Ma'ayan A, Riches DW, Yokoyama WM, Ginhoux F, Henson PM, Randolph GJ. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. 2013 Sep 19; 39(3):599-610. PMID: 24012416; PMCID: PMC3820017.
    9. Keith RC, Sokolove J, Edelman BL, Lahey L, Redente EF, Holers VM, Sakaguchi S, Robinson WH, Riches DW. Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice. Arthritis Rheum. 2013 Jun; 65(6):1487-93. PMID: 23529475; PMCID: PMC3672393.
    10. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan; 43(1):276-85. PMID: 23520315; PMCID: PMC4015132.
    11. Trivedi R, Redente EF, Thakur A, Riches DW, Kompella UB. Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice. Nanotechnology. 2012 Dec 21; 23(50):505101. PMID: 23186914.
      View in: PubMed
    12. Fernandez-Boyanapalli R, Goleva E, Kolakowski C, Min E, Day B, Leung DY, Riches DW, Bratton DL, Sutherland ER. Obesity impairs apoptotic cell clearance in asthma. J Allergy Clin Immunol. 2013 Apr; 131(4):1041-7, 1047.e1-3. PMID: 23154082; PMCID: PMC4190068.
    13. Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Am J Respir Crit Care Med. 2012 Jul 01; 186(1):72-81. PMID: 22582160; PMCID: PMC3400991.
    14. De Arras L, Yang IV, Lackford B, Riches DW, Prekeris R, Freedman JH, Schwartz DA, Alper S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J Immunol. 2012 Mar 15; 188(6):2905-13. PMID: 22312129; PMCID: PMC3293945.
    15. Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, Goleva E. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012 Mar 01; 188(5):2127-35. PMID: 22301548; PMCID: PMC3368346.
    16. Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, Holers VM, Sakaguchi S, Riches DW. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice. Exp Lung Res. 2012 Mar; 38(2):55-66. PMID: 22185348.
      View in: PubMed
    17. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011 Oct; 179(4):1733-45. PMID: 21871427; PMCID: PMC3181358.
    18. Condon TV, Sawyer RT, Fenton MJ, Riches DW. Lung dendritic cells at the innate-adaptive immune interface. J Leukoc Biol. 2011 Nov; 90(5):883-95. PMID: 21807741; PMCID: PMC3206474.
    19. Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V. Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-ß release in lung epithelial cells. Am J Respir Cell Mol Biol. 2012 May; 46(5):573-81. PMID: 21799120; PMCID: PMC3359902.
    20. Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L510-8. PMID: 21743030; PMCID: PMC3191751.
    21. Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, Reisdorph N, Keith RC, Frankel SK, Riches DW. Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol. 2011 Jul 01; 187(1):527-37. PMID: 21632719.
      View in: PubMed
    22. Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL. Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp. 2011 May 02; (51). PMID: 21587154; PMCID: PMC3280633.
    23. Mace KE, Lussier MP, Boulay G, Terry-Powers JL, Parfrey H, Perraud AL, Riches DW. TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling. J Cell Physiol. 2010 Nov; 225(2):444-53. PMID: 20458742; PMCID: PMC4447216.
    24. Tollefson AK, Oberley-Deegan RE, Butterfield KT, Nicks ME, Weaver MR, Remigio LK, Decsesznak J, Chu HW, Bratton DL, Riches DW, Bowler RP. Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress. Free Radic Biol Med. 2010 Dec 15; 49(12):1937-46. PMID: 20887783; PMCID: PMC3780970.
    25. Terry Powers JL, Mace KE, Parfrey H, Lee SJ, Zhang G, Riches DW. TNF receptor-1 (TNF-R1) ubiquitous scaffolding and signaling protein interacts with TNF-R1 and TRAF2 via an N-terminal docking interface. Biochemistry. 2010 Sep 14; 49(36):7821-9. PMID: 20704259; PMCID: PMC2952493.
    26. Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010 Oct 01; 185(7):4030-41. PMID: 20805415; PMCID: PMC4346245.
    27. Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL. PPAR? activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood. 2010 Nov 25; 116(22):4512-22. PMID: 20693431; PMCID: PMC2996113.
    28. Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol. 2010 Sep; 177(3):1549-61. PMID: 20671265; PMCID: PMC2928984.
    29. Redente EF, Dwyer-Nield LD, Barrett BS, Riches DW, Malkinson AM. Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice. Anticancer Res. 2009 Dec; 29(12):5095-101. PMID: 20044622; PMCID: PMC2860728.
    30. Honsho S, Nishikawa S, Amano K, Zen K, Adachi Y, Kishita E, Matsui A, Katsume A, Yamaguchi S, Nishikawa K, Isoda K, Riches DW, Matoba S, Okigaki M, Matsubara H. Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways. Circ Res. 2009 Nov 20; 105(11):1149-58. PMID: 19834007.
      View in: PubMed
    31. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86. PMID: 19633071; PMCID: PMC2770781.
    32. Cha SI, Groshong SD, Frankel SK, Edelman BL, Cosgrove GP, Terry-Powers JL, Remigio LK, Curran-Everett D, Brown KK, Cool CD, Riches DW. Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):140-8. PMID: 19372246; PMCID: PMC2822976.
    33. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009 Apr 17; 324(5925):387-9. PMID: 19264985; PMCID: PMC2707798.
    34. Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009 Feb 26; 113(9):2047-55. PMID: 18952895; PMCID: PMC2651016.
    35. Goleva E, Hauk PJ, Hall CF, Liu AH, Riches DW, Martin RJ, Leung DY. Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol. 2008 Sep; 122(3):550-9.e3. PMID: 18774390; PMCID: PMC3930345.
    36. Riches DW, Cosgrove GP, Frankel SK. Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Introduction and perspective. Proc Am Thorac Soc. 2008 Apr 15; 5(3):287-9. PMID: 18403319.
      View in: PubMed
    37. Saavedra MT, Patterson AD, West J, Randell SH, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):679-88. PMID: 18218994; PMCID: PMC2396247.
    38. Soond SM, Terry JL, Riches DW. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. FEBS Lett. 2006 Aug 21; 580(19):4591-6. PMID: 16876162.
      View in: PubMed
    39. Kostyk AG, Dahl KM, Wynes MW, Whittaker LA, Weiss DJ, Loi R, Riches DW. Regulation of chemokine expression by NaCl occurs independently of cystic fibrosis transmembrane conductance regulator in macrophages. Am J Pathol. 2006 Jul; 169(1):12-20. PMID: 16816357; PMCID: PMC1698750.
    40. Frankel SK, Cosgrove GP, Cha SI, Cool CD, Wynes MW, Edelman BL, Brown KK, Riches DW. TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):293-304. PMID: 16272460; PMCID: PMC2644194.
    41. Soond SM, Everson B, Riches DW, Murphy G. ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J Cell Sci. 2005 Jun 01; 118(Pt 11):2371-80. PMID: 15923650.
      View in: PubMed
    42. Van Linden AA, Cottin V, Frankel SK, Riches DW. Hierarchical phosphorylation of the TNF-alpha receptor, TNF-R1, by p42Mapk/Erk at basic Pro-directed kinase sites. Biochemistry. 2005 May 10; 44(18):6980-9. PMID: 15865443.
      View in: PubMed
    43. Wynes MW, Riches DW. Transcription of macrophage IGF-I exon 1 is positively regulated by the 5'-untranslated region and negatively regulated by the 5'-flanking region. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1089-98. PMID: 15681396.
      View in: PubMed
    44. Frankel SK, Moats-Staats BM, Cool CD, Wynes MW, Stiles AD, Riches DW. Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L805-12. PMID: 15618451.
      View in: PubMed
    45. Wynes MW, Frankel SK, Riches DW. IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal. J Leukoc Biol. 2004 Nov; 76(5):1019-27. PMID: 15316031.
      View in: PubMed
    46. Doan JE, Windmiller DA, Riches DW. Differential regulation of TNF-R1 signaling: lipid raft dependency of p42mapk/erk2 activation, but not NF-kappaB activation. J Immunol. 2004 Jun 15; 172(12):7654-60. PMID: 15187147.
      View in: PubMed
    47. Riches DW. Peroxisome proliferator-active receptor gamma: a legitimate target to control pulmonary inflammation? Am J Respir Crit Care Med. 2004 Jan 15; 169(2):145-6. PMID: 14718232.
      View in: PubMed
    48. Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, Johnson GL. Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. J Cell Sci. 2004 Jan 15; 117(Pt 2):243-55. PMID: 14676277.
      View in: PubMed
    49. Soond SM, Terry JL, Colbert JD, Riches DW. TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB. Mol Cell Biol. 2003 Nov; 23(22):8334-44. PMID: 14585990; PMCID: PMC262424.
    50. Gambelli F, Di P, Niu X, Friedman M, Hammond T, Riches DW, Ortiz LA. Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis. J Biol Chem. 2004 Jan 16; 279(3):2020-9. PMID: 14570868.
      View in: PubMed
    51. Wynes MW, Riches DW. Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J Immunol. 2003 Oct 01; 171(7):3550-9. PMID: 14500651.
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    52. Kerby GS, Cottin V, Accurso FJ, Hoffmann F, Chan ED, Fadok VA, Riches DW. Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L188-97. PMID: 12060576.
      View in: PubMed
    53. Cottin V, Doan JE, Riches DW. Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domain. J Immunol. 2002 Apr 15; 168(8):4095-102. PMID: 11937569.
      View in: PubMed
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