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Ethan G Hughes

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

    Collapse Research 
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    F31NS056549     (HUGHES, ETHAN G)Jul 1, 2007 - Jun 30, 2011
    The role of astrocytes in inhibitory synaptogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017 Sep 13; 37(37):9037-9053. PMID: 28821643.
      View in: PubMed
    2. Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 08; 93(3):587-605.e7. PMID: 28132831.
      View in: PubMed
    3. Hughes EG, Appel B. The cell biology of CNS myelination. Curr Opin Neurobiol. 2016 Aug; 39:93-100. PMID: 27152449; PMCID: PMC4987163 [Available on 08/01/17].
    4. Peng X, Hughes EG, Moscato EH, Parsons TD, Dalmau J, Balice-Gordon RJ. Cellular plasticity induced by anti-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis antibodies. Ann Neurol. 2015 Mar; 77(3):381-98. PMID: 25369168; PMCID: PMC4365686.
    5. Hughes EG, Bergles DE. Hidden progenitors replace microglia in the adult brain. Neuron. 2014 Apr 16; 82(2):253-5. PMID: 24742453.
      View in: PubMed
    6. Hughes EG, Kang SH, Fukaya M, Bergles DE. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci. 2013 Jun; 16(6):668-76. PMID: 23624515; PMCID: PMC3807738.
    7. Moscato EH, Jain A, Peng X, Hughes EG, Dalmau J, Balice-Gordon RJ. Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies. Eur J Neurosci. 2010 Jul; 32(2):298-309. PMID: 20646055; PMCID: PMC2955837.
    8. Hughes EG, Peng X, Gleichman AJ, Lai M, Zhou L, Tsou R, Parsons TD, Lynch DR, Dalmau J, Balice-Gordon RJ. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci. 2010 Apr 28; 30(17):5866-75. PMID: 20427647; PMCID: PMC2868315.
    9. Hughes EG, Elmariah SB, Balice-Gordon RJ. Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis. Mol Cell Neurosci. 2010 Jan; 43(1):136-45. PMID: 19850128; PMCID: PMC2818511.
    10. Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Matà S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, Balice-Gordon R, Dalmau J. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009 Apr; 65(4):424-34. PMID: 19338055; PMCID: PMC2677127.
    11. Keene SD, Greco TM, Parastatidis I, Lee SH, Hughes EG, Balice-Gordon RJ, Speicher DW, Ischiropoulos H. Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics. 2009 Feb; 9(3):768-82. PMID: 19132682; PMCID: PMC2667946.
    12. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008 Dec; 7(12):1091-8. PMID: 18851928; PMCID: PMC2607118.
    13. Kayser MS, McClelland AC, Hughes EG, Dalva MB. Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci. 2006 Nov 22; 26(47):12152-64. PMID: 17122040.
      View in: PubMed
    14. Elmariah SB, Oh EJ, Hughes EG, Balice-Gordon RJ. Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors. J Neurosci. 2005 Apr 06; 25(14):3638-50. PMID: 15814795.
      View in: PubMed
    15. Elmariah SB, Hughes EG, Oh EJ, Balice-Gordon RJ. Neurotrophin signaling among neurons and glia during formation of tripartite synapses. Neuron Glia Biol. 2004 Nov; 1(4):1-11. PMID: 16528404; PMCID: PMC1397704.
    16. Hughes EG, Maguire JL, McMinn MT, Scholz RE, Sutherland ML. Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain Res Mol Brain Res. 2004 May 19; 124(2):114-23. PMID: 15135219.
      View in: PubMed
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