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Vesna Dragomir Todorovic

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology
    Other Positions
    TitleChair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-Anesthesiology


    Collapse Biography 
    Collapse education and training
    Faculty of Medicine, Belgrade, SerbiaMD09/1985Medicine
    University of Illinois, Chicago, ILPhD04/1990Pharmacology
    Darden School of Business, Charlottesville, VAMBA06/2010Business and Administration

    Collapse Research 
    Collapse research activities and funding
    K08DA000406     (JEVTOVIC-TODOROVIC, VESNA JEVTOVIC-TODOROVIC)Feb 5, 1999 - Dec 31, 2004
    NIH
    PSYCHOTIC AND ANALGESIC ACTIONS OF NMDA ANTAGONISTS
    Role: Principal Investigator

    R01HD044517     (JEVTOVIC-TODOROVIC, VESNA JEVTOVIC-TODOROVIC)Jul 1, 2003 - Dec 31, 2015
    NIH
    Anesthesia-induced developmental neurodegeneration
    Role: Principal Investigator

    R01GM118197     (JEVTOVIC-TODOROVIC, VESNA)Jul 1, 2003 - Mar 31, 2020
    NIH
    Anesthesia-induced developmental neurotoxicity.
    Role: Principal Investigator

    R03TW007423     (JEVTOVIC-TODOROVIC, VESNA JEVTOVIC-TODOROVIC)Aug 15, 2006 - Jul 31, 2010
    NIH
    The role of neurotrophins in anesthesia-induced developmental neuroapoptosis
    Role: Principal Investigator

    R21DA029342     (TODOROVIC, SLOBODAN M)May 1, 2010 - Apr 30, 2013
    NIH/NIDA
    Validation of voltage-dependent T-channel blockers in treatment of neuropathic pa
    Role: Principal Investigator

    K02HD075883     (JEVTOVIC-TODOROVIC, VESNA JEVTOVIC-TODOROVIC)Dec 1, 2013 - Nov 30, 2018
    NIH
    Anesthesia-induced developmental neurotoxicity: role of epigenetics
    Role: Principal Investigator

    R21HD080281     (JEVTOVIC-TODOROVIC, VESNA)Apr 1, 2015 - Mar 31, 2017
    NIH
    Anesthesia impairs developmental axon pruning and functional neuronal networks
    Role: Principal Investigator

    R01NS091353     (TODOROVIC, SLOBODAN M.)Jun 1, 2016 - Apr 30, 2021
    NIH/NINDS
    Molecular mechanisms of glycosylation of Cav3.2 channels in pain pathway
    Role: Principal Investigator

    R01GM123746     (TODOROVIC, SLOBODAN M.)Sep 1, 2017 - May 31, 2021
    NIH/NIGMS
    Novel neurosteroid anesthetics and perioperative analgesia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jevtovic-Todorovic V, Brambrick A. General Anesthesia and Young Brain: What is New? J Neurosurg Anesthesiol. 2018 Jul; 30(3):217-222. PMID: 28622158.
      View in: PubMed
    2. Jevtovic-Todorovic V. Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence? Anesthesiology. 2018 Apr; 128(4):832-839. PMID: 29271804.
      View in: PubMed
    3. Jevtovic-Todorovic V. Monkey business: the importance of mounting behavioural evidence for anaesthesia-induced developmental neurotoxicity. Br J Anaesth. 2018 Apr; 120(4):617-619. PMID: 29576100.
      View in: PubMed
    4. Obradovic AL, Atluri N, Dalla Massara L, Oklopcic A, Todorovic NS, Katta G, Osuru HP, Jevtovic-Todorovic V. Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus. Mol Neurobiol. 2018 01; 55(1):164-172. PMID: 28840469.
      View in: PubMed
    5. Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 01; 55(1):222-228. PMID: 28840475.
      View in: PubMed
    6. Jevtovic-Todorovic V. Anesthetics and Cognitive Impairments in Developing Children: What Is Our Responsibility? JAMA Pediatr. 2017 Dec 01; 171(12):1135-1136. PMID: 28973500.
      View in: PubMed
    7. Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2017 Sep 01; 119(3):443-447. PMID: 28969326.
      View in: PubMed
    8. Jevtovic-Todorovic V. Anaesthesia-induced developmental neurotoxicity: reality or fiction? Br J Anaesth. 2017 Sep 01; 119(3):455-457. PMID: 28969321.
      View in: PubMed
    9. Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol. 2017 Oct 01; 595(19):6327-6348. PMID: 28744923.
      View in: PubMed
    10. Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Avramovic V, Tesic V, Jevtovic-Todorovic V, Kanazir S, Ruzdijic S. Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats. Neurotox Res. 2017 Aug; 32(2):247-263. PMID: 28435999.
      View in: PubMed
    11. Jin L, Ding M, Oklopcic A, Aghdasi B, Xiao L, Li Z, Jevtovic-Todorovic V, Li X. Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides. Nanomedicine. 2017 Aug; 13(6):2049-2059. PMID: 28404518.
      View in: PubMed
    12. Weaver JL, Arandjelovic S, Brown G, K Mendu S, S Schappe M, Buckley MW, Chiu YH, Shu S, Kim JK, Chung J, Krupa J, Jevtovic-Todorovic V, Desai BN, Ravichandran KS, Bayliss DA. Hematopoietic pannexin 1 function is critical for neuropathic pain. Sci Rep. 2017 02 14; 7:42550. PMID: 28195232.
      View in: PubMed
    13. Jevtovic-Todorovic V, Bushnell PJ, Paule MG. Introduction to the special issue "Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings". Neurotoxicol Teratol. 2017 Mar - Apr; 60:1. PMID: 28179122.
      View in: PubMed
    14. Zanghi CN, Jevtovic-Todorovic V. A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies. Neurotoxicol Teratol. 2017 Mar - Apr; 60:24-32. PMID: 28039052.
      View in: PubMed
    15. Jevtovic-Todorovic V. General Anesthetics and Neurotoxicity: How Much Do We Know? Anesthesiol Clin. 2016 Sep; 34(3):439-51. PMID: 27521190.
      View in: PubMed
    16. Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology. 2016 06; 124(6):1311-1327. PMID: 27028464.
      View in: PubMed
    17. Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Pavkovic Z, Popic J, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats. Neurotox Res. 2016 10; 30(3):434-52. PMID: 27189477.
      View in: PubMed
    18. Pešic V, Milanovic D, Popic J, Smiljanic K, Tešic V, Kanazir S, Jevtovic-Todorovic V, Ruždijic S. Neonatal propofol anesthesia modifies activity-dependent processes and induces transient hyperlocomotor response to d-amphetamine during adolescence in rats. Int J Dev Neurosci. 2015 Dec; 47(Pt B):266-77. PMID: 26492981.
      View in: PubMed
    19. Obradovic AL, Scarpa J, Osuru HP, Weaver JL, Park JY, Pathirathna S, Peterkin A, Lim Y, Jagodic MM, Todorovic SM, Jevtovic-Todorovic V. Silencing the a2 subunit of ?-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury. Anesthesiology. 2015 Sep; 123(3):654-67. PMID: 26164299; PMCID: PMC4568754.
    20. Lunardi N, Oklopcic A, Prillaman M, Erisir A, Jevtovic-Todorovic V. Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum. Mol Neurobiol. 2015 Oct; 52(2):942-51. PMID: 26048670.
      View in: PubMed
    21. Joksovic PM, Lunardi N, Jevtovic-Todorovic V, Todorovic SM. Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus. Mol Neurobiol. 2015 Oct; 52(2):952-8. PMID: 26048671; PMCID: PMC4558348 [Available on 10/01/16].
    22. DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM. Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development. J Neurosci. 2015 Jan 28; 35(4):1481-92. PMID: 25632125; PMCID: PMC4308595.
    23. Jevtovic-Todorovic V. Good gas, bad gas: isoflurane, carbon monoxide, and which is which? Anesth Analg. 2014 Jun; 118(6):1160-2. PMID: 24842171; PMCID: PMC4030685.
    24. Milanovic D, Pešic V, Popic J, Tanic N, Kanazir S, Jevtovic-Todorovic V, Ruždijic S. Propofol anesthesia induces proapoptotic tumor necrosis factor-a and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain. J Neurosci Res. 2014 Oct; 92(10):1362-73. PMID: 24827783; PMCID: PMC5000575.
    25. Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014 Sep; 231(17):3503-3515. PMID: 24800894; PMCID: PMC4135044.
    26. Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One. 2014; 9(4):e91467. PMID: 24705276; PMCID: PMC3976247.
    27. Todorovic SM, Jevtovic-Todorovic V. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch. 2014 Apr; 466(4):701-6. PMID: 24482063.
      View in: PubMed
    28. Todorovic SM, Jevtovic-Todorovic V. Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal. 2014 Aug 20; 21(6):880-91. PMID: 24161125; PMCID: PMC4116091.
    29. Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM. Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience. 2013 Oct 10; 250:263-74. PMID: 23867767; PMCID: PMC3796369.
    30. Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 2013 Nov; 62(11):3828-38. PMID: 23835327; PMCID: PMC3806612.
    31. Jevtovic-Todorovic V. Functional implications of an early exposure to general anesthesia: are we changing the behavior of our children? Mol Neurobiol. 2013 Oct; 48(2):288-93. PMID: 23821029; PMCID: PMC3779498.
    32. Hemmings HC, Jevtovic-Todorovic V. Special issue on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2013 Jun; 110 Suppl 1:i1-2. PMID: 23722057.
      View in: PubMed
    33. Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth. 2013 Aug; 111(2):143-51. PMID: 23722106; PMCID: PMC3711392.
    34. Boscolo A, Milanovic D, Starr JA, Sanchez V, Oklopcic A, Moy L, Ori C C, Erisir A, Jevtovic-Todorovic V. Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain. Anesthesiology. 2013 May; 118(5):1086-97. PMID: 23411726; PMCID: PMC3879793.
    35. Boscolo A, Ori C, Bennett J, Wiltgen B, Jevtovic-Todorovic V. Mitochondrial protectant pramipexole prevents sex-specific long-term cognitive impairment from early anaesthesia exposure in rats. Br J Anaesth. 2013 Jun; 110 Suppl 1:i47-52. PMID: 23616588; PMCID: PMC3732064.
    36. Abd-Elsayed AA, Díaz-Gómez J, Barnett GH, Kurz A, Inton-Santos M, Barsoum S, Avitsian R, Ebrahim Z, Jevtovic-Todorovic V, Farag E. A case series discussing the anaesthetic management of pregnant patients with brain tumours. F1000Res. 2013; 2:92. PMID: 24358879; PMCID: PMC3814915.
    37. Todorovic SM, Jevtovic-Todorovic V. Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. Pflugers Arch. 2013 Jul; 465(7):921-7. PMID: 23322114.
      View in: PubMed
    38. Jevtovic-Todorovic V, Boscolo A, Sanchez V, Lunardi N. Anesthesia-induced developmental neurodegeneration: the role of neuronal organelles. Front Neurol. 2012; 3:141. PMID: 23087668; PMCID: PMC3468830.
    39. Popic J, Pesic V, Milanovic D, Todorovic S, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo. PLoS One. 2012; 7(4):e34396. PMID: 22496799; PMCID: PMC3319585.
    40. Jevtovic-Todorovic V. Developmental synaptogenesis and general anesthesia: a kiss of death? Curr Pharm Des. 2012; 18(38):6225-31. PMID: 22762476.
      View in: PubMed
    41. Naik AK, Latham JR, Obradovic A, Jevtovic-Todorovic V. Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats. Anesth Analg. 2012 Mar; 114(3):674-82. PMID: 22190549.
      View in: PubMed
    42. Boscolo A, Starr JA, Sanchez V, Lunardi N, DiGruccio MR, Ori C, Erisir A, Trimmer P, Bennett J, Jevtovic-Todorovic V. The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity. Neurobiol Dis. 2012 Mar; 45(3):1031-41. PMID: 22198380; PMCID: PMC3276740.
    43. Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology. 2011 Nov; 115(5):992-1002. PMID: 21909020; PMCID: PMC3203321.
    44. Jevtovic-Todorovic V. Pediatric anesthesia neurotoxicity: an overview of the 2011 SmartTots panel. Anesth Analg. 2011 Nov; 113(5):965-8. PMID: 22021791.
      View in: PubMed
    45. Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011 Nov; 80(5):900-10. PMID: 21821734; PMCID: PMC3198916.
    46. Jevtovic-Todorovic V. Anesthesia and the developing brain: are we getting closer to understanding the truth? Curr Opin Anaesthesiol. 2011 Aug; 24(4):395-9. PMID: 21659871.
      View in: PubMed
    47. Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol. 2011 Jun; 163(3):484-95. PMID: 21306582; PMCID: PMC3101611.
    48. Lunardi N, Hucklenbruch C, Latham JR, Scarpa J, Jevtovic-Todorovic V. Isoflurane impairs immature astroglia development in vitro: the role of actin cytoskeleton. J Neuropathol Exp Neurol. 2011 Apr; 70(4):281-91. PMID: 21412172; PMCID: PMC3063859.
    49. Jevtovic-Todorovic V. Developing brain and general anesthesia - is there a cause for concern? F1000 Med Rep. 2010 Sep 08; 2:68. PMID: 21173870; PMCID: PMC2990541.
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