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Jacob M Basak

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-AN Adult GeneralOperations

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Basak JM, Falk M, Dingman AL, Moore A, Tiemeier E, Aimale G, Quillinan N. Microglia interact with dendritic spines and regulate spine numbers after brain injury following resuscitation from a cardiac arrest. Exp Neurol. 2025 Oct; 392:115364. PMID: 40623512.
      View in: PubMed
    2. Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 11; 43(2_suppl):66-77. PMID: 37150606.
      View in: PubMed
    3. Basak JM, Ferreiro A, Cohen LS, Sheehan PW, Nadarajah CJ, Kanan MF, Sukhum KV, Dantas G, Musiek ES. Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2021 05; 152:105292. PMID: 33556539.
      View in: PubMed
    4. Han BH, Zhou ML, Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):E881-90. PMID: 25675483.
      View in: PubMed
    5. Kim J, Yoon H, Basak J, Kim J. Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms. Mol Cells. 2014 Nov; 37(11):767-76. PMID: 25358504.
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    6. Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aß amyloidosis. J Exp Med. 2012 Nov 19; 209(12):2149-56. PMID: 23129750.
      View in: PubMed
    7. Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, Holtzman DM, Bateman RJ. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PLoS One. 2012; 7(6):e38013. PMID: 22675504.
      View in: PubMed
    8. Basak JM, Kim J, Pyatkivskyy Y, Wildsmith KR, Jiang H, Parsadanian M, Patterson BW, Bateman RJ, Holtzman DM. Measurement of apolipoprotein E and amyloid ß clearance rates in the mouse brain using bolus stable isotope labeling. Mol Neurodegener. 2012 Apr 18; 7:14. PMID: 22512932.
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    9. Basak JM, Verghese PB, Yoon H, Kim J, Holtzman DM. Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aß uptake and degradation by astrocytes. J Biol Chem. 2012 Apr 20; 287(17):13959-71. PMID: 22383525.
      View in: PubMed
    10. Kim J, Jiang H, Park S, Eltorai AE, Stewart FR, Yoon H, Basak JM, Finn MB, Holtzman DM. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-ß amyloidosis. J Neurosci. 2011 Dec 07; 31(49):18007-12. PMID: 22159114.
      View in: PubMed
    11. Basak JM, Kim J. Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations. J Neurosci. 2010 Mar 31; 30(13):4526-7. PMID: 20357102.
      View in: PubMed
    12. Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 2009 Dec 10; 64(5):632-44. PMID: 20005821.
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    13. Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron. 2009 Aug 13; 63(3):287-303. PMID: 19679070.
      View in: PubMed
    14. Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem. 2008 Dec 12; 283(50):34554-62. PMID: 18940800.
      View in: PubMed
    15. Lee J, Basak JM, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development. 2007 Aug; 134(15):2795-806. PMID: 17611229.
      View in: PubMed
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