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Brooks M Hybertson

TitleAffiliate - DHHA
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/315-5510

    Collapse Research 
    Collapse research activities and funding
    R03AI061722     (HYBERTSON, BROOKS MICHAEL)Sep 30, 2004 - Aug 31, 2005
    NIH/NIAID
    Respirable ciprofloxacin aerosol for inhaled anthrax
    Role: Principal Investigator

    R43AI076196     (HYBERTSON, BROOKS MICHAEL)Aug 1, 2007 - Jan 31, 2009
    NIH/NIAID
    Low Cost Production of the Malaria Drug Artemether
    Role: Principal Investigator

    R43DE026086     (HYBERTSON, BROOKS MICHAEL)Mar 15, 2017 - Mar 14, 2018
    NIH/NIDCR
    A Topical Nrf2 Activator for Oral Mucositis
    Role: Principal Investigator

    R43AG053128     (HYBERTSON, BROOKS MICHAEL)Apr 1, 2017 - Sep 30, 2017
    NIH/NIA
    Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf2 Activation Pathway
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Joslin JM, McCall JR, Bzdek JP, Johnson DC, Hybertson BM. Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications. Plasma Med. 2016; 6(2):135-177. PMID: 28428835.
      View in: PubMed
    2. Hybertson BM, Gao B. Role of the Nrf2 signaling system in health and disease. Clin Genet. 2014 Nov; 86(5):447-52. PMID: 25099075.
      View in: PubMed
    3. Gao B, Doan A, Hybertson BM. The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clin Pharmacol. 2014; 6:19-34. PMID: 24520207; PMCID: PMC3917919.
    4. Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; 32(4-6):234-46. PMID: 22020111.
      View in: PubMed
    5. Hybertson BM. Solubility of a-Tocopheryl Succinate in Supercritical Carbon Dioxide Using Offline HPLC-MS/MS Analysis. J Chem Eng Data. 2007 May; 52(3):1123-1127. PMID: 20953319.
      View in: PubMed
    6. Hybertson BM. Solubility of the sesquiterpene alcohol patchoulol in supercritical carbon dioxide. J Chem Eng Data. 2007 Jan 01; 52(1):235-238. PMID: 19424449.
      View in: PubMed
    7. Ng KY, Zhou H, Zhang YL, Hybertson B, Randolph T, Christians U. Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 01; 847(2):188-98. PMID: 17070115.
      View in: PubMed
    8. Zhou H, Zhang Y, Biggs DL, Manning MC, Randolph TW, Christians U, Hybertson BM, Ng KY. Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. J Control Release. 2005 Oct 03; 107(2):288-99. PMID: 16009444.
      View in: PubMed
    9. Dunn JS, Nayar R, Campos J, Hybertson BM, Zhou Y, Manning MC, Repine JE, Stringer KA. Feasibility of tissue plasminogen activator formulated for pulmonary delivery. Pharm Res. 2005 Oct; 22(10):1700-7. PMID: 16180128; PMCID: PMC2040297.
    10. Hybertson BM, Chung JH, Fini MA, Lee YM, Allard JD, Hansen BN, Cho OJ, Shibao GN, Repine JE. Aerosol-administered alpha-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally. Exp Lung Res. 2005 Apr; 31(3):283-94. PMID: 15962709.
      View in: PubMed
    11. Yoon-yub P, Hybertson B, Wright R, Fini M, Elkins N, Repine J. Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment. Exp Lung Res. 2004 Oct-Nov; 30(7):571-84. PMID: 15371093.
      View in: PubMed
    12. Biggs DL, Lengsfeld CS, Hybertson BM, Ng KY, Manning MC, Randolph TW. In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response. J Control Release. 2003 Sep 19; 92(1-2):147-61. PMID: 14499193.
      View in: PubMed
    13. Hybertson BM, Jepson EK, Allard JD, Cho OJ, Lee YM, Huddleston JR, Weinman JP, Oliva AM, Repine JE. Transforming growth factor beta contributes to lung leak in rats given interleukin-1 intratracheally. Exp Lung Res. 2003 Sep; 29(6):361-73. PMID: 12888449.
      View in: PubMed
    14. Park YY, Hybertson BM, Wright RM, Repine JE. Serum ferritin increases in hemorrhaged rats that develop acute lung injury: effect of an iron-deficient diet. Inflammation. 2003 Aug; 27(4):257-63. PMID: 14527178.
      View in: PubMed
    15. Lee YM, Hybertson BM, Cho HG, Repine JE. Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. J Lab Clin Med. 2002 Nov; 140(5):312-9. PMID: 12434132.
      View in: PubMed
    16. Hybertson BM, Connelly KG, Buser RT, Repine JE. Ferritin and desferrioxamine attenuate xanthine oxidase-dependent leak in isolated perfused rat lungs. Inflammation. 2002 Aug; 26(4):153-9. PMID: 12184628.
      View in: PubMed
    17. Zhou H, Lengsfeld C, Claffey DJ, Ruth JA, Hybertson B, Randolph TW, Ng KY, Manning MC. Hydrophobic ion pairing of isoniazid using a prodrug approach. J Pharm Sci. 2002 Jun; 91(6):1502-11. PMID: 12115849.
      View in: PubMed
    18. Hybertson BM, Lee YM, Cho HG, Cho OJ, Repine JE. Alveolar type II cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally. Inflammation. 2000 Aug; 24(4):289-303. PMID: 10850852.
      View in: PubMed
    19. Lee YM, Hybertson BM, Cho HG, Terada LS, Cho O, Repine AJ, Repine JE. Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L75-80. PMID: 10893205.
      View in: PubMed
    20. Guidot DM, Kitlowski AD, Hybertson BM, Repine JE. Mitochondrial antioxidant function is a potential mechanism for organ differences in interleukin-1-mediated tolerance to oxidative injury. Am J Med Sci. 1999 Nov; 318(5):308-15. PMID: 10555093.
      View in: PubMed
    21. Faust-Chan R, Hybertson B, Flores SC, Wright RM, Repine JE. Initiation and tolerance to acute lung injury: yin-yang mechanisms involving interleukin-1. Chest. 1999 Jul; 116(1 Suppl):102S-103S. PMID: 10424624.
      View in: PubMed
    22. Stringer KA, Hybertson BM, Cho OJ, Cohen Z, Repine JE. Tissue plasminogen activator (tPA) inhibits interleukin-1 induced acute lung leak. Free Radic Biol Med. 1998 Jul 15; 25(2):184-8. PMID: 9667494.
      View in: PubMed
    23. Hybertson BM, Kitlowski RP, Jepson EK, Repine JE. Supercritical fluid-aerosolized vitamin E pretreatment decreases leak in isolated oxidant-perfused rat lungs. J Appl Physiol (1985). 1998 Jan; 84(1):263-8. PMID: 9451645.
      View in: PubMed
    24. Hybertson BM, Lee YM, Repine JE. Phagocytes and acute lung injury: dual roles for interleukin-1. Ann N Y Acad Sci. 1997 Dec 15; 832:266-73. PMID: 9704053.
      View in: PubMed
    25. Guidot DM, Bursten SL, Rice GC, Chaney RB, Singer JW, Repine AJ, Hybertson BM, Repine JE. Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. Am J Physiol. 1997 Nov; 273(5 Pt 1):L957-66. PMID: 9374722.
      View in: PubMed
    26. Hybertson BM, Jepson EK, Cho OJ, Clarke JH, Lee YM, Repine JE. TNF mediates lung leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally. Am J Respir Crit Care Med. 1997 Jun; 155(6):1972-6. PMID: 9196104.
      View in: PubMed
    27. Lee YM, Hybertson BM, Terada LS, Repine AJ, Cho HG, Repine JE. Mepacrine decreases lung leak in rats given interleukin-1 intratracheally. Am J Respir Crit Care Med. 1997 May; 155(5):1624-8. PMID: 9154867.
      View in: PubMed
    28. Terada LS, Hybertson BM, Connelly KG, Weill D, Piermattei D, Repine JE. XO increases neutrophil adherence to endothelial cells by a dual ICAM-1 and P-selectin-mediated mechanism. J Appl Physiol (1985). 1997 Mar; 82(3):866-73. PMID: 9074976.
      View in: PubMed
    29. Terada LS, Repine JE, Piermattei D, Hybertson BM. Endogenous nitric oxide decreases xanthine oxidase-mediated neutrophil adherence: role of P-selectin. J Appl Physiol (1985). 1997 Mar; 82(3):913-7. PMID: 9074982.
      View in: PubMed
    30. Hybertson BM, Bursten SL, Leff JA, Lee YM, Jepson EK, Dewitt CR, Zagorski J, Cho HG, Repine JE. Lisofylline prevents leak, but not neutrophil accumulation, in lungs of rats given IL-1 intratracheally. J Appl Physiol (1985). 1997 Jan; 82(1):226-32. PMID: 9029220.
      View in: PubMed
    31. Hybertson BM, Jepson EK, Clarke JH, Spelts RJ, Repine JB. Interleukin-1 stimulates rapid release of cytokine-induced neutrophil chemoattractant (CINC) in rat lungs. Inflammation. 1996 Oct; 20(5):471-83. PMID: 8894712.
      View in: PubMed
    32. Koh Y, Hybertson BM, Jepson EK, Repine JE. Tumor necrosis factor induced acute lung leak in rats: less than with interleukin-1. Inflammation. 1996 Oct; 20(5):461-9. PMID: 8894711.
      View in: PubMed
    33. Guidot DM, Hybertson BM, Kitlowski RP, Repine JE. Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs. Am J Physiol. 1996 Aug; 271(2 Pt 1):L225-9. PMID: 8770060.
      View in: PubMed
    34. Hybertson BM, Lampey AS, Clarke JH, Koh Y, Repine JE. N-acetylcysteine pretreatment attenuates paraquat-induced lung leak in rats. Redox Rep. 1995 Nov; 1(5):337-42. PMID: 27405831.
      View in: PubMed
    35. Koh Y, Hybertson BM, Jepson EK, Cho OJ, Repine JE. Cytokine-induced neutrophil chemoattractant is necessary for interleukin-1-induced lung leak in rats. J Appl Physiol (1985). 1995 Aug; 79(2):472-8. PMID: 7592205.
      View in: PubMed
    36. Guidot DM, Repine MJ, Hybertson BM, Repine JE. Inhaled nitric oxide prevents neutrophil-mediated, oxygen radical-dependent leak in isolated rat lungs. Am J Physiol. 1995 Jul; 269(1 Pt 1):L2-5. PMID: 7631809.
      View in: PubMed
    37. Hybertson BM, Leff JA, Beehler CJ, Barry PC, Repine JE. Effect of vitamin E deficiency and supercritical fluid aerosolized vitamin E supplementation on interleukin-1-induced oxidative lung injury in rats. Free Radic Biol Med. 1995 Mar; 18(3):537-42. PMID: 9101244.
      View in: PubMed
    38. Leff JA, Wilke CP, Hybertson BM, Shanley PF, Beehler CJ, Repine JE. Postinsult treatment with N-acetyl-L-cysteine decreases IL-1-induced neutrophil influx and lung leak in rats. Am J Physiol. 1993 Nov; 265(5 Pt 1):L501-6. PMID: 8238538.
      View in: PubMed
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