Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer.

Cummings CT, Linger RM, Cohen RA, Sather S, Kirkpatrick GD, Davies KD, DeRyckere D, Earp HS, Graham DK. Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer. Oncotarget. 2014 Nov 15; 5(21):10434-45.

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subject areas

Antibodies, Monoclonal
Apoptosis
Carboplatin
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
c-Mer Tyrosine Kinase
Down-Regulation
Drug Resistance
Drug Synergism
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Molecular Targeted Therapy
Oncogene Protein v-akt
Protein Kinase Inhibitors
Proto-Oncogene Proteins
Receptor Protein-Tyrosine Kinases
RNA, Small Interfering
Signal Transduction
STAT6 Transcription Factor
Tumor Stem Cell Assay

authors with profiles

Kurtis Daniel Davies