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Search Results to Thomas R Cech

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Cech, Thomas

One or more keywords matched the following items that are connected to Cech, Thomas

Item Type	Name
Academic Article	Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins.
Academic Article	Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit.
Academic Article	The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA.
Academic Article	Regulation of telomere length and function by a Myb-domain protein in fission yeast.
Academic Article	Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation.
Academic Article	Telomerase and chromosome end maintenance.
Academic Article	Chromosome end games.
Academic Article	Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein.
Academic Article	Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits.
Academic Article	Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.
Academic Article	Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.
Academic Article	Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex.
Academic Article	Human POT1 facilitates telomere elongation by telomerase.
Academic Article	Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Academic Article	Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Academic Article	Switching human telomerase on and off with hPOT1 protein in vitro.
Academic Article	A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Academic Article	POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
Academic Article	Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Academic Article	Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency.
Academic Article	Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Academic Article	How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Academic Article	Functional interaction between telomere protein TPP1 and telomerase.
Academic Article	Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.
Academic Article	Pot1, the putative telomere end-binding protein in fission yeast and humans.
Academic Article	Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova.
Academic Article	The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Academic Article	Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.
Academic Article	The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Academic Article	SnapShot: telomeres and telomerase.
Academic Article	Finding the end: recruitment of telomerase to telomeres.
Academic Article	The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats.
Academic Article	Yeast telomerase is specialized for C/A-rich RNA templates.
Academic Article	Telomerase and DNA end replication: no longer a lagging strand problem?
Academic Article	Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation.
Academic Article	DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Academic Article	Beginning to understand the end of the chromosome.
Academic Article	Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.
Academic Article	Reverse transcriptase motifs in the catalytic subunit of telomerase.
Academic Article	Molecular cloning of telomere-binding protein genes from Stylonychia mytilis.
Academic Article	Telomerase catalytic subunit homologs from fission yeast and human.
Academic Article	Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity.
Academic Article	Telomerase is a true reverse transcriptase. A review.
Academic Article	Two modes of survival of fission yeast without telomerase.
Academic Article	Telomerase and the maintenance of chromosome ends.
Academic Article	Protection of telomeres by the Ku protein in fission yeast.
Academic Article	The POT1-TPP1 telomere complex is a telomerase processivity factor.
Academic Article	Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit.
Academic Article	Global expression changes resulting from loss of telomeric DNA in fission yeast.
Academic Article	Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Academic Article	Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Academic Article	POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
Academic Article	Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Academic Article	Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
Academic Article	Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Academic Article	DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
Academic Article	Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena.
Concept	Telomere
Concept	Telomere-Binding Proteins
Academic Article	Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Academic Article	Inhibition of telomerase recruitment and cancer cell death.
Academic Article	Identification of human TERT elements necessary for telomerase recruitment to telomeres.
Academic Article	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Academic Article	Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.
Academic Article	Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.
Academic Article	A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Academic Article	Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Grant	TERT Promoter Mutations and Telomerase Reactivation in Cancer Cells
Grant	Telomerase and Telomeres: Structure, Function and Regulation
Grant	CHROMATIN STRUCTURE OF A TRANSCRIPTION UNIT
Academic Article	Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
Academic Article	Dynamics of human telomerase recruitment depend on template-telomere base pairing.
Academic Article	Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Concept	Telomere Homeostasis
Academic Article	Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.
Academic Article	The structure of human CST reveals a decameric assembly bound to telomeric DNA.
Academic Article	Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Academic Article	Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Academic Article	CST does not evict elongating telomerase but prevents initiation by ssDNA binding.
Academic Article	Reconstitution of a telomeric replicon organized by CST.

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Telomere