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Search Results to Charles A Dinarello

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Dinarello, Charles

One or more keywords matched the following items that are connected to Dinarello, Charles

Item Type	Name
Academic Article	Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.
Academic Article	Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice.
Academic Article	Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
Academic Article	IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family.
Academic Article	Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme.
Academic Article	Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells.
Academic Article	Interleukin 18 stimulates HIV type 1 in monocytic cells.
Academic Article	Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures.
Academic Article	Interleukin-18.
Academic Article	Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).
Academic Article	Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18.
Academic Article	Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.
Academic Article	IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma.
Academic Article	IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor.
Academic Article	Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
Academic Article	The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense.
Academic Article	Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain.
Academic Article	Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity.
Academic Article	Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells.
Academic Article	Down modulation of IL-18 expression by human papillomavirus type 16 E6 oncogene via binding to IL-18.
Academic Article	Identification of amino acid residues critical for biological activity in human interleukin-18.
Academic Article	Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.
Academic Article	Novel targets for interleukin 18 binding protein.
Academic Article	IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation.
Academic Article	Interleukin-18 binding protein in acute graft versus host disease and engraftment following allogeneic peripheral blood stem cell transplants.
Academic Article	Role of interleukin-18 in host defense against disseminated Candida albicans infection.
Academic Article	Rat interleukin-18 binding protein: cloning, expression, and characterization.
Academic Article	Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction.
Academic Article	Interferon-alpha induces interleukin-18 binding protein in chronic hepatitis C patients.
Academic Article	A surface amebic cysteine proteinase inactivates interleukin-18.
Academic Article	Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF.
Academic Article	Interleukin-18 and host defense against infection.
Academic Article	Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
Academic Article	Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.
Academic Article	Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness.
Academic Article	The IL-1 family and inflammatory diseases.
Academic Article	Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide.
Academic Article	Interleukin-18 and the treatment of rheumatoid arthritis.
Academic Article	Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes.
Academic Article	Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene.
Academic Article	Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release.
Academic Article	Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein.
Academic Article	Interleukin-18 does not modulate the acute-phase response.
Academic Article	IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response.
Academic Article	IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Academic Article	Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.
Academic Article	The paradox of pro-inflammatory cytokines in cancer.
Academic Article	Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.
Academic Article	Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice.
Academic Article	Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury.
Academic Article	IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis.
Academic Article	Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.
Academic Article	IL-18 activity in systemic lupus erythematosus.
Academic Article	Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils.
Academic Article	Interleukin-18 treatment options for inflammatory diseases.
Academic Article	IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
Academic Article	Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus.
Academic Article	A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures.
Academic Article	Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Academic Article	Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein.
Academic Article	?2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.
Academic Article	IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease.
Academic Article	Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
Academic Article	IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components.
Academic Article	Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury.
Academic Article	Membrane interleukin-18 revisits membrane IL-1a in T-helper type 1 responses.
Academic Article	Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein.
Academic Article	Role of IL-18 in second-hand smoke-induced emphysema.
Academic Article	IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease.
Academic Article	Interleukin-18, interleukin-18 binding protein and impaired production of interferon-gamma in chronic renal failure.
Academic Article	The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.
Academic Article	Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.
Academic Article	Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome.
Academic Article	Overview of interleukin-18: more than an interferon-gamma inducing factor.
Academic Article	Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.
Academic Article	Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process.
Academic Article	Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Academic Article	Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.
Academic Article	Targeting interleukin 18 with interleukin 18 binding protein.
Academic Article	An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Academic Article	Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.
Academic Article	Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression.
Academic Article	Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens.
Academic Article	Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury.
Academic Article	Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
Academic Article	IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease.
Academic Article	The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures.
Academic Article	Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.
Academic Article	Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.
Academic Article	Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure.
Academic Article	Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Academic Article	Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.
Academic Article	Differences in signaling pathways by IL-1beta and IL-18.
Academic Article	Interleukin-32: a cytokine and inducer of TNFalpha.
Academic Article	Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease.
Academic Article	Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor.
Academic Article	High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein.
Academic Article	Interleukin-18 and the pathogenesis of inflammatory diseases.
Academic Article	IL-18 in autoimmunity: review.
Academic Article	IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction.
Academic Article	Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis.
Academic Article	Inflammasome activation and IL-1? and IL-18 processing during infection.
Academic Article	Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Concept	Interleukin-18 Receptor alpha Subunit
Concept	Interleukin-18
Concept	Receptors, Interleukin-18
Academic Article	Interleukin-37.
Academic Article	Overview of the interleukin-1 family of ligands and receptors.
Academic Article	Interleukin-18, more than a Th1 cytokine.
Academic Article	Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.
Academic Article	Interleukin-18 and IL-18 binding protein.
Academic Article	IL-37 requires the receptors IL-18Ra and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Academic Article	Normal free interleukin-18 (IL-18) plasma levels in dengue virus infection and the need to measure both total IL-18 and IL-18 binding protein levels.
Academic Article	IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.
Academic Article	Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.
Grant	Pathogenesis of Fever in Man
Grant	Pathogenesis of Fever in Man
Academic Article	IL-18 binding protein reverses the life-threatening hyperinflammation of a baby with the NLRC4 mutation.
Academic Article	OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Academic Article	Indeed, IL-18 is more than an inducer of IFN-?.
Academic Article	IL-18 and infections: Is there a role for targeted therapies?
Academic Article	A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling.

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Interleukin 18