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Katherine B Hisert

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    R01HL167956     (HISERT, KATHERINE B)May 1, 2023 - Apr 30, 2028
    NIH
    GM-CSF, macrophages, and susceptibility to Mycobacterium abscessus pulmonary infection
    Role: Principal Investigator
    K08HL136786     (HISERT, KATHERINE B)Apr 1, 2018 - Jun 30, 2023
    NIH
    Modulating macrophage-mediated Inflammation in cystic fibrosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hisert KB, Vladar EK. Cystic Fibrosis Airways: Does Disease Stem from Faulty Stem Cells? Am J Respir Crit Care Med. 2023 11 01; 208(9):913-914. PMID: 37751560.
      View in: PubMed
    2. Hisert KB, Birket SE, Clancy JP, Downey DG, Engelhardt JF, Fajac I, Gray RD, Lachowicz-Scroggins ME, Mayer-Hamblett N, Thibodeau P, Tuggle KL, Wainwright CE, De Boeck K. Understanding and addressing the needs of people with cystic fibrosis in the era of CFTR modulator therapy. Lancet Respir Med. 2023 10; 11(10):916-931. PMID: 37699420.
      View in: PubMed
    3. Ochoa AE, Congel JH, Corley JM, Janssen WJ, Nick JA, Malcolm KC, Hisert KB. Dectin-1-Independent Macrophage Phagocytosis of Mycobacterium abscessus. Int J Mol Sci. 2023 Jul 04; 24(13). PMID: 37446240.
      View in: PubMed
    4. De M, Hisert KB, Liles WC, Manicone AM, Hemann EA, Long ME. MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection. bioRxiv. 2023 Jan 22. PMID: 36712028.
      View in: PubMed
    5. Caverly LJ, Riquelme SA, Hisert KB. The Impact of Highly Effective Modulator Therapy on Cystic Fibrosis Microbiology and Inflammation. Clin Chest Med. 2022 12; 43(4):647-665. PMID: 36344072.
      View in: PubMed
    6. Nick JA, Malcolm KC, Hisert KB, Wheeler EA, Rysavy NM, Poch K, Caceres S, Lovell VK, Armantrout E, Saavedra MT, Calhoun K, Chatterjee D, Aboellail I, De P, Martiniano SL, Jia F, Davidson RM. Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway. Tuberculosis (Edinb). 2023 01; 138:102276. PMID: 36417800.
      View in: PubMed
    7. Carter SC, Franciosi AN, O'Shea KM, O'Carroll OM, Sharma A, Bell A, Keogan B, O'Reilly P, Coughlan S, Law SM, Gray RD, Hisert KB, Singh PK, Cooke G, Grogan B, De Gascun CF, Gallagher CG, Nicholson TT, Quon BS, McKone EF. Acute Pulmonary Exacerbation Phenotypes in Patients with Cystic Fibrosis. Ann Am Thorac Soc. 2022 11; 19(11):1818-1826. PMID: 35713619.
      View in: PubMed
    8. Nick JA, Dedrick RM, Gray AL, Vladar EK, Smith BE, Freeman KG, Malcolm KC, Epperson LE, Hasan NA, Hendrix J, Callahan K, Walton K, Vestal B, Wheeler E, Rysavy NM, Poch K, Caceres S, Lovell VK, Hisert KB, de Moura VC, Chatterjee D, De P, Weakly N, Martiniano SL, Lynch DA, Daley CL, Strong M, Jia F, Hatfull GF, Davidson RM. Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection. Cell. 2022 05 26; 185(11):1860-1874.e12. PMID: 35568033.
      View in: PubMed
    9. Jennings LK, Dreifus JE, Reichhardt C, Storek KM, Secor PR, Wozniak DJ, Hisert KB, Parsek MR. Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies. Cell Rep. 2021 02 23; 34(8):108782. PMID: 33626358.
      View in: PubMed
    10. Hisert KB. Rats Race to Keep Pace in the Growing Cystic Fibrosis Model Space. Am J Respir Crit Care Med. 2020 11 01; 202(9):1212-1214. PMID: 32692578.
      View in: PubMed
    11. Hisert KB, Birkland TP, Schoenfelt KQ, Long ME, Grogan B, Carter S, Liles WC, McKone EF, Becker L, Manicone AM, Gharib SA. CFTR Modulator Therapy Enhances Peripheral Blood Monocyte Contributions to Immune Responses in People With Cystic Fibrosis. Front Pharmacol. 2020; 11:1219. PMID: 33013356.
      View in: PubMed
    12. Hisert KB, Birkland TP, Schoenfelt KQ, Long ME, Grogan B, Carter S, Liles WC, McKone EF, Becker L, Manicone AM. Ivacaftor decreases monocyte sensitivity to interferon-? in people with cystic fibrosis. ERJ Open Res. 2020 Apr; 6(2). PMID: 32337217.
      View in: PubMed
    13. Kosamo S, Hisert KB, Dmyterko V, Nguyen C, Black RA, Holden TD, Radella F, Cotten PA, Goss CH, Aitken ML, Wurfel MM. Strong toll-like receptor responses in cystic fibrosis patients are associated with higher lung function. J Cyst Fibros. 2020 07; 19(4):608-613. PMID: 31813753.
      View in: PubMed
    14. Hisert KB, Liles WC, Manicone AM. A Flow Cytometric Method for Isolating Cystic Fibrosis Airway Macrophages from Expectorated Sputum. Am J Respir Cell Mol Biol. 2019 07; 61(1):42-50. PMID: 30742539.
      View in: PubMed
    15. Wu X, Siehnel RJ, Garudathri J, Staudinger BJ, Hisert KB, Ozer EA, Hauser AR, Eng JK, Manoil C, Singh PK, Bruce JE. In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients. J Proteome Res. 2019 06 07; 18(6):2601-2612. PMID: 31060355.
      View in: PubMed
    16. Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher CG, Bruce JE, Stoltz DA, Welsh MJ, Hoffman LR, McKone EF, Singh PK. Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections. Am J Respir Crit Care Med. 2017 06 15; 195(12):1617-1628. PMID: 28222269.
      View in: PubMed
    17. Secor PR, Michaels LA, Smigiel KS, Rohani MG, Jennings LK, Hisert KB, Arrigoni A, Braun KR, Birkland TP, Lai Y, Hallstrand TS, Bollyky PL, Singh PK, Parks WC. Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo. Infect Immun. 2017 Jan; 85(1). PMID: 27795361.
      View in: PubMed
    18. Adam RJ, Hisert KB, Dodd JD, Grogan B, Launspach JL, Barnes JK, Gallagher CG, Sieren JP, Gross TJ, Fischer AJ, Cavanaugh JE, Hoffman EA, Singh PK, Welsh MJ, McKone EF, Stoltz DA. Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities. JCI Insight. 2016 Apr 07; 1(4):e86183. PMID: 27158673.
      View in: PubMed
    19. Hisert KB, Schoenfelt KQ, Cooke G, Grogan B, Launspach JL, Gallagher CG, Donnelly SC, Welsh MJ, Singh PK, McKone EF, Becker L. Ivacaftor-Induced Proteomic Changes Suggest Monocyte Defects May Contribute to the Pathogenesis of Cystic Fibrosis. Am J Respir Cell Mol Biol. 2016 Apr; 54(4):594-7. PMID: 27035067.
      View in: PubMed
    20. Kapnadak SG, Hisert KB, Pottinger PS, Limaye AP, Aitken ML. Infection control strategies that successfully controlled an outbreak of Mycobacterium abscessus at a cystic fibrosis center. Am J Infect Control. 2016 Feb; 44(2):154-9. PMID: 26442462.
      View in: PubMed
    21. Jorth P, Staudinger BJ, Wu X, Hisert KB, Hayden H, Garudathri J, Harding CL, Radey MC, Rezayat A, Bautista G, Berrington WR, Goddard AF, Zheng C, Angermeyer A, Brittnacher MJ, Kitzman J, Shendure J, Fligner CL, Mittler J, Aitken ML, Manoil C, Bruce JE, Yahr TL, Singh PK. Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs. Cell Host Microbe. 2015 Sep 09; 18(3):307-19. PMID: 26299432.
      View in: PubMed
    22. Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, Peris E, Schoenfelt KQ, Kuzma JN, Larson I, Billing PS, Landerholm RW, Crouthamel M, Gozal D, Hwang S, Singh PK, Becker L. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab. 2014 Oct 07; 20(4):614-25. PMID: 25242226.
      View in: PubMed
    23. Kirksey MA, Tischler AD, Sim?one R, Hisert KB, Uplekar S, Guilhot C, McKinney JD. Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity. Infect Immun. 2011 Jul; 79(7):2829-38. PMID: 21576344.
      View in: PubMed
    24. Gordon RJ, Chez N, Jia H, Zeller B, Sobieszczyk M, Brennan C, Hisert KB, Lee MH, Vavagiakis P, Lowy FD. The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):466-72. PMID: 20686410.
      View in: PubMed
    25. Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C. A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Mol Microbiol. 2005 Jun; 56(5):1234-45. PMID: 15882417.
      View in: PubMed
    26. Hisert KB, Kirksey MA, Gomez JE, Sousa AO, Cox JS, Jacobs WR, Nathan CF, McKinney JD. Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infect Immun. 2004 Sep; 72(9):5315-21. PMID: 15322028.
      View in: PubMed
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