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Nicholas Walter

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-6038

    Collapse Research 
    Collapse research activities and funding
    I01BX004527     (WALTER, NICHOLAS D)Oct 1, 2019 - Mar 31, 2024
    NIH
    Impact of Sterilizing and Non-sterilizing Antibiotics on M. tuberculosis rRNA Synthesis
    Role: Principal Investigator
    R21AI135652     (WALTER, NICHOLAS D)Jan 10, 2018 - Dec 31, 2019
    NIH
    Precursor-rRNA profiling as a measure of drug activity in tuberculosis
    Role: Principal Investigator
    R01AI127300     (DAVIS, JOHN LUCIAN;NAHID, PAYAM ;SCHOOLNIK, GARY K;WALTER, NICHOLAS D)Aug 3, 2017 - Jul 31, 2023
    NIH
    Sputum Transcriptomic Expression Profiling in Study 31: Express 31
    Role: Co-Principal Investigator
    IK2CX000914     (WALTER, NICHOLAS D)Apr 1, 2014 - Mar 31, 2019
    NIH
    Blood Expression Profiles as a Biomarker for Responses to Tuberculosis Treatment
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lyons MA, Obregon-Henao A, Ramey ME, Bauman AA, Pauly S, Rossmassler K, Reid J, Karger B, Walter ND, Robertson GT. Use of Multiple Pharmacodynamic Measures to Deconstruct the Nix-TB Regimen in a Short-Course Murine Model of Tuberculosis. bioRxiv. 2023 Nov 11. PMID: 37986955.
      View in: PubMed
    2. Wynn EA, Dide-Agossou C, Reichlen M, Rossmassler K, Al Mubarak R, Reid JJ, Tabor ST, Born SEM, Ransom MR, Davidson RM, Walton KN, Benoit JB, Hoppers A, Loy DE, Bauman AA, Massoudi LM, Dolganov G, Strong M, Nahid P, Voskuil MI, Robertson GT, Moore CM, Walter ND. Transcriptional adaptation of Mycobacterium tuberculosis that survives prolonged multi-drug treatment in mice. mBio. 2023 Dec 19; 14(6):e0236323. PMID: 37905920.
      View in: PubMed
    3. Walter ND, Ernest JP, Dide-Agossou C, Bauman AA, Ramey ME, Rossmassler K, Massoudi LM, Pauly S, Al Mubarak R, Voskuil MI, Kaya F, Sarathy JP, Zimmerman MD, Dartois V, Podell BK, Savic RM, Robertson GT. Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses. Antimicrob Agents Chemother. 2023 09 19; 67(9):e0028423. PMID: 37565762.
      View in: PubMed
    4. Wynn EA, Dide-Agossou C, Reichlen M, Rossmassler K, Al Mubarak R, Reid JJ, Tabor ST, Born SEM, Ransom MR, Davidson RM, Walton KN, Benoit JB, Hoppers A, Bauman AA, Massoudi LM, Dolganov G, Nahid P, Voskuil MI, Robertson GT, Moore CM, Walter ND. Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice. bioRxiv. 2023 Mar 08. PMID: 36945388.
      View in: PubMed
    5. Reichlen MJ, Born SEM, Lyons MA, Rossmassler K, Reid J, Robertson GT, Walter ND, Voskuil MI. Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency. Antimicrob Agents Chemother. 2023 01 24; 67(1):e0148322. PMID: 36622159.
      View in: PubMed
    6. Dide-Agossou C, Bauman AA, Ramey ME, Rossmassler K, Al Mubarak R, Pauly S, Voskuil MI, Garcia-Cremades M, Savic RM, Nahid P, Moore CM, Tasneen R, Nuermberger EL, Robertson GT, Walter ND. Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments. Antimicrob Agents Chemother. 2022 04 19; 66(4):e0231021. PMID: 35311519.
      View in: PubMed
    7. Dide-Agossou C, Rossmassler K, Reid J, Purohit J, Savic RM, Nahid P, Phillips PPJ, Moore CM, Walter ND. MOVER approximated CV: A tool for quantifying precision in ratiometric droplet digital PCR assays. J Pharm Biomed Anal. 2022 Apr 01; 212:114664. PMID: 35192991.
      View in: PubMed
    8. Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, Kaswabuli S, Byanyima P, Sanyu I, Zawedde J, Worodria W, Voskuil MI, Savic RM, Nahid P, Davis JL, Huang L, Moore CM, Walter ND. Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden. Microbiol Spectr. 2021 10 31; 9(2):e0048121. PMID: 34494858.
      View in: PubMed
    9. Walter ND, Born SEM, Robertson GT, Reichlen M, Dide-Agossou C, Ektnitphong VA, Rossmassler K, Ramey ME, Bauman AA, Ozols V, Bearrows SC, Schoolnik G, Dolganov G, Garcia B, Musisi E, Worodria W, Huang L, Davis JL, Nguyen NV, Nguyen HV, Nguyen ATV, Phan H, Wilusz C, Podell BK, Sanoussi ND, de Jong BC, Merle CS, Affolabi D, McIlleron H, Garcia-Cremades M, Maidji E, Eshun-Wilson F, Aguilar-Rodriguez B, Karthikeyan D, Mdluli K, Bansbach C, Lenaerts AJ, Savic RM, Nahid P, V?squez JJ, Voskuil MI. Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens. Nat Commun. 2021 05 18; 12(1):2899. PMID: 34006838.
      View in: PubMed
    10. Meyer AJ, Ochom E, Turimumahoro P, Byanyima P, Sanyu I, Lalitha R, Kaswabuli S, Andama A, Walter ND, Katamba A, Cattamanchi A, Worodria W, Huang L, Yoon C, Davis JL. C-Reactive Protein Testing for Active Tuberculosis among Inpatients without HIV in Uganda: a Diagnostic Accuracy Study. J Clin Microbiol. 2020 12 17; 59(1). PMID: 33087439.
      View in: PubMed
    11. Musisi E, Matovu DK, Bukenya A, Kaswabuli S, Zawedde J, Andama A, Byanyima P, Sanyu I, Sessolo A, Seremba E, Davis JL, Worodria W, Huang L, Walter ND, Mayanja-Kizza H. Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB. Afr Health Sci. 2018 Sep; 18(3):512-522. PMID: 30602982.
      View in: PubMed
    12. Voskuil MI, Covey CR, Walter ND. Antibiotic Lethality and Membrane Bioenergetics. Adv Microb Physiol. 2018; 73:77-122. PMID: 30262111.
      View in: PubMed
    13. Ofori-Anyinam B, Dolganov G, Van T, Davis JL, Walter ND, Garcia BJ, Voskuil M, Fissette K, Diels M, Driesen M, Meehan CJ, Yeboah-Manu D, Coscolla M, Gagneux S, Antonio M, Schoolnik G, Gehre F, de Jong BC. Significant under expression of the DosR regulon in M.?tuberculosis complex lineage 6 in sputum. Tuberculosis (Edinb). 2017 05; 104:58-64. PMID: 28454650.
      View in: PubMed
    14. Garcia BJ, Loxton AG, Dolganov GM, Van TT, Davis JL, de Jong BC, Voskuil MI, Leach SM, Schoolnik GK, Walzl G, Strong M, Walter ND. Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients. Tuberculosis (Edinb). 2016 09; 100:89-94. PMID: 27553415.
      View in: PubMed
    15. Katagira W, Walter ND, Den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL. Empiric TB Treatment of Severely Ill Patients With HIV and Presumed Pulmonary TB Improves Survival. J Acquir Immune Defic Syndr. 2016 07 01; 72(3):297-303. PMID: 26918546.
      View in: PubMed
    16. Walter ND, Reves R, Davis JL. Blood transcriptional signatures for tuberculosis diagnosis: a glass half-empty perspective. Lancet Respir Med. 2016 06; 4(6):e28. PMID: 27304799.
      View in: PubMed
    17. Walter ND, Miller MA, Vasquez J, Weiner M, Chapman A, Engle M, Higgins M, Quinones AM, Rosselli V, Canono E, Yoon C, Cattamanchi A, Davis JL, Phang T, Stearman RS, Datta G, Garcia BJ, Daley CL, Strong M, Kechris K, Fingerlin TE, Reves R, Geraci MW. Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation. J Clin Microbiol. 2016 Feb; 54(2):274-82. PMID: 26582831.
      View in: PubMed
    18. Garcia B, Walter ND, Dolganov G, Coram M, Davis JL, Schoolnik GK, Strong M. A minimum variance method for genome-wide data-driven normalization of quantitative real-time polymerase chain reaction expression data. Anal Biochem. 2014 Aug 01; 458:11-3. PMID: 24780223.
      View in: PubMed
    19. Cattamanchi A, Walter ND, Metcalfe JZ, Davis JL. A transcriptional signature for active TB: have we found the needle in the haystack? PLoS Med. 2013 Oct; 10(10):e1001539. PMID: 24167454.
      View in: PubMed
    20. Dowdy DW, Davis JL, den Boon S, Walter ND, Katamba A, Cattamanchi A. Population-level impact of same-day microscopy and Xpert MTB/RIF for tuberculosis diagnosis in Africa. PLoS One. 2013; 8(8):e70485. PMID: 23950942.
      View in: PubMed
    21. Andama AO, den Boon S, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L. Prevalence and outcomes of cryptococcal antigenemia in HIV-seropositive patients hospitalized for suspected tuberculosis in Uganda. J Acquir Immune Defic Syndr. 2013 Jun 01; 63(2):189-94. PMID: 23542636.
      View in: PubMed
    22. Davis JL, Dowdy DW, den Boon S, Walter ND, Katamba A, Cattamanchi A. Test and treat: a new standard for smear-positive tuberculosis. J Acquir Immune Defic Syndr. 2012 Sep 01; 61(1):e6-8. PMID: 22918128.
      View in: PubMed
    23. Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L. Oral antimicrobial rinse to reduce mycobacterial culture contamination among tuberculosis suspects in Uganda: a prospective study. PLoS One. 2012; 7(7):e38888. PMID: 22808020.
      View in: PubMed
    24. Walter ND, Jasmer RM, Grinsdale J, Kawamura LM, Hopewell PC, Nahid P. Reaching the limits of tuberculosis prevention among foreign-born individuals: a tuberculosis-control program perspective. Clin Infect Dis. 2008 Jan 01; 46(1):103-6. PMID: 18171222.
      View in: PubMed
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