 Connection
Thomas Cech to Introns
This is a "connection" page, showing publications Thomas Cech has written about Introns.
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Connection Strength |
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4.667 |
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Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR. Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA. 2008 Oct; 14(10):2013-29.
Score: 0.280
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Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan; 31(1):41-51.
Score: 0.231
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Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 2004 Aug-Oct; 24(4-5):362-85.
Score: 0.211
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Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA. 2002 May; 8(5):647-58.
Score: 0.180
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Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. J Mol Biol. 1997 Aug 01; 270(5):711-23.
Score: 0.130
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Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science. 1997 Feb 07; 275(5301):847-9.
Score: 0.125
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Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science. 1996 Jan 19; 271(5247):345-8.
Score: 0.117
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Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 1995 Jul 28; 82(2):221-30.
Score: 0.113
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Tanner MA, Cech TR. An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs. RNA. 1995 Jun; 1(4):349-50.
Score: 0.112
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Cech T. Group I introns: new molecular mechanisms for mRNA repair. Biotechnology (N Y). 1995 Apr; 13(4):323-6.
Score: 0.110
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Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. RNA. 1995 Mar; 1(1):36-45.
Score: 0.110
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Zaug AJ, D?vila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu). Biochemistry. 1994 Dec 13; 33(49):14935-47.
Score: 0.108
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Downs WD, Cech TR. A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site. Genes Dev. 1994 May 15; 8(10):1198-211.
Score: 0.104
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Cech TR, Damberger SH, Gutell RR. Representation of the secondary and tertiary structure of group I introns. Nat Struct Biol. 1994 May; 1(5):273-80.
Score: 0.103
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Murphy FL, Cech TR. GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. J Mol Biol. 1994 Feb 11; 236(1):49-63.
Score: 0.102
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Zaug AJ, McEvoy MM, Cech TR. Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem. Biochemistry. 1993 Aug 10; 32(31):7946-53.
Score: 0.098
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Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. 1986. Biotechnology. 1992; 24:57-62.
Score: 0.088
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Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR. Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11105-9.
Score: 0.088
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Gampel A, Cech TR. Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes Dev. 1991 Oct; 5(10):1870-80.
Score: 0.087
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D?vila-Aponte JA, Huss VA, Sogin ML, Cech TR. A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus. Nucleic Acids Res. 1991 Aug 25; 19(16):4429-36.
Score: 0.086
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Woodson SA, Cech TR. Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA. Biochemistry. 1991 Feb 26; 30(8):2042-50.
Score: 0.083
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Cech TR. RNA editing: world's smallest introns? Cell. 1991 Feb 22; 64(4):667-9.
Score: 0.083
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Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990; 59:543-68.
Score: 0.077
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Latham JA, Zaug AJ, Cech TR. Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence. Methods Enzymol. 1990; 181:558-69.
Score: 0.077
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Flor PJ, Flanegan JB, Cech TR. A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. EMBO J. 1989 Nov; 8(11):3391-9.
Score: 0.076
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Woodson SA, Cech TR. Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell. 1989 Apr 21; 57(2):335-45.
Score: 0.073
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Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9.
Score: 0.072
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Cech TR. Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review. Gene. 1988 Dec 20; 73(2):259-71.
Score: 0.071
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Barfod ET, Cech TR. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes Dev. 1988 Jun; 2(6):652-63.
Score: 0.069
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Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA. 2007 Apr; 13(4):536-48.
Score: 0.063
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Zaug AJ, Cech TR. The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase. Biochemistry. 1986 Aug 12; 25(16):4478-82.
Score: 0.061
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Cech TR. Ribozymes, the first 20 years. Biochem Soc Trans. 2002 Nov; 30(Pt 6):1162-6.
Score: 0.047
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Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 2002 Jul 11; 418(6894):222-8.
Score: 0.046
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Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308.
Score: 0.042
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Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR. Multiple folding pathways for the P4-P6 RNA domain. Biochemistry. 2000 Oct 10; 39(40):12465-75.
Score: 0.040
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Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. RNA. 1999 Dec; 5(12):1665-74.
Score: 0.038
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Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. EMBO J. 1999 Nov 15; 18(22):6491-500.
Score: 0.038
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Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 1999 Oct 26; 38(43):14224-37.
Score: 0.038
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Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science. 1998 Oct 09; 282(5387):259-64.
Score: 0.035
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Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8479-84.
Score: 0.035
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Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54.
Score: 0.033
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Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997 Sep; 3(9):1037-51.
Score: 0.033
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Weinstein LB, Jones BC, Cosstick R, Cech TR. A second catalytic metal ion in group I ribozyme. Nature. 1997 Aug 21; 388(6644):805-8.
Score: 0.033
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Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997 Aug 15; 277(5328):955-9.
Score: 0.032
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Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 1997 Aug; 3(8):838-49.
Score: 0.032
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Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Res. 1996 Oct 01; 24(19):3722-7.
Score: 0.031
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Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science. 1996 Sep 20; 273(5282):1678-85.
Score: 0.031
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Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science. 1996 Sep 20; 273(5282):1696-9.
Score: 0.031
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Golden BL, Cech TR. Conformational switches involved in orchestrating the successive steps of group I RNA splicing. Biochemistry. 1996 Mar 26; 35(12):3754-63.
Score: 0.030
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Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 1996 Jan 30; 35(4):1201-11.
Score: 0.029
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Tanner M, Cech T. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus. RNA. 1996 Jan; 2(1):74-83.
Score: 0.029
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Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 1995 Jun 13; 34(23):7728-38.
Score: 0.028
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Zaug AJ, Cech TR. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA. 1995 Jun; 1(4):363-74.
Score: 0.028
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Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science. 1995 Feb 03; 267(5198):675-9.
Score: 0.027
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Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 1994 Nov 22; 33(46):13856-63.
Score: 0.027
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Sullenger BA, Cech TR. Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. Nature. 1994 Oct 13; 371(6498):619-22.
Score: 0.027
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Murphy FL, Wang YH, Griffith JD, Cech TR. Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme. Science. 1994 Sep 16; 265(5179):1709-12.
Score: 0.027
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Wang YH, Murphy FL, Cech TR, Griffith JD. Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy. J Mol Biol. 1994 Feb 11; 236(1):64-71.
Score: 0.025
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Strobel SA, Cech TR. Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme. Biochemistry. 1993 Dec 14; 32(49):13593-604.
Score: 0.025
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Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 1993 Jan 07; 361(6407):85-8.
Score: 0.024
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Legault P, Herschlag D, Celander DW, Cech TR. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic Acids Res. 1992 Dec 25; 20(24):6613-9.
Score: 0.024
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Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. J Biol Chem. 1992 Sep 05; 267(25):17479-82.
Score: 0.023
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Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 1992 Jul 09; 358(6382):123-8.
Score: 0.023
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Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry. 1990 Nov 06; 29(44):10159-71.
Score: 0.020
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Cech TR. Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 1990 Jun; 10(3):239-61.
Score: 0.020
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Hicke BJ, Celander DW, MacDonald GH, Price CM, Cech TR. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1481-5.
Score: 0.019
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Murphy FL, Cech TR. Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9218-22.
Score: 0.019
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Yarus M, Levine J, Morin GB, Cech TR. A Tetrahymena intron nucleotide connected to the GTP/arginine site. Nucleic Acids Res. 1989 Sep 12; 17(17):6969-81.
Score: 0.019
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Barfod ET, Cech TR. The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Mol Cell Biol. 1989 Sep; 9(9):3657-66.
Score: 0.019
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Cech TR. RNA as an enzyme. Biochem Int. 1989 Jan; 18(1):7-14.
Score: 0.018
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Cech TR. Ribozymes and their medical implications. JAMA. 1988 Nov 25; 260(20):3030-4.
Score: 0.018
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Price JV, Cech TR. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA. Genes Dev. 1988 Nov; 2(11):1439-47.
Score: 0.018
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Zaug AJ, Cech TR. Self-splicing RNA and an RNA enzyme in Tetrahymena. J Protozool. 1987 Nov; 34(4):416-7.
Score: 0.016
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Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns. Nucleic Acids Res. 1987 Sep 25; 15(18):7217-21.
Score: 0.016
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Been MD, Cech TR. Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. Cell. 1987 Sep 11; 50(6):951-61.
Score: 0.016
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Cech TR. RNA as an enzyme. Sci Am. 1986 Nov; 255(5):64-75.
Score: 0.015
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Been MD, Cech TR. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell. 1986 Oct 24; 47(2):207-16.
Score: 0.015
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Cech TR. Biologic catalysis by RNA. Harvey Lect. 1986-1987; 82:123-44.
Score: 0.015
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Cech TR, Zaug AJ, Grabowski PJ. In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 1981 Dec; 27(3 Pt 2):487-96.
Score: 0.011
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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